Apigenin - Strong cytostatic and anti-angiogenic action in vitro contrasted by lack of efficacy in vivo

Phytomedicine

Volumn 9, Issue 6, 2002, Pages 489-495

  Engelmann, C ^a   Blot, E ^b,d   Panis, Y ^c   Bauer, S ^a   Trochon, V ^b,d   Nagy, H J ^c   Lu, H ^b   Soria, C ^c,d  

^a HUMBOLDT UNIVERSITY   (Germany)

^b SAINT LOUIS HOSPITAL   (France)

^c HÔPITAL LARIBOISIÈRE   (France)

^d UNIVERSITÉ DE ROUEN   (France)

Author keywords

Angiogenesis; Cytostatic effect; Flavonoids; In vivo efficacy; Tumour

Indexed keywords

APIGENIN; FLAVONOID;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL CYCLE G2 PHASE; COMPETITIVE INHIBITION; CYTOSTASIS; ENDOTHELIUM CELL; GROWTH INHIBITION; LEWIS CARCINOMA; MALIGNANT TRANSFORMATION; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; TUMOR GROWTH;

ANIMALIA;

EID: 0036746281     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1078/09447110260573100     Document Type: Article

References (37)

1. Agullo G, Gamet-Payrastre L, Manenti S, Viala C, Remesy C, Chap H, Payrastre B (1997) Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition. Biochem Pharmacol 53: 1649-1657
2. Birt JF, Pelling JC, Nair S, Lepley D (1996) Diet intervention-for modyfying cancer risk. Prog Clin Biol Res 395: 223-234
3. Boehm T, Folkman J, Browder T, O'Reilly MS (1997) Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390: 404-407
4. th ed, Merck Sharp and Dohme Laboratories, Rahway, NJ, U.S.A.
5. Buening MK, Chang RL, Huang MT, Fortner JG, Wood AW, Conney AH (1981) Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally ocurring flavonoids. Cancer Res 41: 68-72
6. Caruso M, Panis Y, Gagandeep S, Houssin D, Salzmann JL, Klatzmann D (1993) Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc Natl Acad Sci USA 90: 7024-7028
7. Caltagirone S, Rossi C, Poggi A, Raneletti FO, Natali PG, Brunetti M, Aiello FB, Pantelli M (2000) Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer 87: 595-600
8. Fotsis T, Pepper MS, Aktas E, Breit S, Rasku S, Adlercreutz H, Wahala K, Montesano R, Schweigerer L (1997) Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res 57: 2916-2921
9. Gerritsen ME, Carley WW, Ranges GE, Shen CP, Phan SA, Ligon GF, Perry CA (1995) Flavonoids inhibit cytokine induced endothelial cell adhesion protein gene expression. Am J Pathol 147: 278-292
10. Giles D, Wei H (1997) Effect of structurally related flavones/isoflavones on hydrogen peroxide production and oxidative DNA damage in phorbol ester-stimulated HL-60 cells. Nutr Cancer 29: 77-82
11. Griffiths LA, Smith GE (1972) Metabolism of apigenin and related compounds in the rat. Biochem J 128: 901-911
12. Griffiths AP, Collison MW (2001) Improved methods for the extraction and analysis of isoflavones from soycontaining foods and nutritional supplements by reversed-phase high performance liquid chromatography-mass spectrometry. J Chromat A 913: 397-413
13. Gupta S, Afaq F, Mukthar H (2000) Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. Biochem Biophys Res Comm 287: 914-920
14. Habtemariam S (1997) Flavonoids as inhibitors or enhancers of the cytotoxicity of tumour necrosis factor alpha in L-929 tumour cells. J Nat Prod 60: 775-778
15. Hirano T, Oka K, Akiba M (1989) Antiproliferative effects of synthetic and naturally occurring flavonoids on tumour cells of the human breast carcinoma cell line ZR-75-1. Res Com Chem Pathol Pharmacol 64: 69-78
16. Hollman PC, Katan MB (1997) Absorption, metabolism and health effects of dietary flavonoids in man. Biomed Pharmacother 51(8): 305-310
