Barriers to the delivery of proteins and peptides

American Pharmaceutical Review

Volumn 5, Issue 3, 2002, Pages 36-40

  Jasti, Bhaskara R ^a   Marasanapalle, Venugopal ^a   Li, Xiaoling ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B INTERFERON; BREFELDIN A; EPIDERMAL GROWTH FACTOR DERIVATIVE; INSULIN; IRON; MACROGOL; PEGINTERFERON ALPHA2A; PEPTIDE; PROTEIN; RECOMBINANT ALPHA2B INTERFERON; SYNTHETIC PEPTIDE; TRANSFERRIN; TRANSFERRIN RECEPTOR; TYRPHOSTIN;

ACTIVE TRANSPORT; ARTICLE; BLOOD BRAIN BARRIER; CHEMICAL PROCEDURES; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG PENETRATION; DRUG SOLUBILITY; ENZYME DEGRADATION; LIPOPHILICITY; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PROTEIN TRANSPORT;

EID: 0036741068     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Harris, J.M., N.E. Martin, and M. Modi, Pegylation: a novel process for modifying pharmacokinetics. Clin Pharmacokinet, 2001. 40(7): p. 539-51.
2. Agu, R.U., et al., The lung as a route for systemic delivery of therapeutic proteins and peptides. Respir Res, 2001. 2(4): p. 198-209.
3. Shah, D. and W.C. Shen, The paradox of transferrin receptor-mediated drug detivery--intracellular targeting or transcellular transport? J Drug Target, 1995. 3(4): p. 243-5.
4. Li, H., H. Sun, and Z.M. Qian, The role of the transferrin-transferrin-receptor system in drug delivery and targeting. Trends Pharmacol Sci, 2002. 23(5): p. 206-9.
5. Brahmankar, M.D. and B.S. Jaiswal, Biopharmaceutics and Pharmacokinetics: A Treatise. Vallabh Prakashan Publishers, Delhi (India), 1999: p. 69.
6. Niven, R.W., et al., Systemic absorption and activity of recombinant consensus interferons after intratracheal instillation and aerosol administration. Pharm Res, 1995. 12(12): p. 1889-95.
7. Kobayashi, S., S. Kondo, and K. Juni, Study on pulmonary delivery of salmon calcitonin in rats: effects of protease inhibitors and absorption enhancers. Pharm Res, 1994. 11(9): p. 1239-43.
8. Forbes, B., C.G. Wilson, and M. Gumbleton, Temporal dependence of ectopeptidase expression in alveolar epithelial cell culture: implications for study of peptide absorption. Int J Pharm, 1999. 180(2): p. 225-34.
9. Yang, X., et al., Characterization of proteolytic activities of pulmonary alveolar epithelium. Int J Pharm, 2000. 195(1-2): p. 93-101.
10. Veronese, F.M. and J.M. Harris, Introduction and overview of peptide and protein pegylation. Adv Drug Deliv Rev, 2002. 54(4): p. 453-6.
11. Bailon, P. and W. Berthold, Polyethylene glycol-conjugated pharmaceutical proteins. Pharmaceutical Science & Technology Today, 1998. 1(8): p. 352-356.
12. Kim, T.H., H. Lee, and T.G. Park, Pegylated recombinant human epidermal growth factor (rhEGF) for sustained release from biodegradable PLGA microspheres. Biomaterials, 2002. 23(11): p. 2311-7.
13. Hinds, K.D. and S.W. Kim, Effects of PEG conjugation on insulin properties. Adv Drug Deliv Rev, 2002. 54(4): p. 505-30.
14. Wang, Y.S., et al., Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications. Adv Drug Deliv Rev, 2002. 54(4): p. 547-70.
15. Xia, C.Q., J. Wang, and W.C. Shen, Hypoglycemic effect of insulin-transferrin conjugate in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther, 2000. 295(2): p. 594-600.
16. Shah, D. and W.C. Shen, Transcellular delivery of an insulintransferrin conjugate in enterocyte-like Caco-2 cells. J Pharm Sci, 1996. 85(12): p. 1306-11.
17. Xia, C.Q. and W.C. Shen, Tyrphostin-8 enhances transferrin receptor-mediated transcytosis in Caco-2- cells and inreases hypoglycemic effect of orally administered insulin-transferrin conjugate in diabetic rats. Pharm Res, 2001. 18(2): p. 191-5.
18. Brightman, M.W., Morphology of blood-brain interfaces. Exp Eye Res, 1977. 25 Suppl: p. 1-25.
19. Schlosshauer, B., The blood-brain barrier: morphology, molecules, and neurothelin. Bioessays, 1993. 15(5): p. 341-6.
20. Temsamani, J., et al., Brain drug delivery technologies: novel approaches for transporting therapeutics. 2000. 3(5): p. 155-162.
21. Drion, N., et al., Role of P-glycoprotein in the blood- rain transport of colchicine and vinblastine. J Neurochem, 1996. 67(4): p. 1688-93.
22. Drion, N., et al., Role of P-170 glycoprotein in colchicine brain uptake. J Neurosci Res, 1997. 49(1): p. 80-8.
23. Bickel, U., T. Yoshikawa, and W.M. Pardridge, Delivery of peptides and proteins through the blood-brain barrier. Adv Drug Deliv Rev, 2001. 46(1-3): p. 247-79.
24. Okumu, F.W., et al., Effect of restricted conformational flexibility on the permeation of model hexapeptides across Caco-2 cell monolayers. Pharm Res, 1997. 14(2): p. 169-75.
25. Muckerheide, A., P.L. Domen, and J.G. Michael, Cationization of protein antigens. II. Alteration of regulatory properties. J Immunol, 1987. 138(9): p. 2800-4.