Correlation of bcl-2 rearrangement with clinical characteristics and outcome in indolent follicular lymphoma

Blood

Volumn 93, Issue 9, 1999, Pages 3081-3087

  López Guillermo, Armando ^a   Cabanillas, Fernando ^a,b   McDonnell, Timothy I ^a   McLaughlin, Peter ^a   Smith, Terry ^a   Pugh, William ^a   Hagemeister, Fredrick ^a   Rodríguez, M Alma ^a   Romaguera, Jorge E ^a   Younes, Anas ^a   Sarris, Andreas H ^a   Preti, H Alejandro ^a   Lee, Ming Seng ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; LACTATE DEHYDROGENASE; PROTEIN BCL 2;

ADULT; AGED; ARTICLE; BONE MARROW BIOPSY; CONTROLLED STUDY; FEMALE; FOLLICULAR LYMPHOMA; GENE REARRANGEMENT; HISTOPATHOLOGY; HUMAN; IMMUNOPHENOTYPING; LACTATE DEHYDROGENASE BLOOD LEVEL; LYMPH NODE BIOPSY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROTO ONCOGENE;

EID: 0033134754     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.9.3081     Document Type: Article

References (44)

1. Yunis JJ, Oken MM, Kaplan ME, Ensrud KM, Howe RR, Theologides A: Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma. N Engl J Med 307:1231, 1982
2. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM: Cloning of the chromosome breakpoint of neoplastic B cell with the t(14;18) chromosome translocation. Science 226:1097, 1984
3. Graninger WB, Seto M, Boutain B, Goldman P, Korsmeyer SJ: Expression of bcl-2 and bcl-2-Ig fusion transcripts in normal and neoplastic cells. J Clin Invest 80:1512, 1987
4. Tsujimoto Y, Croce C: Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA 83:5214, 1986
5. Vaux DL, Cory S, Adams JM: Bcl-2 gene promotes haematopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440, 1988
6. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609, 1993
7. Cory S: Regulation of lymphocyte survival by the bcl-2 gene family. Annu Rev Immunol 13:513, 1995
8. Yang E, Korsmeyer SJ: Molecular thanatopsis: A discourse on the BCL2 family and cell death. Blood 88:386, 1996
9. Lee MS: Molecular aspects of chromosomal translocation t(14; 18). Semin Hematol 30:297, 1993
10. Cleary ML, Sklar J: Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc Natl Acad Sci USA 82:7439, 1985
11. Tsujimoto Y, Cossman J, Jaffe E, Croce CM: Involvement of the bcl-2 gene in human follicular lymphoma. Science 228:1440, 1986
12. Cleary ML, Galili N, Sklar J: Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas. J Exp Med 164:315, 1986
13. Horsman DE, Gascoyne RD, Coupland RW, Coldman AJ, Adomat SA: Comparison of cytogenetic analysis, southern analysis, and polymerase chain reaction for the detection of t(14;18) in follicular lymphoma. Am J Clin Pathol 103:472, 1995
14. Saiki RK, Gelfand DH, Stoffel S, Scharf S, Higuchi R, Horn G, Mullis K, Ehrlich H: Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487, 1988
15. Lee MS, Chang KS, Cabanillas F, Freireich EJ, Trujillo JM, Stass SA: Detection of minimal residual cells carrying the t(14;18) by DNA sequence amplification. Science 237:175, 1987
16. Johnson A, Brun A, Dictor M, Rambech E, Akerman M, Anderson H: Incidence and prognostic significance of t(14;18) translocation in follicle center cell lymphoma of low and high grade. Ann Oncol 6:789, 1995
17. Yunis JJ, Mayer MG, Arnesen MA, Aeppli DP, Oken MM, Frizzera G: Bcl-2 and other genomic alterations in the prognosis of large cell lymphoma. N Engl J Med 320:1047, 1989
18. Levine EG, Arthur DC, Frizzera G, Peterson BA, Hurd DD, Bloomfield CD: Cytogenetic abnormalities predict clinical outcome in non-Hodgkin lymphoma. Ann Intern Med 108:14, 1988
19. Pezzella F, Jones M, Ralfkiaer E, Ersboll J, Gatter KC, Mason DY: Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma. Br J Cancer 65:87, 1992
20. Tilly H, Rossi A, Stamatoullas A, Lenormand B, Bigorgne C, Kunlin A, Monconduit M, Bastard C: Prognostic value of chromosomal abnormalities in follicular lymphomas. Blood 84:1043, 1994
21. Louie DC, Hochauser D, Schluger A, Jaslow R, Roy P, Oliver J, Offit K, Chaganti RSK: BCL6 and BCL2 rearrangement and p53 overexpression as prognostic factors in follicular lymphoma. Ann Oncol 7:16 (051), 1996 (suppl 3)
22. Hermine O, Haioun C, Lepage E, d'Agay MF, Briere J, Lavignac C, Fillet G, Salles G, Marolleau JP, Diebold J, Reyes F, Gaulard P, for the GELA: Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma. Blood 87:265, 1996
23. Hill ME, MacLennan KA, Cunningham DC, Vaughan Hudson B, Burke M, Clarke P, Di Stefano F, Anderson L, Vaughan Hudson G, Mason D, Selby P, Linch DC: Prognostic significance of bcl-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: A British national lymphoma investigation study. Blood 88:1046, 1996
24. Seite P, Hillion J, d'Agay MF, Gaulard P, Cazals D, Badoux F, Berger R, Larsen CJ: BCL2 gene activation and protein expression in follicular lymphoma: A report on 64 cases. Leukemia 7:410, 1993
25. Lister AT: The management of follicular lymphoma. Ann Oncol 2:131, 1991 (suppl 2)
26. López-Guillermo A, Montserrat E, Bosch F, Terol MJ, Campo E, Rozman C: Applicability of the International Index for aggressive lymphomas to patients with low-grade lymphoma. J Clin Oncol 12:1343, 1994
27. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, DeWolf-Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Muller-Hermelink HK, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA: A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 84:1361, 1994
28. McLaughlin P, Hagemeister FB, Swan F, Cabanillas F, Romaguera J, Rodriguez MA, Lee MS, Pate O, Sarris A, Younes A: Intensive conventional-dose chemotherapy for stage IV low-grade lymphoma: High remission rates and reversion to negative of peripheral blood bcl-2 rearrangement. Ann Oncol 5:S73, 1994 (suppl 2)
29. McLaughlin P, Hagemeister FB, Romaguera JE, Sarris AH, Pate O, Younes A, Swan F, Keating M, Cabanillas F: Fludarabine, mitoxantrone and dexamethasone: An effective new regimen for indolent lymphoma. J Clin Oncol 14:1262, 1996
30. Kaplan EL, Meier P: Non-parametric estimation from incomplete observations. J Am Stat Assoc 53:457, 1958
31. Gehan EA: A generalized Wilcoxon test for comparing arbitrarily singly-censored samples. Biometrika 52:203, 1965
32. Cox DR. Regression models and life tables. J Royal Stat Soc 34:187, 1972
33. Dolken G, Illerhaus G, Hirt C, Mertelsmann R: BCL-2/Jh rearrangements in circulating B cells of healthy blood donors and patients with nonmalignant diseases. J Clin Oncol 14:1333, 1996
34. Limpens J, Stad R, Vos C, de Vlaam C, de Jong D, van Ommen GJB, Schuuring E, Kluin PM: Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals. Blood 85:2528, 1995
35. Liu Y, Hernandez AM, Shibata D, Cortopassi GA: Bcl-2 translocation frequency rises with age in humans. Proc Natl Acad Sci USA 91:8910, 1994
36. Yuan R, Dowling P, Zucca E, Diggelmann H, Cavalli F: Detection of bcl-2/JH rearrangement in follicular and diffuse lymphoma: concordant results of peripheral blood and bone marrow analysis at diagnosis. Br J Cancer 67:922, 1993
37. Berinstein NL, Reis MD, Ngan BY, Sawka CA, Jamal HH, Kuzniar B: Detection of occult lymphoma in the peripheral blood and bone marrow of patients with untreated early stage and advanced stage follicular lymphoma. J Clin Oncol 11:1344, 1993
38. Berinstein NL, Jamal HH, Kuzniar B, Klock RJ, Reis MD: Sensitive and reproducible detection of occult disease in patients with follicular lymphoma by PCR amplification of t(14;18) both pre- and post-treatment. Leukemia 7:113, 1993
39. Gribben JG, Neuberg D, Freedman AS, Gimmi CD, Pesek KW, Barber M, Saporito L, Woo SD, Coral F, Spector N, Rabinowe SN, Grossbard ML, Ritz J, Nadler LM: Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma. Blood 81:3449, 1993
40. McLaughlin P, Cabanillas F, Younis A, Lee MS, Rodriguez MA, Hagemeter FB, Sarris A, Preti A: Stage IV low grade lymphoma (LGL): Randomized trial of two innovative regimens, with monitoring of BCL-2 by PCR. Ann Oncol 7:34, 1996 (suppl 3)
41. Offit K, LoCoco F, Loure DC, Parsa NZ, Leung D, Portlock C, Ye BH, Lista F, Filippa DA, Rosenbaum A, Ladanyi M, Jhanwar S, Della-Favera R, Chaganti RSK: Rearrangement of the BCL-6 gene as a prognostic marker in diffuse large-cell lymphoma. N Engl J Med 331:74, 1994
42. Sander CA, Yano T, Clark HM, Harris C, Longo DL, Jaffe ES, Raffeld M: p53 mutation is associated with progression in follicular lymphomas. Blood 82:1994, 1993
43. Yano T, Jaffe ES, Longo DL, Raffeld M: Myc rearrangements in histologically progressed follicular lymphomas. Blood 80:758, 1992
44. INK4A gene with the aggressive variant of non-Hodgkin's lymphomas. Blood 91:2977, 1998