Mechanistic and genetic studies of radiation tumorigenesis in the mouse - Implications for low dose risk estimation

Journal of Radiological Protection

Volumn 22, Issue 3 A, 2002, Pages

  Bouffler, Simon ^a   Silver, Andrew ^a   Cox, Roger ^a  

^a PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGENS; GENETIC ALGORITHMS; RISK ASSESSMENT; TUMORS;

RADIATION TUMORIGENESIS;

RADIOLOGY;

BCR ABL PROTEIN; IMATINIB;

ACCURACY; ACUTE GRANULOCYTIC LEUKEMIA; ANEUPLOIDY; CANCER GENETICS; CANCER RISK; CANCER SUSCEPTIBILITY; CHROMOSOME ABERRATION; CHROMOSOME REARRANGEMENT; CHRONIC GRANULOCYTIC LEUKEMIA; COLON CARCINOGENESIS; COLORECTAL CANCER; CONFERENCE PAPER; CYTOGENETICS; DISEASE ASSOCIATION; DISEASE MODEL; DRUG EFFICACY; DRUG TARGETING; ENVIRONMENTAL FACTOR; EPIDEMIOLOGICAL DATA; EVIDENCE BASED MEDICINE; GENE INACTIVATION; GENE MUTATION; GENETIC SUSCEPTIBILITY; HEREDITY; HETEROZYGOSITY LOSS; HUMAN; INBRED STRAIN; MICROSATELLITE INSTABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIATION DOSE; RADIATION PROTECTION; RADIATION RESPONSE; RADIOSENSITIVITY; RECIPROCAL CHROMOSOME TRANSLOCATION; RETINOBLASTOMA; RISK ASSESSMENT; SOLID TUMOR; TOXICITY; VALIDATION PROCESS;

EID: 0036741087     PISSN: 09524746     EISSN: None     Source Type: Journal    
DOI: 10.1088/0952-4746/22/3A/306     Document Type: Conference Paper

References (35)

