High level of retrovirus-mediated gene transfer into dendritic cells derived from cord blood and mobilized peripheral blood CD34+ cells

Human Gene Therapy

Volumn 10, Issue 2, 1999, Pages 175-187

  Movassagh, Mojgan ^a   Baillou, Claude ^a   Cosset, François Loic ^b   Klatzmann, David ^a   Guigon, Martine ^a   Lemoine, François M ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b CENTRE DE GÉNÉTIQUE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CD34 ANTIGEN; FLT3 LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; METHYLCELLULOSE; STEM CELL FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ASSAY; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITIC CELL; EXPRESSION VECTOR; GENE TRANSFER; GENETIC TRANSDUCTION; GIBBON LEUKEMIA VIRUS; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; PERIPHERAL BLOOD STEM CELL; POLYMERASE CHAIN REACTION; REPORTER GENE; RETROVIRUS; STEM CELL; T LYMPHOCYTE ACTIVATION; UMBILICAL CORD BLOOD;

ANTIGENS, CD34; BASE SEQUENCE; CELL DIVISION; CELL LINE; DENDRITIC CELLS; DNA PRIMERS; FETAL BLOOD; GENE TRANSFER TECHNIQUES; HEMATOPOIETIC STEM CELL MOBILIZATION; HUMANS; IMMUNOPHENOTYPING; RETROVIRIDAE; T-LYMPHOCYTES; TRANSDUCTION, GENETIC;

EID: 0033585461     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950018977     Document Type: Article

References (54)

