-
1
-
-
0034062812
-
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway
-
Apolloni A, Prior IA, Lindsay M, Parton RG, Hancock JF (2000) H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol Cell Biol 20:2475-2487
-
(2000)
Mol Cell Biol
, vol.20
, pp. 2475-2487
-
-
Apolloni, A.1
Prior, I.A.2
Lindsay, M.3
Parton, R.G.4
Hancock, J.F.5
-
2
-
-
0034642495
-
Bioorganic synthesis of Ras proteins for the study of signal transduction
-
Bader B, Kuhn K, Owen DJ, Waldmann H, Wittinghofer A, Kuhlmann J (2000) Bioorganic synthesis of Ras proteins for the study of signal transduction. Nature 403:223-226
-
(2000)
Nature
, vol.403
, pp. 223-226
-
-
Bader, B.1
Kuhn, K.2
Owen, D.J.3
Waldmann, H.4
Wittinghofer, A.5
Kuhlmann, J.6
-
4
-
-
0022137480
-
Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation
-
Bar-Sagi D, Feramisco JR (1985) Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42:841-848
-
(1985)
Cell
, vol.42
, pp. 841-848
-
-
Bar-Sagi, D.1
Feramisco, J.R.2
-
5
-
-
0033556397
-
A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation
-
Booden MA, Baker TL, Solski PA, Der CJ, Punke SG, Buss JE (1999) A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation. J Biol Chem 274:1423-1431
-
(1999)
J Biol Chem
, vol.274
, pp. 1423-1431
-
-
Booden, M.A.1
Baker, T.L.2
Solski, P.A.3
Der, C.J.4
Punke, S.G.5
Buss, J.E.6
-
6
-
-
0026510734
-
Analysis of macromolecular interactions using immobilized ligands
-
Chaiken I, Rose S, Karlsson R (1992) Analysis of macromolecular interactions using immobilized ligands. Anal Biochem 201: 197-210
-
(1992)
Anal Biochem
, vol.201
, pp. 197-210
-
-
Chaiken, I.1
Rose, S.2
Karlsson, R.3
-
7
-
-
0033538559
-
Endomembrane trafficking of Ras: The CAAX motif targets proteins to the ER and Golgi
-
Choy E, Chiu VK, Silletti J, Feoktistov M, Morimoto T, Michaelson D, Ivanov IE, Philips MR (1999) Endomembrane trafficking of Ras: The CAAX motif targets proteins to the ER and Golgi. Cell 98:69-80
-
(1999)
Cell
, vol.98
, pp. 69-80
-
-
Choy, E.1
Chiu, V.K.2
Silletti, J.3
Feoktistov, M.4
Morimoto, T.5
Michaelson, D.6
Ivanov, I.E.7
Philips, M.R.8
-
8
-
-
0032986772
-
Synthesis of the N-terminal lipohexapeptide of human GaO-protein and fluorescent labeled analogues for biological studies
-
Cotté A, Bader B, Kuhlmann J, Waldmann H (1999) Synthesis of the N-terminal lipohexapeptide of human GaO-protein and fluorescent labeled analogues for biological studies. Chem Eur J 5:922-936
-
(1999)
Chem Eur J
, vol.5
, pp. 922-936
-
-
Cotté, A.1
Bader, B.2
Kuhlmann, J.3
Waldmann, H.4
-
9
-
-
0030053105
-
Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation
-
Drugan JD, Khosravi-Far R, White MA, Der CJ, Sung YJ, Hwang YW, Campbell SL (1996) Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation. J Biol Chem 271:233-237
-
(1996)
J Biol Chem
, vol.271
, pp. 233-237
-
-
Drugan, J.D.1
Khosravi-Far, R.2
White, M.A.3
Der, C.J.4
Sung, Y.J.5
Hwang, Y.W.6
Campbell, S.L.7
-
10
-
-
0030749022
-
Replacement of the H-Ras farnesyl group by lipid analogues: Implication for downstream processing and effector activation in Xenopus oocytes
