The phenylpropanoid pathway and plant defence - A genomics perspective

Molecular Plant Pathology

Volumn 3, Issue 5, 2002, Pages 371-390

  Dixon, Richard A ^a   Achnine, Lahoucine ^a   Kota, Parvathi ^a   Liu, Chang Jun ^a   Reddy, M S Srinivasa ^a   Wang, Liangjiang ^a  

^a PLANT BIOLOGY DIVISION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARABIDOPSIS; ARABIDOPSIS THALIANA; EMBRYOPHYTA; GLYCINE MAX; LYCOPERSICON ESCULENTUM; MEDICAGO TRUNCATULA;

EID: 0036733289     PISSN: 14646722     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1364-3703.2002.00131.x     Document Type: Review

References (131)

1. Babiychuk, E., Kushnir, S., Bellesboix, E., Van Montagu, M. and Inzé, D. (1995) Arabidopsis thaliana NADPH oxidoreductase homologs confer tolerance of yeast toward the thiol-oxidizing drug diamide. J. Biol. Chem. 270, 26 224-26 231.
2. Bell, C, Dixon, R.A., Farmer, A.D., Flores, R., Inman, J., Gonzales, R.A., Harrison, MJ., Paiva, N.L., Scott, A.D., Weller, J.W. and May, G.D. (2001) The Medicago genome initiative: a model legume database. Nucl. Acids Res. 29, 114-117.
3. Blount, J.W., Korth, K.L., Masoud, S.A., Rasmussen, S., Lamb, C. and Dixon, R.A. (2000) Altering expression of cinnamic acid 4-hydroxylase in transgenic plants provides evidence for a feedback loop at the entry point into the phenylpropanoid pathway. Plant Physiol. 122, 107-116.
4. Borevitz, J., Xia, Y., Blount, J.W., Dixon, R.A. and Lamb, C. (2001) Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis. Plant Cell, 12, 2383-2393.
5. Chong, J., Pierrel, M.A., Atanassova, R., WerckReichhart, D., Fritig, B. and Saindrenan, P. (2001) Free and conjugated benzoic acid in tobacco plants and cell cultures. Induced accumulation upon elicitation of defense responses and role as salicylic acid precursors. Plant Physiol. 125, 318-328.
6. Covert, S.F., Enkerli, J., Miao, V.P.W. and VanEtten, H.D. (1996) A gene for maackiain detoxification from a dispensable chromosome of Nectria haematococca. Mol. Gen. Genet. 251, 397-406.
7. Cukovic, D., Ehlting, J., VanZiffle, J. and Douglas, C.J. (2001) Structure and evolution of 4-coumarate:coenzyme A ligase (4CL) gene families. Biol. Chem. 382, 645-654.
8. Czichi, U. and Kindl, H. (1975) Formation of p-coumaric acid and o-coumaric acid from L-phenylalanine by microsomal membrane fractions from potato: evidence of membrane-bound enzyme complexes. Planta, 125, 115-125.
9. Davin, L.B. and Lewis, N.G. (1992) Phenylpropanoid metabolism: Biosynthesis of monolignols, lignans and neolignans, lignins and suberins. Rec. Adv. Phytochem. 26, 325-375.
10. Davin, L.B., Wang, H.-B., Crowell, A.L., Bedgar, D.L., Martin, D.M., Sarkanen, S. and Lewis, N.G. (1997) Stereoselective bimolecular coupling by an auxiliary (dirigent) protein without an active center. Science, 275, 362-366.
11. Delaney, T.P., Uknes, S., Vernooij, B., Friedrich, L., Weymann, K., Negrotto, D., Gaffney, T., Gut-Rella, M., Kessmann, H., Ward, E. and Ryals, J. (1994) A central role of salicylic acid in plant disease resistance. Science, 266, 1247-1250.
12. Dempsey, D.A., Shah, J. and Klessig, D.F. (1999) Salicylic acid and disease resistance in plants. Crit. Rev. Plant Sci. 18, 547-575.
13. Dewick, P.M. (1994) The isoflavonoids. In: The Flavonoids. Advances in Research Since 1986 (Harborne, J.B., ed.). London: Chapman & Hall, pp. 117-238.
