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Volumn 2, Issue 5, 2002, Pages 593-603

Potential of DMXAA combination therapy for solid tumors

Author keywords

Antivascular; Cytotoxic; DMXAA; Gene therapy; Immunomodulation; Radiation; Tumor necrosis factor

Indexed keywords

1,2,3 BENZOTRIAZINE DERIVATIVE; 1,4 BIS[[2 (DIMETHYLAMINO N OXIDE)ETHYL]AMINO] 5,8 DIHYDROXYANTHRAQUINONE; 5 HYDROXYINDOLEACETIC ACID; 5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; ANGIOGENESIS INHIBITOR; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; CARBOPLATIN; CISPLATIN; COLCHICINE; COMBRETASTATIN A4; CYCLOPHOSPHAMIDE; CYTOKINE; CYTOTOXIC AGENT; DOCETAXEL; DOXORUBICIN; ENDOTOXIN; ETOPOSIDE; FLUOROURACIL; MELPHALAN; MITOFLAXONE; PACLITAXEL; THALIDOMIDE; TIRAPAZAMINE; TUMOR NECROSIS FACTOR; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE; XANTHONE 4 ACETIC ACID; 5,6 DIMETHYLXANTHENONEACETIC ACID; 5,6-DIMETHYLXANTHENONEACETIC ACID; XANTHENE DERIVATIVE; XANTHONE DERIVATIVE;

EID: 0036796195     PISSN: 14737140     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737140.2.5.593     Document Type: Review
Times cited : (26)

References (84)
  • 1
    • 0025093973 scopus 로고
    • Vascular attack as a therapeutic strategy for cancer
    • Denekamp J. Vascular attack as a therapeutic strategy for cancer Cancer Metastasis Rev. 9(3), 267-282 (1990).
    • (1990) Cancer Metastasis Rev , vol.9 , Issue.3 , pp. 267-282
    • Denekamp, J.1
  • 2
    • 0028028308 scopus 로고
    • Angiogenesis inhibition: A review
    • Auerbach W, Auerbach P, Angiogenesis inhibition: a review. Pharmacol. Ther. 63, 265-311 (1994).
    • (1994) Pharmacol. Ther , vol.63 , pp. 265-311
    • Auerbach, W.1    Auerbach, P.2
  • 3
    • 0026100365 scopus 로고
    • Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids
    • Rewcastle GW, Atwell GJ, Zhuang I, Baguley BC, Denny WA. Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids. J. Med. Chem. 34(1), 217-222 (1991).
    • (1991) J. Med. Chem , vol.34 , Issue.1 , pp. 217-222
    • Rewcastle, G.W.1    Atwell, G.J.2    Zhuang, I.3    Baguley, B.C.4    Denny, W.A.5
  • 4
    • 0000677063 scopus 로고    scopus 로고
    • Impact on tumour perfusion measured by dynamic magnetic resonance imaging (MRI), in the Phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Rustin G, Galbraith S, Taylor N et al. Impact on tumour perfusion measured by dynamic magnetic resonance imaging (MRI), in the Phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Ann. Oncol. 9, 126 (1998).
    • (1998) Ann. Oncol , vol.9 , pp. 126
    • Rustin, G.1    Galbraith, S.2    Taylor, N.3
  • 5
    • 0000226885 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent
    • Jameson MB, Thompson PI, Baguley BC et al. Phase I pharmacokinetic and pharmacodynamic study of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent. Proc. Am. Soc. Clin. Oncol. 19, 182a (2000).
    • (2000) Proc. Am. Soc. Clin. Oncol , vol.19
    • Jameson, M.B.1    Thompson, P.I.2    Baguley, B.C.3
  • 6
    • 0026602628 scopus 로고
    • Coley's toxins in perspective
    • Starnes CO. Coley's toxins in perspective. Nature 357, 11-12 (1992).
    • (1992) Nature , vol.357 , pp. 11-12
    • Starnes, C.O.1
  • 7
    • 0034754259 scopus 로고    scopus 로고
    • Fever and cancer in perspective
    • Hobohm U. Fever and cancer in perspective. Cancer Immunol. Immunother. 50, 391-396 (2001).
    • (2001) Cancer Immunol. Immunother , vol.50 , pp. 391-396
    • Hobohm, U.1
  • 8
    • 0022369998 scopus 로고
    • Tumor necrosis factor (TNF)
    • Old LJ. Tumor necrosis factor (TNF). Science 230, 630-632 (1985).
    • (1985) Science , vol.230 , pp. 630-632
    • Old, L.J.1
  • 10
    • 0026531756 scopus 로고
    • High-dose recombinant tumor necrosis factor-α in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma
    • Lienard D, Ewalenko P, Delmotte P, Renard JJ, Lejeune F. High-dose recombinant tumor necrosis factor-α in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. J. Clin. Oncol. 10, 52-60 (1992).
    • (1992) J. Clin. Oncol , vol.10 , pp. 52-60
    • Lienard, D.1    Ewalenko, P.2    Delmotte, P.3    Renard, J.J.4    Lejeune, F.5
  • 11
    • 0022640318 scopus 로고
    • Endotoxin-mediated necrosis and regression of established tumours in die mouse. A corrlative study of quantitative changes in blood flow and morphology
    • MacPherson GG, Niorth RJ. Endotoxin-mediated necrosis and regression of established tumours in die mouse. A corrlative study of quantitative changes in blood flow and morphology. Cancer Immunol. Immunother 21(3), 209-216 (1986).
