Virus-Mediated Delivery of Antigenic Epitopes into Dendritic Cells as a Means to Induce CTL

Journal of Immunology

Volumn 158, Issue 7, 1997, Pages 3270-3276

  Brossart, Peter ^a   Goldrath, Ananda W ^a   Butz, Eric A ^a   Martin, Stefan ^a   Bevan, Michael J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD51 ANTIGEN; EPITOPE; INTEGRIN; LEUKOCYTE ANTIGEN; VIRUS ANTIBODY;

ADENOVIRUS; ANIMAL; ANTIGEN PRESENTATION; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; COMPARATIVE STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FEMALE; GENE TRANSFER; GENE VECTOR; IMMUNIZATION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; MOUSE MUTANT; VIROLOGY;

ADENOVIRIDAE; ANIMALS; ANTIBODIES, VIRAL; ANTIGEN PRESENTATION; ANTIGENS, CD; DENDRITIC CELLS; EPITOPES; FEMALE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; IMMUNIZATION SCHEDULE; INTEGRIN ALPHAV; INTEGRINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0031113954     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Ertl, H. C. J., and Z. Xiang. 1996. Novel vaccine approaches. J. Immunol. 156: 3579.
2. Xiang, Z. Q., Y. Yang, J. M. Wilson, and H. C. Ertl. 1996. A replication-defective human adenovirus recombinant serves as a highly efficacious vaccine carrier. Virology 219:220.
3. Pardoll, D. M. 1994. Tumour antigens: a new look for the 1990s. Nature 369:357.
4. Boon, T., J, Cerottini, B. Van den Eynde, P. Van der Bruggen, and A. Van Pel. 1994. Tumor antigens recognized by T lymphocytes. Annu. Rev. Immunol. 12: 337.
5. Slingluff, C. L., Jr., D. F. Hunt, and V. H. Engelhard. 1994. Direct analysis of tumor-associated peptide antigens. Curr. Opin. Immunol. 6:733.
6. Rao, J. B., R. S. Chamberlain, V. Bronte, M. W. Carroll, K. R. Irvine, B. Moss, S. A. Rosenberg, and N. P. Restifo. 1996. IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines. J. Immunol. 156:3357.
7. Zhai, Y., J. C. Yang, Y. Kawakami, P. Spiess, S. C. Wadsworth, L. M. Cardoza, L. A. Couture, A, E. Smith, and S. A. Rosenberg. 1996. Antigen-specific tumor vaccines: development and characterization of recombinant adenoviruses encoding MART1 or gp100 for cancer. J. Immunol. 156:700.
8. McCabe, B. J., K. R, Irvine, M. I. Nishimura, J. C. Yang, P. J. Spiess, E. P. Shulman, S. A. Rosenberg, and N. P. Restifo. 1994. Minimal determinant expressed by a recombinant vaccinia virus elicits therapeutic antitumor cytolytic T lymphocyte responses. Cancer Res. 55:1741.
9. Mullbacher, A., A. Bellett, and R. Hla. 1989. The murine cellular immune response to adenovirus type 5. Immunol. Cell Biol. 67:31.
10. Julliard, V., P. Villefroy, D. Godfrin, A. Pavirani, A. Venet, and J. G. Guillet. 1995. Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector. Eur. J. Immunol. 25:3467.
11. Yei, S., N. Mittereder, K. Tang, C. O'Sullivan, and B. C. Trapnell. 1994. Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung. Gene Ther. 1:192.
12. Kazarsky, K. F., D. R. McKinley, L. L. Austin, and S. E. Raper. 1994. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J. Biol. Chem. 269: 13695.
13. Yang, Y., H. C. J. Ertl, and J. M. Wilson. 1995. MHC class I-restricted cytotoxic T lymphocytes to virai antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1:433.
14. Yang, Y , Q. Li. H. C. J. Ertl, and J. M. Wilson. 1995. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004.
15. Janeway, C. A., Jr., and K. Bottomly. 1994. Signals and signs for lymphocyte responses. Cell 76:275.
16. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
17. Steinman, R. M., M. Witmer-Pack, and K. Inaba. 1993. Dendritic cells: antigen presentation, accessory function and clinical relevance. Adv. Exp. Med. Biol. 329:1.