14. Dhawale, S., Souciet, G. and Kuhn, D.N. (1989) Increase of chalcone synthase mRNA in pathogen-induced soybeans with race-specific resistance is different in leaves and roots. Plant Physiol. 91, 911-916.
15. Dixon, R.A. (2001) Natural products and disease resistance. Nature, 411, 843-847.
16. Dixon, R.A. and Paiva, N.L. (1995) Stress-induced phenylpropanoid metabolism. Plant Cell, 7, 1085-1097.
17. Dröge-Laser, W., Kaiser, A., Lindsay, W.R, Halkier, B., Loake, G.A., Doerner, P.W., Dixon, R.A. and Lamb, C.J. (1997) Rapid stimulation of a soybean protein-serine kinase that phosphorylates a novel bZlP transcription factor, G/HBF-1, in the induction of early transcription-dependent defenses. EMBO J. 16, 726-738.
18. Eckerman, S., Schröder, G., Schmidt, J., Strack, D., Edrada, R.A., Helariutta, Y., Elomaa, P., Kotilainen, M., Kilpeläinen, I., Proksch, P., Teeri, T.H. and Schröder, J. (1998) New pathway to polyketides in plants. Nature, 396, 387-390.
19. Ehlting, J., Shin, J.J.K. and Douglas, C.J. (2001) Identification of 4-coumarate:coenzyme A ligase (4CL) substrate recognition domains. Plant J. 27, 455-465.
20. van Eldik, G.J., Ruiter, R.K., Colla, P.H.W.N., van Herpen, M.M.A., Schrauwen, J.A.M. and Wultems, G.J. (1997) Expression of an isoflavone reductase-like gene enhanced by pollen tube growth in pistils of Solanum tuberosum. Plant Mol. Biol. 33, 923-929.
21. El-Mawla, A.M.A.A. and Beerhues, L. (2002) Benzoic acid biosynthesis in cell cultures of Hypericum androsaemum. Planta, 214, 727-733.
22. El-Mawla, A.M.A.A., Schmidt, W. and Beerhues, L. (2001) Cinnamic acid is a precursor of benzoic acids in cell cultures of Hypericum androsaemum L., but not in cell cultures of Centaurium erythraea RAFN. Planta, 212, 288-293.
23. Enkerli, J., Bhatt, G. and Covert, S.F. (1998) Maackiain detoxification contributes to the virulence of Nectria haematococca MP VI on chickpea. Mol. Plant-Microbe Interact. 11, 317-326.
24. Eulgem, T., Rushton, P.J., Robatez, S. and Somssich, I.E. (2000) The WRKY superfamily of plant transcription factors. Trends Plant Sci. 5, 199-206.
25. Eulgem, T., Rushton, P.J., Schmelzer, E., Hahlbrock, K. and Somssich, I.E. (1999) Early nuclear events in plant defence signalling: rapid gene activation by WRKY transcription factors. EMBO J. 18, 4689-4699.
26. Fahrendorf, T., Ni, W., Shorrosh, B.S. and Dixon, R.A. (1995) Stress responses in alfalfa (Medicago sativa L.) XIX. Transcriptional activation of oxidative pentose phosphate pathway genes at the onset of the isoflavonoid phytoalexin response. Plant Mol. Biol. 28, 885-900.
27. Feinbaum, R.L. and Ausubel, F.M. (1992) Transcriptional regulation of the Arabidopsis thaliana chalcone synthase gene. Mol. Cell. Biol. 8, 1985-1992.
28. Felton, G.W., Korth, K.L., Bi, J.L., Wesley, S.V., Huhman, D.V., Mathews, M.C., Murphy, J.B., Lamb, C. and Dixon, R.A. (1999) Inverse relationship between systemic resistance of plants to microorganisms and to insect herbivory. Curr. Biol. 9, 317-320.
29. Ferrer, J.-L., Jez, J.M., Bowman, M.E., Dixon, R.A. and Noel, J.P. (1999) Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Nature Struct. Biol. 6, 775-784.
30. Fiehn, O., Kopka, J., Trethewey, R.N. and Willmitzer, L. (2000) Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry. Anal. Chem. 72, 3573-3580.