    • (1986) Cancer Immunol. Immunother , vol.21 , Issue.3 , pp. 209-216
    • MacPherson, G.G.1    Niorth, R.J.2
  • 12
    • 0026038527 scopus 로고
    • Influence of recombinant tumour necrosis factor-α on blood flow and antibody localisation in human tumour xenografts in nude mice
    • Pimm MV, Gribben SJ, Morris TM. Influence of recombinant tumour necrosis factor-α on blood flow and antibody localisation in human tumour xenografts in nude mice. J. Cancer Res. Clin. Oncol. 117(6), 543-548 (1991).
    • (1991) J. Cancer Res. Clin. Oncol , vol.117 , Issue.6 , pp. 543-548
    • Pimm, M.V.1    Gribben, S.J.2    Morris, T.M.3
  • 13
    • 0023215827 scopus 로고
    • Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours
    • Smith GP, Calveley SB, Smith MJ, Baguley BC. Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours. Eur. J. Cancer Clin. Oncol. 23, 1209-1212 (1987).
    • (1987) Eur. J. Cancer Clin. Oncol , vol.23 , pp. 1209-1212
    • Smith, G.P.1    Calveley, S.B.2    Smith, M.J.3    Baguley, B.C.4
  • 14
    • 0024571314 scopus 로고
    • Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor-a on Colon 38 tumors in mice
    • Baguley BC, Calveley SB, Crowe KK, Fray LM, O'Rourke SA, Smith GP. Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor-a on Colon 38 tumors in mice. Eur. J. Cancer Clin. Oncol. 25, 263-269 (1989).
    • (1989) Eur. J. Cancer Clin. Oncol , vol.25 , pp. 263-269
    • Baguley, B.C.1    Calveley, S.B.2    Crowe, K.K.3    Fray, L.M.4    O'Rourke, S.A.5    Smith, G.P.6
  • 15
    • 0022589148 scopus 로고
    • Flavone acetic acid: A novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice
    • Plowman J, Narayanan VL, Dykes D et al. Flavone acetic acid. a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. Cancer Treat. Rep. 70, 631-638 (1986).
    • (1986) Cancer Treat. Rep , vol.70 , pp. 631-638
    • Plowman, J.1    Narayanan, V.L.2    Dykes, D.3
  • 16
    • 0023809013 scopus 로고
    • Flavone acetic add (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy
    • Evelhoch JL, Bissery M-C, Chabot GG et al. Flavone acetic add (NSC 347512)-induced modulation of murine tumor physiology monitored by in vivo nuclear magnetic resonance spectroscopy. Cancer Res. 48, 4749-4755 (1988).
    • (1988) Cancer Res , vol.48 , pp. 4749-4755
    • Evelhoch, J.L.1    Bissery, M.-C.2    Chabot, G.G.3
  • 17
    • 0024335180 scopus 로고
    • Blood flow failure as a major determinant in the antitumor action of flavone acetic acid (NSC 347512)
    • Zwi LJ, Baguley BC, Gavin JB, Wilson WR. Blood flow failure as a major determinant in the antitumor action of flavone acetic acid (NSC 347512). J. Natl Cancer Inst. 81, 1005-1013 (1989).
    • (1989) J. Natl. Cancer Inst , vol.81 , pp. 1005-1013
    • Zwi, L.J.1    Baguley, B.C.2    Gavin, J.B.3    Wilson, W.R.4
  • 18
    • 0025320055 scopus 로고
    • Correlation between in vivo induction of cytokine gene expression by flavone acetic acid and strict close-denpency and therapeutic efficacy against murine renal cancer
    • Mace KF, Hornung RL, Wiltrout RH, Young HA. Correlation between in vivo induction of cytokine gene expression by flavone acetic acid and strict close-denpency and therapeutic efficacy against murine renal cancer. Cancer Res. 50(6), 1742-1747 (1990).
    • (1990) Cancer Res , vol.50 , Issue.6 , pp. 1742-1747
    • Mace, K.F.1    Hornung, R.L.2    Wiltrout, R.H.3    Young, H.A.4
  • 19
    • 0024330132 scopus 로고
    • Flavone acetic acid-preclinical and clinical activity
    • Kerr DJ, Kaye SB. Flavone acetic acid-preclinical and clinical activity. Eur. J. Cancer Clin. Oncol. 25, 1271-1272 (1989).
    • (1989) Eur. J. Cancer Clin. Oncol , vol.25 , pp. 1271-1272
    • Kerr, D.J.1    Kaye, S.B.2
  • 20
    • 0028124643 scopus 로고
    • Correlation between immune and vascular activities of xanthenone acetic acid antitumor agents
    • Zwi LJ, Baguley BC, Gavin JB, Wilson WR. Correlation between immune and vascular activities of xanthenone acetic acid antitumor agents. Oncol. Res. 6, 79-85 (1994).
    • (1994) Oncol. Res , vol.6 , pp. 79-85
    • Zwi, L.J.1    Baguley, B.C.2    Gavin, J.B.3    Wilson, W.R.4
  • 21
    • 0025317052 scopus 로고
    • Potential antitumor agents. 60. Relationships between structure and in vivo colon 38 activity for 5-substituted 9-oxoxanthene-4-acetic acids
    • Atwell GJ, Rewcastle GW, Baguley BC, Denny WA. Potential antitumor agents. 60. Relationships between structure and in vivo colon 38 activity for 5-substituted 9-oxoxanthene-4-acetic acids. J. Med. Chem. 33, 1375-1379 (1990).
