c-Cbl is a negative regulator of GH-stimulated STAT5-mediated transcription

Endocrinology

Volumn 143, Issue 9, 2002, Pages 3590-3603

  Goh, Eyleen L K ^a   Zhu, Tao ^a   Leong, Wan Ying ^a   Lobie, Peter E ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CBL PROTEIN; DNA; GROWTH HORMONE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ENZYME DEGRADATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; CELL NUCLEUS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DNA; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMAN GROWTH HORMONE; JANUS KINASE 2; LEUPEPTINS; MICE; MILK PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIENZYME COMPLEXES; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTORS, SOMATOTROPIN; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 0036720691     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-220374     Document Type: Article

References (98)

1. v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas
2. The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein
3. Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins
4. CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2
5. Activation-modulated association of 14-3-3 proteins with Cbl in T cells
6. Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G
7. The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration
8. A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes
9. Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins
10. sli-1, a negative regulator of let-23-mediated signaling in C. elegans
11. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation
12. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
13. The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α
14. The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells
15. Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins
16. The product of the proto-oncogene c-cbl: A negative regulator of the Syk tyrosine kinase
17. The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation
18. Signal transduction via the growth hormone receptor
19. Molecular mechanism of growth hormone action
20. Growth hormone (GH), GH receptor, and signal transduction
21. Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone
22. Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK)
23. Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription
24. Growth hormone (GH) induction of tyrosine phosphorylation and activation of mitogen-activated protein kinases in cells transfected with rat GH receptor cDNA
25. Growth hormone stimulates the tyrosine phosphorylation of 42- and 45- kDa ERK-related proteins
26. Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts
27. Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis
28. Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1,-2, and-3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase
29. Growth hormone, interferon-γ, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1
30. Growth hormone stimulates tyrosine phosphorylation of insulin receptor substrate-1
31. Growth hormone, interferon-γ, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling
32. Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes
33. JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone
34. Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2
35. Activation of acute phase response factor (APRF)/Stat3 transcription factor by growth hormone
36. The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3
37. Growth hormone induces a DNA binding factor related to the interferon-stimulated 91-kDa transcription factor
38. Growth hormone-induced tyrosyl phosphorylation and deoxyribonucleic acid binding activity of Stat5A and Stat5B
39. CrkII participation in the cellular effects of growth hormone and insulin-like growth factor-1. Phosphatidylinositol-3 kinase dependent and independent effects
40. Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10
41. Association of Shc, Cbl, Grb2, and Sos following treatment with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in primary rat hepatocytes
42. Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2
43. Hypothesis: Progesterone primes breast cancer cells for cross-talk with proliferative or antiproliferative signals
44. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice
45. Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling
46. Growth hormone specifically regulates serine protease inhibitor gene transcription via gamma-activated sequence-like DNA elements
47. The Cbl protooncoprotein: A negative regulator of immune receptor signal transduction
48. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
49. The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases
50. Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain
51. Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation
52. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation
53. Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase
54. Fc receptor-mediated platelet activation is dependent on phosphatidylinositol 3-kinase activation and involves p120(Cbl)
55. Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl
56. c-Cbl is tyrosme-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3′-kinase pathway
57. p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells
58. Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase
59. Growth hormone- and prolactin-binding proteins: Soluble forms of receptors
60. Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene
61. Growth hormone-mediated regulation of insulin-like growth factor I promoter activity in C6 glioma cells
62. Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two γ-activated sites
63. Linkage of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor
64. Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor
65. Endocytosis and degradation of the growth hormone receptor are proteasome-dependent
66. Signaling via JAK tyrosine kinases: Growth hormone receptor as a model system
67. C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus
68. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
69. Cbl: Many adaptations to regulate protein tyrosine kinases
70. The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor
71. The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase
72. Regulation of STAT protein synthesis by c-Cbl
73. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl
74. The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor
75. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7
76. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
77. Coupling of the c-Cbl proto-oncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins
78. A β1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration
79. c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology
80. The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3′-kinase to the integrin signaling pathway
81. Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)
82. Regulation of β1-integrin-mediated cell adhesion by the Cbl adaptor protein
83. Growth hormone-induced reorganization of the actin cytoskeleton is not required for STAT5 (signal transducer and activator of transcription-5)-mediated transcription
84. Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase
85. PTGF-β, a type β transforming growth factor (TGF-β) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-β signaling pathway
86. Termination of growth hormone pulse-induced STAT5b signaling
87. Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation
88. Proteasome- and p53-dependent masking of signal transducer and activator of transcription (STAT) factors
89. Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells
90. The thymus gland: A target organ for growth hormone
91. Growth inhibition in giant growth hormone transgenic mice by overexpression of insulin-like growth factor-binding protein-2
92. High frequency of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice created from two different strains of mice
93. Fetal anemia and apoptosis of red cell progenitors in Stat5a--/-5b-/- mice: A direct role for Stat5 in Bcl-X(L) induction
94. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
95. Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2
96. Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium
97. Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice
98. Cis desensitizes GH induced Stat5 signaling in rat liver cells