RNA silencing: Small RNAs as ubiquitous regulators of gene expression

Current Opinion in Plant Biology

Volumn 5, Issue 5, 2002, Pages 444-451

  Voinnet, Olivier ^a,b  

^a SAINSBURY LABORATORY   (United Kingdom)

^b INST DE BIOL MOLEC DES PLANTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EUKARYOTA; TRANSPOSONS;

EID: 0036779333     PISSN: 13695266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5266(02)00291-1     Document Type: Review

References (62)

1. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
2. Total silencing by intron-spliced hairpin RNAs
3. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells
4. An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus
5. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance
6. On the role of RNA amplification in dsRNA-triggered gene silencing
7. A novel species of small antisense RNA in post-transcriptional gene silencing
8. RNA interference is mediated by 21- and 22-nucleotide RNAs
9. Role for a bidentate ribonuclease in the initiation step of RNA interference
10. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cell extracts
11. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
12. Systemic spread of sequence-specific transgene RNA degradation is initiated by localised introduction of ectopic promoterless DNA
13. Systemic acquired silencing: Transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions
14. Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1
15. The rde-1 gene, RNA interference and transposon silencing in C. elegans
16. mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
17. Taming of transposable elements by homology-dependent gene silencing
18. Transgene and transposon silencing in Chlamydomonas reinhardtii by a DEAH-box RNA helicase
19. RNA silencing as a plant immune system against viruses
20. Gene silencing as an adaptive defence against viruses
21. A viral movement protein prevents systemic spread of the gene silencing signal in Nicotiana benthamiana
22. The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans
23. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
24. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor
25. Postranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
26. The C elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
27. The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA
28. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
29. Two genetic circuits repress the C. elegans heterochronic gene lin-28 after translation initiation
30. Mutations that lead to reiterations in the cell lineage of C. elegans
31. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
32. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
33. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
34. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
35. Identification of novel genes coding for small expressed RNAs
36. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
37. An extensive class of small RNAs in Caenorhabditis elegans
38. Endogenous and silencing-associated small RNAs in plants
39. MicroRNAs in plants
40. Disruption of an RNA helicase/RNAse III gene in Arabidopsis causes unregulated cell division in floral meristems
41. SHORT INTEGUMENT (SIN1), a gene required for ovule development in Arabidopsis, also controls flowering time
42. Domains in gene silencing and cell differentiation proteins: The novel PAZ domain and redefinition of the Piwi domain
43. AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals
44. A branched pathway for transgene-induced RNA silencing in plants
45. Genetic requirements for inheritance of RNAi in C. elegans
46. Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance
47. Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation
48. Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamiana
49. A counterdefensive strategy of plant viruses: Suppression of post-transcriptional gene silencing
50. A viral suppressor of gene silencing in plants
51. Suppression of gene silencing: A general strategy used by diverse DNA and RNA viruses
52. A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants
53. A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs
54. Virus-encoded suppressor of posttranscriptional gene silencing targets a maintenance step in the silencing pathway
55. A viral protein inhibits the long range signaling activity of the gene silencing signal
56. Induction and suppression of RNA silencing by an animal virus
57. Two classes of short interfering RNA in RNA silencing
58. Resistance of RNA-mediated TGS to HC-Pro, a viral suppressor of PTGS, suggests alternative pathways for dsRNA processing
59. Epialleles - A source of random variation in times of stress
60. Transcriptional silencing and promoter methylation triggered by double-stranded RNA
61. Transcriptional and posttranscriptional gene silencing are mechanistically related
62. Flowering time: From photoperiodism to florigen