    • (1990) J. Med. Chem , vol.33 , pp. 1375-1379
    • Atwell, G.J.1    Rewcastle, G.W.2    Baguley, B.C.3    Denny, W.A.4
  • 22
    • 0031858141 scopus 로고    scopus 로고
    • Enhancement of the antitumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs
    • Lash CJ, Li AE, Rutland M, Baguley BC, Zwi LJ, Wilson WR. Enhancement of the antitumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs. Br. J. Cancer 78, 439-445 (1998).
    • (1998) Br. J. Cancer , vol.78 , pp. 439-445
    • Lash, C.J.1    Li, A.E.2    Rutland, M.3    Baguley, B.C.4    Zwi, L.J.5    Wilson, W.R.6
  • 23
    • 0033567097 scopus 로고    scopus 로고
    • Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent
    • Pedley RB, Sharma SK, Boxer GM et al. Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent. Cancer Res. 59(16), 3998-4003 (1999).
    • (1999) Cancer Res , vol.59 , Issue.16 , pp. 3998-4003
    • Pedley, R.B.1    Sharma, S.K.2    Boxer, G.M.3
  • 24
    • 0034662648 scopus 로고    scopus 로고
    • Scintigraphic imaging of the hypoxia marker (99m)Techtnetium-labeled 2,2′-1,4-diaminobutane)bis(2-methyl-3-butanone) dioxime (Tc-99m-labeled HL-91; Prognox): Noninvasive detection of tumor response to the antivascular agent 5,6-dimethylxanthenone-4-acetic acid
    • Siim BG, Laux WT, Rutland MD, Palmer BN, Wilson WR. Scintigraphic imaging of the hypoxia marker (99m)Techtnetium-labeled 2,2′-1,4-diaminobutane)bis(2-methyl-3-butanone) dioxime (Tc-99m-labeled HL-91; Prognox): noninvasive detection of tumor response to the antivascular agent 5,6-dimethylxanthenone-4-acetic acid. Cancer Res. 60(16), 4582-4588 (2000).
    • (2000) Cancer Res , vol.60 , Issue.16 , pp. 4582-4588
    • Siim, B.G.1    Laux, W.T.2    Rutland, M.D.3    Palmer, B.N.4    Wilson, W.R.5
  • 25
    • 0029063213 scopus 로고
    • Induction of tumour necrosis factor-α by single and repeated doses of the antitumor agent 5,6-dimethylxanthenone4-acetic acid
    • Philpott M, Baguley BC, Ching L-M. Induction of tumour necrosis factor-α by single and repeated doses of the antitumor agent 5,6-dimethylxanthenone4-acetic acid. Cancer Chemother. Pharmacol. 36, 143-148 (1995).
    • (1995) Cancer Chemother. Pharmacol , vol.36 , pp. 143-148
    • Philpott, M.1    Baguley, B.C.2    Ching, L.-M.3
  • 26
    • 0029087486 scopus 로고
    • Effect of thalidomide on tumour necrosis factor production and antitumour activity induced by 5,6-dimethylxanthenone-4-acetic acid
    • Ching L-M, Xu Z-F, Gummer BH, Palmer BD, Joseph WR, Baguley BC. Effect of thalidomide on tumour necrosis factor production and antitumour activity induced by 5,6-dimethylxanthenone-4-acetic acid. Br. J. Cancer 72, 339-343 (1995).
    • (1995) Br. J. Cancer , vol.72 , pp. 339-343
    • Ching, L.-M.1    Xu, Z.-F.2    Gummer, B.H.3    Palmer, B.D.4    Joseph, W.R.5    Baguley, B.C.6
  • 27
    • 0032895102 scopus 로고    scopus 로고
    • Thalidomide increases both intra-tumoural tumour necrosis factors production and antitumour activity in response to 5,6-dimethylxanthenone-4-acetic acid
    • Cao Z, Joseph WR, Browne WL et al. Thalidomide increases both intra-tumoural tumour necrosis factors production and antitumour activity in response to 5,6-dimethylxanthenone-4-acetic acid. Br. J. Cancer 80(5-6), 716-723 (1999).
    • (1999) Br. J. Cancer , vol.80 , Issue.5-6 , pp. 716-723
    • Cao, Z.1    Joseph, W.R.2    Browne, W.L.3
  • 28
    • 0033565644 scopus 로고    scopus 로고
    • Induction of intratumoral tumor necrosis factor (INF) synthesis and hemorrhagic necrosis by 5,6-dimethylxantenone-4-acetic acid (DMXAA) in TNF knockout mice
    • Ching LM, Goldsmith D, Joseph WR, Korner H, Sedgwick JD, Baguley BC. Induction of intratumoral tumor necrosis factor (INF) synthesis and hemorrhagic necrosis by 5,6-dimethylxantenone-4-acetic acid (DMXAA) in TNF knockout mice. Cancer Res. 59(14), 3304-3307 (1999).
    • (1999) Cancer Res , vol.59 , Issue.14 , pp. 3304-3307
    • Ching, L.M.1    Goldsmith, D.2    Joseph, W.R.3    Korner, H.4    Sedgwick, J.D.5    Baguley, B.C.6
  • 29
    • 0037068317 scopus 로고    scopus 로고
    • The antitumour activity of 5,6-dimethylxanthenone-4-acedc acid (DMXAA) in TNF receptors-1 knockout mice
    • (In Press)
    • Zhao L, Baguley BC, Kestell P, Ching L-M. The antitumour activity of 5,6-dimethylxanthenone-4-acedc acid (DMXAA) in TNF receptors-1 knockout mice. Br. J. Cancer (2002) (In Press).
