Murine dendritic cells transfected with human GP100 elicit both antigen- specific CD8+ and CD4+ T-cell responses and are more effective than DNA vaccines at generating anti-tumor immunity

International Journal of Cancer

Volumn 83, Issue 4, 1999, Pages 532-540

  Yang, Sixun ^a   Vervaert, Carol E ^a   Burch Jr , James ^a   Grichnik, James ^a   Seigler, Hilliard F ^a   Darrow, Timothy L ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; CANCER IMMUNOTHERAPY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FEMALE; FIBROSARCOMA; GENE TRANSFER; IMMUNOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, NEOPLASM; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOTOXICITY TESTS, IMMUNOLOGIC; DENDRITIC CELLS; EPITOPES; FEMALE; IMMUNIZATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; VACCINES, DNA;

EID: 0032869074     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19991112)83:4<532::AID-IJC16>3.0.CO;2-K     Document Type: Article

References (21)

1. CONDON, C., WATKINS, S.C., CELLUZZI, C.M., THOMPSON, K. and FALO, L.D., Jr. DNA-based immunization by in vivo transfection of dendritic cells. Nature (Med.), 2, 1122-1128 (1996).
2. CONRY, R.M., LOBUGLIO, A.F., LOECHEL, F., MOORE, S.E., SUMEREL, L.A., BARLOW, D.L. and CURIEL, D.T., A carcinoembryonic antigen polynucleotide vaccine has in vivo anti-tumor activity. Gene Ther., 2, 59-65 (1995).
3. CORR, M., TIGHE, H., LEE, D., DUDLER, J., TRIEU, M., BRINSON, D.C. and CARSON, D.A., Costimulation provided by DNA immunization enhances anti-tumor immunity. J. Immunol., 159, 4999-5004 (1997).
4. DOE, B., SELBY, M., BARNETT, S., BAENZIGER, J. and WALKER, C.H., Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells. Proc. nat. Acad. Sci. (Wash.), 93, 8578-8583 (1996).
5. GABRILOVICH, D.I., NADAF, S., CORAK, J., BERZOFSKY, J.A. and CARBONE, D.P., Dendritic cells in anti-tumor immune responses. II. Dendritic cells grown from bone marrow precursors, but not mature DC from tumor-bearing mice, are effective antigen carriers in the therapy of established tumors. Cell, Immunol., 170, 111-119 (1996).
6. INABA, K., INABA, M., ROMANI, N., AYA, H., DEGUCHI, M., IKEHARA, S., MURAMATSU, S. and STEINMAN, R.M., Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. exp. Med., 176, 1693-1702 (1992).
7. IRVINE, K.R., RAO, J.B., ROSENBERG, S.A. and RESTIFO, N.P., Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases. J. Immunol., 156, 238-245 (1996).
8. IWASAKI, A., TORRES, C.A.T., OHASHI, P.S., ROBINSON, H.L. and BARBER, B.H., The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites. J. Immunol., 159, 11-14 (1997).
9. KAWAKAMI, Y., ELIYAHU, S., JENNINGS, C., SAKAGUCHI, K., KANG, X., SOUTHWOOD, S., ROBBINS, P.F., SETTE, A., APPELLA, E. and ROSENBERG, S.A., Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression. J. Immunol., 154, 3961-3968 (1995).
10. NESTLE, F.O., ALIJAGIC, S., GILLIET, M., SUN, Y., GRABBE, S., DUMMER, R., BURG, G. and SCHADENDORF, D., Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nature (Med.), 4, 328-332 (1998).
11. OVERWUK, W.W., TSUNG, A., IRVINE, K.R., PARKHURST, M.R., GOLETZ, T.J., TSUNG, K., CARROLL, MW., LIU, C., MOSS, B., ROSENBERG, S. A. and RESTIFO, N.P., gp100/pmel 17 is a murine tumor rejection antigen: induction of "self"-reactive, tumoricidal T cells using high-affinity, altered peptide ligand. J. exp. Med., 188, 277-286 (1998).
12. PORGADOR, A. and GILBOA, A., Bone marrow generated dendritic cells pulsed with a class I restricted peptide are potent inducers of cytotoxic T lymphocytes. J. exp. Med., 182, 255-260 (1995).
13. RAZ, E., CARSON, D.A., PARKER, S.E., PARR, T.B., ABAI, A.M., AICHINGER, G., GROMKOWSKI, S.H., SINGH, M., LEW, D., YANKAUCKAS, M.A., BAIRD, S.M. and RHODES, G.H., Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. nat. Acad. Sci. (Wash.), 91, 9519-9523 (1994).
14. SCHREURS, M.W.J., DE BOER, A.J., FIGDOR, C.G. and ADEMA, G.J., Genetic vaccination against the melanocyte lineage-specific antigen gp100 induces cytotoxic T lymphocyte-mediated tumor protection. Cancer Res., 58, 2509-2514 (1998).
15. SHU, S.Y. and ROSENBERG, S.A., Adoptive immunotherapy of newly induced murine sarcomas. Cancer Res., 45, 1657-1662 (1985).
16. SKIPPER, J.C.A., KITTLESEN, D.J., HENDRICKSON, R.C., DEACON, D.D., HARTHUN, N.L., WAGNER, S.N., HUNT, D.F., ENGELHARD, V.H. and SLINGLUFF, C.L., JR., Shared epitopes for HLA-A3-restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100. J. Immunol., 157, 5027-5033 (1996).
17. SONG, W., KONG, H.L., CARPENTER, H., TORII, H., GRANSTEIN, R., RAFTI, S., MOORE, M.A. and CRYSTAL, G.R., Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic anti-tumor immunity. J. exp. Med., 186, 1247-56 (1997).
18. SPECHT, J.M., WANG, G., MY, T., LAM, J. S., ROYAL, R.E., REEVES, M.E., ROSENBERG, S.A. and HWU, P., Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases. J. exp. Med., 186, 1213-1221 (1997).
19. STEINMAN, R.M., The dendritic cell system and its role in immunogenicity. Ann. Rev. Immunol., 9, 271-296 (1991).
20. YANG, S., DARROW, T.L., VERVAERT, C.E. and SEIGLER, H.F., Immunotherapeutic potential of tumor antigen-pulsed and impulsed dendritic cells generated from murine bone marrow. Cell, Immunol., 179, 84-95 (1997).
21. ZITVOGEL, L., MAYORDOMO, J.I., TJAANDRAWAN, T., DELEO, A.B., CLARKE, M.R., LOTZE, M.T. and STORKUS, W.J., Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependent on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J. exp. Med., 183, 87-97 (1996).