Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the Nf1: p53 mouse tumor model

Cancer Research

Volumn 62, Issue 15, 2002, Pages 4507-4513

  Li, Hongzhen ^a   Velasco Miguel, Susana ^b   Vass, William C ^a   Parada, Luis F ^b   DeClue, Jeffrey E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; COMPLEMENTARY DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UO 126;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL GROWTH; GENE EXPRESSION; MOUSE; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR MODEL;

ANIMALS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GENES, NEUROFIBROMATOSIS 1; GENES, P53; MAP KINASE SIGNALING SYSTEM; MICE; NEUROFIBROMATOSIS 1; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR CELLS, CULTURED;

EID: 0036682199     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Von Recklinghausen neurofibromatosis: A clinical and population study in south-east Wales
2. S-100 protein in soft tissue tumors derived from Schwann cells and melanocytes
3. Cellular differentiation andexpression of matrix genes in type 1 neurofibromatosis
4. The NF1 gene as a tumor suppressor
5. Gene structure and expression
6. Neurofibromatosis type 1 GTPase activating protein-related domain and its functional significance
7. Mutation and cancer: Statistical study of retinoblastoma
8. The P53 tumour suppressor gene
9. Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis
10. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
11. Cytogenetic analysis of soft tissue sarcomas: Recurrent chromosome abnormalities in malignant peripheral nerve sheath tumors (MPNST)
12. Protein-tyrosine kinases
13. Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukemia
14. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in murine and human hematopoietic cells
15. Nf1 and Gmcsf interact in myeloid leukemiagenesis
16. Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo
17. Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models
18. Neuregulins and their receptors: A versatile signaling molecule in organogenesis and oncogenesis
19. The influence of heregulins on human Schwann cell proliferation
20. Neurofibromatosis type 1: Genetic and cellular mechanisms of peripheral nerve tumor formation
21. Neuregulin, a factor with many functions in the life of a Schwann cell
22. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues
23. Tumor predisposition in mice heterozygous for a targeted mutation in NF1
24. Mouse models of tumor development in neurofibromatosis type 1
25. Mouse tumor model for neurofibromatosis type 1
26. ras contributes to malignant tumor growth in Vonrecklinghausen (Type-1) neurofibromatosis
27. ErbB receptors and EGF-like ligands: Cell lineage determination and oncogenesis through combinatorial signaling
28. Oncogenic kinase signalling
29. Cell signaling by receptor tyrosine kinases
30. The Regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
31. Tyrosine kinase inhibition: An approach to drug development
32. A specific inhibitor of phosphatidylinositol 3-kinase. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
33. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
34. The EGF receptor family as targets for cancer therapy
35. Epidermal growth factor-related peptides and their receptors in human malignancies
36. Tumorigenic conversion of primary fibroblasts requires at least two cooperating oncogenes
37. Cooperation between gene encoding p53 tumor antigen and ras in cellular transformation
38. Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation
39. Transforming growth factor α
40. ras, inhibition of cell proliferation and morphological changes
41. Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts
42. The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
43. The ErbB signaling network: Receptor heterodimerization in development and cancer
44. Induction of apoptosis and cell cycle arrest by CP-358, 774, an inhibitor of epidermal growth factor receptor tyrosine kinase
45. 1
46. Cellular survival: A play in three Akts
47. Identification of NF1 mutations in both alleles of a dermal neurofibroma
48. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas
49. Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma
50. Schwann cells harbor the somatic NF1 mutation in neurofibromas: Evidence of two different Schwann cell subpopulations
51. Toward a survey of somatic mutation in benign neurofibromas of patients with neurofibromatosis type 1
52. Culture of cytogenetically abnormal Schwann cells from benign and malignant NF1 tumors
53. Schwann Cell Differentiation