    • (2002) Br. J. Cancer
    • Zhao, L.1    Baguley, B.C.2    Kestell, P.3    Ching, L.-M.4
  • 30
    • 0028280239 scopus 로고
    • Induction of tumor necrosis factors messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimedithylxanthenone-4-acetic acid (NSC 640488)
    • Ching LM, Joseph WF, Crosier KE, Baguley BC. Induction of tumor necrosis factors messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimedithylxanthenone-4-acetic acid (NSC 640488). Cancer Res. 54, 870 872 (1994).
    • (1994) Cancer Res , vol.54 , pp. 870-872
    • Ching, L.M.1    Joseph, W.F.2    Crosier, K.E.3    Baguley, B.C.4
  • 31
    • 0025793698 scopus 로고
    • Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine - Evidence for a vascular mechanism
    • Baguley BC, Holdaway KM, Thomsen LL, Zhuang L, Zwi LJ. Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine - evidence for a vascular mechanism. Eur. J. Cancer 27(4), 482-487 (1991).
    • (1991) Eur. J. Cancer , vol.27 , Issue.4 , pp. 482-487
    • Baguley, B.C.1    Holdaway, K.M.2    Thomsen, L.L.3    Zhuang, L.4    Zwi, L.J.5
  • 32
    • 0001851181 scopus 로고
    • Colchicine in the experimental chemotherapy of cancer
    • Ludford RJ. Colchicine in the experimental chemotherapy of cancer. J. Natl Cancer Inst. 6, 411-441 (1945).
    • (1945) J. Natl. Cancer Inst , vol.6 , pp. 411-441
    • Ludford, R.J.1
  • 35
    • 0030625644 scopus 로고    scopus 로고
    • Increased Plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethlylxanthenone-4-acetic acid, vinblastine and colchicine - Relation to vascular effects
    • Baguley BC, Zhuang L, Kestell P. Increased Plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethlylxanthenone-4-acetic acid, vinblastine and colchicine - relation to vascular effects. Oncol. Res. 9(2), 55-60 (1997).
    • (1997) Oncol. Res , vol.9 , Issue.2 , pp. 55-60
    • Baguley, B.C.1    Zhuang, L.2    Kestell, P.3
  • 36
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by Taxol
    • Schiff PB, Fant J, Horwitz SB. Promotion of microtubule assembly in vitro by Taxol. Nature 277, 665-667 (1979).
    • (1979) Nature , vol.277 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 37
    • 0030951899 scopus 로고    scopus 로고
    • Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
    • Dark GG, Hill SA, Prise VE, Tozer GM, Pettit GR, Chaplin DJ. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Res. 57(10), 1829-1834 (1997).
    • (1997) Cancer Res , vol.57 , Issue.10 , pp. 1829-1834
    • Dark, G.G.1    Hill, S.A.2    Prise, V.E.3    Tozer, G.M.4    Pettit, G.R.5    Chaplin, D.J.6
  • 38
    • 0000266648 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and toxicity study of weekly iv. combretastatin A4 phosphate (CA4P)
    • Stratford M, Folkes L, Galbraith S et al. Phase I pharmacokinetic and toxicity study of weekly iv. combretastatin A4 phosphate (CA4P). Clin. Cancer Res. 6, S280 (2000).
    • (2000) Clin. Cancer Res , vol.6
    • Stratford, M.1    Folkes, L.2    Galbraith, S.3
  • 39
    • 0037125028 scopus 로고    scopus 로고
    • Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethyl xanthenone-4-acetic acid
    • Ching L-M, Cao Z, Kieda C, Swain S, Jameson MB, Baguley BC. Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid. Br. Cancer 86, 1937-1942 (2002).
    • (2002) Br. Cancer , vol.86 , pp. 1937-1942
    • Ching, L.-M.1    Cao, Z.2    Kieda, C.3    Swain, S.4    Jameson, M.B.5    Baguley, B.C.6
  • 40
    • 0035164766 scopus 로고    scopus 로고
    • Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents
    • Kestell P, Zhao L, Jameson M, Stratford MRL, Folkes LY, Baguley BC. Measurement of plasma 5-hydroxyindoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents. Clin. Chim. Acta 314, 159-166 (2001).
    • (2001) Clin. Chim. Acta , vol.314 , pp. 159-166
    • Kestell, P.1    Zhao, L.2    Jameson, M.3    Stratford, M.R.L.4    Folkes, L.Y.5    Baguley, B.C.6
  • 41
    • 0026587009 scopus 로고
    • Endotoxin, interieukin-1 and tumor necrosis factor cause neutrophil dependent microvascular leakage in postcapillary venules
    • Yi ES, Ulich TR. Endotoxin, interieukin-1 and tumor necrosis factor cause neutrophil dependent microvascular leakage in postcapillary venules. Am. J. Pathol. 140(3), 659-663 (1992).
    • (1992) Am. J. Pathol , vol.140 , Issue.3 , pp. 659-663
    • Yi, E.S.1    Ulich, T.R.2
  • 42
    • 0026089375 scopus 로고
    • Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice
    • Thomsen LL, Ching LM Zhuang I, Gavin JB, Baguley BC. Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice. Cancer Res. 510), 77-81 (1991).
    • (1991) Cancer Res , vol.51 , Issue.1 , pp. 77-81
    • Thomsen, L.L.1    Ching, L.M.2    Zhuang, I.3    Gavin, J.B.4    Baguley, B.C.5
  • 43
    • 0034812637 scopus 로고    scopus 로고
    • The antitumour agent 5,6-dimethylxan thenone4-aceric acid acts in vitro on human mononuclear cells as a co-stimulator to other inducers of tumour necrosis factor
    • Philpott M, Ching LM, Baguley BC. The antitumour agent 5,6-dimethylxanthenone4-aceric acid acts in vitro on human mononuclear cells as a co-stimulator to other inducers of tumour necrosis factor. Eur. J. Cancer 37, 1930-1937 (2001).
