Detection of bcl-2/JH translocation by polymerase chain reaction: A summary of the experience of the Molecular Oncology Survey of the College of American Pathologists

Archives of Pathology and Laboratory Medicine

Volumn 126, Issue 8, 2002, Pages 902-908

  Hsi, Eric D ^a   Tubbs, Raymond R ^a   Lovell, Mark A ^a   Braziel, Rita M ^a   Gulley, Margaret L ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; PROTEIN BCL 2;

ARTICLE; CHROMOSOME 14Q; CHROMOSOME 18Q; CHROMOSOME BREAKAGE; FOLLICULAR LYMPHOMA; GENE CLUSTER; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; GENES, BCL-2; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN J-CHAINS; POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; TRANSLOCATION, GENETIC;

EID: 0036676116     PISSN: 00039985     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma
2. Involvement of the bcl-2 gene in human follicular lymphoma
3. Recurrent chromosomal defects are found in most patients with non-Hodgkin's-lymphoma
4. Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma
5. Expression of the bcl-2 gene product in follicular lymphoma
6. Incidence and prognostic significance of t(14;18) translocation in follicle center cell lymphoma of low and high grade: A report from southern Sweden
7. Clinical significance of the t(14;18) and BCL2 overexpression in follicular large cell lymphoma
8. Molecular analysis of the t(14; 18) chromosomal translocation in malignant lymphomas
9. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
10. The Bcl-2 protein family: Arbiters of cell survival
11. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
12. Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
13. Detection of chromosomal translocation t(14;18) within the minor cluster region of bcl-2 by polymerase chain reaction and direct genomic sequencing of the enzymatically amplified DNA in follicular lymphomas
14. Molecular diagnostics in follicular non-Hodgkin's lymphoma: A review
15. Rearrangement of the BCL-2 gene in follicular lymphoma: Detection by PCR in both fresh and fixed tissue samples
16. Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma
17. Bcl-2 rearrangements in de novo diffuse large cell lymphoma: Association with distinctive clinical features
18. Detection of monoclonality in low-grade B-cell lymphomas using the polymerase chain reaction is dependent on primer selection and lymphoma type
19. Optimal primer selection for clonality assessment by polymerase chain reaction analysis, II: Follicular lymphomas
20. Use of novel t(11;14) and t(14; 18) dual fusion FISH probes in the differential diagnosis of lymphomas of small lymphocytes
21. Correlation of bcl-2 rearrangement with clinical characteristics and outcome in indolent follicular lymphoma
22. Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma
23. The clinical significance of molecular response in indolent follicular lymphomas
24. A validated real-time quantitative PCR approach shows a correlation between tumor burden and successful ex vivo purging in follicular lymphoma patients
25. Real-time t(11;14) and t(14;18) PCR assays provide sensitive and quantitative assessments of minimal residual disease (MRD)
26. Rapid simultaneous amplification and detection of the MBR/JH chromosomal translocation by fluorescence melting curve analysis
27. Establishing a molecular diagnostics laboratory
28. Comparison of t(14;18) positive and t(14;18) negative follicular lymphoma: Clinical characteristics, outcome, and cytogenetics
29. Enhanced detection of the t(14;18) translocation in malignant lymphoma using pulsed-field gel electrophoresis
30. Comparison of cytogenetic analysis, Southern analysis, and polymerase chain reaction for the detection of t(14;18) in follicular lymphoma
31. Primary cutaneous follicle center cell lymphoma with follicular growth pattern
32. EORTC classification for primary cutaneous lymphomas: A proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer
33. Clinicopathologic reassessment of primary cutaneous B-cell lymphomas with immunophenotypic and molecular genetic characterization
34. Cutaneous follicle center lymphoma: A clinicopathologic study of 19 cases
35. Cutaneous B-cell lymphomas of follicular and marginal zone types: Use of Bcl-6, CD10, Bcl-2, and CD21 in differential diagnosis and classification
36. Primary cutaneous follicle center lymphoma: An assessment of clinical, histopathologic, immunophenotypic, and molecular features
37. H rearrangements in benign lymphoid tissues with follicular hyperplasia
38. Standard polymerase chain reaction analysis does not detect t(14;18) in reactive lymphoid hyperplasia
39. All patients with persistent polyclonal B cell lymphocytosis present Bcl-2/lg gene rearrangements
40. Frequency of the Bcl-2/lgH rearrangement in normal individuals: Implications for the monitoring of disease in patients with follicular lymphoma