18. Inaba, K., J. P. Metlay, M. T. Crowley, and R. M. Steinman. 1990. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific. MHC-restricted T cells in situ. J. Exp. Med. 172:631.
19. Nair, S., F. Zhou, R. Reddy, L. Huang, and B. T. Rouse. 1992. Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. J. Exp. Med. 175:609.
20. Cohen, P. J., P. A. Cohen, S. A. Rosenberg, S. I. Katz, and J. J. Mule. 1994. Murine epidermal Langerhans cells and splenic dendritic cells present tumor-associated antigens to primed T cells. Eur. J. Immunol. 24:315.
21. Porgador, A., and E. Gilboa. 1995. Bone-marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes J. Exp. Med. 182:255.
22. Porgador, A., D. Snyder, and E. Gilboa. 1996. Induction of antitumor immunity using bone marrow-generated dendritic cells. J. Immunol. 156:2918.
23. Paglia, P., C. Chiodoni, M. Rodolfo, and M. P. Colombo. 1996. Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo. J. Exp. Med. 183:317.
24. Celluzzi, C, M., J. I. Mayordomo, W. J. Storkus, M. T. Lotze, and L. D. Falo. 1996. Peptide-pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity. J. Exp. Med. 183:283.
25. Zitvogel, L., J. I. Mayordomo, T. Tjandrawan, A. B. DeLeo, M. R, Clarke, M. T. Lotze, and W. J. Storkus. 1996. Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells. B7 costimulation, and T helper cell I-associated cytokines. J. Exp. Med. 183:87.
26. Fung-Leung, W. P., M. W. Schilham, A. Rahemtulla, T. M. Kundig, M. Vollenweider, J. Potter, W. vanEwijk, and T. W. Mak. 1991. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65:443.
27. Jameson, S. C., F. R. Carbone, and M. J. Bevan. 1993. Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J. Exp. Med. 177:1541.
28. Metlay, J. P., M. D. Witmer-Pack, R. Agger, M. T. Crowley, D. Lawless, and R. M. Steinman. 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171: 1753.
29. Oukka, M., M. Cohen-Tannoudji, Y. Tanaka, C. Babinet, and K. Kosmatopoulos. 1996. Medullary thymic epithelial cells induce tolerance to intracellular proteins. J. Immunol. 156:968.
30. Stratford-Perricaudet, L. D., I. Makeh, M. Perricaudet, and P. Briand. 1992. Widespread long-term gene transfer to mouse skeletal muscles and heart. J. Clin. Invest. 90:626.
31. Bacik, I., J. H. Cox, R. Anderson, J. W. Yewdell, and J. R. Bennink. 1994. TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmatic reticulum insertion sequences located at the amino but not carboxyl terminus of the peptide. J. Immunol. 152:381.
32. Steinmann, R. M., G. Kaplan, M. D. Witmer, and Z. A. Conn. 1979. Identification of a novel cell type in peripheral lymphoid organs of mice V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro. J. Exp. Med. 149:1.
33. 5 promote adenovirus internalization but not virus attachment. Cell 73:309.
34. 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery. J. Virol. 69:2257.
35. Sallusto, F., M. Cella, C. Danieli, and A. Lanzavecchia. 1995. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182:389.
36. Norbury, C. C., L. J. Hewlett, A. R. Prescott, N. Shastri, and C. Watts. 1995. Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages. Immunity 3:783.
37. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-sumulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179:1109.
38. Romani, N., S. Gruner, D. Brang, E. Kampgen, A. Lenz, B. Trockenbacher, G. Konwalinka, P. O. Fritsch, R. M. Steinman, and G. Schuler. 1994. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180:83.
39. + hematopoietic progenitor cells of the bone marrow and peripheral blood. Cancer Res. 55:1099.