DNA and RNA modified dendritic cell vaccines

World Journal of Surgery

Volumn 26, Issue 7, 2002, Pages 819-825

  Morse, Michael A ^a   Lyerly, H Kim ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CYTOKINE; DNA; RNA; TUMOR ANTIGEN;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; CANCER; CANCER IMMUNOTHERAPY; CONFERENCE PAPER; DENDRITIC CELL; DNA MODIFICATION; DRUG DELIVERY SYSTEM; IMMUNE RESPONSE; IMMUNE SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VACCINATION; ACTIVE IMMUNIZATION; ANIMAL; CYTOLOGY; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; HUMAN; IMMUNOLOGY; METHODOLOGY; NEOPLASM; REVIEW;

ANIMALS; CANCER VACCINES; DENDRITIC CELLS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; IMMUNOTHERAPY, ACTIVE; NEOPLASMS;

EID: 0036631695     PISSN: 03642313     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00268-002-4058-0     Document Type: Conference Paper

References (54)

1. Morse MA, Lyerly HK. Dendritic cell-based approaches to cancer immunotherapy. Exp. Opin. Invest. Drugs 1998;7:1617
2. Takashima A, Morita A. Dendritic cells in genetic immunization. J. Leukoc. Biol. 1999;66:350
3. Yang S, Vervaert CE, Burch J Jr, et al. Murine dendritic cells transfected with human GP100 elicit both antigen-specific CD8(+) and CD4(+) T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity. Int. J. Cancer 1999;83:532
4. Vollmer CM Jr, Eilber FC, Butterfield LH, et al. Alpha-fetoprotein-specific genetic immunotherapy for hepatocellular carcinoma. Cancer Res. 1999;59:3064
5. Westermann J, Aicher A, Qin Z, et al. Retroviral interleukin-7 gene transfer into human dendritic cells enhances T cell activation. Gene Ther. 1998;5:264
6. Ahuja SS, Reddick RL, Sato N, et al. Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection. J. Immunol. 1999;163:3890
7. Lu L, Lee WC, Takayama T, et al. Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-beta, and CTLA4Ig). J. Leukoc. Biol. 1999;66:293-296
8. Zhang W, He L, Yuan Z, et al. Enhanced therapeutic efficacy of tumor RNA-pulsed dendritic cells after genetic modification with lymphotactin. Hum. Gene Ther. 1999;10:1151
9. Cella M, Salio M, Sakakibara Y, et al. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J. Exp. Med. 1999;189:821.
10. Leitner WW, Ying H, Restifo NP. DNA and RNA-based vaccines: principles, progress and prospects. Vaccine 1999;18:765
11. Hartmann G, Weiner GJ, Krieg AM. CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells. Proc. Natl. Acad. Sci. U.S.A. 1999;96:9305
12. Cusack JC Jr, Tanabe KK. Cancer gene therapy. Surg. Oncol. Clin. N. Am. 1998;7:421
13. Wivel NA, Wilson JM. Methods of gene delivery. Hematol. Oncol. Clin. N. Am. 1998;12:483
14. Aicher A, Westermann J, Cayeux S, et al. Successful retroviral mediated transduction of a reporter gene in human dendritic cells: feasibility of therapy with gene-modified antigen presenting cells. Exp. Hematol. 1997;25:39
15. Cassel A, Cottler-Fox M, Doren S, et al. Retroviral-mediated gene transfer into CD34-enriched human peripheral blood stem cells. Exp. Hematol. 1993;21:585
16. Henderson RA, Nimgaonkar MT, Watkins SC, et al. Human dendritic cells genetically engineered to express high levels of the human epithelial tumor antigen mucin (MUC-1). Cancer Res. 1996;56:3763
17. Reeves ME, Royal RE, Lam JS, et al. Retroviral transduction of human dendritic cells with a tumor-associated antigen gene. Cancer Res. 1996;56:5672
18. Szabolcs P, Gallardo HF, Ciocon DH, et al. Retrovirally transduced human dendritic cells express a normal phenotype and potent T-cell stimulatory capacity. Blood 1997;90:2160
19. Bello-Fernandez C, Matyash M, Strobl H, et al. Efficient retrovirus-mediated gene transfer of dendritic cells generated from CD34+ cord blood cells under serum-free conditions. Hum. Gene Ther. 1997;8:1651
20. Specht JM, Wang G, Do MT, et al. Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases. J. Exp. Med. 1997;186:1213
21. Heemskerk MH, Hooijberg E, Ruizendaal JJ, et al. Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells. Cell Immunol. 1999;195:10
22. Movassagh M, Baillou C, Cosset FL, et al. High level of retrovirus-mediated gene transfer into dendritic cells derived from cord blood and mobilized peripheral blood CD34+ cells. Hum. Gene Ther. 1999;10:175
23. Song W, Kong H, Traktman P, et al. Cytotoxic T lymphocyte responses to proteins encoded by heterologous transgenes transferred in vivo by adenoviral vectors. Hum. Gene Ther. 1997;8:1207-1217
24. Wan Y, Emtage P, Foley R, et al. Murine dendritic cells transduced with an adenoviral vector expressing a defined tumor antigen can overcome anti-adenovirus neutralizing immunity and induce effective tumor regression. Int. J. Oncol. 1999;14:771
25. Kaplan JM, Yu Q, Piraino ST, et al. Induction of antitumor immunity with dendritic cells transduced with adenovirus vector-encoding endogenous tumor-associated antigens. J. Immunol. 1999;163:699