1. AICHER, A., WESTERMANN, J., CAYEUX, S., WILLIMSKY, G., DAEMEN, K., BLANKENSTEIN, T., UCKERT, W., DORKEN, B., and PEZZUTO, A. (1997). Successful retroviral mediated transduction of a reporter gene in human dendritic cells: Feasibility of therapy with gene-modified antigen presenting cells. Exp. Hematol. 25, 39-44.
2. ANDERLINI, P., and KORBLING, M. (1997). The use of mobilized peripheral blood stem cells from normal donors for allografting. Stem Cells 15, 9-17.
3. BELLO-FERNANDEZ, C., MATYASH, M., STROBL, H., PICKL, W.F., MAJDIC, O., LYMAN, S.D., and KNAPP, W. (1997). Efficient retrovirus-mediated gene transfer of dendritic cells generated from CD34+ cord blood cells under serum-free conditions. Hum. Gene Ther. 8, 1651-1658.
4. BERTOLINI, F., BATTAGLIA, M., LANZA, A., PALERMO, B., CUOMO, A., PRETI, P., and ROBUSTELLI DELLA CUNA, G. (1998). Hematopoietic stem cells from different sources: Biological and technical aspects. Bone Marrow Transpl. 21(Suppl. 2), S5-S7.
5. BHARDWAJ, N., BENDER, A., and GONZALEZ, N. (1994). Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells. J. Clin. Invest. 94, 797-807.
6. BOCZKOWSKI, D., NAIR, S.K., SNYDER, D., and GILBOA, E. (1996). Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J. Exp. Med. 184, 465-472.
7. BREGNI, M., MAGNI, M., SIENA, S., DI NICOLA, M., BONADONNA, G., and GIANNI, A.M. (1992). Human peripheral blood hematopoietic progenitors are optimal targets of retroviral-mediated gene transfer. Blood 80, 1418-1422.
8. CAUX, C., DEZUTTER-DAMBUYANT, C., SCHMITT, D., and BANCHEREAU. J. (1992). GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature (London) 360, 258-261.
9. CAUX, C., LIU, Y.J., and BANCHEREAU, J. (1995). Recent advances in the study of dendritic cells and follicular dendritic cells. Immunol. Today 16, 2-4.
10. CELLUZZI, C.M., MAYORDOMO, J.I., STORKUS, W.J., LOTZE, M.T., and FALO, L.D., JR. (1996). Peptide-pulsed dendritic cells induced antigen-specific CTL-mediated protective tumor immunity. J. Exp. Med. 183, 283-287.
11. CHALLITA, P.M., SKELTON, D., EL-KHOUEIRY, A., YU, X.J., WEINBERG, K., and KOHN, D.B. (1995). Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells. J. Virol. 69, 748-755.
12. CHAPUIS, F., ROSENZWAJG, M., YAGELLO, M., EKMAN, M., BIBERFELD, P., and GLUCKMAN, J.C. (1997). Differentiation of human dendritic cells from monocytes in vitro. Eur. J. Immunol. 27, 431-437.
13. COSSET, F.L., TAKEUCHI, Y., BATTINI, J.L., WEISS, R.A., and COLLINS, M.K.L. (1995). High-titer packaging cells producing recombinant retroviruses resistant to human serum. J. Virol. 69, 7430-7436.
14. FLAMAND, V., SORNASSE, T., THIELEMANS, K., DEMANET, C., BAKKUS, M., BAZIN, H., TIELEMANS, F., LEO, O., URBAIN, J., and MOSER, M. (1994). Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo. Eur. J. Immunol. 24, 605-610.
15. GUERY, J.C., and ADORINI, L. (1995). Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells. J. Immunol. 154, 536-544.
16. GUIGON, M., HATTON, G., ROSENZWAJG, M., BAILLOU, C., CAMUS, S., GLUCKMAN, J.C., and LEMOINE, F.M. (1997). Characterization of clonogenic dendritic cells (DC) progenitors in umbilical cord blood (CB). Blood 90, 3364. [Abstract]
17. GUIGON, M., KORWIN-ZMIJOWSKI, C., DIACONESCU, L., BALLOU, C., ROZENZWAJG, M., and LEMOINE, F.M. (1999). Effects of various cytokines and CD40-ligand on the growth of dendritic progenitors derived from cord blood and mobilized peripheral blood CD34+ cells. Submitted.
18. HANENBERG, H., XIAO, X.L., DILLOO, D., HASHINO, K., KATO, I., and WILLIAMS, D.A. (1996). Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells. Nature Med. 2, 876-882.
19. HAO, Q.L., THIEMANN, F.., PETERSEN, D., SMOGORZEWSKA, E.M., and CROOKS, G.M. (1996). Extended long-term culture reveals a highly quiescent and primitive human hematopoietic progenitor population. Blood 88, 3306-3313.
20. HENDERSON, R.A., NIMGAONKAR, M.T., WATKINS, S.C., ROBBINS, P.D., BALL, E.D., and FINN, O.J. (1996). Human dendritic cells genetically engineered to express high levels of the human epithelial tumor antigen mucin (MUC-1 ). Cancer Res. 56, 3763-3770.
21. HERBST, B., KOHLER, G., MACKENSEN, A., VEELKEN, H., KULMBURG, P., ROSENTHAL, F.M., SCHAEFER, H.E., MERTELSMANN, R., FISCH, P., and LINDEMANN, A. (1996). In vitro differentiation of CD34+ hematopoietic progenitor cells toward distinct dendritic cell subsets of the birbeck granule and MIIC-positive Langerhans cell and the interdigitating dendritic cell type. Blood 88, 2541-2548.
22. HSU, F.J., BENIKE, C., FAGNONI, F., LILES, T.M., CZERWlNSKI, D., TAIDI, B., ENGLEMAN, E.G., and LEVY, R. (1996). Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nature Med. 2, 52-58.
23. KIMIZUKA, F., TAGUCHI, Y., OHDATE, Y., KAWASE, Y., SHIMOJO, T., HASHINO, K., KATO, I., SEKIGUCHI, K., and TITANI, K. (1991). Production and characterization of functional domains of human fibronectin expressed in Escherichia coli. J. Biochem. 110, 284-291.
24. LANSDORP, P.M., DRAGOWSKA, W., and MAYANI, H. (1993). Ontogeny-related changes in proliferative potential of human hematopoietic cells. J. Exp. Med. 178, 787-791.
25. LANZAVECCHIA, A. (1996). Mechanisms of antigen uptake for presentation. Curr. Opin. Immunol. 8, 348-354.
26. LAROCHELLE, A., VORMOOR, J., HANENBERG, H., WANG, J.C.Y., BHATIA, M., LAPIDOT, T., MORITZ, T., MURDOCH, B., XIAO, X.L., KATO, I., WILLIAMS, D.A., and DICK, J.E. (1996). Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy. Nature Med. 2, 1329-1337.