31. Gagnon, H., Tahara, S. and Ibrahim, R.K. (1995) Biosynthesis, accumulation and secretion of isoflavonoids during germination and development of white lupin (Lupinus albus L.). J. Exp. Bot. 46, 609-616.
32. Gang, D.R., Kasahara, H., Xia, Z.Q., Mijnsbrugge, K.V., Bauw, G., Boerjan, W., Van Montagu, M., Davin, L.B. and Lewis, N.G. (1999) Evolution of plant defense mechanisms: relationships of phenylcoumaran benzylic ether reductases to pinoresinol-lariciresinol and isoflavone reductases. J. Biol. Chem. 274, 7516-7527.
33. Grayer, R.J. and Harborne, J.B. (1994) A survey of antifungal compounds from higher plants. Phytochemistry, 37, 19-42.
34. Hain, R., Reif, H.-J., Krause, E., Langebartels, R., Kindl, H., Vornam, B., Weiese, W., Schmelzer, E., Schrier, P.H., Stocker, R.H. and Stenzel, K. (1993) Disease resistance results from foreign phytoalexin expression in a novel plant. Nature, 361, 153-156.
35. Hammerschmidt, R. (1999) Phytoalexins: what have we learned after 60 years? Annu. Rev. Phytopathol. 37, 285-306.
36. He, X.-Z. and Dixon, R.A. (2000) Genetic manipulation of isoflavone 7-O-methyltransferase enhances the biosynthesis of 4′-O-methylated isoflavonoid phytoalexins and disease resistance in alfalfa. Plant Cell 12, 1689-1702.
37. Hipskind, J.D. and Paiva, N.L. (2000) Constitutive accumulation of a resveratrol-glucoside in transgenic alfalfa increases resistance to Phoma medicaginis. Mol. Plant-Microbe Interact. 13, 551-562.
38. Howles, P.A., Paiva, N.L., Sewalt, VJ.H., Elkind, N.L., Bate, Y., Lamb, C.J. and Dixon, R.A. (1996) Overexpression of L-phenylalanine ammonia-lyase in transgenic tobacco plants reveals control points for flux into phenylpropanoid biosynthesis. Plant Physiol. 112, 1617-1624.
39. Hrazdina, G. and Jensen, R.A. (1992) Spatial organization of enzymes in plant metabolic pathways. Annu. Rev. Plant Physiol. Plant Mol. Biol. 43, 241-267.
40. Hrazdina, G. and Wagner, G.J. (1985) Metabolic pathways as enzyme complexes: evidence for the synthesis of phenylpropanoids and flavonoids on membrane associated enzyme complexes. Arch. Biochem. Biophys. 237, 88-100.
41. Jacobs, M. and Rubery, P.H. (1988) Naturally occurring auxin transport regulators. Science, 241, 346-349.
42. Jarvis, A.P., Schaaf, O. and Oldham, N.J. (2000) 3-Hydroxy-3-phenylpropanoic acid is an intermediate in the biosynthesis of benzoic acid and salicylic acid, but benzaldehyde is not. Planta, 212, 119-126.
43. Jez, J.M., Austin, M.B., Ferrer, J.-L, Bowman, M.E., Schröder, J. and Noel, J.P. (2000a) Structural control of polyketide formation in plant-specific polyketide synthesis. Chem. Biol. 7, 919-930.
44. Jez, J.M., Bowman, M.E., Dixon, R.A. and Noel, J.P. (2000b) Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. Nature Struct. Biol. 7, 786-791.
45. Jez, J.M., Bowman, M.E. and Noel, J.P. (2002) Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. Proc. Natl. Acad. Sci. USA, 99, 5319-5324.
46. Jung, W., Yu O., Lau, S.-M.C., O'Keefe, D.P., Odell, J., Fader, G. and McGonigle, B. (2000) Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes. Nature Biotechnol. 18, 208-212.
47. Junghans, H., Dalkin, K. and Dixon, R.A. (1993) Stress responses in alfalfa (Medicago sativa L.) XV. Characterization and expression patterns of members of a subset of the chalcone synthase multigene family. Plant Mol. Biol. 22, 239-253.
48. Karamloo, F., Wangorsch, A., Kasahara, H., Davin, L.B., Haustein, D., Lewis, N.G. and Vieths, S. (2001) Phenylcoumaran benzylic ether and isoflavonoid reductases are a new class of cross-reactive allergens in birch pollen, fruits and vegetables. Eur. J. Biochem. 268, 5310-5320.
49. 2. Plant Physiol. 108, 1171-1178.
50. Kawaoka, A., Kaothien, P., Yoshida, K., Endo, S., Yamada, K. and Ebinuma, H. (2000) Functional analysis of tobacco LIM protein Ntlim1 involved in lignin biosynthesis. Plant J. 22, 289-301.
51. Klessig, D.F. and Malamy, J. (1994) The salicylic acid signal in plants. Plant Mol. Biol. 26, 1439-1458.
52. Knobloch, K.H. and Hahlbrock, K. (1975) Isoenzymes of p-coumarate:CoA ligase from cell suspension cultures of Glycine max. Eur. J. Biochem. 52, 311-320.
53. Kuć, J. (1995) Phytoalexins, stress metabolism, and disease resistance in plants. Annu. Rev. Phytopathol. 33, 275-297.
54. Kumar, A. and Ellis, B.E. (2001) The phenylalanine ammonia-lyase gene family in raspberry. Structure, expression, and evolution. Plant Physiol. 127, 230-239.
55. LaFlamme, P., Khouri, H., Gulick, P. and Ibrahim, R. (1993) Enzymatic prenylation of isoflavones in white lupin. Phytochemistry, 34, 147-151.
56. Latunde Dada, A.D., Cabello Hurtado, F., Czittrich, N., Didierjean, L., Schopfer, C., Hertkorn, N., WerckReichhart, D. and Ebel, J. (2001) Flavonoid 6-hydroxylase from soybean (Glycine max L.), a novel plant P-450 monooxygenase. J. Biol. Chem. 276, 1688-1695.
57. Lawton, M.A., Dixon, R.A., Hahlbrock, K. and Lamb, C.J. (1983) Elicitor induction of mRNA activity: rapid effects of elicitor on phenylalanine ammonia-lyase and chalcone synthase mRNA activities in bean cells. Eur. J. Biochem. 130, 131-139.
58. Lee, D. and Douglas, C.J. (1996) Two divergent members of a tobacco 4-coumarate:coenzyme A ligase (4Cl) gene family. Plant Physiol. 112, 193-2205.
59. Lee, H.I., Leon, J. and Raskin, I. (1995) Biosynthesis and metabolism of salicylic acid. Proc. Natl. Acad. Sci. USA, 92, 4076-4079.
60. Lehfeldt, C., Shirley, A.M., Meyer, K., Ruegger, M.O., Cusumano, J.C., Viitanen, P.V., Strack, D. and Chapple, C. (2000) Cloning of the SNG1 gene of Arabidopsis reveals a role for a serine carboxypeptidase-like protein as an acyltransferase in secondary metabolism. Plant Cell, 12, 1295-1306.
61. León, J., Shulaev, V., Yalpani, N., Lawton, M.A. and Raskin, I. (1995) Benzoic acid 2-hydroxylase, a soluble oxygenase from tobacco, catalyzes salicylic acid biosynthesis. Proc. Natl. Acad. Sci. USA, 92, 10 413-10 417.
62. Lers, A., Burd, S., Lomaniec, E., Droby, S. and Chalutz, E. (1998) The expression of a grapefruit gene encoding an isoflavone reductase-like protein is induced in response to UV irradiation. Plant Mol. Biol. 36, 847-856.
63. Lindsay, W.P., McAlister, F.M., Zhu, Q., He, X.-Z., Droge-Laser, W., Hedrick, S., Doerner, P., Lamb, C. and Dixon, R.A. (2002) KAP-2, a protein that binds to the H-box in a bean chalcone synthase promoter, is a novel plant transcription factor with sequence identity to the large subunit of human Ku autoantigen. Plant Mol. Biol. 49, 503-514.
64. Liu, C.-J. and Dixon, R.A. (2001) Elicitor-induced association of isoflavone O-methyltransferase with endomembranes prevents formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis. Plant Cell, 13, 2643-2658.
65. Liu, L.S., White, M.J. and MacRae, T.H. (1999) Transcription factors and their genes in higher plants - functional domains, evolution and regulation. Eur. J. Biochem. 262, 247-257.
