A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction

Biochemical Journal

Volumn 366, Issue 2, 2002, Pages 501-510

  Reilly, John F ^a   Martinez, Shawndra D ^a   Mickey, Gregory ^a   Maher, Pamela A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cell proliferation; Cyclin; ERK; Farnesylation; Ras

Indexed keywords

BIOASSAY; BIOSYNTHESIS; CELLS; ENZYMES; METABOLISM;

FIBROBLASTS;

BIOCHEMISTRY;

CYCLIN D1; CYCLIN E; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR; GERANYLTRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CATALYSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; FIBROBLAST; IMMUNOPRECIPITATION; METABOLISM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; TWO HYBRID SYSTEM;

3T3 CELLS; ALKYL AND ARYL TRANSFERASES; ANIMALS; CELL CYCLE PROTEINS; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTORS; GERANYLTRANSTRANSFERASE; KINETICS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; RECEPTORS, FIBROBLAST GROWTH FACTOR; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TRANSFECTION;

ANIMALIA;

EID: 0036711586     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020560     Document Type: Article

References (52)

1. Fibroblast growth factors: Activities and significance of non-neurotrophin neurotrophic factors
2. Structural and functional diversity in the FGF receptor multigene family
3. Identification of a novel alternative splicing of human FGF receptor 4: Soluble-form splice variant expressed in human gastrointestinal epithelial cells
4. A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-γl
5. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
6. Signal transduction by fibroblast growth factor receptors
7. Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14
8. Signalling molecules derived from the cholesterol biosynthetic pathway
9. Protein prenylation: Molecular mechanisms and functional consequences
10. Identification of geranylgeranyl-modified proteins in HeLa cells
11. p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation
12. Differential binding of proteins to peroxisomes in rat hepatoma cells: Unique association of enzymes involved in isoprenoid metabolism
13. Comparative studies of the tyrosine phosphorylation of proteins in Swiss 3T3 fibroblasts stimulated by a variety of mitogenic agents
14. Cell cycle-dependent activation of Ras
15. Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes
16. Calcium influx activates extracellular-regulated kinase/mitogen-activated protein kinase pathway through a calmodulin-sensitive mechanism in PC12 cells
17. Effect of site-directed mutagenesis of conserved aspartate and arginine residues upon farnesyl diphosphate synthase activity
18. Effects of site-directed mutagenesis of the highly conserved aspartate residues in domain II of farnesyl diphosphate synthase activity
19. Ligand-induced transphosphorylation between different FGF receptors
20. The significance of the cholesterol biosynthetic pathway in cell growth and carcinogenesis
21. Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of Src and Ras actions
22. Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF
23. Protein kinase B (c-Akt) in phosphatidyl-3-OH kinase signal transduction
24. Activation of phosphatidylinositol 3-kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells
25. Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells
26. Phase separation of integral membrane proteins in Triton X-114 solution
27. Kip1 by cDNA antisense supresses quiescence (Go state) in fibroblasts
28. ras activity and consequent prolonged ERK activity
29. Double agent: Translational regulation by a transcription factor
30. A double life: Cytosolic aconitase as a regulatory RNA binding protein
31. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
32. Farnesyl-diphosphate synthase is localized in peroxisomes
33. Induction of the cholesterol metabolic pathway regulates the farnesylation of Ras in embryonic chick heart cells: A new role for Ras in regulating the expression of muscarinic receptors and G proteins
34. Constitutive association of c-N-Ras with c-Raf-1 and protein kinase Cε in latent signaling modules
35. Post-translational modifications of p21rho proteins
36. Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB
37. Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice
38. Effect of insulin on farnesyltransferase. Specificity of insulin action and potentiation of nuclear effects on insulin-like growth factor-1, epidermal growth factor and platelet-derived growth factor
39. Determination of isopentenyl diphosphate and farnesyl diphosphate in tissue samples with a comment on secondary regulation of polyisoprenoid biosynthesis
40. Protein farnesyltransferase: Kinetics of farnesyl pyrophosphate binding and product release
41. Substrate binding is required for release of product from mammalian protein farnesyltransferase
42. Tools of the trade: Use of dominant-inhibitory mutants of Ras-family GTPases
43. Intersubunit location of the active site of farnesyl diphosphate synthase: Reconstruction of active enzymes by hybrid-type heteromeric dimers of site-directed mutants
44. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
45. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
46. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
47. Cip1/WAF1 in NIH-3T3 cells expressing TrkA
48. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway
49. The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic
50. Functional Rac-1 and Nck signaling networks are required for FGF-2-induced DNA synthesis in MCF-7 cells
51. Cip1
52. Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation