Survival of docetaxel-resistant prostate cancer cells in vitro depends on phenotype alterations and continuity of drug exposure

Cellular and Molecular Life Sciences

Volumn 59, Issue 7, 2002, Pages 1198-1211

  Makarovskiy, A N ^a   Siryaporn, E ^a   Hixson, D C ^a   Akerley, W ^b  

^a RHODE ISLAND HOSPITAL   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cancer; Cytotoxicity; Endoreduplication; Phenotype; Prostate; Resistance; Taxane

Indexed keywords

BETA TUBULIN; DOCETAXEL; GLYCOPROTEIN P; PACLITAXEL; PROTEIN BCL 2; PROTEIN BCL XL;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COLORIMETRY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EXPOSURE; GIANT CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IN VITRO STUDY; PHENOTYPE; PROSTATE CANCER; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BCL-X PROTEIN; CELL DIVISION; CELL SURVIVAL; CLONE CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; GIANT CELLS; HUMANS; KINETICS; MALE; P-GLYCOPROTEIN; PACLITAXEL; PHENOTYPE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; TAXOIDS; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0036634786     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8498-3     Document Type: Article

References (34)

1. A phase II trial of docetaxel (Taxotere) in hormone-refractory prostate cancer: Correlation of antitumor effect to phosphorilation of BCL-2
2. Mechanisms of action of taxanes in prostate cancer
3. Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel
4. Tubulin alterations in taxol induced apoptosis parallel those observed with other drugs
5. Different docetaxel-induced apoptotic pathways are present in prostate cancer cell lines LNCaP and PC-3
6. Coupling cell division and cell death to microtubule dynamics
7. Paclitaxel-associated multimininucleation is permitted by the inhibition of caspase activation: A potential early step in drug resistance
8. Development of apoptosis and polyploidy in human lymphoblast cells as a function of the cell cycle and the time of irradiation
9. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function
10. A p53-dependent mouse spindle checkpoint
11. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
12. p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest
13. Uncoupling of S phase and mitosis induced by anti-cancer agents in cells lacking p21
14. p21 Waf1/Cip1 inhibition of cyclin E/Cdk2 activity prevents endoreduplication after mitotic spindle disruption
15. Resistance to anticancer drugs
16. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
17. CHO mutants resistant to colchicine, Colcemid, or Griseofulvin have an altered β-tubulin
18. Altered β-tubulin isotype expression in paclitaxel resistant human prostate carcinoma cells
19. Expression of oncogenic epidermal growth factor receptor family kinases induces paclitaxel resistance and alters beta-tubulin isotype expression
20. Loss of normal p53 function confers sensitization to taxol by increasing G2/M arrest and apoptosis
21. BCL-xL in prostate cancer cells: Effects of overexpression and down-regulation on chemosensitivity
22. Targeting bcl-2 gene to delay androgen-independent progression and enhance chemosensitivity in prostate cancer using antisense bcl-2 oligodeoxynucleotides
23. Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genes
24. New colorimetric cytotoxicity assay for anticancer-drug screening
25. Effects of Taxotere on murine and human tumor cell lines
26. A stem cell model of human tumor growth: Implications for tumor cell clonogenic assays
27. A case of docetaxel-resistant breast cancer responsive to paclitaxel therapy
28. Genetic instabilities in human cancers
29. Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization
30. Micronuclei as an index of cytogenetic damage: Past, present, and future
31. Polyploid giant cells provide a survival mechanism for p53 mutant cells after DNA damage
32. Release of mitotic descendants by giant cells from irradiated Burkitt's lymphoma cell line
33. Coadministration of oral cyclosporin A enables oral therapy with paclitaxel
34. Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel