Transgene-mediated and elicitor-induced perturbation of metabolic channeling at the entry point into the phenylpropanoid pathway

Plant Cell

Volumn 11, Issue 8, 1999, Pages 1537-1551

  Rasmussen, Susanne ^a   Dixon, Richard A ^a  

^a PLANT BIOLOGY DIVISION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTIANA TABACUM; PHASEOLUS (ANGIOSPERM);

EID: 0032725627     PISSN: 10404651     EISSN: None     Source Type: Journal    
DOI: 10.1105/tpc.11.8.1537     Document Type: Article

References (61)

1. Ahl Goy, P., Signer, H., Reist, R., Aichholz, R., Blum, W., Schmidt, E., and Kessmann, H. (1993). Accumulation of scopoletin is associated with the high disease resistance of the hybrid Nicotiana glutinosa x Nicotiana debneyi. Planta 191, 200-206.
2. Alibert, G., Ranjeva, R., and Boudet, A. (1972). Recherches sur les enzymes catalysant la formation des acides phenoliques chez Quercus pedunculata (Ehrh.). II. Localisation intracellulaire de la phenylalanine ammonia-lyase, de la cinnamate 4-hydroxylase, et de la "benzoate synthase." Biochim. Biophys. Acta 279, 282-288.
3. Ausubel, F.M., Brent, R., Kingston, R.I.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K., eds (1994). Current Protocols in Molecular Biology. (New York: John Wiley and Sons).
4. Batard, Y., Schalk, M., Pierrel, M.-A., Zimmerlin, A., Durst, F., and Werck-Reichhart, D. (1997). Regulation of the cinnamate 4-hydroxylase (CYP73A1) in Jerusalem artichoke tubers in response to wounding and chemical treatments. Plant Physiol. 111, 951-959.
5. Bate, N.J., Orr, J., Ni, W., Meromi, A., Nadler-Hassar, T., Doerner, P.W., Dixon, R.A., Lamb, C.J., and Elkind, Y. (1994). Quantitative relationship between phenylalanine ammonia-lyase levels and phenylpropanoid accumulation in transgenic tobacco identifies a rate-determining step in natural product synthesis. Proc. Natl. Acad. Sci. USA 91, 7608-7612.
6. Bell-Lelong, D.A., Cusumano, U.C., Meyer, K., and Chapple, C. (1997). Cinnamate 4-hydroxylase expression in Arabidopsis. Plant Physiol. 113, 729-738.
7. Bolwell, G.P., Cramer, C.L., Lamb, C.J., Schuch, W., and Dixon, R.A. (1986). L-Phenylalanine ammonia-lyase from Phaseolus vulgaris. Modulation of the levels of active enzyme by trans-cinnamic acid. Planta 169, 97-107.
8. Bolwell, G.P., Mavandad, M., Millar, D.J., Edwards, K.J., Schuch, W., and Dixon, R.A. (1988). Inhibition of mRNA levels and activities by frans-cinnamic acid in elicitor-induced bean cells. Phytochemistry 27, 2109-2117.
9. Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
10. Breton, F., Sanier, C., and D'Auzac, J. (1997). Scopoletin production and degradation in relation to resistance of Hevea brasiliensis to Corynespora cassiicola. J. Plant Physiol. 151, 595-602.
11. Buell, C.R., and Somerville, S.C. (1995). Expression of defense-related and putative signaling genes during tolerant and susceptible interactions of Arabidopsis with Xanthomonas campestris pv. campestris. Mol. Plant-Microbe Interact. 8, 435-443.
12. Burns, V.W. (1964). Reversible sonic inhibition of protein, purine, and pyrimidine biosynthesis in the living cell. Science 146, 1056-1058.
13. Chapple, C. (1998). Molecular-genetic analysis of plant cytochrome P450-dependent monooxygenases. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49, 311-343.
