메뉴 건너뛰기




Volumn 11, Issue 5, 2002, Pages 293-297

Cyclooxygenase as a target for the antiamyloidogenic activities of nonsteroidal anti-inflammatory drugs in Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloidosis; Cell cycle; Cyclooxygenase 2; Inflammation

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN SYNTHASE; SULINDAC; AMYLOID BETA PROTEIN; CELL RECEPTOR; NEUROPROTECTIVE AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; TRANSCRIPTION FACTOR;

EID: 0036770205     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000067428     Document Type: Review
Times cited : (19)

References (43)
  • 2
    • 0025801468 scopus 로고
    • Is amyloidogenesis during Alzheimer's disease due to an IL-1/IL-6-mediated 'acute phase response' in the brain?
    • Vandenabeele P, Fiers W: Is amyloidogenesis during Alzheimer's disease due to an IL-1/IL-6-mediated 'acute phase response' in the brain? Immunol Today 1991;12:217-219.
    • (1991) Immunol Today , vol.12 , pp. 217-219
    • Vandenabeele, P.1    Fiers, W.2
  • 3
    • 0030250826 scopus 로고    scopus 로고
    • Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: The role of the complement system
    • Pasinetti GM: Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: The role of the complement system. Neurobiol Aging 1996;17:707-716
    • (1996) Neurobiol Aging , vol.17 , pp. 707-716
    • Pasinetti, G.M.1
  • 5
    • 0003056313 scopus 로고
    • Complement and beta-amyloid neurotoxicity in vitro: A model for Alzheimer disease
    • Oda T, Lehrer-Graiwer J, Finch CE, Pasinetti GM: Complement and beta-amyloid neurotoxicity in vitro: A model for Alzheimer disease. Alzheimers Res 1995;1:29-34.
    • (1995) Alzheimers Res , vol.1 , pp. 29-34
    • Oda, T.1    Lehrer-Graiwer, J.2    Finch, C.E.3    Pasinetti, G.M.4
  • 7
    • 0032551633 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain
    • Pasinetti GM, Aisen PS: Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience 1998;87: 319-324.
    • (1998) Neuroscience , vol.87 , pp. 319-324
    • Pasinetti, G.M.1    Aisen, P.S.2
  • 8
    • 0033178889 scopus 로고    scopus 로고
    • Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease
    • Ho L, Pieroni C, Winger D, Purohit DP, Aisen P, Pasinetti GM: Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease. J Neurosci Res 1999;57:295-303.
    • (1999) J Neurosci Res , vol.57 , pp. 295-303
    • Ho, L.1    Pieroni, C.2    Winger, D.3    Purohit, D.P.4    Aisen, P.5    Pasinetti, G.M.6
  • 9
    • 0032725481 scopus 로고    scopus 로고
    • Cyclooxygenase-1 in human Alzheimer and control brain: Quantitative analysis of expression by microglia and CA3 hippocampal neurons
    • Yermakova AV, Rollins J, Callahan LM, Rogers J, O'Banion MK: Cyclooxygenase-1 in human Alzheimer and control brain: Quantitative analysis of expression by microglia and CA3 hippocampal neurons. J Neuropathol Exp Neurol 1999;58:1135-1146.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 1135-1146
    • Yermakova, A.V.1    Rollins, J.2    Callahan, L.M.3    Rogers, J.4    O'Banion, M.K.5
  • 10
    • 0031031312 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease: Mechanisms and therapeutic strategies
    • Aisen PS: Inflammation and Alzheimer's disease: Mechanisms and therapeutic strategies. Gerontology 1997;43:143-149.
    • (1997) Gerontology , vol.43 , pp. 143-149
    • Aisen, P.S.1
  • 11
    • 0032190264 scopus 로고    scopus 로고
    • Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions
    • Pasinetti GM: Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions. J Neurosci Res 1998;54:1-6.
    • (1998) J Neurosci Res , vol.54 , pp. 1-6
    • Pasinetti, G.M.1
  • 15
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • McGeer PL, Schulzer M, McGeer EG: Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies. Neurology 1996;47:425-432.
    • (1996) Neurology , vol.47 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 18
