Heterogeneity of serum albumin samples with respect to solid-state aggregation via thiol-disulfide interchange - Implications for sustained release from polymers

Journal of Controlled Release

Volumn 44, Issue 2-3, 1997, Pages 255-261

  Costantino, Henry R ^a,b   Shieh, Lisa ^a   Klibanov, Alexander M ^a   Langer, Robert ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b GENENTECH INC   (United States)

Author keywords

albumin; lyophilization; poly(fatty acid dimer:sebacic acid); thiol disulfide interchange

Indexed keywords

BOVINE SERUM ALBUMIN; DIMER; DISULFIDE; FATTY ACID; HUMAN SERUM ALBUMIN; POLYMER; RECOMBINANT ALBUMIN; SEBACIC ACID; SERUM ALBUMIN; THIOL; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CONTROLLED STUDY; FREEZE DRYING; MODEL; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN MODIFICATION; PROTEIN SECRETION; PROTEIN STABILITY; SOLID STATE; SUSTAINED DRUG RELEASE; TEMPERATURE;

EID: 0031575559     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(96)01528-3     Document Type: Article

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