K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers

Anticancer Research

Volumn 16, Issue 6 B, 1996, Pages 3839-3844

  Lee, Jenq Chang ^a   Wang, Shan Tair ^a   Lai, Ming Derg ^a   Lin, Yih Jyn ^a   Yang, Hsiao Bai ^a  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Colorectal cancer; Direct cycle sequencing; k ras gene; Mutation

Indexed keywords

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; CANCER MORTALITY; CANCER STAGING; CANCER SURVIVAL; CODON; COLORECTAL CANCER; CONTROLLED STUDY; DNA DETERMINATION; DNA SEQUENCE; FEMALE; GENE AMPLIFICATION; GENE FREQUENCY; GENE MUTATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; ONCOGENE K RAS; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGRESSION ANALYSIS;

ADULT; AGED; COLONIC NEOPLASMS; FEMALE; GENES, RAS; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; POINT MUTATION; PROGNOSIS; RECTAL NEOPLASMS;

EID: 0030499353     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Fearon FR and Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61:754-767, 1990.
2. Vogelstein B, Fearon ER, Hamilton SR, Kern S, Preisinger A, Leppert M, Nukamura Y, White R, Smits A and Bos JL: Genetic alterations during colorectal tumor development. N Engl J Med 319:525-532, 1988.
3. Barbacid M: Rus genes. Ann Rev Biochem 56:779-827, 1987.
4. Bos JL, Fearon ER, Hamilton SR, Verlaan-de Vries M, Van Boom JH, Van der Eb AJ and Vogelstein B: Prevalence of ras mutations in human eolorectal cancers. Nature 327:293-297, 1987.
5. Forrester K, Almoguera C, Han K, Grizzle WE and Perrucho M: Detection of high incidence of K-ras oneogenes during human carcinogenesis. Nature 327:298-303, 1989.
6. Bell SM, Scott N, Cross D, Sagar P, Lewis FA, Blair GE, Taylor GR, Dixon MF and Quirke P: Prognostic value of P53 overexpression and c-ki-ras gene mutations in colorectal cancer. Gastroenterology 104:57-67, 1993.
7. Jiang W, Kahn SM, Guillem JG, Lu SH and Weinstein B: Rapid detection of ras oneogenes in human tumors: Applications to colon, esophageal and gastric cancer. Oncogene 4:923-928, 1989.
8. Slebos R, Kibbelaar R, Dalesio O, Kooistra A, Stam J, Meijer C, Wagenaar S, Vanderschueren R, Zandwijk N, Mooi W, Bos J and Rodenhuis S: K ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. N. Engl J Med 323:561-565, 1990.
9. Mitsudomi T, Steinberg SM, Oie HK, Mulshine JL, Phelps R, Viallet J, Pass M, Minna JD and Gazdar AF: Ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent. Cancer Res 51: 4999-5005, 1991.
10. Enomoto T, Weghorst CM, Inoue M, Tanizawa O and Rice JM: K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary. Am J Pathol 139:777-785, 1991.
11. Lübbert M, Mirro JJ, Miller CW, Kahan J, Isaac G, Kitchingman G, Mertelsmann R, Herrmann F, McCormick F and Koeffler HP: N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis. Blood 75: 1163-1169, 1990.
12. Benhattar J, Losi L, Chaubert P, Givel JC and Costa J: Prognostic significance of K-ras mutations in colorectal carcinoma, Gastroenterology 104: 1044-048, 1993.
13. Finkelstein S, Sayegh R, Christensen S and Swalsky P: Genotypic classification of colorectal adenocarcinoma. Cancer(Phila) 71: 3827-3838, 1993.
14. Kern S, Fearon E, Tersmette K, Enterline J, Leppert M, Nakamura Y, White R, Vogelstein B and Hamilton S: Allelic loss in colorectal carcinoma. JAMA 261: 3099-3103, 1991.
15. Laurent-Puig P, Olschwang S, Delattre O, Remvikos V, Asselain B, Melot T, Validive P, Muleris M, Girodet J, Salmon R and Thomas G: Survival and acquired mendie alterations in colorectal cancer. Gastroenterology 102: 1136-1141, 1992.
16. Markowitz S, Hines JD, Lutterbaugh J, Mycroff L, Mackay W. Gordon N, Rustum Y, Luna E and Kleinerman J: Mutant K-ras oncogenes in colon cancers do not predict patient's chemotherapy response or survival. Clinical Cancel Res 1:441-445, 1995.
17. Turnbull Jr. RB, Kyle K, Watson FR and Spratt J: Cancer of the colon: The influence of the no-touch isolation technic on survival rates. Ann Surg 166:420-427, 1967.
18. Shibata DK, Arnheim N and Martin WJ: Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction. J Exp Med 167:225-230, 1988.
19. Kaplan EL and Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958.
20. Lee JC, Chow NH, Cheng: YT, Tzeng CC and Lai MD: Analysis ol K-ras gene mutation and DNA ploidy stains from parattin-embedded colorectal cancer tissue sections. JS CRS ROC 5:40-47, 1994.
21. Enomoto T, Inoue M, Perantoni AO, Terakawa N, Tanizawa O and Rice JM: K-ras, activation in neoplasms ol the human female reproductive tract. Cancer Res. 50: 6139-6145, 1990.
22. Morson BC: The polyp-cancer sequence in the large bowel Proc Soc Med 67:451-457, 1974.
23. Fenoglio CM and Lane N: The anatomical precursor colorectal carcinoma. Cancer 34:819-823, 1974.
24. Mutou T, Bussey HJR and Morson BC: The evolusion ot cancer of the colon and rectum. Cancer 36: 2251-2270, 1975.
25. Ackerman LV and Spratt JS: Do adenomatous polyps became cancer? Gastroenterology 44:905-908, 1963.
26. Spratt JS and Ackerman LV: The growth of a colonic adenocarcinoma. Am Surg 27:23-28, 1961.
27. Shimoda T, Ikegami M, Fujisaki J, Matsui T, Aizawa S and Ishikawa E: Early colorectal carcinoma with special reference to its development de novo. Cancer 64: 1138-1146, 1989.
28. Muto T, Kamiya J and Sawada T: Small "flat adenoma" of the large bowel with special reference to its clinicopathological feature. Dis Colon Rectum 28:847-851, 1985.
29. Yamagata S, Muto T, Uchida Y, Masaki T, Sawada T Tsuno N and Hirooka T: Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas. Jpn J Cancer Res 85:147-151, 1994.
30. Fujimori T, Nagasako K, Satonaka K, Hirayama D, Harada M, Muratani A, Tabata T, Kitazawa S, Ikehara H and Maeda S: Expression of ras oneogene product (P21) and point mutation of ki-ras codon 12 in superficial early coloreetal cancer. I to cho 27:111-117 (in Japanese), 1992.
31. Burmer GC, Levine DS, Kulander GB, Haggitt RC, Rubin CE and Rabinovitch PS: C Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma. Gastroenterology 99:416-420, 1990.
32. Ando M, Maruyama M, Oto M, Takemura K, Endo M and Yuasa Y: Higher frequency of point mutations in the c-k-ras 2 gene in human colorectal adenomas with severe atypia than in carcinomas. Jpn J CancerRes 82:245-249, 1991.