    • 0033551547 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease
    • Scharf S, Mander A, Ugoni A, Vajda F, Christophidis N: A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease. Neurology 1999;53:197-201
    • (1999) Neurology , vol.53 , pp. 197-201
    • Scharf, S.1    Mander, A.2    Ugoni, A.3    Vajda, F.4    Christophidis, N.5
  • 21
    • 0031781988 scopus 로고    scopus 로고
    • Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
    • Haroutunian V, Perl DP, Purohit DP, Marin D, Khan K, Lantz M, Davis KL, Mohs RC: Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease. Arch Neurol 1998;55:1185-1191.
    • (1998) Arch Neurol , vol.55 , pp. 1185-1191
    • Haroutunian, V.1    Perl, D.P.2    Purohit, D.P.3    Marin, D.4    Khan, K.5    Lantz, M.6    Davis, K.L.7    Mohs, R.C.8
  • 22
    • 0033833320 scopus 로고    scopus 로고
    • Cyclooxygenase-2: Its rich diversity of roles and possible application of its selective inhibitors
    • Katori M, Majima M: Cyclooxygenase-2: Its rich diversity of roles and possible application of its selective inhibitors. Inflamm Res 2000;49:367-392.
    • (2000) Inflamm Res , vol.49 , pp. 367-392
    • Katori, M.1    Majima, M.2
  • 23
    • 0035829592 scopus 로고    scopus 로고
    • A subset of NSAIDs lower amyloidogenic A β1-42 independently of cyclooxygenase activity
    • Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU: A subset of NSAIDs lower amyloidogenic A β1-42 independently of cyclooxygenase activity. Nature 2001;414:212-216.
    • (2001) Nature , vol.414 , pp. 212-216
    • Weggen, S.1    Eriksen, J.L.2    Das, P.3    Sagi, S.A.4    Wang, R.5    Pietrzik, C.U.6
  • 24
    • 0036424134 scopus 로고    scopus 로고
    • Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology
    • Xiang Z, Ho L, Yemul S, Zhao Z, Pompl P, Kelley K, Dang A, Teplow D, Pasinetti GM: Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. Gene Expr 2002;10:271-278.
    • (2002) Gene Expr , vol.10 , pp. 271-278
    • Xiang, Z.1    Ho, L.2    Yemul, S.3    Zhao, Z.4    Pompl, P.5    Kelley, K.6    Dang, A.7    Teplow, D.8    Pasinetti, G.M.9
  • 25
    • 0028803728 scopus 로고
    • Alterations in cellular adhesion and apoptosis in epithelial cells over-expressing prostaglandin endoperoxide synthase 2
    • Tsujii M, DuBois RN: Alterations in cellular adhesion and apoptosis in epithelial cells over-expressing prostaglandin endoperoxide synthase 2. Cell 1995;83:493-501.
    • (1995) Cell , vol.83 , pp. 493-501
    • Tsujii, M.1    DuBois, R.N.2
  • 26
    • 0034661784 scopus 로고    scopus 로고
    • Cyclin' toward dementia: Cell cycle abnormalities and abortive oncogenesis in Alzheimer disease
    • Raina AK, Zhu X, Rottkamp CA, Monteiro M, Takeda A, Smith MA: Cyclin' toward dementia: Cell cycle abnormalities and abortive oncogenesis in Alzheimer disease. J Neurosci Res 2000;61:128-133.
    • (2000) J Neurosci Res , vol.61 , pp. 128-133
    • Raina, A.K.1    Zhu, X.2    Rottkamp, C.A.3    Monteiro, M.4    Takeda, A.5    Smith, M.A.6
  • 27
    • 0036231413 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate mediated excitotoxicity
    • Mirjany M, Ho L, Pasinetti GM: Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate mediated excitotoxicity. J Pharmacol Exp Ther 2002;301:494-500.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 494-500
    • Mirjany, M.1    Ho, L.2    Pasinetti, G.M.3
  • 29
    • 0030921323 scopus 로고    scopus 로고
    • Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
    • McShea A, Harris PL, Webster KR, Wahl AF, Smith MA: Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am J Pathol 1997;150:1933-1939.
    • (1997) Am J Pathol , vol.150 , pp. 1933-1939
    • McShea, A.1    Harris, P.L.2    Webster, K.R.3    Wahl, A.F.4    Smith, M.A.5
  • 30
    • 0030038519 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: Effects on cell cycle and apoptosis