-
Dudler T, Gelb MH (1997) Replacement of the H-Ras farnesyl group by lipid analogues: Implication for downstream processing and effector activation in Xenopus oocytes. Biochemistry 36:12434-12441
-
(1997)
Biochemistry
, vol.36
, pp. 12434-12441
-
-
Dudler, T.1
Gelb, M.H.2
-
11
-
-
0033004827
-
Chemoenzymatic synthesis of nucleopeptides
-
Flohr S, Jungmann V, Waldmann H (1999) Chemoenzymatic synthesis of nucleopeptides. Chem Eur J 5:669-681
-
(1999)
Chem Eur J
, vol.5
, pp. 669-681
-
-
Flohr, S.1
Jungmann, V.2
Waldmann, H.3
-
12
-
-
0031452275
-
GEFs, GAPs, GDIs and effectors: Taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins
-
Geyer M, Wittinghofer A (1997) GEFs, GAPs, GDIs and effectors: Taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins. Curr Opin Struct Biol 7:786-792
-
(1997)
Curr Opin Struct Biol
, vol.7
, pp. 786-792
-
-
Geyer, M.1
Wittinghofer, A.2
-
13
-
-
0030934020
-
Allylic protecting groups and their use in a complex environment. I. Allylic protection of alcohols
-
Guibé F (1997) Allylic protecting groups and their use in a complex environment. I. Allylic protection of alcohols. Tetrahedron 53:13509-13556
-
(1997)
Tetrahedron
, vol.53
, pp. 13509-13556
-
-
Guibé, F.1
-
14
-
-
0032568384
-
Allylic protecting groups and their use in a complex environment. II. Allylic protecting groups and their removal through catalytic palladium p-allyl methodology
-
Guibé F (1998) Allylic protecting groups and their use in a complex environment. II. Allylic protecting groups and their removal through catalytic palladium p-allyl methodology. Tetrahedron 54:2967-3042
-
(1998)
Tetrahedron
, vol.54
, pp. 2967-3042
-
-
Guibé, F.1
-
15
-
-
0032477606
-
Dislodgement and accelerated degradation of Ras
-
Haklai P, Gana-Weisz M, Elad G, Paz A, Marciano D, Egozi Y, Ben-Baruch G, Kloog Y (1998) Dislodgement and accelerated degradation of Ras. Biochemistry 37:1306-1314
-
(1998)
Biochemistry
, vol.37
, pp. 1306-1314
-
-
Haklai, P.1
Gana-Weisz, M.2
Elad, G.3
Paz, A.4
Marciano, D.5
Egozi, Y.6
Ben-Baruch, G.7
Kloog, Y.8
-
17
-
-
0029587739
-
Cystein-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras
-
Hu CD, Kariya KI, Tamaoka M, Akasaka K, Shirouzu M, Yokoyama S, Kataoka T (1995) Cystein-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras. J Biol Chem 270:30274-30277
-
(1995)
J Biol Chem
, vol.270
, pp. 30274-30277
-
-
Hu, C.D.1
Kariya, K.I.2
Tamaoka, M.3
Akasaka, K.4
Shirouzu, M.5
Yokoyama, S.6
Kataoka, T.7
-
18
-
-
0035857550
-
1H High-resolution magic angle spinning NMR spectroscopy for the investigation of a Ras lipopeptide in a lipid membrane
-
Huster D, Kuhn K, Kadereit D, Waldmann H, Arnold K (2001) 1H High-resolution magic angle spinning NMR spectroscopy for the investigation of a Ras lipopeptide in a lipid membrane. Angew Chem Int Ed 40:1056-1058
-
(2001)
Angew Chem Int Ed
, vol.40
, pp. 1056-1058
-
-
Huster, D.1
Kuhn, K.2
Kadereit, D.3
Waldmann, H.4
Arnold, K.5
-
19
-
-
0034597446
-
Linking the fields - The interplay of organic synthesis, biophysical chemistry, and cell biology in the chemical biology of protein lipidation
