Growth hormone-mediated regulation of insulin-like growth factor I promoter activity in C6 glioma cells

Endocrinology

Volumn 140, Issue 7, 1999, Pages 3073-3081

  Benbassat, Carlos ^a   Shoba, Lungile N N ^a   Newman, Marsha ^a   Adamo, Martin L ^a,b   Frank, Stuart J ^a,c   Lowe Jr , William L ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; LUCIFERASE; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPRESSION VECTOR; FUSION GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GLIOMA CELL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR GENE; RIBONUCLEASE PROTECTION ASSAY; SEQUENCE ANALYSIS; WESTERN BLOTTING;

EID: 0033304816     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.7.6762     Document Type: Article

References (61)

1. Insulin-like growth factor I: Physiology, metabolic effects and clinical uses
2. The insulin-like growth factors
3. Insulin-like growth factors and their binding proteins: Biological actions
4. Regulation of IGF-I gene expression. Implications for normal and pathological growth
5. Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo
6. Acute regulation of insulin-like growth factor-I gene expression by growth hormone during adipose cell differentiation
7. Structure, evolution, expression and regulation of insulin-like growth factors I and II
8. Distinct promoters in the rat insulin-like growth factor-I (IGF-I) gene are active in CHO cells
9. Structure and function of a human insulin-like growth factor-1 gene promoter
10. The major promoter of the rat insulin-like growth factor-I gene binds a protein complex that is required for basal expression
11. The human IGF-I gene contains two cell type-specifically regulated promoters
12. Essential promoter elements are located within the 5' untranslated region of human insulin-like growth factor-I exon I
13. Characterization of a rat insulin-like growth factor I gene promoter
14. Functional analysis of the rat insulin-like growth factor I gene and identification of an IGF-I gene promoter
15. Characterization of the rat insulin-like growth factor 1 gene promoters and identification of a minimal exon 2 promoter
16. Regulation of start site usage in the leader exons of the rat insulin-like growth factor-I gene by development, fasting, and diabetes
17. Multiple transcription start sites in the rat insulin-like growth factor-I gene give rise to IGF-I mRNAs that encode different IGF-I precursors and are processed differently in vitro
18. Tissue-specific transcription start site usage in the leader exons of the rat insulin-like growth factor-I gene: Evidence for differential regulation in the developing kidney
19. Identification of multiple transcription start sites in the human insulin-like growth factor-I gene
20. A CACCC box in the proximal exon 2 promoter of the rat insulin-like growth factor I gene is required for basal promoter activity
21. Transcriptional regulation of the rat insulin-like growth factor-I gene involves metabolism-dependent binding of nuclear proteins to a downstream region
22. Rapid activation of rat insulin-like growth factor-I gene transcription by growth hormone reveals no alterations in deoxyribonucleic acid-protein interactions within the major promoter
23. Rapid activation of rat insulin-like growth factor-I gene transcription by growth hormone reveals no changes in deoxyribonucleic acid-protein interactions within the second promoter
24. Molecular mechanism of growth hormone action
25. Regulation of insulin-like growth factor I (IGF-I) gene expression in brain of transgenic mice expressing an IGF-I-luciferase fusion gene
26. Differential regulation of transcription initiation from insulin-like growth factor-I (IGF-I) leader exons and of tissue IGF-I expression in response to changed growth hormone and nutritional status in sheep
27. Differential expression of alternative 5' untranslated regions in mRNAs encoding rat insulin-like growth factor I
28. Characterization of deoxyribonucleic acid-protein interactions at a growth hormone-inducible nuclease hypersensitive site in the rat insulin-like growth factor-I gene
29. Regulation of insulin-like growth factor I production in rat C6 glioma cells: Possible role as an autocrine/paracrine growth factor
30. Regulation of insulin-like growth factor I messenger ribonucleic acid levels by serum in cultured rat fibroblasts
31. Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor
32. Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase
33. Growth factor-induced transcription via the serum response element is inhibited by cyclic adenosine 3',5'-monophosphate in MCF-7 breast cancer cells
34. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
35. Stimulation of mitogen-activated protein kinase by gonadotropin-releasing hormone: Evidence for the involvement of protein kinase C
36. Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation
37. cis-Acting elements controlling transcription from rat serine protease inhibitor 2.1 gene promoter. Characterization of two growth hormone response sites and a dominant purine-rich element
38. The role of GH receptor tyrosine phosphorylation in Stat5 activation
39. Protein measurement with the Folin phenol reagent
40. Activation of acute phase response factor (APRF)/Stat3 transcription factor by growth hormone
41. Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Identification of phosphorylated mitogen-activated protein kinase and STAT91
42. In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3
43. The serum response element can mediate induction of c-fos by growth hormone
44. Growth hormone and colony-stimulating factor 1 share multiple response elements in the c-fos promoter
45. Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two gamma-activated sites
46. Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/Stat 5
47. Rapid changes in gene expression after in vivo growth hormone treatment
48. Acute nuclear actions of growth hormone (GH): Cycloheximide inhibits inducible activator protein-1 activity, but does not block GH-regulated signal transducer and activator of transcription activation or gene expression
49. Rat C6 glial cells synthesize insulin-like growth factor I (IGF-I) and express IGF-I receptors and IGF-II/mannose 6-phosphate receptors
50. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression
51. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
52. Stat5a is mandatory for adult mammary gland development and lactogenesis
53. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
54. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
55. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
56. Growth hormone regulates ternary complex factors and serum response factor associated with the c-fos serum response element
57. Regulation of glucose transport and c-fos and egr-1 expression in cells with mutated or endogenous growth hormone receptors
58. JAK2, Ras, and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone
59. Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation
60. Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse
61. Hepatocyte nuclear factor 1 alpha activates promoter 1 of the human insulin-like growth factor I gene via two distinct binding sites