    • Shiff SJ, Koutsos MI, Qiao L, Rigas B: Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: Effects on cell cycle and apoptosis. Exp Cell Res 1996;222:179-188.
    • (1996) Exp Cell Res , vol.222 , pp. 179-188
    • Shiff, S.J.1    Koutsos, M.I.2    Qiao, L.3    Rigas, B.4
  • 31
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA: Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 1997;272:3406-3410.
    • (1997) J Biol Chem , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 32
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
    • Jiang C, Ting AT, Seed B: PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 1998;391:82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 33
    • 0035693506 scopus 로고    scopus 로고
    • Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease
    • Landreth GE, Heneka MT: Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease. Neurobiol Aging 2001;22:937-944.
    • (2001) Neurobiol Aging , vol.22 , pp. 937-944
    • Landreth, G.E.1    Heneka, M.T.2
  • 34
    • 0036140937 scopus 로고    scopus 로고
    • Diclofenac antagonizes peroxisome proliferator-activated receptor-gamma signaling
    • Adamson DJ, Frew D, Tatoud R, Wolf CR, Palmer CN: Diclofenac antagonizes peroxisome proliferator-activated receptor-gamma signaling. Mol Pharmacol 2002;61:7-12.
    • (2002) Mol Pharmacol , vol.61 , pp. 7-12
    • Adamson, D.J.1    Frew, D.2    Tatoud, R.3    Wolf, C.R.4    Palmer, C.N.5
  • 35
    • 0033608169 scopus 로고    scopus 로고
    • Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains
    • Kitamura Y, Shimohama S, Koike H, Kakimura J, Matsuoka Y, Nomura Y, et al: Increased expression of cyclooxygenases and peroxisome proliferator- activated receptor-gamma in Alzheimer's disease brains. Biochem Biophys Res Commun 1999;254:582-586.
    • (1999) Biochem Biophys Res Commun , vol.254 , pp. 582-586
    • Kitamura, Y.1    Shimohama, S.2    Koike, H.3    Kakimura, J.4    Matsuoka, Y.5    Nomura, Y.6
  • 37
  • 38
    • 0029899039 scopus 로고    scopus 로고
    • The risks and costs of upper gastrointestinal disease attributable to NSAIDs
    • Smalley WE, Griffin MR: The risks and costs of upper gastrointestinal disease attributable to NSAIDs. Gastroenterol Clin North Am 1996;25:373-396.
    • (1996) Gastroenterol Clin North Am , vol.25 , pp. 373-396
    • Smalley, W.E.1    Griffin, M.R.2
  • 40
    • 0034644396 scopus 로고    scopus 로고
    • Gastrointestinal toxicity with celecoxib vs. nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial. Celecoxib Long-Term Arthritis Safety Study
    • Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, et al: Gastrointestinal toxicity with celecoxib vs. nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial. Celecoxib Long-Term Arthritis Safety Study. JAMA 2000;284:1247-1255.
    • (2000) JAMA , vol.284 , pp. 1247-1255
    • Silverstein, F.E.1    Faich, G.2    Goldstein, J.L.3    Simon, L.S.4    Pincus, T.5    Whelton, A.6
  • 41
    • 0037046179 scopus 로고    scopus 로고
    • Randomized pilot study of nimesulide treatment in Alzheimer's disease
    • Aisen PS, Schmeidler J, Pasinetti GM: Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology 2002;58:1050-1054.
    • (2002) Neurology , vol.58 , pp. 1050-1054
    • Aisen, P.S.1    Schmeidler, J.2    Pasinetti, G.M.3
  • 42
    • 0036159469 scopus 로고    scopus 로고
    • Differential binding mode of diverse cyclooxygenase inhibitors
    • Llorens O, Perez JJ, Palomer A, Mauleon D: Differential binding mode of diverse cyclooxygenase inhibitors. J Mol Graph Model 2002;20:359-371.
    • (2002) J Mol Graph Model , vol.20 , pp. 359-371
    • Llorens, O.1    Perez, J.J.2    Palomer, A.3    Mauleon, D.4
  • 43
    • 0036156424 scopus 로고    scopus 로고
    • Cyclooxygenase-2-10 years later
    • Hinz B, Brune K: Cyclooxygenase-2-10 years later. J Pharmacol Exp Ther 2002;300:367-375.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 367-375
    • Hinz, B.1    Brune, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.