-
1
-
-
0034660560
-
Pharmacogenetics and the practice of medicine
-
Roses AD. Pharmacogenetics and the practice of medicine. Nature 2000; 405:857-865.
-
(2000)
Nature
, vol.405
, pp. 857-865
-
-
Roses, A.D.1
-
3
-
-
0034443957
-
Heterogeneity of therapeutic responses in asthma
-
Drazen JM, Silverman EK, Lee TH. Heterogeneity of therapeutic responses in asthma. Br Med Bull 2000; 56:1054-1070.
-
(2000)
Br Med Bull
, vol.56
, pp. 1054-1070
-
-
Drazen, J.M.1
Silverman, E.K.2
Lee, T.H.3
-
4
-
-
0029850530
-
A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
-
Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88:3698-3703.
-
(1996)
Blood
, vol.88
, pp. 3698-3703
-
-
Poort, S.R.1
Rosendaal, F.R.2
Reitsma, P.H.3
Bertina, R.M.4
-
5
-
-
9544253883
-
Comparison of regularly scheduled with as-needed use of albuterol in mild asthma
-
Drazen JM, Israel E, Boushey HA, et al. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. N Engl J Med 1996; 335:841-847.
-
(1996)
N Engl J Med
, vol.335
, pp. 841-847
-
-
Drazen, J.M.1
Israel, E.2
Boushey, H.A.3
-
7
-
-
0031466866
-
Association between genetic polymorphisms of the beta (2)-adrenoceptor and response to albuterol in children with and without a history of wheezing
-
Martinez FD, Graves PE, Baldini M, et al. Association between genetic polymorphisms of the beta (2)-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997; 100:3184-3188.
-
(1997)
J Clin Invest
, vol.100
, pp. 3184-3188
-
-
Martinez, F.D.1
Graves, P.E.2
Baldini, M.3
-
8
-
-
0033915078
-
The effect of polymorphisms of the beta2-adrenergic receptor on the response to regular use of albuterol in asthma
-
Israel E, Drazen JM, Liggett SB, et al. The effect of polymorphisms of the beta2-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med 2000; 162:75-80. A key beta-agonist pharmacogenetics study demonstrating tachyphylaxis with regular beta-agonist use depending on beta receptor genotype.
-
(2000)
Am J Respir Crit Care Med
, vol.162
, pp. 75-80
-
-
Israel, E.1
Drazen, J.M.2
Liggett, S.B.3
-
9
-
-
0033841788
-
Asthma exacerbations during long term beta-agonist use: Influence of beta2 adrenoceptor polymorphism
-
Taylor DR, Drazen JM, Herbison GP, et al. Asthma exacerbations during long term beta-agonist use: Influence of beta2 adrenoceptor polymorphism. Thorax 2000; 55:762-767. Another important beta agonist receptor gene pharmacogenetics study demonstrating an association between beta receptor genotype and asthma exacerbations.
-
(2000)
Thorax
, vol.55
, pp. 762-767
-
-
Taylor, D.R.1
Drazen, J.M.2
Herbison, G.P.3
-
10
-
-
0034017468
-
Pharmacogenetics of asthma
-
Hall IP. Pharmacogenetics of asthma. Eur Respir J 2000; 15:449-451.
-
(2000)
Eur Respir J
, vol.15
, pp. 449-451
-
-
Hall, I.P.1
-
11
-
-
0032415907
-
Association of persistent bronchial hyperresponsiveness with beta2-adrenoceptor (ADRB2) haplotypes. A population study
-
D'Amato M, Vitiani LR, Petrelli G, et al. Association of persistent bronchial hyperresponsiveness with beta2-adrenoceptor (ADRB2) haplotypes. A population study. Am J Respir Crit Care Med 1998; 158:1968-1973.
-
(1998)
Am J Respir Crit Care Med
, vol.158
, pp. 1968-1973
-
-
D'Amato, M.1
Vitiani, L.R.2
Petrelli, G.3
-
12
-
-
0033840451
-
Atopy and asthma genes - Where do we stand?
-
Barnes KC. Atopy and asthma genes - Where do we stand? Allergy 2000; 55:803-817.
-
(2000)
Allergy
, vol.55
, pp. 803-817
-
-
Barnes, K.C.1
-
13
-
-
0034641736
-
Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness
-
Drysdale CM, McGraw DW, Stack CB, et al. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci U S A 2000; 97:10483-10488. This highlights the importance of looking at haplotypes when assessing genotypephenotype associations.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10483-10488
-
-
Drysdale, C.M.1
McGraw, D.W.2
Stack, C.B.3
-
14
-
-
0033590513
-
Treatment of asthma with drugs modifying the leukotriene pathway
-
Drazen JM, Israel E, O'Byrne PM. Treatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med 1999; 340:197-206.
