A new millenium for spinal cord regeneration: Growth-associated genes

Spine

Volumn 27, Issue 17, 2002, Pages 1946-1949

  Bulsara, Ketan R ^a   Iskandar, Bermans J ^b   Villavicencio, Alan T ^a   Skene, J H Pate ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

CAP 23; GAP 43; NOGO; Olfactory ensheathing glia; Regeneration; Spinal cord

Indexed keywords

GROWTH FACTOR; NERVE PROTEIN; NEUROMODULIN; PROTEIN CAP 23; PROTEIN NOGO; UNCLASSIFIED DRUG;

CENTRAL NERVOUS SYSTEM; ENVIRONMENTAL FACTOR; GENE ACTIVATION; GROWTH CONE; NERVE CELL; NERVE FIBER REGENERATION; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; REVIEW; SPINAL CORD INJURY;

ANIMALS; CALMODULIN-BINDING PROTEINS; CYTOSKELETAL PROTEINS; GAP-43 PROTEIN; GROWTH CONES; HUMANS; MICE; MICE, TRANSGENIC; MYELIN PROTEINS; NERVE GROWTH FACTORS; NERVE REGENERATION; NERVE TISSUE PROTEINS; NEURONS; SPINAL CORD DISEASES;

EID: 0036713947     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-200209010-00030     Document Type: Review

References (78)

1. Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice
2. Cellular and molecular correlates of the regeneration of adult mammalian CNS axons into peripheral nerve grafts
3. The spatiotemporal distribution of N-CAM in the retinotectal pathway of adult goldfish detected by the monoclonal antibody D3
4. Extensive elongation of axons from rat brain into peripheral nerve grafts
5. Increased transport of 44,000 to 49,000-dalton acidic proteins during regeneration of the goldfish optic nerve: Two dimensional gel analysis
6. A membrane phosphoprotein associated with neural development, axonal regeneration, phospholipid metabolism, and synaptic plasticity
7. Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons
8. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors
9. Does the binding of clusters of basic residues to acidic lipids induce domain formation in membranes?
10. Expression of a developmentally regulated, phosphorylated isoform of microtubule-associated protein 1B in regenerating axons of the sciatic nerve
11. GAP-43 in the axons of mammalian CNS neurons regenerating into peripheral nerve grafts
12. Intrinsic neuronal determinants that promote axonal sprouting and elongation
13. Overexpression of growth-associated proteins in the neurons of adult transgenic mice
14. Intrinsic neuronal determinants locally regulate extrasynaptic and synaptic growth at the adult neuromuscular junction
15. Central nervous system regeneration: Oligodendrocytes and myelin as non-permissive substrates for neurite growth
16. Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter
17. Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading
18. Ca2+-calmodulin and protein kinase Cs: A hypothetical synthesis of their conflicting convergences on shared substrate domains
19. The downregulation of GAP-43 is not responsible for the failure of regeneration in freeze-killed nerve grafts in the rat
20. Intrinsic versus extrinsic factors in determining the regeneration of the central processes of rat dorsal root ganglion neurons: The influence of a peripheral nerve graft
21. Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats
22. GAP-43 gene expression during development: Persistence in a distinctive set of neurons in the mature central nervous system
23. Binding of basic peptides to membranes produces lateral domains enriched in the acidic lipids phosphatidylserine and phosphatidylinositol 4,5-bisphosphate: An electrostatic model and experimental results
24. Expression of the growth-associated protein GAP-43 in adult rat retinal ganglion cells following axon injury
25. Injured neurons in the olfactory bulb of the adult rat grow axons along grafts of peripheral nerve
26. Expression pattern of candidate cell death effector proteins Bax, Bcl-2, Bcl-X, and c-Jun in sensory and motor neurons following sciatic nerve transection in the rat
27. The T alpha 1 alpha-tubulin promoter specifies gene expression as a function of neuronal growth and regeneration in transgenic mice
28. Nogo in nerve regeneration
29. Isolation and partial characterisation of neuronal growth cones from neonatal rat forebrain
30. The c-Jun transcription factor: Bipotential mediator of neuronal death, survival and regeneration
31. Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: Induction of a specific beta-tubulin isotype
32. A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord
33. Effect of folic acid on CNS regeneration
34. Axon-regenerating retinal ganglion cells in adult rats synthesize the cell adhesion molecule L1 but not TAG-1 or SC-1
35. Elevated synthesis of an axonally transported protein correlates with axon outgrowth in normal and injured pyramidal tracts
36. Changes in neuronal mRNAs induced by a local inflammatory reaction
37. Calcium/calmodulin-dependent protein kinase II expression in motor neurons: Effect of axotomy
38. Purification and molecular cloning of a novel acidic calmodulin binding protein from rat brain
39. Phosphorylation of MARCKS, neuromodulin, and neurogranin by protein kinase C exhibits differential responses to diacylglycerols
40. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord
41. Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones
42. Neurite outgrowth stimulated by neural cell adhesion molecules requires growth-associated protein-43 (GAP-43) function and is associated with GAP-43 phosphorylation in growth cones
43. The BASP1 family of myristoylated proteins abundant in axonal termini: Primary structure analysis and physico-chemical properties
44. Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury
45. Axotomy-induced alterations in the synthesis and transport of neurofilaments and microtubules in dorsal root ganglion cells
46. Neurolin, a cell surface glycoprotein on growing retinal axons in the goldfish visual system, is reexpressed during retinal axonal regeneration
47. Olfactory ensheathing glia transplantation into the injured spinal cord
48. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia
49. Peripheral injury enhances central regeneration of primary sensory neurones
50. Regeneration and retrograde degeneration of axons in the rat optic nerve
51. Influences of peripheral nerve components on axonal growth
52. GAP-43 immunoreactivity and axon regeneration in retinal ganglion cells of the rat
53. Fate of GAP-43 in ascending spinal axons of DRG neurons after peripheral nerve injury: Delayed accumulation and correlation with regenerative potential
54. Regeneration of lesioned corticospinal tract fibers in the adult rat spinal cord under experimental conditions
55. Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro
56. Differential responses of protein kinase C substrates (MARCKS, neuromodulin, and neurogranin) phosphorylation to calmodulin and S100
57. Membrane proteins of the nerve growth cone and their developmental regulation
58. A protein induced during nerve growth (GAP-43) is a major component of growth-cone membranes
59. Axonal growth-associated proteins
60. Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systems
61. A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth
62. Lengthy regrowth of cut axons from ganglion cells after peripheral nerve transplantation into the retina of adult rats
63. Randomized retinal ganglion cell axon routing at the optic chiasm of GAP-43-deficient mice: Association with midline recrossing and lack of normal ipsilateral axon turning
64. Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43
65. Biology of neurological recovery and functional restoration after spinal cord injury
66. Perspectives: Neurobiology: Regeneration in the Nogo zone
67. Response of facial and rubro-spinal neurons to axotomy: Changes in mRNA expression for cytoskeletal proteins and GAP-43
68. Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions
69. Restorative neurosurgery: Opportunities for restoration of function in acquired, degenerative, and idiopathic neurological diseases
70. Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: Responses to injury and infusion of NGF
71. Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat
72. The monoclonal antibody E587 recognizes growing (new and regenerating) retinal axons in the goldfish retinotectal pathway
73. Regenerating retinal axons of goldfish respond to a repellent guiding component on caudal tectal membranes of adult fish and embryonic chick
74. Cell signalling and CAM-mediated neurite outgrowth
75. The motility-associated proteins GAP-43, MARCKS, and CAP-23 share unique targeting and surface activity-inducing properties
76. A comparison of peripheral and central axotomy effects on neurofilament and tubulin gene expression in rat dorsal root ganglion neurons
77. Regulation of nitric oxide synthase expression in motoneurons following nerve injury
78. A key role for GAP-43 in the retinotectal topographic organization