Probes for chemical genomics by design

Drug Discovery Today

Volumn 7, Issue 13, 2002, Pages 711-718

  Zanders, Edward D ^a   Bailey, David S ^a   Dean, Philip M ^a  

^a De Nove Pharmaceuticals   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; DRUG; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLOSPORIN A; HISTAMINE H3 RECEPTOR; LIGAND; ORGANIC COMPOUND; TACROLIMUS; WORTMANNIN;

AMINO ACID SEQUENCE; BIOLOGY; CHEMISTRY; CONFORMATION; DRUG DESIGN; GENOMICS; HUMAN; MOLECULAR GENETICS; REVIEW; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; BINDING AFFINITY; BINDING SITE; BIOINFORMATICS; CHEMICAL GENETICS; COMPUTER MODEL; DRUG ACTIVITY; DRUG SCREENING; DRUG TARGETING; ENZYME ANALYSIS; EXPERIMENTAL DESIGN; GENETIC SCREENING; HISTORY; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR PROBE; MOLECULE; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN STRUCTURE; SCREENING TEST; VALIDATION PROCESS;

AMINO ACID SEQUENCE; ASPARTIC ENDOPEPTIDASES; BIOLOGY; CHEMISTRY; DRUG DESIGN; GENOMICS; HUMANS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PHARMACEUTICAL PREPARATIONS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; HUMAN;

EID: 0036629241     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(02)02325-5     Document Type: Review

References (42)

1. Chemical genetics: Ligand-based discovery of gene function
2. Chemical genomics: What it will take and who gets to play?
3. Chemotherapeutics: Scientific principles, methods and results
4. Drug discovery: A historical perspective
5. High-throughput chemistry and structure-based design: Survival of the smartest
6. Functional cell-based uHTS in chemical genomic drug discovery
7. FK506: A novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation and physico-chemical and biological characteristics
8. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
9. A gene expression database for the molecular pharmacology of cancer
10. Functional discovery via a compendium of expression profiles
11. A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR)
12. Small-molecule developmental screens reveal the logic and timing of vertebrate development
13. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
14. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
15. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
16. Target-oriented and diversity-oriented organic synthesis in drug discovery
17. Global efforts in structural genomics
18. MODBASE, a database of annotated comparative protein structure models
19. The PROSITE database, its status in 2002
20. From structure to function: Approaches and limitations
21. Databases for protein-ligand complexes
22. Automated site-directed drug design: The prediction and observation of ligand point positions at hydrogen-bonding regions on protein surfaces
23. Automated site-directed drug design: A general algorithm for knowledge acquisition about hydrogen-bonding regions at protein surfaces
24. Defining and using molecular similarity or complementarity for drug design
25. Computational tools for structure-based ligand design
26. Automated site-directed drug design: The formation of molecular templates in primary structure generation
27. CONCERTS: Dynamic connection of fragments as an approach to de novo ligand design
28. Structure-based ligand design by dynamically assembling molecular building blocks at binding site
29. GroupBuild: A fragment-based method for de novo drug design
30. Comparative protein structure modeling. Introduction and practical examples with modeller
31. Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein
32. Structure-based drug design: The discovery of novel nonpeptide orally active inhibitors of human renin
33. Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE
34. SLATE: A method for the superposition of flexible ligands
35. Initial sequencing and analysis of the human genome
36. The sequence of the human genome
37. The commercial use of structural genomics
38. Completeness in structural genomics