ErbB receptors and EGF-like ligands: Cell lineage determination and oncogenesis through combinatorial signaling

Journal of Mammary Gland Biology and Neoplasia

Volumn 2, Issue 2, 1997, Pages 97-107

  Pinkas Kramarski, Ronit ^a   Alroy, Iris ^a   Yarden, Yosef ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Cancer; Growth factor; Receptor; Signal transduction; Tyrosine kinase

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2;

ANIMAL; CELL TRANSFORMATION; HUMAN; PHYSIOLOGY; PROTO ONCOGENE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; EPIDERMAL GROWTH FACTOR; GENES, ERBB-2; HUMANS; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION;

EID: 0031107208     PISSN: 10833021     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026343528967     Document Type: Article

References (60)

1. D. J. Slamon, G. M. Clark, S. G. Wong, W. J. Levin, A. Ullrich, and W. L. McGuire (1987). Human breast cancer: correlation of relapse and survival with amplification of the HER-2//neu oncogene. Science 235:177-182.
2. D. J. Slamon, W. Godolphin, L. A. Jones, J. A. Holt, S. G. Wong, D. E. Keith, W. J. Levin, S. G. Stuart, J. Udove, A. Ullrich, and M. F. Press (1989). Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244:707-712.
3. P. van der Geer, T. Hunter, and R. A. Lindberg (1994). Receptor protein-tyrosine kinases and their signal transduction pathways. Ann. Rev. Cell Biol. 10:251-337.
4. H. Toyoda, T. Komursaki, D. Uchida, Y. Takayama, T. Isobe, T. Okuyama, and K. Hanada (1995). Epiregulin, a novel epidermal growth factor with mitogenic activity for rat primary hepatocytes. J. Biol. Chem. 270:7495-7500.
5. D. J. Riese, Y. Bermingham, T. M. van Raaij, S. Buckley, G. D. Plowman, and D. F. Stern (1996). Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta. Oncogene 12:345-353.
6. E. Peles and Y. Yarden (1993). Neu and its ligands: from an oncogene to neural factors. BioEssays 15:815-824.
7. M. A. Marchionni, A. D. J. Goodearl, M. S. Chen, O. Bermingham-McDonogh, C. Kirk, M. Hendricks, F. Denehy, D. Misumi, J. Sudhalter, K. Kobayashi, D. Wroblewski, C. Lynch, M. Baldassare, I. Hiles, J. B. Davis, J. J. Hsuan, N. F. Totty, M. Otsu, R. N. McBury, M. D. Waterfield, P. Stroobant, and D. Gwynne (1993). Glial growth factors are alternatively spliced erbB-2 ligands expressed in the nervous system. Nature 362:312-318.
8. D. L. Falls, K. M. Rosen, G. Corfas, W. S. Lane, and G. D. Fischbach (1993). ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family. Cell. 72:801-815.
9. A. Orr-Urtreger, L. Trakhtenbrot, R. Ben-Levi, D. Wen, G. Rechavi, P. Lonai, and Y. Yarden (1993). Neural expression and chromosomal mapping of Neu Differentiation factor Çto 8p12-p21. Proc. Natl. Acad. Sci. U.S.A. 90:1867-1871.
10. D. Wen, S. V. Suggs, D. Karunagaran, N. Liu, R. L. Cupples, Y. Luo, A. M. Jansen, N. Ben-Baruch, D. B. Trollinger, V. L. Jacobson, T. Meng, H. S. Lu, S. Hu, D. Chang, D. Yanigahara, R. A. Koski, and Y. Yarden (1994). Structural and functional aspects of the multiplicity of Neu differentiation factors. Mol. Cell Biol. 14:1909-1919.
11. R. R. Beerli and N. E. Hynes (1996). Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities. J. Biol. Chem. 271:6071-6076.
12. E. G. Barbacci, B. C. Guarino, J. G. Stroh, D. H. Singleton, K. J. Rosnack, J. D. Moyer, and G. C. Andrews (1995). The structural basis for the specificity of epidermal growth factor and heregulin binding. J. Biol. Chem. 270:9585-9589.
13. N. E. Jacobsen, N. Abadi, M. X. Sliwkowski, D. Reilly, N. J. Skelton, and W. J. Fairbrother (1996). High-resolution solution structure of the EGF-like domain of heregulin-alpha. Biochemistry 35:3402-3417.
14. K. Nagata, D. Kohda, H. Hatanaka, S. Ichikawa, S. Matsuda, T. Yamamoto, A. Suzuki, and F. Inagaki (1994). Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4. EMBO J. 13:3517-3523.
15. R. Pinkas-Kramarski, M. Shelly, S. Glathe, B. J. Ratzkin, and Y. Yarden (1996). Neu differentiation factor/neuregulin isoforms activate distinct receptor combinations. J. Biol. Chem. 271:19029-19032.
16. P. M. Guy, J. V. Platko, L. C. Cantley, R. A. Cerione, and K. L. Carraway (1994). Insect cell-expressed p180ErbB3 possesses an impaired tyrosine kinase activity. Proc. Natl. Acad. Sci. U.S.A. 91:8132-8136.
17. K. L. Carraway and L. C. Cantley (1994). A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling. Cell. 78:5-8.
18. J. Baulida, M. H. Kraus, M. Alimandi, P. P. Di Fiore, and G. Carpenter (1996). All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J. Biol. Chem. 271:5251-5257.
19. R. Pinkas-Kramarski, L. Soussan, H. Waterman, G. Levkowitz, I. Alroy, L. Klapper, S. Lavi, R. Seger, B. Ratzkin, M. Sela, and Y. Yarden (1996). Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J. 15:2452-2467.
20. M. Marikovsky, S. Lavi, R. Pinkas-Kramarski, D. Karunagaran, N. Liu, D. Wen, and Y. Yarden (1995). ErbB-3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytes. Oncogene 10:1403-1411.
21. Y. Yang, E. Spitzer, D. Meyer, M. Sachs, C. Niemann, G. Hartmann, K. M. Weidner, C. Birchmeier, and W. Birchmeier (1995). Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. J. Cell. Biol. 131:215-226.
22. D. M. Danilenko, B. D. Ring, J. Z. Lu, J. E. Tarpley, D. Chang, N. Liu, D. Wen, and G. F. Pierce (1995). Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds. J. Clin. Invest. 95:842-851.
23. J. T. Trachtenberg and W. J. Thompson (1996). Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor. Nature 379:174-177.
24. R. Pinkas-Kramarski, R. Eilam, O. Spiegler, S. Lavi, N. Liu, D. Chang, D. Wen, M. Schwartz, and Y. Yarden (1994). Brain neurons and glial cells express Neu differentiation factor/heregulin: a survival factor for astrocytes. Proc. Natl. Acad. Sci. U.S.A. 91:9387-9391.
25. N. M. Shah, M. A. Marchionni, I. Isaacs, P. Stroobant, and D. J. Anderson (1994). Glial growth factor restricts mammalian neural crest stem cells to a glial fate. Cell. 77:349-360.
26. Z. Dong, A. Brennan, N. Liu, Y. Yarden, G. Lefkowitz, R. Mirsky, and K. R. Jessen (1995). Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors. Neuron 15:585-596.
27. J. R. Florini, D. S. Samuel, D. Z. Ewton, C. Kirk, and R. M. Sklar (1996). Stimulation of myogenic differentiation by a neuregulin, glial growth factor 2. Are neuregulins the long-sought muscle trophic factors secreted by nerves? J. Biol. Chem. 271:12699-12702.
28. L. M. Moscoso, G. C. Chu, M. Gautam, P. G. Noakes, J. P. Merlie, and J. R. Sanes (1995). Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2, and ErbB3, in developing mammalian muscle. Develop. Biol. 172:158-169.
29. J. M. Verdi, A. K. Groves, I. Farinas, K. Jones, M. A. Marchionni, L. F. Reichardt, and D. J. Anderson (1996). A reciprocal cell-cell interaction mediated by NT-3 and neuregulins controls the early survival and development of sympathetic neuroblasts. Neuron. 16:515-527.
30. D. Meyer and C. Birchmeier (1995). Multiple essential functions of neuregulin in development [see comments]. Nature 378:386-390.
31. M. Gassmann, F. Casagranda, D. Orioli, H. Simon, C. Lai, R. Klein, and G. Lemke (1995). Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378:390-394.
32. K.-F. Lee, H. Simon, H. Chen, B. Bates, M.-C. Hung, and C. Hauser (1995). Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378:394-398.
33. M. Sibilia and E. F. Wagner (1995). Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234-238.
34. P. J. Miettinen, J. E. Berger, J. Meneses, Y. Phung, R. A. Pedersen, Z. Werb, and R. Derynck (1995). Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376:337-341.
35. D. W. Threadgill, A. A. Dlugosz, L. A. Hansen, T. Tennenbaum, U. Lichti, D. Yee, C. LaMantia, T. Mourton, K. Herrup, and R. C. Harris (1995). Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 269:230-234.
36. N. E. Hynes and D. F. Stern (1994). The biology of erbB-2/ neu/HER-2 and its role in cancer. Biochem. Biophys. Acta. 1198:165-184.
37. D. S. Salomon, R. Brandt, F. Ciardiello, and N. Normanno (1995). Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19:183-232.
38. W. Li, J. W. Park, A. Nuijens, M. X. Sliwkowski, and G. A. Keller (1996). Heregulin is rapidly translocated to the nucleus and its transport is correlated with c-myc induction in breast cancer cells. Oncogene. 12:2473-2477.
39. K. Pavelic, Z. Benjac, J. Pavelic, and S. Spaventi (1993). Evidence for a role of EGF receptor in the progression of human lung carcinoma. Anticancer Res. 13:1133-1138.
