Development of apoptosis and polyploidy in human lymphoblast cells as a function of position in the cell cycle at the time of irradiation

Radiation Research

Volumn 146, Issue 6, 1996, Pages 595-602

  Olive, P L ^a   Banath J P ^a   Durand, R E ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL LINE; CELL SURVIVAL; CLONOGENESIS; ETIOLOGY; HUMAN; HUMAN CELL; LYMPHOBLAST; POLYPLOIDY; PRIORITY JOURNAL; X IRRADIATION;

EID: 0029842036     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579374     Document Type: Article

References (24)

1. F. Xia, X. Wang, Y. Wang, N. Tsang, D. W. Yandell, K. T. Kelsey and H. L. Liber, Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines. Cancer Res. 55, 12-15 (1995).
2. W. Zhen, C. M. Denault, K. Loviscek, S. Walter, L. Geng and A. T. Vaughan, The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status. Mutat. Res. 346, 85-92 (1995).
3. P. L. Olive, G. Frazer and J. P. Banáth, Radiation-induced apoptosis measured in TK6 human B-lymphoblast cells using the comet assay. Radiat. Res. 136, 130-136 (1993).
4. J. L. Schwartz, R. Jordan, B. A. Sedita, M. J. Swenningson, J. P. Banáth and P. L. Olive, Different sensitivity to cell killing and chromosome mutation induction by gamma rays in two human lymphoblastoid cell lines derived from a single donor: possible role of apoptosis. Mutagenesis 10, 227-233 (1995).
5. W. C. Dewey, C. C. Ling and R. E. Meyn, Radiation-induced apoptosis: relevance to radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 33, 781-796 (1995).
6. C. C. Ling, M. Guo, G. H. Chen and T. Deloherey, Radiationinduced apoptosis: Effects of cell age and dose fractionation. Cancer Res. 55, 5207-5212 (1995).
7. M. G. Ormerod, X. M. Sun, D. Brown, R. T. Snowden and G. M. Cohen, Quantification of apoptosis and necrosis by flow cytometry. Acta Oncol. 32, 417-424 (1993).
8. F. Belloc, P. Dumain, M. R. Boisseau, C. Jalloustre, J. Reiffers, P. Bernard and F. Lacombe, A flow cytometric method using Hoechst 33342 and PI for simultaneous cell cycle analysis and apoptosis determination in unfixed cells. Cytometry 17, 59-65 (1994).
9. S. A. Amundson, F. Xia, K. Wolfson and H. L. Liber, Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor. Mutat. Res. 286, 223-241 (1993).
10. T. G. Pretlow and T. P. Pretlow, Centrifugal elutriation (counter-streaming centrifugation) of cells. Cell Biophys. 1, 195-210 (1979).
11. L. L. Vindelov, Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and staining of nuclei. Cell Pathol. 24, 227-242 (1977).
12. 125IdUrd. Int. J. Radiat. Biol. 64, 349-358 (1993).
13. P. L. Olive, J. P. Banáth and R. E. Durand, Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. Radiat. Res. 122, 69-72 (1990).
14. R. E. Durand and S. L. Vanderbyl, Sequencing radiation and adriamycin exposures in spheroids to maximize therapeutic gain. Int. J. Radiat. Oncol. Biol. Phys. 17, 345-350 (1989).
15. I. R. Radford, Radiation response of mouse lymphoid and myeloid cell lines. Part I. Sensitivity to killing by ionizing radiation, rate of loss of viability and cell type of origin. Int. J. Radiat. Biol. 65, 203-215 (1994).
16. G. L. Yount, D. A. Haas-Kogan, C. A. Vidair, M. Haas, W. C. Dewey and M. Israel, Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells. Cancer Res. 56, 500-506 (1996).
17. Y. Xiong, G. J. Hannon, H. Zhang, D. Casso, R. Kobayashi and D. Beach, p21 is a universal inhibitor of cyclin kinases. Nature 366, 704-707 (1993).
18. 1 checkpoint control. Cell 82, 675-684 (1995).
19. T. Waldman, C. Lengauer, D. W. Kinzler and B. Vogelstein, Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381, 713-716 (1996).
20. S. M. Cross, C. A. Sanchez, C. A. Morgan, M. K. Schimke, S. Ramel, R. L. Idzerda, W. H. Raskind and B. J. Beid, A p53-dependent mouse spindle checkpoint. Science 267, 1353-1356 (1995).
21. waf1/cip1 expression in normal and neoplastic tissues. Cancer Res. 55, 2910-2919 (1995).
22. M. B. Kastan, O. Zhan, W. S. el-Deiry, F. Carrier, T. Jacks, W. V. Walsh, B. S. Plunkett, B. Vogelstein and A. J. Fornace, Jr., A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597 (1992).
23. A. J. McIlwrath, P. A. Vasey, G. M. Ross and R. Brown, Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity. Cancer Res. 54, 3718-3722 (1994).
24. J. B. Little, H. Nagasawa, P. C. Keng, Y. Yu and C. Li, Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status. J. Biol. Chem. 270, 11033-11036 (1995).