-
(1999)
N Engl J Med
, vol.340
, pp. 197-206
-
-
Drazen, J.M.1
Israel, E.2
O'Byrne, P.M.3
-
16
-
-
0023947133
-
Release of leukotrienes in patients with bronchial asthma
-
Lam S, Chan H, LeRiche JC, et al. Release of leukotrienes in patients with bronchial asthma. J Allergy Clin Immunol 1988; 81:711-717.
-
(1988)
J Allergy Clin Immunol
, vol.81
, pp. 711-717
-
-
Lam, S.1
Chan, H.2
LeRiche, J.C.3
-
17
-
-
0025284206
-
4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge
-
4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge. Am Rev Respir Dis 1990; 142:112-119.
-
(1990)
Am Rev Respir Dis
, vol.142
, pp. 112-119
-
-
Wenzel, S.E.1
Larsen, G.L.2
Johnston, K.3
-
18
-
-
0022641518
-
Inhalation challenge with sulfidopeptide leukotrienes in human subjects
-
Drazen JM. Inhalation challenge with sulfidopeptide leukotrienes in human subjects. Chest 1986; 89:414-419.
-
(1986)
Chest
, vol.89
, pp. 414-419
-
-
Drazen, J.M.1
-
19
-
-
0033574195
-
Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized controlled trial
-
Malmstrom K, Rodriguez-Gomez G, Guerra J, et al. Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized controlled trial. Ann Intern Med 1999; 130:487-495.
-
(1999)
Ann Intern Med
, vol.130
, pp. 487-495
-
-
Malmstrom, K.1
Rodriguez-Gomez, G.2
Guerra, J.3
-
20
-
-
0027504207
-
5-Lipoxygenase and 5-lipoxygenase activating protein are localized in the nuclear envelope of activated human leukocytes
-
Woods JW, Evans JF, Ethier D, et al. 5-Lipoxygenase and 5-lipoxygenase activating protein are localized in the nuclear envelope of activated human leukocytes. J Exp Med 1993; 178:1935-1946.
-
(1993)
J Exp Med
, vol.178
, pp. 1935-1946
-
-
Woods, J.W.1
Evans, J.F.2
Ethier, D.3
-
21
-
-
0022654367
-
Characterization of inflammatory mediator release from purified human lung mast cells
-
Schleimer RP, MacGlashan Jr DW, Peters SP, et al. Characterization of inflammatory mediator release from purified human lung mast cells. Am Rev Respir Dis 1986; 133:614-617.
-
(1986)
Am Rev Respir Dis
, vol.133
, pp. 614-617
-
-
Schleimer, R.P.1
MacGlashan D.W., Jr.2
Peters, S.P.3
-
24
-
-
0024212248
-
Leukotriene generation and metabolism in isolated human lung macrophages
-
Schonfeld W, Schluter B, Hilger R, Konig W. Leukotriene generation and metabolism in isolated human lung macrophages. Immunology 1988; 65:529-536.
-
(1988)
Immunology
, vol.65
, pp. 529-536
-
-
Schonfeld, W.1
Schluter, B.2
Hilger, R.3
Konig, W.4
-
25
-
-
0026511180
-
Arachidonic acid metabolism in airway epithelial cells
-
Holtzman MJ. Arachidonic acid metabolism in airway epithelial cells. Annu Rev Physiol 1992; 54:303-329.
-
(1992)
Annu Rev Physiol
, vol.54
, pp. 303-329
-
-
Holtzman, M.J.1
-
26
-
-
0022997831
-
Arachidonic acid metabolism by canine tracheal epithelial cells. Product formation and relationship to chloride secretion
-
Eling TE, Danilowicz RM, Henke DC, et al. Arachidonic acid metabolism by canine tracheal epithelial cells. Product formation and relationship to chloride secretion. J Biol Chem 1986; 261:12841-12849.
-
(1986)
J Biol Chem
, vol.261
, pp. 12841-12849
-
-
Eling, T.E.1
Danilowicz, R.M.2
Henke, D.C.3
-
27
-
-
0022878291
-
4 synthesized by polymorphonuclear leukocytes
-
4 synthesized by polymorphonuclear leukocytes. J Biol Chem 1986; 261:16466-16472.
-
(1986)
J Biol Chem
, vol.261
, pp. 16466-16472
-
-
Feinmark, S.J.1
Cannon, P.J.2
-
28
-
-
0022481996
-
Production of arachidonic acid metabolites by endothelial cells in hyperoxia
-
Jackson RM, Chandler DB, Fulmer JD. Production of arachidonic acid metabolites by endothelial cells in hyperoxia. J Appl Physiol 1986; 61:584-591.