17. Huang YT, Kuo ML, Liu JY, Huang SY, Lin JK (1996) Inhibition of protein kinase C and proto-oncogene expressions in NIH 3T3 cells by apigenin. Eur J Cancer 32A: 146-151
18. Jankun J, Selman SH, Swiercz R, Skrypzak-Jankun E (1997) Why drinking green tea could prevent cancer. Nature 387: 561
19. Kandel J, Bossy-Wetzel E, Radvani F (1991) Neovascularization is associated with a switch to export β-FGF in the multistep development of fibrosarcoma. Cell 66: 1095-1104
20. Kruse FE, Joussen AM, Fotsis T, Schweigerer L, Rohrschneider K, Volcker HE (1997) Inhibition of neovascularization of the eye by dietary factors exemplified by isoflavonoids. Ophthalmologe 94: 152-156
21. Kuo ML, Yang NC (1995) Reversion of v-H-ras transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem Biophys Res Com 212: 767-775
22. Lepley DM, Pelling JC (1997) Induction of p 21/WAF1 and G 1 cell cycle arrest by the chemopreventive agent apigenin. Mol Carcinog 19: 74-82
23. Lindenmeyer F, Li H, Menashi S, Soria C, Lu H (2001) Apigenin acts on the tumour cell invasion process and regulates protease production. Nutr cancer 39: 139-147
24. Liu D, Pearlman E, Diaconu E, Guo K, Mori K, Haquqi T, Markowitz S, Wilson J, Sy MS (1996) Expression of hyaluronidase by tumour cells induces angiogenesis in vivo. Proc Natl Acad Sci USA. 93: 7832-7837
25. Montesano R, Kumar S, Orci L, Pepper MS (1996) Synergistic effect of hyaluronan oligosaccharides and vascular endothelial growth factor on angiogenesis in vitro. Lab Invest 75: 249-262
26. Nielsen SE, Young JF, Daneshvar B, Lauridsen ST, Knuthsen P, Sandström B, Dragsted LO (1999) Effect of parsley (petroselium crispium) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects. Br J Nutr 81: 447-455
27. Phan HT, Block N, Lokeshwar VR (1997) Tumour derived hyaluronidase: a diagnostic urine marker for high-grade bladder cancer. Cancer Re 57: 778-783
28. Plaumann B, Fritsche M, Rimpler H, Brandener G, Hess RD (1996) Flavonoids activate wild type p-53. Oncogene 13: 1605-1614
29. Romanova D, Grancai D, Jozova B, Bozek P, Vachalkova A (2000) Determination of apigenin in rat plasma by high performance liquid chromatography. J Chromatogr A 870: 463-467
30. Saarinen N, Joshi Sc, Ahotupa M, Ammala J, Makela S, Santti R (2001) No evidence for the in vivo activity of aromatase-inhibiting flavonoids. J Steroid Biochem Mol Biol 78: 231-239
31. Saleh M, Stacker SA, Wilks AF (1996) Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence. Cancer Res 56: 393-401
32. Thiersch K, Hoelzl J (1993) Absorption and excretion of apigenin, apigenin-7-glycoside and hemian after oral administration of extracts of Matricaria recutitia. Pharmazie 48: 554-555
33. Trochon V, Mabilat C, Bertrand P, Legrand Y, Smadja-Joffe F, Soria C, Delpech B, Lu X (1996) Evidence of involvement of CD 44 in endothelial cell proliferation, migration and angiogenesis in vitro. Int J Cancer 66: 664-668
34. Trochon V, Blot E, Cymbalista F, Engelmann C, Tang RP, Thomaidis A, Soria J, Lu H, Soria C (2000) Apigenin inhibits endothelial cell proliferation in G2/M phase whereas it stimulates smooth muscle cells by inhibiting p21 and p27 expression. Int J Cancer 85: 691-696
35. Tsubono Y, Nishino Y, Komatsu S, Hsieh CC, Kanemura S, Tsuji I, Nakatsuka H, Fukao A, Satoh H, Hisamichi S (2001) Green Tea and the Risk of Gastric Cancer in Japan. N Engl J Med 344(9): 632-636
36. Wei H, Tye L, Bresnick E, Birt DF (1990) Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumour promotion in mice. Cancer Res 50(3): 499-502, 1990
37. Weidner N (1995) Current pathologic methods for measuring intratumoural microvessel density within breast carcinoma and other solid tumours. Breast Cancer Res Treat 36:169-180