    • (2001) Eur. J. Cancer , vol.37 , pp. 1930-1937
    • Philpott, M.1    Ching, L.M.2    Baguley, B.C.3
  • 44
    • 0026686247 scopus 로고
    • Antitumour responses to flavone-8-acetic acid and 5,6-dimethylx andienone-4-acetic acid in immune deficient mice
    • Ching LM, Joseph WP, Baguley BC. Antitumour responses to flavone-8-acetic acid and 5,6-dimethylxandienone-4-acetic acid in immune deficient mice. Br. J Cancer 66(1), 128-130 (1992).
    • (1992) Br. J. Cancer , vol.66 , Issue.1 , pp. 128-130
    • Ching, L.M.1    Joseph, W.P.2    Baguley, B.C.3
  • 45
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammitory agents aspirin and salicylate inhibit the activity of IκB kinase-P
    • 6706
    • Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammitory agents aspirin and salicylate inhibit the activity of IκB kinase-P. Nature 396(6706), 77-80 (1998).
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3
  • 46
    • 0030002174 scopus 로고    scopus 로고
    • Ablation of colorectal xenografts with combined radioinimunotherapy and tumor blood flow-modifying agents
    • Pedley RB, Boden JA. Boden R et al. Ablation of colorectal xenografts with combined radioinimunotherapy and tumor blood flow-modifying agents. Cancer Res. 56(14), 3293-3300 (1996).
    • (1996) Cancer Res , vol.56 , Issue.14 , pp. 3293-3300
    • Pedley, R.B.1    Boden, J.A.2    Boden, R.3
  • 47
    • 0029902597 scopus 로고    scopus 로고
    • Antivascular approaches to solid tumour therapy - Evaluation of tubulin binding agents
    • Chaplin DJ, Pettit GR. Parkins CS, Hill SA. Antivascular approaches to solid tumour therapy - evaluation of tubulin binding agents. Br. J. Cancer 74, S86-S88 (1996).
    • (1996) Br. J. Cancer , vol.74
    • Chaplin, D.J.1    Pettit, G.R.2    Parkins, C.S.3    Hill, S.A.4
  • 48
    • 0032053823 scopus 로고    scopus 로고
    • The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
    • Brown JM, Giaccia AJ. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res. 58(7), 1408-1416 (1998).
    • (1998) Cancer Res , vol.58 , Issue.7 , pp. 1408-1416
    • Brown, J.M.1    Giaccia, A.J.2
  • 49
    • 0010992283 scopus 로고    scopus 로고
    • Tumor physiology and drug resistance
    • Tannock IF. Tumor physiology and drug resistance. Lancet 351, 9-16 (1998).
    • (1998) Lancet , vol.351 , pp. 9-16
    • Tannock, I.F.1
  • 50
    • 0031016945 scopus 로고    scopus 로고
    • Mechanisms of enhancement of the antitumour activity of melphalan by the tumour blood flow inhibitor 5,6-dimethylxanthenone-4-acetic acid
    • Pruijn FB, van Daalen M, Holford NHG, Wilson WR. Mechanisms of enhancement of the antitumour activity of melphalan by the tumour blood flow inhibitor 5,6-dimethylxanthenone-4-acetic acid. Cancer Chemother Pharmacol. 39, 541-546 (1997).
    • (1997) Cancer Chemother. Pharmacol , vol.39 , pp. 541-546
    • Pruijn, F.B.1    van Daalen, M.2    Holford, N.H.G.3    Wilson, W.R.4
  • 51
    • 0034923996 scopus 로고    scopus 로고
    • Improving local tumor control by combining vascular targeting drugs, mild hyperthermia and radiation
    • Horsman MR, Murata R, Overgaard J. Improving local tumor control by combining vascular targeting drugs, mild hyperthermia and radiation. Acta Oncol. 40(4), 497-503 (2001).
    • (2001) Acta Oncol , vol.40 , Issue.4 , pp. 497-503
    • Horsman, M.R.1    Murata, R.2    Overgaard, J.3
  • 52
    • 0026970404 scopus 로고
    • Nuclear factor kappa B - An oxidative stress-responsive transcription factor of eukaryotic cells (a review)
    • Schreck R, Albermann K, Baeuerle PA. Nuclear factor kappa B - an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free. Radic. Res. Commun. 17, 221-237 (1992).
    • (1992) Free. Radic. Res. Commun , vol.17 , pp. 221-237
    • Schreck, R.1    Albermann, K.2    Baeuerle, P.A.3
  • 53
    • 0031775298 scopus 로고    scopus 로고
    • Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Wilson WR, Li AE, Cowan DSM, Siim BG. Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Int. J. Radiat. Oncol. Biol. Phys. 42(4), 905-908 (1998).
    • (1998) Int. J. Radiat. Oncol. Biol. Phys , vol.42 , Issue.4 , pp. 905-908
    • Wilson, W.R.1    Li, A.E.2    Cowan, D.S.M.3    Siim, B.G.4
  • 54
    • 0034759198 scopus 로고    scopus 로고
    • Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethy lxanthenone-4-acetic acid
    • Murata R, Siemann DW, Overgaard J, Horsman MR. Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-acetic acid. Radiat. Res. 156, 503-509 (2001).