-
(1986)
J Appl Physiol
, vol.61
, pp. 584-591
-
-
Jackson, R.M.1
Chandler, D.B.2
Fulmer, J.D.3
-
30
-
-
85045781575
-
Newer therapeutic agents for asthma
-
Deykin A, Israel E. Newer therapeutic agents for asthma. Dis Month 1999; 45:117-144.
-
(1999)
Dis Month
, vol.45
, pp. 117-144
-
-
Deykin, A.1
Israel, E.2
-
40
-
-
0033059209
-
Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment
-
Drazen JM, Yandava C, Dube L, et al. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat Genet 1999; 22:170-172.
-
(1999)
Nat Genet
, vol.22
, pp. 170-172
-
-
Drazen, J.M.1
Yandava, C.2
Dube, L.3
-
41
-
-
0000451558
-
Effects of polymorphisms in the promoter region of 5-lipoxygenase and LTC4 synthase on the clinical response to zafirlukast and fluticasone
-
Anderson W, Kalberg C, Edwards L, et al. Effects of polymorphisms in the promoter region of 5-lipoxygenase and LTC4 synthase on the clinical response to zafirlukast and fluticasone. Eur Resp J 2000; 16 (Suppl B):183S. One of few pharmacogenetic studies of LTMs, it corroborates Drazen 5-LO promoter data.
-
(2000)
Eur Resp J
, vol.16
, Issue.SUPPL. B
-
-
Anderson, W.1
Kalberg, C.2
Edwards, L.3
-
42
-
-
0033803781
-
Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast
-
Sampson AP, Siddiqui S, Buchanan D, et al. Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast. Thorax 2000; 55 (Suppl 2):S28-S31. Although it is a study with a small number of subjects, the trend in differential response based on LTC4 synthase polymorphisms suggests that this locus too may have role in determining response to asthma therapy.
-
(2000)
Thorax
, vol.55
, Issue.SUPPL. 2
-
-
Sampson, A.P.1
Siddiqui, S.2
Buchanan, D.3
-
43
-
-
0025642424
-
Characterization of the human 5-lipoxygenase gene promoter
-
Hoshiko S, Radmark O, Samuelsson B. Characterization of the human 5-lipoxygenase gene promoter. Proc Natl Acad Sci USA 1990; 87:9073-9077.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 9073-9077
-
-
Hoshiko, S.1
Radmark, O.2
Samuelsson, B.3
-
44
-
-
0031003816
-
Naturally occurring mutations in the human 5-lipoxygenase gene promoter which modify transcription factor binding and reporter gene transcription
-
In KH, Asano K, Beier J, et al. Naturally occurring mutations in the human 5-lipoxygenase gene promoter which modify transcription factor binding and reporter gene transcription. J Clin Invest 1997; 99:1130-1137.
-
(1997)
J Clin Invest
, vol.99
, pp. 1130-1137
-
-
In, K.H.1
Asano, K.2
Beier, J.3
-
45
-
-
0032132831
-
Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants
-
Silverman ES, Du J, DeSanctis GT, et al. Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants. Am J Respir Cell Mol Biol 1998; 19:316-323.
-
(1998)
Am J Respir Cell Mol Biol
, vol.19
, pp. 316-323
-
-
Silverman, E.S.1
Du, J.2
DeSanctis, G.T.3
-
46
-
-
0027762572
-
The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin
-
Israel E, Fischer AR, Rosenberg MA, et al. The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. ARRD 1993; 148:1447-1451.
-
(1993)
ARRD
, vol.148
, pp. 1447-1451
-
-
Israel, E.1
Fischer, A.R.2
Rosenberg, M.A.3
-
48
-
-
0032519008
-
4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma
-
4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J Clin Invest 1998; 101:834-846.
-
(1998)
J Clin Invest
, vol.101
, pp. 834-846
-
-
Cowburn, A.S.1
Sladek, K.2
Soja, J.3
-
49
-
-
0033941793
-
4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States
-
4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States. J Allergy Clin Immunol 2000; 106:72-76.
-
(2000)
J Allergy Clin Immunol
, vol.106
, pp. 72-76
-
-
Van Sambeek, R.1
Stevenson, D.D.2
Baldasaro, M.3
-
50
-
-
0035141851
-
The health economics of asthma and rhinitis. I. Assessing the economic impact
-
Weiss KB, Sullivan SD. The health economics of asthma and rhinitis. I. Assessing the economic impact. J Allergy Clin Immunol 2001; 107:3-8.
-
(2001)
J Allergy Clin Immunol
, vol.107
, pp. 3-8
-
-
Weiss, K.B.1
Sullivan, S.D.2
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