-
Kadereit D, Kuhlmann J, Waldmann H (2000) Linking the fields - The interplay of organic synthesis, biophysical chemistry, and cell biology in the chemical biology of protein lipidation, ChemBioChem 1:144-169
-
(2000)
ChemBioChem
, vol.1
, pp. 144-169
-
-
Kadereit, D.1
Kuhlmann, J.2
Waldmann, H.3
-
20
-
-
0031398922
-
The tetrabenzylglycosyloxycarbonyl (BGloc)-group - An enzyme labile carbohydrate-derived urethane blocking group
-
Kappes T, Waldmann H (1998) The tetrabenzylglycosyloxycarbonyl (BGloc)-group - An enzyme labile carbohydrate-derived urethane blocking group. Carbohydr Res 305:341-349
-
(1998)
Carbohydr Res
, vol.305
, pp. 341-349
-
-
Kappes, T.1
Waldmann, H.2
-
21
-
-
0035857413
-
Synthesis of fluorescent functional Ras lipoproteins and fluorescent derivatives
-
Kuhn K, Owen DJ, Bader B, Wittinghofer A, Kuhlmann J, Waldmann H (2001) Synthesis of fluorescent functional Ras lipoproteins and fluorescent derivatives. J Am Chem Soc 123: 1023-1035
-
(2001)
J Am Chem Soc
, vol.123
, pp. 1023-1035
-
-
Kuhn, K.1
Owen, D.J.2
Bader, B.3
Wittinghofer, A.4
Kuhlmann, J.5
Waldmann, H.6
-
22
-
-
84985624920
-
Der allyloxycarbonyl(aloc)-rest - Die verwandlung einer untauglichen in eine wertvolle Amino-schutzgruppe für die Peptidsynthese
-
Kunz H, Unverzagt C (1984) Der Allyloxycarbonyl(Aloc)-Rest - Die Verwandlung einer untauglichen in eine wertvolle Amino-schutzgruppe für die Peptidsynthese. Angew Chem Int Ed 23: 436-437
-
(1984)
Angew Chem Int Ed
, vol.23
, pp. 436-437
-
-
Kunz, H.1
Unverzagt, C.2
-
23
-
-
84985516446
-
Die allylgruppe als mild und selektiv abspaltbare carboxy-schutzgruppe zur synthese empfindlicher O-glycopeptide
-
Kunz H, Waldmann H (1984) Die Allylgruppe als mild und selektiv abspaltbare Carboxy-Schutzgruppe zur Synthese empfindlicher O-Glycopeptide. Angew Chem Int Ed 23:71-72
-
(1984)
Angew Chem Int Ed
, vol.23
, pp. 71-72
-
-
Kunz, H.1
Waldmann, H.2
-
24
-
-
0031024585
-
An intact Raf zinc finger is required for optimal binding to processed Ras and for Ras-dependent Raf activation in situ
-
Luo Z, Diaz B, Marshall MS, Avruch J (1997) An intact Raf zinc finger is required for optimal binding to processed Ras and for Ras-dependent Raf activation in situ. Mol Cell Biol 17:46-53
-
(1997)
Mol Cell Biol
, vol.17
, pp. 46-53
-
-
Luo, Z.1
Diaz, B.2
Marshall, M.S.3
Avruch, J.4
-
25
-
-
0034672716
-
Cholesterol modifications of proteins
-
Mann RK, Beachy PA (2000) Cholesterol modifications of proteins. Biochim Biophys Acta 1529:188-202
-
(2000)
Biochim Biophys Acta
, vol.1529
, pp. 188-202
-
-
Mann, R.K.1
Beachy, P.A.2
-
26
-
-
0028848171
-
The farnesyl group of H-Ras facilitates the activation of a soluble upstream activator of mitogen-activated protein kinase
-
McGeady P, Kuroda S, Shimizu K, Takai Y, Gelb MH (1995) The farnesyl group of H-Ras facilitates the activation of a soluble upstream activator of mitogen-activated protein kinase. J Biol Chem 270:26347-26351
-
(1995)
J Biol Chem
, vol.270
, pp. 26347-26351
-
-
McGeady, P.1
Kuroda, S.2
Shimizu, K.3
Takai, Y.4
Gelb, M.H.5
-
28
-
-
0029919472
-
Post-translational modification of H-Ras is required for activation of, but not for association with, B-Raf
-
Okada T, Masuda T, Shinkai M, Kariya KI, Kataoka T (1996) Post-translational modification of H-Ras is required for activation of, but not for association with, B-Raf. J Biol Chem 271
-
(1996)
J Biol Chem
, pp. 271
-
-
Okada, T.1
Masuda, T.2
Shinkai, M.3
Kariya, K.I.4
Kataoka, T.5
-
29
-
-
0031994482
-
Enzymes and protecting group chemistry
-
Pathak T, Waldmann H (1998) Enzymes and protecting group chemistry. Curr Opin Chem Biol 2:112-120
-
(1998)
Curr Opin Chem Biol
, vol.2
, pp. 112-120
-
-
Pathak, T.1
Waldmann, H.2
-
30
-
-
0029844192
-
Cholesterol modification of hedgehog signaling proteins in animal development
-
Porter JA, Young KE, Beachy PA (1996) Cholesterol modification of hedgehog signaling proteins in animal development. Science 274:255-259
-
(1996)
Science
, vol.274
, pp. 255-259
-
-
Porter, J.A.1
Young, K.E.2
Beachy, P.A.3
-
31
-
-
0032875098
-
Fatty acylation of proteins: New insights into membrane targeting of myristoylated and palmitoylated proteins
-
Resh MD (1999) Fatty acylation of proteins: New insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim Biophys Acta 1451:1-16
-
(1999)
Biochim Biophys Acta
, vol.1451
, pp. 1-16
-
-
Resh, M.D.1
-
33
-
-
0033519343
-
Chemoenzymatic synthesis of a characteristic glycophosphopeptide from the transactivation domain of the serum response factor
-
Sander J, Waldmann H (1999) Chemoenzymatic synthesis of a characteristic glycophosphopeptide from the transactivation domain of the serum response factor. Angew Chem Int Ed 38:1250-1252
-
(1999)
Angew Chem Int Ed
, vol.38
, pp. 1250-1252
-
-
Sander, J.1
Waldmann, H.2
-
34
-
-
0030772378
-
The Ras-RasGAP-complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
-
Scheffzek K, Ahmadian MR, Kabsch W, Wiesmüller L, Lantwein A, Schmitz F, Wittinghofer A (1997) The Ras-RasGAP-complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277: 333-338
-
(1997)
Science
, vol.277
, pp. 333-338
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Kabsch, W.3
Wiesmüller, L.4
Lantwein, A.5
Schmitz, F.6
Wittinghofer, A.7
-
35
-
-
0030056960
-
Enzymatic synthesis of peptides and Ras lipopeptides employing choline ester as a solubilizing, protecting, and activating group
-
Schelhaas M, Glomsda S, Hänsler M, Jakubke HD, Waldmann H (1996) Enzymatic synthesis of peptides and Ras lipopeptides employing choline ester as a solubilizing, protecting, and activating group. Angew Chem Int Ed 35:106-109
-
(1996)
Angew Chem Int Ed
, vol.35
, pp. 106-109
-
-
Schelhaas, M.1
Glomsda, S.2
Hänsler, M.3
Jakubke, H.D.4
Waldmann, H.5
-
36
-
-
0344197079
-
Chemoenzymatic synthesis of biotinylated Ras peptides and their use in membrane binding studies of lipidated model proteins by surface plasmon resonance
-
Schelhaas M, Nägele E, Kuder N, Bader B, Kuhlmann J, Wittinghofer A, Waldmann H (1999) Chemoenzymatic synthesis of biotinylated Ras peptides and their use in membrane binding studies of lipidated model proteins by surface plasmon resonance. Chem Eur J 5:1239-1252
