Highly efficient and consistent gene transfer into dendritic cells utilizing a combination of ultraviolet-irradiated adenovirus and poly(L- lysine) conjugates

Cancer Research

Volumn 58, Issue 5, 1998, Pages 956-961

  Mulders, Peter ^a   Pang, Shen ^a   Dannull, Jens ^a   Kaboo, Randhir ^a   Hinkel, Andreas ^a   Michel, Kiarash ^a   Tso, Cho Lea ^a   Roth, Michael ^b   Belldegrun, Arie ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYLYSINE; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; DENDRITIC CELL; GENE TRANSFER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TRANSGENE; ULTRAVIOLET RADIATION;

ADENOVIRIDAE; CELLS, CULTURED; DENDRITIC CELLS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; POLYLYSINE; ULTRAVIOLET RAYS;

EID: 0032032696     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Steinman, R. M. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol., 9: 271-296, 1991.
2. Freudenthal, P. S., and Steinman, R. M. The distinct surface of human blood dendritic cells, as observed after an improved isolation method. Proc. Natl. Acad. Sci. USA, 87: 7698-7702, 1990.
3. Caux, C., Dezutter-Dambuyant, C., Schmitt, D., and Banchereau, J. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature (Lond.), 360: 258-261, 1992.
4. Romani, N., Gruner, S., Brang, D., Kampgen, E., Lenz, A., Trockenbacher, B., Konwalinka, G., Fritsch, P. O., Steinman, R. M., and Schuler, G. Proliferating dendritic cell progenitors in human blood. J. Exp. Med., 180: 83-93, 1994.
5. Sallusto, F., and Lanzavecchia, A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med., 179: 1109-1118, 1994.
6. + leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4. J. Leukoc. Biol., 59: 208-218, 1996.
7. + peripheral blood monocytes. J. Immunol., 157: 3850-3859, 1996.
8. Bender, A., Sapp, M., Schuler, G., Steinman, R. M., and Bhardwaj, N. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J. Immunol. Methods, 196: 121-135, 1996.
9. Boon, T., Cerottini, J. C., Van den Eynde, B., van der Bruggen, P., and Van Pel, A. Tumor antigens recognized by T lymphocytes. Annu. Rev. Immunol., 12: 337-356, 1994.
10. Kawakami, Y., Eliyahu, S., Delgado, C. H., Robbins, P. F., Rivoltini, L., Topalian, S. L., Miki, T., and Rosenberg, S. A. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. Natl. Acad. Sci. USA, 91: 3515-3519, 1994.
11. Bakker, A. B., Schreurs, M. W., de Boer, A. J., Kawakami, Y., Rosenberg, S. A., Adema, G. J., and Figdor, C. G. Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes. J. Exp. Med., 179: 1005-1009, 1994.
12. Kawakami, Y., Eliyahu, S., Delgado, C. H., Robbins, P. F., Rivoltini, L., Topalian, S. L., Miki, T., and Rosenberg, S. A. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Proc. Natl. Acad. Sci. USA, 91: 3515-3519, 1994.
13. + T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene. Proc. Natl. Acad. Sci. USA, 91: 9461-9465, 1994.
14. Peoples, G. E., Goedegebuure, P. S., Smith, R., Linehan, D. C., Yoshino, I., and Eberlein, T. J. Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide. Proc. Natl. Acad. Sci. USA, 92: 432-436, 1995.
15. Oosterwijk, E., de Weijert, M., vanBokhoven, A., Brakenhoff, R., Peelen, W., and Debruyne, F. Molecular characterization of the renal cell carcinoma-associated antigen G250. J. Urol., 155: 925a, 1996.
16. Conry, R. M., LoBuglio, A. F., Kantor, J., Schlom, J., Loechel, F., Moore, S. E., Sumerel, L. A., Barlow, D. L., Abrams, S., and Curiel, D. T. Immune response to a carcinoembryonic antigen polynucleotide vaccine. Cancer Res., 54: 1164-1168, 1994.
17. Descamps, V., Duffour, M. T., Mathieu, M. C., Fernandez, N., Cordier, L., Abina, M. A., Kremer, E., Perricaudet, M., and Haddada, H. Strategies for cancer gene therapy using adenoviral vectors. J. Mol. Med., 74: 183-189. 1996.
18. Kremer, E. J., and Perricaudet, M. Adenovirus and adeno-associated virus mediated gene transfer. Br. Med. Bull., 51: 31-44, 1995.