66. Löscher, R. and Heide, L. (1994) Biosynthesis of p-hydroxybenzoate from p-coumarate and p-coumaroyl-coenzyme A in cell-free extracts of Lithospermum erythrorhizon cell cultures. Plant Physiol. 106, 271-279.
67. Malamy, J., Sanchez-Casas, P., Hennig, J., Guo, A. and Klessig, D.F. (1996) Dissection of the salicylic acid signaling pathway in tobacco. Mol. Plant-Microbe Interact. 9, 474-482.
68. Mansfield, J.W. (2000) Antimicrobial compounds and resistance. The role of phytoalexins and phytoanticipins. In: Mechanisms of Resistance to Plant Diseases (Slusarenko, A., Fraser, R.S.S. and van Loon, L.C., eds). Dordrecht: Kluwer Academic Publishers, pp. 325-370.
69. Meshi, T. and Iwabuchi, M. (1995) Plant transcription factors. Plant Cell Physiol. 36, 1405-1420.
70. Mitchell, H.J., Hall, S.A., Stratford, R., Hall, J.L. and Barber, M.S. (1999) Differential induction of cinnamyl alcohol dehydrogenase during defensive lignification in wheat (Triticum aestivum L.): Characterisation of the major inducible form. Planta, 208, 31-37.
71. Muir, S.R., Collins, G.J., Robinson, S., Hughes, S., Bovy, A., De Vos, C.H.R., van Tunen, A.J. and Verhoeyen, M.E. (2001) Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols. Nature Biotechnol. 19, 470-474.
72. Muljono, R.A.B., Scheffer, J.J.C. and Verpoorte, R. (2002) Isochorismate is an intermediate in 2,3-dihydroxybenzoic acid biosynthesis in Catharanthus roseus cell cultures. Plant Physiol. Biochem. 40, 231-234.
73. Mur, L.A.J., Bi, Y.M., Darby, R.M., Firek, S. and Draper, J. (1997) Compromising early salicylic acid accumulation delays the hypersensitive response and increases viral dispersal during lesion establishment in TMV-infected tobacco. Plant J. 12, 1113-1126.
74. Murphy, A.M., Chivasa, S., Singh, D.P. and Carr, J.P. (1999) Salicylic acid-induced resistance to viruses and other pathogens: a parting of the ways? Trends Plant Sci. 4, 155-160.
75. Nagai, N., Kitauchi, F., Shimosaka, M. and Okazaki, M. (1994) Cloning and sequencing of a full-length cDNA coding for phenylalanine ammonia-lyase from tobacco cell culture. Plant Physiol. 104, 1091-1092.
76. Nesi, N., Debeaujon, I., Jond, C., Pelletier, G., Caboche, M. and Lepiniec, L. (2000) The TT8 gene encodes a basic helix-loop-helix domain protein required for expression of DFR and BAN genes in Arabidopsis siliques. Plant Cell, 12, 1863-1878.
77. Nesi, N., Jond, C., Debeaujon, I., Caboche, M. and Lepiniec, L. (2001) The Arabidopsis TT2 gene encodes an R2R3 MYB domain protein that acts as a key determinant for proanthocyanidin accumulation in developing seed. Plant Cell, 13, 2099-2114.
78. Ni, W., Fahrendorf, T., Ballance, G.M., Lamb, C.J. and Dixon, R.A. (1996) Stress responses in alfalfa (Medicago sativa L). XX. Transcriptional activation of phenylpropanoid pathway genes in elicitor-treated cell suspension cultures. Plant Mol. Biol. 30, 427-438.
79. Norin, M. and Sundstrom, M. (2002) Structural proteomics: developments in structure-to-function predictions. Trends Biotechnol. 20, 79-84.
80. Paiva, N.L., Edwards, R., Sun, Y., Hrazdina, G. and Dixon, R.A. (1991) Stress responses in alfalfa (Medicago sativa L.) XI. Molecular cloning and expression of alfalfa isoflavone reductase, a key enzyme of isoflavonoid phytoalexin biosynthesis. Plant Mol. Biol. 17, 653-667.