14. Cramer, C.L., Bell, J.N., Ryder, T.B., Bailey, J.A., Schuch, W., Bolwell, G.P., Robbins, M.P., Dixon, R.A., and Lamb, C.J. (1985). Coordinated synthesis of phytoalexin biosynthetic enzymes in biologically-stressed cells of bean (Phaseolus vulgaris L.). EMBO J. 4, 285-289.
15. Cramer, C.L., Edwards, K., Dron, M., Liang, X., Dildine, S.L., Bolwell, G.P., Dixon, R.A., Lamb, C.J., and Schuch, W. (1989). Phenylalanine ammonia-lyase gene organization and structure. Plant Mol. Biol. 12, 367-383.
16. Cutler, A.J., and Conn, E.E. (1981). The biosynthesis of cyanogenic glucosides in Linum usitatissimum (linen flax) in vitro. Arch. Biochem. Biophys. 212, 468-474.
17. Cutler, A.J., Hösel, W., Sternberg, M., and Conn, E.E. (1981). The in vitro biosynthesis of taxiphyllin and the channeling of intermediates in Triglochin maritima. J. Biol. Chem. 256, 4253-4258.
18. Czichi, U., and Kindl, H. (1975). Formation of p-coumaric acid and o-coumaric acid from L-phenylalanine by microsomal membrane fractions from potato: Evidence of membrane-bound enzyme complexes. Planta 125, 115-125.
19. Czichi, U., and Kindl, H. (1977). Phenylalanine ammonia-lyase and cinnamic acid hydroxylases as assembled consecutive enzymes on microsomal membranes of cucumber cotyledons: Cooperation and subcellular distribution. Planta 134, 133-143.
20. Dixon, R.A., and Paiva, N.L. (1995). Stress-induced phenylpropanoid metabolism. Plant Cell 7, 1085-1097.
21. Dixon, R.A., Dey, P.M., Murphy, D.L., and Whitehead, I.M. (1981). Dose responses for Colletotrichum lindemuthianum elicitor-mediated enzyme induction in French bean cell suspension cultures. Planta 151, 272-280.
22. Edwards, K., Cramer, C.L., Bolwell, G.P., Dixon, R.A., Schuch, W., and Lamb, C.J. (1985). Rapid transient induction of phenylalanine ammonia-lyase mRNA in elicitor-treated bean cells. Proc. Natl. Acad. Sci. USA 82, 6731-6735.
23. Edwards, R., and Kessmann, H. (1992). Isoflavonoid phytoalexins and their biosynthetic enzymes. In Molecular Plant Pathology - A Practical Approach, S.J. Gurr, M.J. McPherson, and D.J. Bowles, eds (Oxford, UK: IRL Press), pp. 45-62.
24. Edwards, R., Stones, S.M., Gutierrez-Mellado, M.-C., and Jorrin, J. (1997). Characterization and inducibility of a scopoletindegrading enzyme from sunflower. Phytochemistry 45, 1109-1114.
25. Elkind, Y., Edwards, R., Mavandad, M., Hedrick, S.A., Ribak, O., Dixon, R.A., and Lamb, C.J. (1990). Abnormal plant development and downregulation of phenylpropanoid biosynthesis in transgenic tobacco containing a heterologous phenylalanine ammonialyase gene. Proc. Natl. Acad. Sci. USA 87, 9057-9061.
26. Fahrendorf, T., and Dixon, R.A. (1993). Stress responses in alfalfa (Medicago sativa L.). XVIII. Molecular cloning and expression of the elicitor-inducible cinnamic acid 4-hydroxylase cytochrome P450. Arch. Biochem. Biophys. 305, 509-515.
27. Felton, G.W., Korth, K.L., Bi, J.L., Wesley, S.V., Huhman, D.V., Mathews, M.C., Murphy, J.B., Lamb, C., and Dixon, R.A. (1999). Inverse relationship between systemic resistance of plants to microorganisms and to insect herbivory. Curr. Biol. 9, 317-320.
28. Fukasawa-Akada, T., Kung, S., and Watson, J.C. (1996). Phenylalanine ammonia-lyase gene structure, expression, and evolution in Nicotiana. Plant Mol. Biol. 30, 711-722.
29. Funk, C., and Brodelius, P.E. (1990). Phenylpropanoid metabolism in suspension cultures of Vanilla planifolia Andr. III. Conversion of 4-methoxycinnamic acids into 4-hydroxybenzoic acids. Plant Physiol. 94, 102-108.
30. Gutierrez, M.C., Parry, A., Tena, M., Jorrin, J., and Edwards, R. (1995). Abiotic elicitation of coumarin phytoalexins in sunflower. Phytochemistry 38, 1185-1191.
31. Hahlbrock, K., and Grisebach, H. (1979). Enzymic controls in the biosynthesis of lignin and flavonoids. Annu. Rev. Plant Physiol. 30, 105-130.
32. Hahlbrock, K., and Scheel, D. (1989). Physiology and molecular biology of phenylpropanoid metabolism. Annu. Rev. Plant Physiol. Plant Mol. Biol. 40, 347-349.
33. Howles, P.A., Sewalt, V.J.H., Paiva, N.L., Elkind, Y., Bate, N.J., Lamb, C.J., and Dixon, R.A. (1996). Overexpression of L-phenylalanine ammonia-lyase in transgenic tobacco plants reveals control points for flux into phenylpropanoid biosynthesis. Plant Physiol. 112, 1617-1624.
34. Howles, P., Masoud, S.A., Blount, J.W., Rasmussen, S., Lamb, C., and Dixon, R.A. (1999). Over-expression of L-phenylalanine ammonia-lyase and cinnamate 4-hydroxylase in tobacco cell suspension cultures. In Proceedings of the IX International Congress on Plant Cell and Tissue Culture, A. Altmann, ed (Jerusalem, Israel: Elsevier Publishing Co.), in press.
35. Hrazdina, G. (1992). Compartmentation in aromatic metabolism. Rec. Adv. Phytochem. 26, 1-23.
36. Hrazdina, G., and Jensen, R.A. (1992). Spatial organization of enzymes in plant metabolic pathways. Annu. Rev. Plant Physiol. Plant Mol. Biol. 43, 241-267.
37. Hrazdina, G., and Wagner, G. (1985). Metabolic pathways as enzyme complexes: Evidence for the synthesis of phenylpropanoids and flavonoids on membrane-associated enzyme complexes. Arch. Biochem. Biophys. 237, 88-100.
38. Jones, D.H. (1984). Phenylalanine ammonia-lyase: Regulation of its induction, and its role in plant development. Phytochemistry 23, 1349-1359.
39. Kindl, H. (1979). Compartments and microcompartments channeling intermediates in phenylpropanoid metabolism. In Regulation of Secondary Product and Plant Hormone Metabolism. Proceedings of the Twelfth Federation of European Biochemical Societies Meeting, Vol. 55, M. Luckner and K. Schreiber, eds (Oxford, UK: Pergamon Press), pp. 49-61.
40. Lawton, M.A., and Lamb, C.J. (1987). Transcriptional activation of plant defense genes by fungal elicitor, wounding and infection. Mol. Cell. Biol. 7, 335-341.
41. Lee, H.I., Leon, J., and Raskin, I. (1995). Biosynthesis and metabolism of salicylic acid. Proc. Natl. Acad. Sci. USA 92, 4076-4079.
42. Legrand, M., Fritig, B., and Hirth, L. (1976). Enzymes of the phenylpropanoid pathway and the necrotic reaction of hypersensitive tobacco to tobacco mosaic virus. Phytochemistry 15, 1353-1359.
43. Margna, U., and Margna, E. (1978). Incorporation of exogenous L-phenylalanine into C-glucosylflavones in buckwheat cotyledons. Biochem. Physiol. Pflanzen. 173, 2-10.
44. Mizutani, M., Ohta, D., and Sato, R. (1997). Isolation of cDNA and a genomic clone encoding cinnamate 4-hydroxylase from Arabidopsis and its expression manner in planta. Plant Physiol. 113, 755-763.
45. Nagai, N., Kitauchi, F., Shimosaka, M., and Okazaki, M. (1994). Cloning and sequencing of a full length cDNA coding for phenylalanine ammonia-lyase from tobacco cell culture. Plant Physiol. 104, 1091-1092.
46. Noe, W., Langebartels, C., and Seitz, H. (1980). Anthocyanin accumulation and PAL activity in a suspension culture of Daucus carota L. Inhibition by L-α-aminooxy-β-phenylpropionic acid and t-cinnamic acid. Planta 149, 283-287.
47. O'Neal, D., and Keller, C.J. (1970). Partial purification and some properties of phenylalanine ammonia-lyase of tobacco (Nicotiana tabacum). Phytochemistry 9, 1373-1383.
48. Park, H.-H., Hakamatsuka, T., Sankawa, U., and Ebizuka, Y. (1995). Rapid metabolism of isoflavonoids in elicitor-treated cell suspension cultures of Pueraria lobata. Phytochemistry 38, 373-380.
49. Pellegrini, L., Rohfritsch, O., Fritig, B., and Legrand, M. (1994). Phenylalanine ammonia-lyase in tobacco. Plant Physiol. 106, 877-886.
50. Russell, D.W., and Conn, E.E. (1967). The cinnamic acid 4-hydroxylase of pea seedlings. Arch. Biochem. Biophys. 122, 256-258.
51. Schnitzler, J.-P., Madlung, J., Rose, A., and Seitz, H.U. (1992). Biosynthesis of p-hydroxybenzoic acid in elicitor-treated carrot cell cultures. Planta 188, 594-600.
52. Schumacher, H.-M., Gundlach, H., Fiedler, F., and Zenk, M.H. (1987). Elicitation of benzophenanthridine alkaloid synthesis in Eschscholtzia cell cultures. Plant Cell Rep. 6, 410-413.
53. Sewalt, V.J.H., Ni, W., Blount, J.W., Jung, H.G., Masoud, S.A., Howles, P.A., Lamb, C.J., and Dixon, R.A. (1997). Reduced lignin content and altered lignin composition in transgenic tobacco down-regulated in expression of L-phenylalanine ammonia-lyase or cinnamate 4-hydroxylase. Plant Physiol. 115, 41-50.
54. Srere, P.A. (1987). Complexes of sequential metabolic enzymes. Annu. Rev. Biochem. 56, 89-124.
55. Stafford, H. (1981). Compartmentation in natural product biosynthesis by multienzyme complexes. In The Biochemistry of Plants, Vol. 7, E.E. Conn, ed (New York: Academic Press), pp. 117-137.
56. Subramanian, K.N., Weiss, R.L., and Davis, R.H. (1973). Use of external biosynthetic and organellar arginine by Neurospora. J. Bacteriol. 115, 284-290.
57. Teutscn, H.G., Hasenfratz, M.P., Lesot, A., Stoltz, C., Garnier, J.M., Jeltsch, J.M., Durst, F., and Werck-Reichhart, D. (1993). Isolation and sequence of a cDNA encoding the Jerusalem artichoke cinnamate 4-hydroxylase, a major plant cytochrome P450 involved in the general phenylpropanoid pathway. Proc. Natl. Acad. Sci. USA 90, 4102-4106.
58. Wagner, G.J., and Hrazdina, G. (1984). Endoplasmic reticulum as a site of phenylpropanoid and flavonoid metabolism in Hippeastrum. Plant Physiol. 74, 901-906.
59. Wanner, L.A., Li, G., Ware, D., Somssich, I.E., and Davis, K.R. (1995). The phenylalanine ammonia-lyase gene family in Arabidopsis thaliana. Plant Mol. Biol. 27, 327-338.
60. Yazaki, K., Heide, L., and Tabata, M. (1991). Formation of p-hydroxybenzoic acid from p-coumaric acid by cell free extract of Lithospermum erythrorhizon cell cultures. Phytochemistry 30, 2233-2236.
61. Zenk, M.H. (1965). Biosynthese von vanillin in Vanilla planifolia Andr. Z. Pflanzenphysiol. 53, 404-414.