The Ets family contains transcriptional activators and repressors involved in angiogenesis

International Journal of Biochemistry and Cell Biology

Volumn 33, Issue 4, 2001, Pages 391-407

  Lelièvre, Etienne ^a   Lionneton, Frédéric ^a   Soncin, Fabrice ^a   Vandenbunder, Bernard ^a  

^a INSTITUT DE BIOLOGIE DE LILLE   (France)

Author keywords

Adhesion; Angiogenesis; Embryos; Transcription factors; Tumours

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; NERVE CELL ADHESION MOLECULE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ERG 1; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR ETS 2; TRANSCRIPTION FACTOR FLI 1; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; CELL ADHESION; CELL MATURATION; DNA BINDING; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; GENE INACTIVATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; KNOCKOUT MOUSE; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTO ONCOGENE; REVIEW; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; TUNICA MEDIA; YOLK SAC;

ANIMALS; ENDOTHELIUM; GENE EXPRESSION REGULATION; HUMANS; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; REPRESSOR PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

GALLUS GALLUS; MURINAE; MUS MUSCULUS;

EID: 0035053713     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(01)00025-5     Document Type: Review

References (116)

1. A putative second cell-derived oncogene of the avian leukaemia retrovirus E26
2. Tripartite structure of the avian erythroblastosis virus E26 transforming gene
3. Molecular phylogeny of the ETS gene family
4. The ETS family of transcriptional regulators
5. Modulation of transcription factor Ets-1 DNA binding: DNA-induced unfolding of an alpha helix
6. Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2
7. Calcium-induced phosphorylation of ETS1 inhibits its specific DNA binding activity
8. Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition
9. Isoforms of the human ets-1 protein: Generation by alternative splicing and differential phosphorylation
10. ERF: An ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation
11. The cets proto-oncogenes encode transcription factors that cooperate with c-fos and c-jun for transcriptional activation
12. Erg, an Ets-family member, differentially regulates human collagenasel (MMP1) and stromelysini (MMP3) gene expression by physically interacting with the Fos/Jun complex
13. The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner
14. MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation
15. EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS 1 target genes
16. A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions
17. p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter
18. TEL is a sequence-specific transcriptional repressor
19. The ets family member Tel binds to the Fli-l oncoprotein and inhibits its transcriptional activity
20. Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage
21. Expression of C-ETS1 in early chick embryo mesoderm: Relationship to the hemangioblastic lineage
22. c-ets1, the two transcription factors encoded by the c-ets-1 locus, are differentially expressed during the development of the chick embryo
23. The c-ets 1 protooncogene is expressed in human trophoblast during the first trimester of pregnancy
24. Involvement of the proto-oncogene c-ets 1 and the urokinase plasminogen activator during mouse implantation and placentation
25. Complementary patterns of expression of c-etsl, c-myb and c-myc in the blood-forming system of the chick embryo
26. Expression of the c-etsl gene in the hypothalamus and pituitary during rat development
27. Induction of Ets-1 in endothelial cells during reendothelialization after denuding injury
28. The c-ets 1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularisation and other forms of angiogenesis in man
29. Expression of the Ets-l transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis
30. Expression of Ets-1 transcription factor in relation to angiogenesis in the healing process of gastric ulcer
31. The Etsl transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenic processes such as organ formation
32. Stromal expression of c-etsl transcription factor correlates with tumor invasion
33. Expression of c-ets-1, collagenase1 and urokinase-type plasminogen activator genes in lung carcinomas
34. Changes in the expression of matrix proteases and of the transcription factor c-Ets1 during progression of precancerous bronchial lesions
35. The Etsl transcription factor is expressed during epithelial-mesenchymal transitions in the chick embryo and is activated in scatter-factor stimulated MDCK epithelial cells
36. Expression of c-ets-1 and uPA genes is associated with mammary epithelial cell tubulogenesis or neoplastic scattering
37. Mesodermal expression of the chicken erg gene associated with precartilaginous condensation and cartilage differentiation
38. Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia
39. The avian fli gene is specifically expressed during embryogenesis in a subset of neural crest cells giving rise to mesenchyme
40. Insights into early vasculogenesis revealed by expression of the ETSdomain transcription factor Fli-1 in wild-type and mutant zebrafish embryos
41. Differential expression patterns of the PEA3 group transcription factors through murine embryonic development
42. c-Ets-1 protein is hyperphosphorylated during mitosis
43. Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metolloproteinase-1 and the migration of vascular endothelial cells
44. Inhibition of vascular endothelial growth factor-induced endothelial cell migration by ETS 1 anti sense oligonucleotides
45. Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells
46. The ETS-related factor TEL is regulated by angiogenic growth factor VEGF in HUVE-cells
47. Requirement of a GT box (Sp1 site) and two Ets binding sites for vascular endothelial cadherin gene transcription
48. Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets 1 and c-Ets2
49. Calcium-induced phosphorylation of Etsl inhibits its specific DNA binding activity