81. Paiva, N.L., Sun, Y., Dixon, R.A., VanEtten, H.D. and Hrazdina, G. (1994) Molecular cloning of isoflavone reductase from pea (Pisum sativum L.): Evidence for a 3R-isoflavanone intermediate in (+)-pisatin biosynthesis. Arch. Biochem. Biophys. 312, 501-510.
82. Pakusch, A.E., Kneusel, R.E. and Matern, U. (1989) S-adenosyl-L-methionine:trans-caffeoyl-coenzyme A 3-O-methyltransferase from elicitor-treated parsley cell suspension cultures. Arch. Biochem. Biophys. 271, 488-494.
83. Pallas, J.A., Paiva, N.L., Lamb, C.J. and Dixon, R.A. (1996) Tobacco plants epigenetically suppressed in phenylalanine ammonia-lyase expression do not develop systemic acquired resistance in response to infection by tobacco mosaic virus. Plant J. 10, 281-293.
84. Pellegrini, L., Rohfritsch, O., Fritig, B. and Legrand, M. (1994) Phenylalanine ammonia-lyase in tobacco. Molecular cloning and gene expression during the hypersensitive reaction to tobacco mosaic virus and the response to a fungal elicitor. Plant Physiol. 106, 877-886.
85. Petrucco, S., Bolchi, A., Foroni, C., Percudani, R., Rossi, G.L. and Ottonello, S. (1996) A maize gene encoding a NADPH binding enzyme highly homologous to isoflavone reductases is activated in response to sulfur starvation. Plant Cell, 8, 69-80.
86. Pierpoint, W.S. (1997) The natural history of salicylic acid. Interdisciplinary Sci. Rev. 22, 45-52.
87. Quackenbush, J., Liang, F., Holt, I., Pertea, G. and Upton, J. (2000) The TIGR gene indices: reconstruction and representation of expressed gene sequences. Nucl. Acids Res. 28, 141-145.
88. Rakwal, R., Agrawal, G.K., Yonekura, M. and Kodama, O. (2000) Naringenin 7-O-methyltransferase involved in the biosynthesis of the flavanone phytoalexin sakuranetin from rice (Oryza sativa L.). Plant Sci. 155, 213-221.
89. 2. Plant Physiol. 115, 137-149.
90. Rasmussen, S. and Dixon, R.A. (1999) Transgene-mediated and elicitor-induced perturbation of metabolic channeling at the entry point into the phenylpropanoid pathway. Plant Cell, 11, 1537-1551.
91. Rate, D.N., Cuenca, J.V., Bowman, G.R., Guttman, D.S. and Greenberg, J.T. (1999) The gain-of-function Arabidopsis acd6 mutant reveals novel regulation and function of the salicylic acid signaling pathway in controlling cell death, defenses, and cell growth. Plant Cell, 11, 1695-1708.
92. Reymond, P. (2001) DNA microarrays and plant defence. Plant Physiol. Biochem. 39, 313-321.
93. Riggleman, R.C., Fristensky, B. and Hadwiger, L.A. (1985) The disease resistance response in pea is associated with increased levels of specific mRNAs. Plant Mol. Biol. 4, 81-86.
94. Roessner, U., Wagner, C., Kopka, J., Trethewey, R.N. and Willmitzer, L. (2000) Simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry. Plant J. 23, 131-142.
95. von Röpenack, E., Parr, A. and Schulze-Lefert, R (1998) Structural analyses and dynamics of soluble and cell wall-bound phenolics in a broad spectrum resistance to the powdery mildew fungus in barley. J. Biol. Chem. 273, 9013-9022.
96. Rushton, P.J. and Somssich, I.E. (1999) Transcriptional regulation of plant genes responsive to pathogens and elicitors. In: Plant-Microbe Interactions, 4 (Stacey, G. and Keen, N.T., eds). St Paul, MN: American Phytopathological Society, pp. 251-274.
97. Sallaud, C., Zuanazzi, J., El-Turk, J., Leymarie, J., Breda, C., Buffard, D., de Kozak, I., Ratet, P., Husson, P., Kondorosi, A. and Esnault, R. (1997) Gene expression is not systemically linked to phytoalexin production during alfalfa leaf interaction with pathogenic bacteria. Mol. Plant-Microbe Interact. 10, 257-267.