    • (2001) Radiat. Res , vol.156 , pp. 503-509
    • Murata, R.1    Siemann, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 55
    • 0028234390 scopus 로고
    • Combining bioreductive drugs (SR 4233 or SN 23862) with the vasoactive agents flavone acetic acid or 5,6-dimethy lxanthenone acetic acid
    • Cliffe S, Taylor ML, Rutland M, Baguley BC, Hill RP, Wilson WR. Combining bioreductive drugs (SR 4233 or SN 23862) with the vasoactive agents flavone acetic acid or 5,6-dimethylxanthenone acetic acid. Int. J. Radiat. Oncol. Biol. Phys. 29, 373 377 (1994).
    • (1994) Int. J. Radiat. Oncol. Biol. Phys , vol.29 , pp. 373-377
    • Cliffe, S.1    Taylor, M.L.2    Rutland, M.3    Baguley, B.C.4    Hill, R.P.5    Wilson, W.R.6
  • 56
    • 0028864273 scopus 로고
    • Hypoxia-activated prodrugs as antitumour agents: Strategies for maximising tumour cell killing
    • Wilson WR, Pruijn FB. Hypoxia-activated prodrugs as antitumour agents: strategies for maximising tumour cell killing. Clin. Exp. Pharmacol. Physiol. 22, 881-885 (1995).
    • (1995) Clin. Exp. Pharmacol. Physiol , vol.22 , pp. 881-885
    • Wilson, W.R.1    Pruijn, F.B.2
  • 57
    • 0029935930 scopus 로고    scopus 로고
    • Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide, nitracrine N-oxide and AQ4N
    • Wilson WR, Denny WA, Pullen SM et al. Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide, nitracrine N-oxide and AQ4N. Br. J. Cancer 74, S43-S47 (1996).
    • (1996) Br. J. Cancer , vol.74
    • Wilson, W.R.1    Denny, W.A.2    Pullen, S.M.3
  • 58
    • 0031017640 scopus 로고    scopus 로고
    • Chemotherapy with DMXAA (5,6-dimethylxanthenone-4-acetic acid) in combination with CI-1010 (1H-in,imidazole-1-ethanol,alpha-[ [(2-bromoethyl)amino]methyl]-2-nitro-,monohydrobromide (R isomer)) against advanced stage murine colon carcinoma 26
    • Vincent PW, Roberts BJ, Elliott WL, Leopold WR. Chemotherapy with DMXAA (5,6-dimethylxanthenone-4-acetic acid) in combination with CI-1010 (1H-in,imidazole-1-ethanol,alpha-[[(2-bromoethyl)amino]methyl] -2-nitro-, monohydrobromide (R isomer)) against advanced stage murine colon carcinoma 26. Oncol. Rep. 4(1), 143-147 (1997).
    • (1997) Oncol. Rep , vol.4 , Issue.1 , pp. 143-147
    • Vincent, P.W.1    Roberts, B.J.2    Elliott, W.L.3    Leopold, W.R.4
  • 59
    • 0026520313 scopus 로고
    • Bisbioreductive agents as hypoxia-selective cytotoxins - Nitracrine N-oxide
    • Wilson WR, Vanzijl P, Denny WA. Bisbioreductive agents as hypoxia-selective cytotoxins - nitracrine N-oxide. Int. J. Radiat. Oncol. Biol. Phys. 22, 693-696 (1992).
    • (1992) Int. J. Radiat. Oncol. Biol. Phys , vol.22 , pp. 693-696
    • Wilson, W.R.1    Vanzijl, P.2    Denny, W.A.3
  • 60
    • 0026775234 scopus 로고
    • 5-nitro-4-(N,N-dimethy laminopropylamino)quinoline (5-nitraquine), a new DNA-affinic hypoxic cell radiosensitizer and bioreductive agent comparison with nitracrine
    • Wilson WR, Siim BG, Denny WA et al. 5-nitro-4-(N,N-dimethylaminopropylamino)quinoline (5-nitraquine), a new DNA-affinic hypoxic cell radiosensitizer and bioreductive agent comparison with nitracrine. Radiat. Res. 131(3), 257-265 (1992).
    • (1992) Radiat. Res , vol.131 , Issue.3 , pp. 257-265
    • Wilson, W.R.1    Siim, B.G.2    Denny, W.A.3
  • 61
    • 0028263652 scopus 로고
    • Does DNA targeting affect the cytotoxicity and cell uptake of basic nitroquinoline bioreductive drugs?
    • Siim BG, Denny WA, Wilson WR. Does DNA targeting affect the cytotoxicity and cell uptake of basic nitroquinoline bioreductive drugs? Int. J. Radiat. Oncol. Biol. Phys. 29, 311-315 (1994).
    • (1994) Int. J. Radiat. Oncol. Biol. Phys , vol.29 , pp. 311-315
    • Siim, B.G.1    Denny, W.A.2    Wilson, W.R.3
  • 62
    • 0036093852 scopus 로고    scopus 로고
    • Novel strategies for overcoming multi-drug resistance in cancer
    • Baguley BC. Novel strategies for overcoming multi-drug resistance in cancer. BioDrugs 16, 97-103 (2002).
    • (2002) BioDrugs , vol.16 , pp. 97-103
    • Baguley, B.C.1
  • 63
    • 0029858387 scopus 로고    scopus 로고
    • TNF and cancer therapy-induced apoptosis - Potentiation by inhibition of NFκB
    • 5288
    • Wang CY, Mayo MW, Baldwin AS. TNF and cancer therapy-induced apoptosis - potentiation by inhibition of NFκB. Science 274(5288), 784-787 (1996).
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin, A.S.3
  • 64
    • 0001296910 scopus 로고    scopus 로고
    • Combination of the antivascular agent DMXAA with radiation and chemotherapy
    • Wilson WR, Baguley BC. Combination of the antivascular agent DMXAA with radiation and chemotherapy. Int. J. Radiat. Oncol. Biol. Phys. 46, 706 (2000).
    • (2000) Int. J. Radiat. Oncol. Biol. Phys , vol.46 , pp. 706
    • Wilson, W.R.1    Baguley, B.C.2
  • 65
    • 0036568457 scopus 로고    scopus 로고
    • Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy
    • Siemann DW, Mercer E, Lepler S, Rojiani AM. Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy. Int. J. Cancer 99 (1), 1-6 (2002).
    • (2002) Int. J. Cancer , vol.99 , Issue.1 , pp. 1-6
    • Siemann, D.W.1    Mercer, E.2    Lepler, S.3    Rojiani, A.M.4
  • 66
    • 0028263706 scopus 로고
    • Enhancement of radioimmunotherapy by drugs modifying tumour blood flow in a colonic xenograft model
    • Pedley RB, Begent RH, Boden JA, Boxer GM, Boden R, Keep PA. Enhancement of radioimmunotherapy by drugs modifying tumour blood flow in a colonic xenograft model. Int. J. Cancer 57(6), 830-835 (1994).
    • (1994) Int. J. Cancer , vol.57 , Issue.6 , pp. 830-835
    • Pedley, R.B.1    Begent, R.H.2    Boden, J.A.3    Boxer, G.M.4    Boden, R.5    Keep, P.A.6
  • 67
    • 0035158004 scopus 로고    scopus 로고
    • Potentiation of the antitumour effect of hyperthermia by combining with the vascular targeting agent 5,6-dimethylxa nthenone-4-acetic acid
    • Murata F. Overgaard J, Horsman MR. Potentiation of the antitumour effect of hyperthermia by combining with the vascular targeting agent 5,6-dimethylxanthenone-4-acetic acid. Int. J. Hyperthermia 17(6), 508-519 (2001).
    • (2001) Int. J. Hyperthermia , vol.17 , Issue.6 , pp. 508-519
    • Murata, F.1    Overgaard, J.2    Horsman, M.R.3
  • 68
    • 0036284788 scopus 로고    scopus 로고
    • HSP70 protects against TNF-induced lethal inflammatory shock
    • Van MW, Welockx B, Mahieu T et al. HSP70 protects against TNF-induced lethal inflammatory shock. Immunity 16(5), 685-695 (2002).
    • (2002) Immunity , vol.16 , Issue.5 , pp. 685-695
    • Van, M.W.1    Welockx, B.2    Mahieu, T.3
  • 69
    • 0035866391 scopus 로고    scopus 로고
    • Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Cao Z, Baguley BC, Ching L-M. Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Cancer Res. 61, 1517-1521 (2001).
    • (2001) Cancer Res , vol.61 , pp. 1517-1521
    • Cao, Z.1    Baguley, B.C.2    Ching, L.-M.3
  • 71
    • 0031760365 scopus 로고    scopus 로고
    • Thalidomide revisited: Pharmacology and clinical applications
    • Calabrese L, Resztak K. Thalidomide revisited: pharmacology and clinical applications. Exp. Opin. Investig. Drugs 7 (1998).
    • (1998) Exp. Opin. Investig. Drugs , pp. 7
    • Calabrese, L.1    Resztak, K.2
  • 72
    • 0003211696 scopus 로고    scopus 로고
    • Anti-angiogenic treatment of metatstatic melanoma, renal cell, ovarian and breast cancers with thalidomide: A Phase II study
    • Eisen T, Boshoff C, Vaughan MM. Anti-angiogenic treatment of metatstatic melanoma, renal cell, ovarian and breast cancers with thalidomide: a Phase II study. Proc. Am. Soc. Clin. Oncol. 17, 441a (1998).
    • (1998) Proc. Am. Soc. Clin. Oncol , vol.17
    • Eisen, T.1    Boshoff, C.2    Vaughan, M.M.3
  • 73
    • 0026080801 scopus 로고
    • Thalidomide selectively inhibits tumor necrosis factor-α production by stimulated human monocytes
    • Sampaio EP, Sarno EN, Galilly R, Cohn ZA, Kaplan G. Thalidomide selectively inhibits tumor necrosis factor-α production by stimulated human monocytes. J. Exp. Med 173(3), 699-703 (1991).
    • (1991) J. Exp. Med , vol.173 , Issue.3 , pp. 699-703
    • Sampaio, E.P.1    Sarno, E.N.2    Galilly, R.3    Cohn, Z.A.4    Kaplan, G.5
  • 74
    • 0031846669 scopus 로고    scopus 로고
    • Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the antitumour agent 5,6-dimethylxanthenone-4-acetic acid: Concomitant reduction of serum tumour necrosis factor-α and enhancement of antitumour activity
    • Ching LM, Browne WL, Tchernegovski R, Gregory T, Baguley BC, Palmer BD. Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the antitumour agent 5,6-dimethylxanthenone-4-acetic acid: concomitant reduction of serum tumour necrosis factor-α and enhancement of antitumour activity, Br J. Cancer 78, 336-343 (1998).