27. MAYORDOMO, J.I., ZORINA, T., STORKUS, W.J., ZITVOGEL, L., CELLUZZI, C., FALO, L.D., MELIEF, C.J., ILDSTAD, S.T., KAST, W.M., DELEO, A.B., and LOTZE, M.T. (1995). Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Nature Med. 1, 1297-1302.
28. MEHTA-DAMANI, A., MARKOWICS, S., and ENGLEMAN, E.G. (1994). Generation of antigen-specific CD8+ CTLs from naive precursors. J. Immunol. 153, 996-1003.
29. + progenitor cells by human cytomegalovirus: Evidence for inhibition of hematopoiesis and viral replication. Blood 88, 1277-1283.
30. MOVASSAGH, M., DESMYTER, C., BAILLOU, C., CHAPEL-FERNANDES, S., GUIGON, M., KLATZMANN, D., and LEMOINE, P.M. (1998). High level gene transfer to cord blood progenitors using gibbon ape leukemia virus pseudotype retroviral vectors and an improved clinically applicable protocol. Hum. Gene Ther. 9, 225-234.
31. MULLIGAN, R.C. (1993). The basic science of gene therapy. Science 260, 926-932.
32. NESTLE, P.O., ALIJAGIC, S., GILLIET, M., SUN, Y., GRABBE, S., DUMMER, R., BURG, G., and SCHADENDORF, D. (1998). Vaccination of melanoma patients with peptide-or tumor lysate-pulsed dendritic cells. Nature Med. 4, 328-332.
33. PAGLIA, P., CHIODONI, C., RODOLFO, M., and COLOMBO, M. (1996). Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo. J. Exp. Med. 183, 317-322.
34. PETZER, A.L., ZANDSTRA, P.W., PIRET, J.M., and EAVES, C.J. (1996). Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: Novel responses to Flt3-ligand and thrombopoietin. J. Exp. Med. 183, 2551-2558.
35. REEVES, M.E., ROYAL, R.E., and LAM, J.S. (1996). Retroviral transduction of human dendritics cells with a tumor-associated antigen gene. Cancer Res. 56, 5672-5677.
36. REID, C.D., STACKPOOLE, A., MEAGER, A., and TIKERPAE, J. (1992). Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow. J. Immunol. 149, 2681-2688.
37. ROMANI, N., GRUNER, S., BRANG, D., KAMPGEN, E., LENZ, A., TROCKNBACHER, B., KONWALINKA, G., FRITSCH, P.O., STEINMAN, R.M., and SCHULER, G. (1994). Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180, 83-93.
38. ROSENZWAJG, M., CANQUE, B., and GLUCKMAN, J.C. (1996). Human dendritic cell differentiation pathway from CD34+ hematopoietic precursor cells. Blood 87, 535-544.
39. ROSENZWAJG, M., CAMUS, S., GUIGON, M., and GLUCKMAN, J.C. (1998). The influence of interleukin (IL)-4, IL-13, and Flt3 ligand on human dendritic cell differentiation from cord blood CD34+ progenitor cells. Exp. Hematol. 26, 63-72.
40. RUSTEN, L.S., LYMAN, S.D., VEIBY, O.P., and JACOBSEN, E.W. (1996). The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor cells in vitro. Blood 87, 1317-1325.
41. SALLUSTO, F., and LANZAVECCHIA, A. (1994). Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte-macrophage colony-stimulating factor plus interleukin-4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179, 1109-1118.
42. SALLUSTO, F., CELLA, M., DANIELI, C., and LANZAVECCHIA, A. (1995). Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products. J. Exp. Med. 182, 389-400.
43. SANTIAGO-SCHWARZ, F., BELILOS, E., DIAMOND, B., and CARSONS, S.E. (1992). TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages. J. Leukocyte Biol. 52, 274-281.
44. SIENA, S., DI NICOLA, M., BREGNI, M., MORTARINI, R., ANICHINI, A., LOMBARDI, L., RAVAGNANI, F., PARMIANI, F., and GIANNI, A.M. (1995). Massive ex vivo generation of functional dendritic cells from mobilized CD34+ blood progenitors for anticancer therapy. Exp. Hematol. 23, 1463-1471.
45. SPECHT, J.M., WANG, G., DO, M.T., LAM, J.S., ROYAL, R.E., REEVES, M.E., ROSENBERG, S.A., and HWU, P. (1997). Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases. J. Exp. Med. 186, 1213-1221.
46. STEINMAN, R.M. (1991). The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271-296.
47. STROBL, H., RIEDL, E., and SCHEINECKER, C. (1996). TGFβ1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors. J. Immunol. 157, 1499-1507.
48. STROBL, H., BELLO-FERNANADEZ, C., RIEDL, E., PICKL, W.F., MAJDIC, O., LYMAN, S.D., and KNAPP, W. (1997). Flt3 ligand in cooperation with transforming growth factor-beta 1 potentiates in vitro development of Langerhans-type dendritic cell cluster formation under serum-free conditions. Blood 90, 1425-1434.
49. STRUNK, D., RAPPERSBERGER, K., EGGER, C., STROBL, H., KROMER, E., ELBE, A., MAURER, D., and STINGL, G. (1996). Generation of human dendritic cells. Langerhans cells from circulating CD34+ hematopoietic progenitor cells. Blood 87, 1292-1302.
50. SZABOLCS, P., MOORE, M.A., and YOUNG, J.W. (1995). Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-Kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-alpha. J. Immunol. 154, 5851-5861.
51. SZABOLCS, P., GALLARDO, H.F., CIOCON, D.H., SADELAIN, M., and YOUNG, J.W. (1997). Retrovirally transduced human dendritic cells express a normal phenotype and potent T-cell stimulatory capacity. Blood 90, 2160-2167.
52. YOUNG, J.W., and INABA, K. (1996). Dendritic cells as adjuvants for class I major histocompatibility complex-restricted antitumor immunity. J. Exp. Med. 183, 7-11. [Comment]
53. YOUNG, J.W., and STEIMANN, R.M. (1990). Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells. J. Exp. Med. 171, 1315-1332.
54. ZITVOGEL, L., MAYORDOMO, J.I., TJANDRAWAN, T., DELEO, A.B., CLARKE, M.R., LOTZE, M.T., and STORKUS, W.J. (1996). Therapy of murine tumors with tumor peptide-pulsed dendritic cells: Dependence on T cells, B7 costimulation and T helper cell 1-associated cytokines. J. Exp. Med. 183, 87-97.