-
(1999)
Chem Eur J
, vol.5
, pp. 1239-1252
-
-
Schelhaas, M.1
Nägele, E.2
Kuder, N.3
Bader, B.4
Kuhlmann, J.5
Wittinghofer, A.6
Waldmann, H.7
-
37
-
-
0030046054
-
Biochemical and biological consequences of changing the specificity of p21(Ras) from guanosine to xanthosine nucleotides
-
Schmidt G, Lenzen C, Simon I, Deuter R, Cool RH, Goody RS, Wittinghofer A (1996) Biochemical and biological consequences of changing the specificity of p21(Ras) from guanosine to xanthosine nucleotides. Oncogene 12:87-96
-
(1996)
Oncogene
, vol.12
, pp. 87-96
-
-
Schmidt, G.1
Lenzen, C.2
Simon, I.3
Deuter, R.4
Cool, R.H.5
Goody, R.S.6
Wittinghofer, A.7
-
38
-
-
0033135758
-
Synthesis of the palmitoylated and prenylated C-terminal lipopeptides of the human R- and N-Ras proteins
-
Schmittberger T, Waldmann H (1999) Synthesis of the palmitoylated and prenylated C-terminal lipopeptides of the human R- and N-Ras proteins. Bioorg Med Chem 7:749-762
-
(1999)
Bioorg Med Chem
, vol.7
, pp. 749-762
-
-
Schmittberger, T.1
Waldmann, H.2
-
39
-
-
0030696229
-
S-acylation and plasma membrane targeting of the farnesylated carboxyl-terminal peptide of N-Ras in mammalian fibroblasts
-
Schroeder H, Leventis R, Rex S, Schelhaas M, Nägele E, Waldmann H, Silvius JR (1997) S-acylation and plasma membrane targeting of the farnesylated carboxyl-terminal peptide of N-Ras in mammalian fibroblasts. Biochemistry 36: 13102-13109
-
(1997)
Biochemistry
, vol.36
, pp. 13102-13109
-
-
Schroeder, H.1
Leventis, R.2
Rex, S.3
Schelhaas, M.4
Nägele, E.5
Waldmann, H.6
Silvius, J.R.7
-
40
-
-
0028968896
-
Doubly-lipid modified protein sequence motifs exhibit long-lived anchorage to lipid bilayer membranes
-
Shahinian S, Silvius JR (1995) Doubly-lipid modified protein sequence motifs exhibit long-lived anchorage to lipid bilayer membranes. Biochemistry 34:3813-3822
-
(1995)
Biochemistry
, vol.34
, pp. 3813-3822
-
-
Shahinian, S.1
Silvius, J.R.2
-
41
-
-
0032488969
-
Evidence for a high affinity, saturable, prenylation-dependant p21Ha-ras binding site in plasma membranes
-
Siddiqui AA, Garland JR, Dalton MB, Sinensky M (1998) Evidence for a high affinity, saturable, prenylation-dependant p21Ha-ras binding site in plasma membranes. J Biol Chem 273:3712-3717
-
(1998)
J Biol Chem
, vol.273
, pp. 3712-3717
-
-
Siddiqui, A.A.1
Garland, J.R.2
Dalton, M.B.3
Sinensky, M.4
-
42
-
-
0027769775
-
Spontaneous interbilayer transfer of phospholipids: Dependence on acyl chain composition
-
Silvius JR, Leventis R (1993) Spontaneous interbilayer transfer of phospholipids: Dependence on acyl chain composition. Biochemistry 32:13318-13326
-
(1993)
Biochemistry
, vol.32
, pp. 13318-13326
-
-
Silvius, J.R.1
Leventis, R.2
-
43
-
-
0028196986
-
Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers
-
Silvius JR, l'Heureux F (1994) Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers. Biochemistry 33:3014-3022
-
(1994)
Biochemistry
, vol.33
, pp. 3014-3022
-
-
Silvius, J.R.1
L'Heureux, F.2
-
44
-
-
0027415097
-