    • (1998) Br. J. Cancer , vol.78 , pp. 336-343
    • Ching, L.M.1    Browne, W.L.2    Tchernegovski, R.3    Gregory, T.4    Baguley, B.C.5    Palmer, B.D.6
  • 75
    • 0035933772 scopus 로고    scopus 로고
    • Inhibition of NF-κB activity by thalidomide through suppression of I-κB kinase activity
    • Keifer JA, Guttridge DC, Ashburner BP, Baldwin AS Jr. Inhibition of NF-κB activity by thalidomide through suppression of I-κB kinase activity. J. Biol. Chem 276, 22382-22387 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 22382-22387
    • Keifer, J.A.1    Guttridge, D.C.2    Ashburner, B.P.3    Baldwin A.S., Jr.4
  • 76
    • 0029922290 scopus 로고    scopus 로고
    • Thalidomide can be either agonistic or antagonistic to LPS evoked synthesis of TNF-α by mononuclear cells
    • Shannon EJ, Sandoval F. Thalidomide can be either agonistic or antagonistic to LPS evoked synthesis of TNF-α by mononuclear cells. Immunopharmacol. Immunotoxicol. 18(1), 59-72 (1996).
    • (1996) Immunopharmacol. Immunotoxicol , vol.18 , Issue.1 , pp. 59-72
    • Shannon, E.J.1    Sandoval, F.2
  • 77
    • 0033895294 scopus 로고    scopus 로고
    • Modulation of the pharmacokinetics of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice by thalidomide
    • Kestell P, Zhao, L, Baguley BC et al. Modulation of the pharmacokinetics of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice by thalidomide. Cancer Chemother. Pharmacol. 46, 135-141 (2000).
    • (2000) Cancer Chemother. Pharmacol , vol.46 , pp. 135-141
    • Kestell, P.1    Zhao, L.2    Baguley, B.C.3
  • 78
    • 0035064594 scopus 로고    scopus 로고
    • Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo
    • Galbraith SM, Chaplin DJ, Lee F et al. Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo. Anticancer Res. 21 (1A), 93-102 (2001).
    • (2001) Anticancer Res , vol.21 , Issue.1 A , pp. 93-102
    • Galbraith, S.M.1    Chaplin, D.J.2    Lee, F.3
  • 79
    • 0011004229 scopus 로고
    • Effect of 5-hydroxytryptamine and cyproheptadine on tumour blood flow. Estimation by rate of cooling after microwave diathermy
    • Cater DB, Petrie X Watkinson DA. Effect of 5-hydroxytryptamine and cyproheptadine on tumour blood flow. Estimation by rate of cooling after microwave diathermy. Acta Radiolog. Ther. Phys. Biol. 3, 109-128 (1965).
    • (1965) Acta Radiolog. Ther. Phys. Biol , vol.3 , pp. 109-128
    • Cater, D.B.1    Petrie, X.2    Watkinson, D.A.3
  • 80
    • 0027375380 scopus 로고
    • Serotonin involvement in the antitumour and host effects of flavone-8 acetic acid and 5,6-dimethylxanthenone-4 acetic acid
    • Baguley BC, Cole G, Thomsen LL, Zhuang L. Serotonin involvement in the antitumour and host effects of flavone-8 acetic acid and 5,6-dimethylxanthenone-4 acetic acid. Cancer Chemother Pharmacol. 33, 77-81 (1993).
    • (1993) Cancer Chemother. Pharmacol , vol.33 , pp. 77-81
    • Baguley, B.C.1    Cole, G.2    Thomsen, L.L.3    Zhuang, L.4
  • 81
    • 0035001007 scopus 로고    scopus 로고
    • Effects of the serotonin receptor antagonist cyproheptadine on the activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Zhao L, Kestell P, Philpott M, Ching L-M, Zhuang L, Baguley BC. Effects of the serotonin receptor antagonist cyproheptadine on the activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Cancer Chemother. Pharmacol. 47, 491-497 (2001).
    • (2001) Cancer Chemother. Pharmacol , vol.47 , pp. 491-497
    • Zhao, L.1    Kestell, P.2    Philpott, M.3    Ching, L.-M.4    Zhuang, L.5    Baguley, B.C.6
  • 82
    • 0026624915 scopus 로고
    • Reversal of multi-drug resistance by phenothiazines and structurally related compounds
    • Ramu A, Ramu N. Reversal of multi-drug resistance by phenothiazines and structurally related compounds. Cancer Chemother. Pharmacol. 30(3), 165-173 (1992).
    • (1992) Cancer Chemother. Pharmacol , vol.30 , Issue.3 , pp. 165-173
    • Ramu, A.1    Ramu, N.2
  • 83
    • 0035266136 scopus 로고    scopus 로고
    • Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci
    • Kanwar JR, Kanwar RK, Pandey S, Ching LM, Krissansen GW. Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci. Cancer Res. 61(5), 1948-1956 (2001).
    • (2001) Cancer Res , vol.61 , Issue.5 , pp. 1948-1956
    • Kanwar, J.R.1    Kanwar, R.K.2    Pandey, S.3    Ching, L.M.4    Krissansen, G.W.5
  • 84
    • 0037222218 scopus 로고    scopus 로고
    • Marked potentiation of the aintitumor activity of chemotherapeutic drugs by antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • (In Press)
    • Simm BG, Lee AE, Shalal-Zwain S, Pruijn FB, McKeage W, Wilson WR. Marked potentiation of the aintitumor activity of chemotherapeutic drugs by antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Cancer Chemother. Pharmacol. (2002) (In Press).
    • (2002) Cancer Chemother. Pharmacol
    • Simm, B.G.1    Lee, A.E.2    Shalal-Zwain, S.3    Pruijn, F.B.4    McKeage, W.5    Wilson, W.R.6


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