26. Mulders P, Pang S, Dannull J, et al. Highly efficient and consistent gene transfer into dendritic cells utilizing a combination of ultraviolet-irradiated adenovirus and poly(L-lysine) conjugates. Cancer Res. 1998;58:956
27. Amalfitano A, Hauser MA, Hu H, et al. Production and characterization of improved adenovirus vectors with the E1, E2b, and E3 genes deleted. J. Virol. 1998;72:926
28. Hu H, Serra D, Amalfitano A. Persistence of an [E1-, polymerase-] adenovirus vector despite transduction of a neoantigen into immune-competent mice. Hum. Gene Ther. 1999;10:355
29. Gong J, Chen L, Chen D, et al. Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells. Gene Ther. 1997;4:1023
30. Song W, Kong HL, Carpenter H, et al. Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity. J. Exp. Med. 1997;186:1247
31. Wan Y, Emtage P, Zhu Q, et al. Enhanced immune response to the melanoma antigen gp100 using recombinant adenovirus-transduced dendritic cells. Cell. Immunol. 1999;198:131
32. Ishida T, Chada S, Stipanov M, et al. Dendritic cells transduced with wild-type p53 gene elicit potent anti-tumour immune responses. Clin. Exp. Immunol. 1999;117:244
33. Brossart P, Goldrath AW, Butz EA, et al. Virus-mediated delivery of antigenic epitopes into dendritic cells as a means to induce CTL. J. Immunol. 1997;158:3270
34. Ribas A, Butterfield LH, McBride WH, et al. Genetic immunization for the melanoma antigen MART-1/Melan-A using recombinant adenovirus-transduced murine dendritic cells. Cancer Res. 1997;57:2865
35. Sonderbye L, Feng S, Yacoubian S, et al. In vivo and in vitro modulation of immune stimulatory capacity of primary dendritic cells by adenovirus-mediated gene transduction. Exp. Clin. Immunogenet. 1998;15:100
36. Diao J, Smythe JA, Smyth C, et al. Human PBMC-derived dendritic cells transduced with an adenovirus vector induce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro. Gene Ther. 1999;6:845-853
37. Butterfield LH, Jilani SM, Chakraborty NG, et al. Generation of melanoma-specific cytotoxic T lymphocytes by dendritic cells transduced with a MART-1 adenovirus. J. Immunol. 1998;161:5607
38. Ranieri E, Herr W, Gambotto A, et al. Dendritic cells transduced with an adenovirus vector encoding Epstein-Barr virus latent membrane protein 2B: a new modality for vaccination. J. Virol. 1999;73:10416
39. Zhong L, Granelli-Piperno A, Choi Y, et al. Recombinant adenovirus is an efficient and non-perturbing genetic vector for human dendritic cells. Eur. J. Immunol. 1999;29:964
40. Di Nicola M, Siena S, Bregni M, et al. Gene transfer into human dendritic antigen-presenting cells by vaccinia virus and adenovirus vectors. Cancer Gene Ther. 1998;5:350
41. Dietz AB, Vuk-Pavlovic S. High efficiency adenovirus-mediated gene transfer to human dendritic cells. Blood 1998;91:392
42. Diebold SS, Lehrmann H, Kursa M, et al. Efficient gene delivery into human dendritic cells by adenovirus polyethylenimine and mannose polyethylenimine transfection. Hum. Gene Ther. 1999;10:775
43. Tillman BW, de Gruijl TD, Luykx-de Bakker SA, et al. Maturation of dendritic cells accompanies high-efficiency gene transfer by a CD40-targeted adenoviral vector. J. Immunol. 1999;162:6378
44. Arthur JF, Butterfield LH, Roth MD, et al. A comparison of gene transfer methods in human dendritic cells. Cancer Gene Ther. 1997;4:17
45. Brown M, Davies DH, Skinner MA, et al. Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors. Cancer Gene Ther. 1999;6:238
46. Kim CJ, Cormier J, Roden M, et al. Use of recombinant poxviruses to stimulate anti-melanoma T cell reactivity. Ann. Surg. Oncol. 1998;5:64
47. Van Tendeloo VF, Snoeck HW, Lardon F, et al. Nonviral transfection of distinct types of human dendritic cells: high-efficiency gene transfer by electroporation into hematopoietic progenitor- but not monocyte-derived dendritic cells. Gene Ther. 1998;5:700
48. Philip R, Brunette E, Ashton J, et al. Transgene expression in dendritic cells to induce antigen-specific cytotoxic T cells in healthy donors. Cancer Gene Ther. 1998;5:236
49. Tuting T, DeLeo AB, Lotze MT, et al. Genetically modified bone marrow-derived dendritic cells expressing tumor-associated viral or "self" antigens induce antitumor immunity in vivo. Eur. J. Immunol. 1997;27:2702
50. Boczkowski D, Nair SK, Snyder D, et al. Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J. Exp. Med. 1996;184:465
51. Ashley DM, Faiola B, Nair S, et al. Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. J. Exp. Med. 1997;186:1177
52. Nair SK, Boczkowski D, Morse M, et al. Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA. Nat. Biotechnol. 1998;16:364
53. Nair SK, Hull S, Coleman D, et al. Induction of carcinoembryonic antigen (CEA)-specific cytotoxic T-lymphocyte responses in vitro using autologous dendritic cells loaded with CEA peptide or CEA RNA in patients with metastatic malignancies expressing CEA. Int. J. Cancer 1999;82:121
54. Morse MA, Coleman RE, Akabani G, et al. Migration of human dendritic cells after injection in patients with metastatic malignancies. Cancer Res. 1999;59:56