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+ Schwann cell precursors, indicating that neuregulin receptor signaling is important for early generation of the Schwann cell lineage.
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of special interest. As a follow-up to [11], the authors show that neuregulins are also capable of preventing apoptosis of Schwann cell precursors, stimulating their division, and causing their maturation.
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Dong Z, Brennan A, Liu N, Yarden Y, Lefkowitz G, Mirsky R, Jessen KR. Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors. of special interest Neuron. 15:1995;585-596 As a follow-up to [11], the authors show that neuregulins are also capable of preventing apoptosis of Schwann cell precursors, stimulating their division, and causing their maturation.
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Dong, Z.1
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Axon-induced mitogenesis of human Schwann cells involves heregulin and p185erbB2
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of special interest. Using human Schwann cells cultured in the presence of neuregulins, the authors show that signaling through the ErbB2 NRG receptor is essential for mitogenesis.
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Morrissey, T.K.1
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The influence of heregulins on human Schwann cell proliferation
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Levi, A.D.1
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Schumacher, M.1
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Fibroblast growth factors and insulin growth factors combine to promote survival of rat Schwann cell precursors without induction of DNA synthesis
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of special interest. Using their previously described cultured E14 Schwann cell precursors, the authors show a potentiation of the ability of FGFs to rescue apoptotic death when combined with IGFs, implicating IGFs as survival factors for embryonic Schwann cell culture.
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Gavrilovic J, Brennan A, Mirsky R, Jessen KR. Fibroblast growth factors and insulin growth factors combine to promote survival of rat Schwann cell precursors without induction of DNA synthesis. of special interest Eur J Neurosci. 7:1995;77-85 Using their previously described cultured E14 Schwann cell precursors, the authors show a potentiation of the ability of FGFs to rescue apoptotic death when combined with IGFs, implicating IGFs as survival factors for embryonic Schwann cell culture.
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Gavrilovic, J.1
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Jessen, K.R.4
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Characterization of insulin-like growth factor-I and its receptor and binding proteins in transected nerves and cultured Schwann cells
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of special interest. Increased expression of Schwann cell generated IGF-I and the IGF-I receptor is observed upon adult peripheral nerve lesion. IGF-I is shown to be a mitogenic factor for cultured neonatal Schwann cells, and the IGF-I receptor is detected in vitro.
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Cheng H-L, Randolph A, Yee D, Delafontaine P, Tennekoon G, Feldman EL. Characterization of insulin-like growth factor-I and its receptor and binding proteins in transected nerves and cultured Schwann cells. of special interest J Neurochem. 66:1996;525-536 Increased expression of Schwann cell generated IGF-I and the IGF-I receptor is observed upon adult peripheral nerve lesion. IGF-I is shown to be a mitogenic factor for cultured neonatal Schwann cells, and the IGF-I receptor is detected in vitro.
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Cheng, H.-L.1
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0 expresison and DNA synthesis by insulin-like growth factors in vitro
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0 expression. When grown in the presence of IGFs and FGF, TGF-β, PDGF, or neuregulins, a potentiated mitogenic response is seen in the absence of myelin-specific gene expression.
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0 expression. When grown in the presence of IGFs and FGF, TGF-β, PDGF, or neuregulins, a potentiated mitogenic response is seen in the absence of myelin-specific gene expression.
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Stewart, H.J.S.1
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Morgan L, Jessen KR, Mirsky R. Negative regulation of the P0 gene in Schwann cells: suppression of P0 mRNA and protein induction in cultured Schwann cells by FGF2 and TGF beta 1, TGF beta 2 and TGF beta 3. Development. 120:1994;1399-1409.
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Morgan, L.1
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of special interest. See annotation [27].
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Guenard V, Gwynn LA, Wood PM. Transforming growth factor-beta blocks myelination but not ensheathment of axons by Schwann cells in vitro. of special interest J Neurosci. 15:1995;419-428 See annotation [27].
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Guenard, V.1
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Wood, P.M.3
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27
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0028986744
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Transforming growth factor-beta 1 regulates axon/Schwann cell interactions
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of special interest. Two groups [26,27] demonstrate that in a Schwann cell: DRG neuronal coculture system, exogenous TGF-β prevents myelination, decreases the expression of myelin-specific gene products, and causes Schwann cells to adopt a nonmyelinating-like phenotype in vitro.
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Einheber S, Hannocks MJ, Metz CN, Rifkin DB, Salzer JL. Transforming growth factor-beta 1 regulates axon/Schwann cell interactions. of special interest J Cell Biol. 129:1995;443-458 Two groups [26,27] demonstrate that in a Schwann cell: DRG neuronal coculture system, exogenous TGF-β prevents myelination, decreases the expression of myelin-specific gene products, and causes Schwann cells to adopt a nonmyelinating-like phenotype in vitro.
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Einheber, S.1
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Salzer, J.L.5
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Effect of transforming growth factor-beta 1 and -beta 2 on Schwann cell proliferation on neurites
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Guenard V, Rosenbaum T, Gwynn LA, Doetschman T, Ratner N, Wood PM. Effect of transforming growth factor-beta 1 and -beta 2 on Schwann cell proliferation on neurites. Glia. 13:1995;309-318.
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Guenard, V.1
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Ratner, N.5
Wood, P.M.6
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29
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0028913076
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The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
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of outstanding interest. The authors demonstrate that Gas6 is a ligand for Tyro 3, and that both molecules are expressed in Schwann cells in vitro.
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Stitt TN, Conn G, Gore M, Lai C, Bruno J, Radziejewski C, Mattsson K, Fisher J, Gies DR, Jones PF, et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. of outstanding interest Cell. 80:1995;661-670 The authors demonstrate that Gas6 is a ligand for Tyro 3, and that both molecules are expressed in Schwann cells in vitro.