40. A. J. Wong, J. M. Ruppert, S. H. Bigner, C. H. Grzeschik, P. A. Humphrey, D. S. Bigner, and B. Vogelstein (1992). Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc. Natl. Acad. Sci U.S.A. 89:2965-2969.
41. J. Baselga, D. Tripathy, J. Mendelsohn, S. Baughman, C. C. Benz, L. Dantis, N. T. Sklarin, A. D. Seidman, C. A. Hudis, J. Moore, P. P. Rosen, T. Twaddell, I C. Henderson, and L. Norton (1996). Phase II study of weekly intravenous recombinant humanized anti-p185 HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J. Clin. Oncol. 14:737-744.
42. D. Yu, S. Wang, K. M. Dulski, C. Tsai, G. L. Nicolson, and M. Hung (1994). c-erbB-2/neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastatsis-associated properties. Cancer Res. 54:3260-3266.
43. M. van de Vijver, J. L. Peterse, W. J. Mooi, P. Wisman, J. Lomans, O. Dalesio, and R. Nusse (1988). Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer. N. Engl. J. Med. 319:1239-1245.
44. A. K. Tandon, G. M. Clark, G. C. Chamness, A. Ullrich, and W. L. McGuire (1989). HER-2/neu oncogene protein and prognosis in breast cancer. J. Clin. Oncol. 7:1120-1128.
45. H. B. Muss, A. D. Thorr, D. A. Berry, T. Kute, E. T. Liu, F. Koerner, C. T. Cirrincione, D. R. Rudman, W. C. Wood, M. Barcos, and I. C. Henderson (1994). c-erbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer. New Eng. J. Med. 330:1260-1266.
46. I. Stancovski, M. Sela, and Y. Yarden (1994). Molecular and clinical aspects of the Neu/ErbB-2 receptor tyrosine kinase. Cancer Treat Res. 71:161-191.
47. C. Wallasch, F. U. Weiss, G. Niederfellner, B. Jallal, W. Issing, and A. Ullrich (1995). Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. EMBO J. 14:4267-4275.
48. M. Alimandi, A. Romano, M. C. Curia, R. Muraro, P. Fedi, S. A. Aaronson, P. P. Di Fiore, and M. H. Kraus (1995). Cooperative signaling of ErbB-3 and ErbB-2 in neoplastic transformation of human mammary carcinoma cells. Oncogene 10:1813-1821.
49. K. Zhang, J. Sun, N. Liu, D. Wen, D. Chang, A. Thomason, and S. K. Yoshinaga (1996). Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2. J. Biol. Chem. 271:3884-3890.
50. G. Gasparini, W. J. Gullick, S. Maluta, P. D. Palma, O. Caffo, E. Leonardi, P. Boracchi, O. F. P, N R. Lemoine, and P. Bevilacqua (1994). c-erbB-3 and c-erbB-2 protein expression in node-negative breast carcinoma - an immunocytochemical study. Eur. J. Cancer. 30a:V2.
51. S. P. Soltoff, K. L. Carraway, S. A. Prigent, W. G. Gullick, and L. C. Cantley (1994). ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol. Cell Biol. 14:3550-3558.
52. G. Levkowitz, L. N. Klapper, E. Tzahar, A. Freywald, M. Sela, and Y. Yarden (1996). Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins. Oncogene 12:1117-1125.
53. Y. Kokai, J. N. Myers, T. Wada, V. I. Brown, C. M. LeVea, J. G. Davis, K. Dobashi, and M. I. Greene (1989). Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts. Cell 58:287-292.
54. D. J. Riese, T. M. van Raaij, G. D. Plowman, G. C. Andrews, and D. F. Stern (1995). The cellular response to neuregulins is governed by complex interactions of the ErbB receptor family. Mol. Cell Biol. 15:5770-5776.
55. E. Tzahar, H. Waterman, X. Chen, G. Levkowitz, D. Karunagaran, S. Lavi, B. J. Ratzkin, and Y. Yarden (1996). A hierarchical network of inter-receptor interactions determines signal transduction by NDF/neuregulin and EGF. Mol. Cell Biol. 16:5276-5287.
56. D. Karunagaran, E. Tzahar, N. Liu, D. Wen, and Y. Yarden (1995). Neu differentiation factor inhibits EGF binding: a model for trans-regulation within the ErbB family of receptor tyrosine kinases. J. Biol. Chem. 270:9982-9990.
57. neu protein and EGF receptor modulates EGF receptor function. Cell. 61:1339-1347.
58. M. X. Sliwkowski, G. Schaefer, R. W. Akita, J. A. Lofgren, V. D. Fitzpatrick, A. Nuijens, B. M. Fendly, R. A. Cerione, R. L. Vandlen, and K. L. R. Carraway (1994). Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin. J. Biol. Chem. 269:14661-14665.
59. D. Graus-Porta, R. R. Beerli, and N. E. Hynes (1995). Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling. Mol. Cell Biol. 15:1182-1191.
60. D. Karunagaran, E. Tzahar, R. R. Beerli, X. Chen, D. Graus-Porta, B. J. Ratzkin, R. Seger, N. E. Hynes, and Y. Yarden (1996). ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J. 15:254-264.