1. United Nations Committee on the Effects of Atomic Radiation (UNSCEAR) 1994 UNSCEAR 1994 Report to the General Assembly, Annex E Epidemiological Studies of Radiation Carcinogenesis (New York: United Nations)
2. United Nations Committee on the Effects of Atomic Radiation (UNSCEAR) 2000 UNSCEAR 2000 Report to the General Assembly, Annex I Epidemiological Evaluation of Radiation-Induced Cancer (New York: United Nations)
3. Boveri T 1914 Zur Frage der Entstehung Maligner Tumoren (Jena: Fischer)
4. Nowell P C and Hungerford D A 1960 A minute chromosome in human chronic granulocytic leukaemia Science 132 1497
5. Rowley J D 1973 A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and giemsa staining Nature 243 290-3
6. Daley G Q, van Etten R A and Baltimore D 1990 Induction of chronic myelogenous leukaemia in mice by the p210 (bcr/abl) gene of the Philadelphia chromosome Science 247 824-30
7. Heisterkamp N, Jenster G, ten Hoeve J, Zovich D, Pattengale P K and Groffen J 1990 Acute leukaemia in bcr/abl transgenic mice Nature 344 251
8. Druker B J et al 2001 Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia New Engl. J. Med. 344 1031-7
9. Cavanee W K, Dryja T P, Phillips R A, Benedict W F, Godbout R, Gallie B L, Murphree A L, Strong L C and White R L 1983 Expression of recessive alleles by chromosomal mechanisms in retinoblastoma Nature 305 779-84
10. Knudson A G 2001 Two genetic hits (more or less) to cancer Nat. Rev. Cancer 1 157-62
11. Fearon E R and Vogelstein B 1990 A genetic model for colorectal tumorigenesis Cell 61 759-67
12. Tomlinson I and Bodmer W 1999 Selection, the mutation rate and cancer: ensuring the tail does not wag the dog Nat. Med. 5 11-12
13. Shih I M, Zhou W, Goodman S N, Lengauer C, Kinzler K W and Vogelstein B 2001 Evidence that genomic instability occurs at an early stage of colorectal tumorigenesis Cancer Res. 61 818-22
14. Stoler D L, Chen N, Basik M, Kahlenberg M S, Rodriguez-Bigas M A, Petrelli N J and Anderson G R 1999 The onset and extent of genomic instability in sporadic colorectal tumour progression Proc. Natl. Acad. Sci. USA 96 15 121-6
15. Jallipalli P V and Lengauer C 2001 Chromosome segregation and cancer: cutting through the mystery Nat. Rev. Cancer 1 109-17
16. Lynch H T and de la Chapelle A 1999 Genetic susceptibility to non-polyposis colorectal cancer J. Med. Genet. 36 801-18
17. Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A and Oren M 1991 Wild type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6 Nature 352 345-7
18. Fukasawa K, Choi T, Kuriyama R, Rulong S and van de Woude G F 1996 Abnormal centrosome amplification in the absence of p53 Science 271 1744-7
19. Bouffler S D, Kemp C J, Balmain A and Cox R 1995 Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice Cancer Res. 55 3883-9
20. Barlow C, Eckhaus M A, Schaffer A A and Wynshaw-Boris A 1999 ATM haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice Nat. Genet. 21 359-60
21. Michel L S, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerals W, Dobles M, Sorger P K, Murty V V and Benezra R 2001 MAD2 haploinsufficiency causes premature anaphase and chromosome instability in mammalian cells Nature 409 355-9
22. Alexander B J, Rasko J E J, Morahan G and Cook W D 1995 Gene deletion explains both in vivo and in vitro generated chromosome 2 aberration associated with murine myeloid leukaemia Leukaemia 9 2009-15
23. Silver A et al 1999 Molecular mapping of chromosome 2 deletions in murine radiation-induced AML localizes a putative tumour suppressor gene to a 1.0 cM region homologous to human chromosome segment 11p11-12 Genes Chrom. Cancer 24 95-104
24. Bouffler S D, Meijne E I M, Huiskamp R and Cox R 1996 Chromosomal abnormalities in neutron-induced acute myeloid leukaemias in CBA/H mice Radiat. Res. 146 349-52
25. Meijne E et al 2001 Analysis of loss of heterozygosity in lymphoma and leukaemia arising in F1 hybrid mice locates a common region of chromosome 4 loss Genes Chrom. Cancer 31 373-81
26. Cleary H J, Wright E and Plumb M 1999 Secificity of loss of heterozygosity in radiation induced mouse myeloid and lymphoid leukaemias Int. J. Radiat. Biol. 75 1223-30
27. Wilding J, Meijne E, Haines J, Moody J, Edwards A, Newbold R, Parris C, Cox R and Silver A 2002 Functional evidence from microcell-mediated chromosome transfer of myeloid leukaemia suppressor genes on human chromosomes 7 and 11 Genes Chrom. Cancer 34 390-7
28. MacDonald D, Boulton E, Pocock D, Goodhead D, Kadhim M and Plumb M 2001 Evidence of genetic instability in 3 Gy X-ray-induced mouse leukaemias and 3 Gy X-irradiated haemopoietic stem cells Int. J. Radiat. Biol. 77 1023-31
29. Bouffler S D, Meijne E I M, Morris D J and Papworth D 1997 Chromosome 2 hypersensitivity and clonal development in murine radiation acute myeloid leukaemia Int. J. Radiat. Biol. 72 181-9
30. + and Dpc4 in tumour development Genes Chrom. Cancer 28 387-94
31. International Commission on Radiological Protection 1998 Genetic susceptibility to cancer ICRP Publication 79 Ann. ICRP 28 1-157
32. Tripodes N, Hart A A M, Fijneman R J A and Demant P 2001 Complexity of lung cancer modifiers: mapping of thirty genes and twenty five interactions in half of the mouse genome J. Natl Cancer Inst. 93 1484-91
33. Ponnaiya B, Cornforth M N and Ullrich R 1997 Radiation induced chromosomal instability in BALB/c and C57BL/6 mice: the difference is as clear as black and white Radiat. Res. 147 121-5
34. Okayasu R, Suetomi K, Silver A, Bedford J, Cox R and Ullrich R 2000 A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse Cancer Res. 60 4342-5
35. Yu Y, Okayasu R, Weil M, Silver A, Cox R, McCarthy M, Zabriskie R, Long S and Ullrich R 2001 Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-PKcs) gene Cancer Res. 61 1820-4