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Stitt, T.N.1
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Lai, C.4
Bruno, J.5
Radziejewski, C.6
Mattsson, K.7
Fisher, J.8
Gies, D.R.9
Jones, P.F.10
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30
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Identification of Gas6 as a growth factor for human Schwann cells
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of special interest. The authors demonstrate the physiological relevance of Gas6 and Tyro 3 to Schwann cells, both in vitro by showing the mitogenic effect of Gas6 on cultured Schwann cells, and in vivo by showing the developmental expression of Gas6 mRNA in peripheral neurons.
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Li R, Chen J, Hammonds G, Phillips H, Armanini M, Wood P, Bunge R, Godowski PJ, Sliwkowski MX, Mather JP. Identification of Gas6 as a growth factor for human Schwann cells. of special interest J Neurosci. 16:1996;2012-2019 The authors demonstrate the physiological relevance of Gas6 and Tyro 3 to Schwann cells, both in vitro by showing the mitogenic effect of Gas6 on cultured Schwann cells, and in vivo by showing the developmental expression of Gas6 mRNA in peripheral neurons.
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Li, R.1
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Wood, P.6
Bunge, R.7
Godowski, P.J.8
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Cell death in the Schwann cell lineage and its regulation by neuregulin
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of special interest. Apoptosis is shown to occur during the normal development of postnatal rodent peripheral nerve Schwann cells. In vitro, neonatal Schwann cells undergo apoptosis upon serum withdrawal. This apoptosis can be prevented by addition of NRGs to serum-free medium.
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Syroid DE, Maycox PR, Burrola PG, Liu N, Wen D, Lee K-F, Lemke G, Kilpatrick TJ. Cell death in the Schwann cell lineage and its regulation by neuregulin. of special interest Proc Natl Acad Sci USA. 93:1996;9229-9234 Apoptosis is shown to occur during the normal development of postnatal rodent peripheral nerve Schwann cells. In vitro, neonatal Schwann cells undergo apoptosis upon serum withdrawal. This apoptosis can be prevented by addition of NRGs to serum-free medium.
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Proc Natl Acad Sci USA
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Syroid, D.E.1
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Axonal interactions regulate Schwann cell apoptosis in developing peripheral nerve: Neuregulin receptors and the role of neuregulins
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of special interest
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Grinspan JB, Marchionni MA, Reeves M, Coulaloglou M, Scherer SS. Axonal interactions regulate Schwann cell apoptosis in developing peripheral nerve: neuregulin receptors and the role of neuregulins. of special interest J Neurosci. 1996; The authors demonstrate that apoptosis occurs in vivo in sciatic nerve Schwann cells during the first two weeks of postnatal development, that sciatic nerve axotomy caused increased apoptosis in distal nerve stumps of newborn animals, but not in adult animals which are rescued by in vivo GGF2 infusion, and that neonatal sciatic nerve Schwann cells express phosphorylated forms of the ErbB2 and ErbB3 NRG receptors.
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Grinspan, J.B.1
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Scherer, S.S.5
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35
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0030045796
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Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor
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of special interest. In contrast to in adults, denervation of neonatal nerve terminals is shown to result in Schwann cell apoptosis, which is prevented by the in vivo infusion of NRG (GGF), implicating NRG as an axonal survival factor for neonatal terminal Schwann cells.
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Trachtenberg JT, Thompson WJ. Schwann cell apoptosis at developing neuromuscular junctions is regulated by glial growth factor. of special interest Nature. 379:1996;174-177 In contrast to in adults, denervation of neonatal nerve terminals is shown to result in Schwann cell apoptosis, which is prevented by the in vivo infusion of NRG (GGF), implicating NRG as an axonal survival factor for neonatal terminal Schwann cells.
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Nature
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Trachtenberg, J.T.1
Thompson, W.J.2
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0029922538
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Schwann cell apoptosis during normal development and after axonal degeneration induced by neurotoxins in the chick embryo
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of special interest. In embryonic chick peripheral nerves, Schwann cell apoptosis is shown to occur during the normal course of development, and is increased in extent after experimentally induced axonal degeneration, indicating that in vivo embryonic Schwann cell apoptosis is regulated by axons.
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Ciutat D, Caldero J, Oppenheim RW, Esquerda JE. Schwann cell apoptosis during normal development and after axonal degeneration induced by neurotoxins in the chick embryo. of special interest J Neurosci. 16:1996;3979-3990 In embryonic chick peripheral nerves, Schwann cell apoptosis is shown to occur during the normal course of development, and is increased in extent after experimentally induced axonal degeneration, indicating that in vivo embryonic Schwann cell apoptosis is regulated by axons.
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Ciutat, D.1
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Selective activation of NF-kappa B by nerve growth factor through the neutrophin receptor p75
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of special interest. Cultured neonatal Schwann cells are found to express the transcription factor NF-κB, which is translocated to the nucleus by addition of NGF to the culture medium. This response is dependent on Schwann cell expression of the LNGFR.
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Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhauser N, Bohm-Matthaei R, Baeuerle PA, Barde YA. Selective activation of NF-kappa B by nerve growth factor through the neutrophin receptor p75. of special interest Science. 272:1996;542-545 Cultured neonatal Schwann cells are found to express the transcription factor NF-κB, which is translocated to the nucleus by addition of NGF to the culture medium. This response is dependent on Schwann cell expression of the LNGFR.
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Science
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Carter, B.D.1
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Expression of c-Jun, Jun B, Jun D and cAMP response element binding protein by Schwann cells and their precursors in vivo and in vitro
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