98. Schnitzler, J.P., Madlung, J., Rose, A. and Seitz, H.U. (1992) Biosynthesis of p-hydroxybenzoic acid in elicitor-treated carrot cell cultures. Planta, 188, 594-600.
99. Schopfer, C.R., Kochs, G., Lottspeich, F. and Ebel, J. (1998) Molecular characterization and functional expression of dihydroxypterocarpan 6a-hydroxylase, an enzyme specific for pterocarpanoid phytoalexin biosynthesis in soybean (Glycine max L). FEBS Lett. 432, 182-186.
100. Schröder, J. (1997) A family of plant-specific polyketide synthases: facts and predictions. Trends Plant Sci. 2, 373-378.
101. Schroeder, G., Wehinger, E. and Schroeder, J. (2002) Predicting the substrates of cloned plant O-methyltransferases. Phytochemistry, 59, 1-8.
102. Shirasu, K., Nakajima, H., Rajasekhar, V.K., Dixon, R.A. and Lamb, C.J. (1997) Salicylic acid potentiates an agonist-dependent gain control that amplifies pathogen signals in the activation of defense mechanisms. Plant Cell, 9, 261-270.
103. Somssich, I.E. and Hahlbrock, K. (1998) Pathogen defence in plants - a paradigm of biological complexity. Trends Plant Sci. 3, 86-90.
104. Srere, P.A. (1987) Complexes of sequential metabolic enzymes. Annu. Rev. Biochem. 56, 89-124.
105. Steele, C.L., Gijzen, M., Qutob, D. and Dixon, R.A. (1999) Molecular characterization of the enzyme catalyzing the aryl migration reaction of isoflavonoid biosynthesis in soybean. Arch. Biochem. Biophys. 367, 147-150.
106. Stuiver, M.H. and Custers, J.H.H.V. (2001) Engineering disease resistance in plants. Nature, 411, 865-868.
107. Sugimoto, K., Takeda, S. and Horochika, H. (2000) MYB-related transcription factor NtMYB2 induced by wounding and elicitors is a regulator of the tobacco retrotransposon Tto1 and defense-related genes. Plant Cell, 12, 2511-2528.
108. Tamagnone, L., Merida, A., Parr, A., Mackay, S., Culianez-Macia, F.A., Roberts, K. and Martin, C. (1998) The AmMYB308 and AmMYB330 transcription factors from antirrhinum regulate phenylpropanoid and lignin biosynthesis in transgenic tobacco. Plant Cell, 10, 135-154.
109. Teutonico, R.T., Dudley, M.W., Orr, J.D., Lynn, D.G. and Binns, A.N. (1991) Activity and accumulation of cell division-promoting phenolics in tobacco tissue cultures. Plant Physiol. 97, 288-297.
110. Tiemann, K., Inzé, D., Van Montagu, M. and Barz, W. (1991) Pterocarpan phytoalexin biosynthesis in elicitor-challenged chickpea (Cicer arietinum L.) cell cultures. Purification, characterization and cDNA cloning of NADPH:isoflavone oxidoreductase. Eur. J. Biochem. 200, 751-757.
111. Trethewey, R.N., Krotzky, A.J. and Willmitzer, L. (1999) Metabolic profiling: a Rosetta Stone for genomics? Curr. Opin. Plant Biol. 2, 83-85.
112. Uhlmann, A. and Ebel, J. (1993) Molecular cloning and expression of 4-coumarate:coenzyme A ligase, an enzyme involved in the resistance response of soybean (Glycine max L.) against pathogen attack. Plant Physiol. 102, 1147-1156.
113. VanEtten, H.D., Mansfield, J.W., Bailey, J.A. and Farmer, E.E. (1994) Two classes of plant antibiotics: phytoalexins versus 'phytoanticipins'. Plant Cell, 6, 1191-1192.
114. Verberne, M.C., Muljono, R.A.B. and Verpoorte, R. (1999) Salicylic acid biosynthesis. In: Biochemistry and Molecular Biology of Plant Hormones (Hooykaas, P.J.J., Hall, M.A. and Libbenga, K.R., eds). Amsterdam: Elsevier Science Publishers, pp. 295-312.
115. Verberne, M.C., Verpoorte, R., Bol, J.F., MercadoBlanco, J. and Linthorst, H.J.M. (2000) Overproduction of salicylic acid in plants by bacterial transgenes enhances pathogen resistance. Nature Biotechnol. 18, 779-783.
116. Vernooij, B., Friedrich, L., Morse, A., Reist, R., Kolditz-Jawhar, R., Ward, E., Uknes, S., Kessmann, H. and Ryals, J. (1994) Salicylic acid is not the translocated signal responsible for inducing systemic acquired resistance but is required in signal transduction. Plant Cell, 6, 959-965.
117. Vincent, J.R. and Nicholson, R.L. (1987) Evidence for isoenzymes of 4-hydroxycinnamic acid:CoA ligase in maize mesocotyls and their response to infection by Helminthosporium maydis race O. Physiol. Mol. Plant Pathol. 30, 121-129.
118. Wang, Y. and Fristensky, B. (2001) Transgenic canola lines expressing pea defense gene DRR206 have resistance to aggressive blackleg isolates and to Rhizoctonia solani. Mol. Breed. 8, 263-271.
119. Wang, Y., Nowak, G., Culley, D., Hadwiger, L.A. and Fristensky, B. (1999) Constitutive expression of pea defense gene DRR206 confers resistance to blackleg (Leptosphaeria maculans) disease in transgenic canola (Brassica napus). Mol. Plant-Microbe Interact. 12, 410-418.
120. Wasmann, C.C. and VanEtten, H.D. (1996) Transformation-mediated chromosome loss and disruption of a gene for pisatin demethylase decrease the virulence of Nectria haematococca on pea. Mol. Plant-Microbe Interact. 9, 793-803.
121. Weisshaar, B. and Jenkins, G.I. (1998) Phenylpropanoid biosynthesis and its regulation. Curr. Opin. Plant Biol. 1, 251-257.
122. Wesley, V.S., Helliwell, C.A., Smith, N.A., Wang, M.B., Rouse, D.T., Liu, Q., Gooding, P.S., Singh, S.P., Abbott, D., Stoutjesdijk, P.A., Robinson, S.P., Gleave, A.P., Green, A.G. and Waterhouse, P.M. (2001) Construct design for efficient, effective and high-throughput gene silencing in plants. Plant J. 27, 581-590.
123. Wildermuth, M.C., Dewdney, J., Wu, G. and Ausubel, F.M. (2001) Isochorismate synthase is required to synthesize salicylic acid for plant defence. Nature, 414, 562-565.
124. Winkel-Shirley, B. (1999) Evidence for enzyme complexes in the phenylpropanoid and flavonoid pathways. Physiol. Plant. 107, 142-149.
125. Woo, H.H., Orbach, M.J., Hirsch, A.M. and Hawes, M.C. (1999) Meristem-localized inducible expression of a UDP-glycosyltransferase gene is essential for growth and development in pea and alfalfa. Plant Cell, 11, 2303-2315.
126. Yalpani, N., Léon, J., Lawton, M.A. and Raskin, I. (1993) Pathway of salicylic acid biosynthesis in healthy and virus-inoculated tobacco. Plant Physiol. 103, 315-321.
127. Yao, K.N., Deluca, V. and Brisson, N. (1995) Creation of a metabolic sink for tryptophan alters the phenylpropanoid pathway and the susceptibility of potato to Phytophthora infestans. Plant Cell, 7, 1787-1799.
128. Yazaki, K., Heide, L. and Tabata, M. (1991) Formation of p-hydroxybenzoic acid from p-coumaric acid by cell free extract of Lithospermum erythrorhizon cell cultures. Phytochemistry, 30, 2233-2236.
129. Ye ZH., Kneusel, R.E., Matern, U. and Varner, J.E. (1994) An alternative methylation pathway in lignin biosynthesis in Zinnia. Plant Cell, 6, 1427-1439.
130. Zubieta, C., Dixon, R.A. and Noel, J.P. (2001) Crystal structures of chalcone O-methyltransferase and isoflavone O-methyltransferase reveal the structural basis for substrate specificity in plant O-methyltransferases. Nature Struct. Biol. 8, 271-279.
131. Zubieta, C., Kota, P., Ferrer, J.-L., Dixon, R.A. and Noel, J. (2002) Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase. Plant Cell, 14, 1265-1277.