19. Curiel, D. T., Agarwal, S., Wagner, E., and Cotten, M. Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc. Natl. Acad. Sci. USA, 88: 8850-8854, 1991.
20. Yang, Y., Nunes, F. A., Berencsi, K., Furth, E. E., Gonczol, E., and Wilson, J. M. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA, 91: 4407-4411, 1994.
21. Yang, Y., Li, Q., Ertl, H. C., and Wilson, J. M. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol., 69: 2004-2015, 1995.
22. Teramoto, S., Johnson, L. G., Huang, W., Leigh, M. W., and Boucher, R. C. Effect of adenoviral vector infection on cell proliferation in cultured primary human airway epithelial cells. Hum. Gene Ther., 6: 1045-1053, 1995.
23. Cristiano, R. J., Smith, L. C., Kay, M. A., Brinkley, B. R., and Woo, S. L. Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex. Proc. Natl. Acad. Sci. USA, 90: 11548-11552, 1993.
24. Buschle, M., Schmidt, W., Zauner, W., Mechtler, K., Trska, B., Kirlappos, H., and Birnstiel, M. L. Transloading of tumor antigen-derived peptides into antigen-presenting cells. Proc. Natl. Acad. Sci. USA, 94: 3256-3261, 1997.
25. Curiel, D. T. High-efficiency gene transfer mediated by adenovirus-polylysine-DNA complexes. Ann. NY Acad. Sci., 716: 36-56, 1994.
26. Zeigler, S. T., Kerby, J. D., Curiel, D. T., Diethelm, A. G., and Thompson, J. A. Molecular conjugate-mediated gene transfer into isolated human kidneys. Transplantation (Baltimore), 61: 812-817, 1996.
27. Wagner, E., Zatloukal, K., Cotten, M., Kirlappos, H., Mechtler, K., Curiel, D. T., and Birnstiel, M. L. Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proc. Natl. Acad. Sci. USA, 89: 6099-6103, 1992.
28. Wan, Y., Bramson, J., Carter, R., Graham, F., and Gauldie, J. Dendritic cells transduced with an adenoviral vector encoding a model tumor-associated antigen for tumor vaccination. Hum. Gene Ther., 8: 1355-1363, 1997.
29. Graham, F. L., and van de Erb, A. J. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology, 52: 456-457, 1973.
30. Arthur, J. F., Butterfield, L. H., Roth, M. D., Bui, L. A., Kiertscher, S. M., Lau, R., Dubinett, S., Glaspy, J., McBride, W. H., and Economou J. S. A comparison of gene transfer methods in human dendritic cells. Cancer Gene Ther., 4: 17-25, 1997.
31. Hsu, F. J., Benike, C., Fagnoni, F., Liles, T. M., Czerwinski, D., Taidi, B., Engleman, E. G., and Levy, R. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat. Med., 2: 52-58, 1996.
32. Mukherji, B., Chakraborty, N. H., Yamasaki, S., Okino, T., Yamase, H., Sporn, J. R., Kurtzman, S. K., Ergin, M. T., Ozols, J., and Meehan, J. Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells. Proc. Natl. Acad. Sci. USA, 92: 8078-8082, 1995.
33. Murphy, G., Tjoa, B., Ragde, H., Kenny, G., and Boynton, A. Phase I clinical trial: T-cell therapy for prostate cancer using autologous dendritic cells pulsed with HLA-A0201-specific peptides from prostate-specific membrane antigen. Prostate, 29: 371-380, 1996.
34. Boczkowski, D., Nair, S. K., Snyder, D., and Gilboa, E. Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J. Exp. Med., 184: 465-472, 1996.
35. Koch, F., Stanzl, U., Jennewein, P., Janke, K., Heufler, C., Kampgen, E., Romani, N., and Schuler, G. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med., 184: 741-746, 1996.
36. Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A., and Alber, G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med., 184: 747-752, 1996.
37. Germann, T., and Rude, E. Interleukin-12. Int. Arch. Allergy Immunol., 108: 103-112.
38. Kochanek, S., Clemens, P. R., Mitani, K., Chen, H. H., Chan, S., and Caskey, C. T. A new adenoviral vector: replacement of all viral coding sequences with 28kb of DNA independently expressing both full-length dystrophin and β-galactosidase. Proc. Natl. Acad. Sci. USA. 93: 5731-5736, 1996.
39. Nair, S., Zhou, F., Reddy, R., Huang, L., and Rouse, B. T. Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro. J. Exp. Med., 175: 609-612, 1992.