Interbilayer transfer of phospholipid-anchored macromolecules via monomer diffusion
-
Silvius JR, Zuckermann MJ (1993) Interbilayer transfer of phospholipid-anchored macromolecules via monomer diffusion. Biochemistry 32:3153-3161
-
(1993)
Biochemistry
, vol.32
, pp. 3153-3161
-
-
Silvius, J.R.1
Zuckermann, M.J.2
-
45
-
-
0030919893
-
Activation of c-Raf-1 by Ras and Src through different mechanisms: Activation in vivo and in vitro
-
Stokoe D, McCormick F (1997) Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro. EMBO J 16:2384-2396
-
(1997)
EMBO J
, vol.16
, pp. 2384-2396
-
-
Stokoe, D.1
McCormick, F.2
-
46
-
-
0032493812
-
Increasing complexity of the Ras signaling pathway
-
Vojtek AB, Der CJ (1998) Increasing complexity of the Ras signaling pathway. J Biol Chem 273:19925-19928
-
(1998)
J Biol Chem
, vol.273
, pp. 19925-19928
-
-
Vojtek, A.B.1
Der, C.J.2
-
47
-
-
0028887941
-
Synthesis of the palmitoylated and farnesylated C-terminal lipohexapeptide of the human N-Ras protein by employing an enzymatically removable urethane protecting group
-
Waldmann H, Nägele E (1995) Synthesis of the palmitoylated and farnesylated C-terminal lipohexapeptide of the human N-Ras protein by employing an enzymatically removable urethane protecting group. Angew Chem Int Ed 34:2259-2262
-
(1995)
Angew Chem Int Ed
, vol.34
, pp. 2259-2262
-
-
Waldmann, H.1
Nägele, E.2
-
48
-
-
0000680497
-
Enzymatic protecting group techniques
-
Waldmann H, Sebastian D (1994) Enzymatic protecting group techniques. Chem Rev 94:911-937
-
(1994)
Chem Rev
, vol.94
, pp. 911-937
-
-
Waldmann, H.1
Sebastian, D.2
-
49
-
-
0034605862
-
Ras - A molecular switch involved in tumor formation
-
Waldmann H, Wittinghofer A (2000) Ras - A molecular switch involved in tumor formation. Angew Chem Int Ed 39:4192-4214
-
(2000)
Angew Chem Int Ed
, vol.39
, pp. 4192-4214
-
-
Waldmann, H.1
Wittinghofer, A.2
-
50
-
-
0030708812
-
Chemoenzymatic synthesis of fluorescent N-Ras lipopeptides and their use in membrane localization studies in vivo
-
Waldmann H, Schelhaas M, Nägele E, Kuhlmann J, Wittinghofer A, Schroeder H, Silvius JR (1997) Chemoenzymatic synthesis of fluorescent N-Ras lipopeptides and their use in membrane localization studies in vivo. Angew Chem Int Ed 36:2238-2241
-
(1997)
Angew Chem Int Ed
, vol.36
, pp. 2238-2241
-
-
Waldmann, H.1
Schelhaas, M.2
Nägele, E.3
Kuhlmann, J.4
Wittinghofer, A.5
Schroeder, H.6
Silvius, J.R.7
-
51
-
-
0029956855
-
Novel determination of H-Ras plasma membrane localization and transformation
-
Willumsen BM, Cox AD, Solski PA, Der CJ, Buss JE (1996) Novel determination of H-Ras plasma membrane localization and transformation. Oncogene 13:1901-1909
-
(1996)
Oncogene
, vol.13
, pp. 1901-1909
-
-
Willumsen, B.M.1
Cox, A.D.2
Solski, P.A.3
Der, C.J.4
Buss, J.E.5
-
52
-
-
0029898894
-
Protein prenylation: Molecular mechanisms and functional consequences
-
Zhang FL, Casey PJ (1996) Protein prenylation: Molecular mechanisms and functional consequences. Annu Rev Biochem 65: 241-269
-
(1996)
Annu Rev Biochem
, vol.65
, pp. 241-269
-
-
Zhang, F.L.1
Casey, P.J.2
|