Functional impairment of human T-lymphocytes following PHA-induced expansion and retroviral transduction: Implications for gene therapy

Gene Therapy

Volumn 9, Issue 20, 2002, Pages 1359-1368

  Duarte, R F ^a,b   Chen, F E ^a,b   Lowdell, M W ^b   Potter, M N ^b   Lamana, M L ^c   Prentice, H G ^b   Madrigal, J A ^a,b  

^a ANTHONY NOLAN RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CIEMAT   (Spain)

Author keywords

Gene therapy; Immune function; Phytohemagglutinin; Retroviral transduction; T lymphocytes

Indexed keywords

ALLOANTIGEN; CD28 ANTIGEN; CD3 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR7; DNA; GAMMA INTERFERON; PERFORIN; PHYTOHEMAGGLUTININ; RETROVIRUS VECTOR; VIRUS ANTIGEN;

ADOPTIVE IMMUNOTHERAPY; ARTICLE; CELL LINEAGE; CLINICAL PROTOCOL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DNA MODIFICATION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOTOXICITY; MIXED LYMPHOCYTE REACTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TREATMENT OUTCOME; VIRAL GENE THERAPY;

ANTIGENS, CD28; ANTIGENS, CD3; ANTIGENS, CD45; CELL DIFFERENTIATION; CELL DIVISION; GENE THERAPY; GENETIC VECTORS; HUMANS; PHYTOHEMAGGLUTININS; RETROVIRIDAE; STIMULATION, CHEMICAL; T-LYMPHOCYTE SUBSETS; TRANSDUCTION, GENETIC;

UNIDENTIFIED RETROVIRUS;

EID: 0036773419     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301807     Document Type: Article

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