50. The PEA3 Ets transcription factor is a downstream target of the HER2/Neu receptor tyrosine kinase
51. Regulation of transcription by MAP kinase cascades
52. Small mechanical strains selectively suppress matrix metalloproteinase-1 expression by human vascular smooth muscle cells
53. Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus
54. Common sequence and structural features in the heat-shock factor and Ets families of DNA-binding domains
55. Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells
56. 2 and tumor necrosis factor-alpha activate intercellular adhesion molecule 1 (ICAM-1) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter
57. Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor
58. ETS1 and ETS2 in p53 regulation: Spatial separation of ETS binding sites (EBS) modulate protein: DNA interaction
59. Regulation of the human stress response gene GADD153 expression: Role of ETS1 and FLI-1 gene products
60. Hypotonicity activates transcription through ERK-dependent and-independent pathways in renal cells
61. Ets target genes: Identification of Egri as a target by RNA differential display and xhole genome PCR techniques
62. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells
63. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
64. Endothelial-specific gene expression directed by the tie gene promoter in vivo
65. Role of Ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter
66. Vascular endothelial cell lineage-specific promoter in transgenic mice
67. Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice
68. Role of the ets transcription factors in the regulation of the vascular-specific tie2 gene
69. Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system
70. Role of vascular endothelial-cadherin in vascular morphogenesis
71. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
72. The vascular endothelial-cadherin promoter directs endothelial-specific expression in transgenic mice
73. Regulation of angiogenesis via vascular endothelial growth factor receptors
74. A novel promoter for vascular endothelial growth factor receptor (fit-1) that confers endothelial-specific gene expression
75. Characterization of the promoter region for fit-1 tyrosine kinase gene, a receptor for vascular endothelial growth factor
76. A cyclic AMP response element and an ETS motif are involved in the transcriptional regulation of fit-1 tyrosine kinase (VEGF receptor 1) gene
77. Identification of vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice
78. Reversion of Ras transformed cells by Ets transdominant mutants
79. Constitutive expression of the DNA-binding domain of Etsl increases endothelial cell adhesion and stimulates their organization into capillary-like structures
80. Angiogenesis inhibition by transdominant mutant ets-1
81. ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin beta3
82. Inhibition of angiogenesis in vivo by ets-1 antisense oligonucleotides-inhibition of Ets-1 transcription factor expression by the antibiotic fumagillin
83. The Ets-1 transcription factor is required for the development of natural killer cells in mice
84. Xl erg: Expression pattern and overexpression during development plead for a role in endothelial cell differentiation
85. Overexpression of the Xenopus Xl-fli gene during early embryogenesis leads to anomalies in head and heart development and erythroid differenciation
86. An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes
87. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the flu transcription factor
88. Thymidine phosphorylase (platelet-derived endothelial cell growth factor), microvessel density and clinical outcome in hepatocellular carcinoma
89. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL
90. Ets-2 transdominant mutant abolishes anchorage-independent growth and macrophage colony-stimulating factor-stimulated invasion by BT20 breast carcinoma cells
91. ETS target genes: Identification of egri as a target by RNA differential display and whole genome PCR techniques
92. The c-ets-1 proto-oncogene has oncogenic activity and is positively autoregulated
93. Transactivation of GATA-1 promoter with ETS1, ETS2 and ERGB/Hu-FLI-1 proteins stabilization of the ETS 1 protein binding on GATA-1 promoter sequences by monoclonal antibody
94. Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1
95. junB promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2
96. Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells
97. Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression
98. Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1
99. Ets up-regulates MET transcription
100. Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter
101. Maspin is an angiogenesis inhibitor
102. A polyoma enhancer A-binding protein-3 site and Ets-2 protein have a major role in the 12-O-tetradecanoylphorbol-13-acetate response of the human stromelysin gene
103. c-ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins
104. A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells
105. Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors
106. Transcription of human cathepsin B is mediated by Sp1 and Ets family factors in glioma
107. Ets1 lowers capillary endothelial cell density at confluence and induces the expression of VE-cadherin
108. The human beta 2 integrin CD 18 promoter consists of two inverted Ets cis elements
109. An intricate arrangement of binding sites for the Ets family of transcription factors regulates activity of the alpha 4 integrin gene promoter
110. The transcription of the intercellular adhesion molecule-1 is regulated by Ets transcription factors
111. Ets transcription factors bind and transactivate the core promoter of the von Willebrand factor gene
112. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
113. Characterization of the human endothelial nitric-oxide synthase promoter
114. Upregulation of human heme oxygenase gene expression by Ets-family proteins
115. Endothelial expression of endothelin-converting enzyme-1 beta mRNA is regulated by the transcription factor Ets-1
116. Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of Flk-1 expression during murine vascular development