Nicergoline enhances glutamate re-uptake and protects against brain damage in rat global brain ischemia

European Journal of Pharmacology

Volumn 383, Issue 3, 1999, Pages 267-274

  Asai, Satoshi ^a   Zhao, Heng ^a   Yamashita, Akiko ^a   Jike, Toyoharu ^a   Kunimatsu, Teruhito ^b   Nagata, Toshihito ^a   Kohno, Tadashi ^c   Ishikawa, Koichi ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c Frontier Technol Research Institute   (Japan)

Author keywords

Dialysis electrode; Electron microscopy; Glutamate; Glutamate re uptake; Glutamate release; Hyperthermia, mild; In vivo; Ischemia; Nicergoline; Real time monitoring; Uptake, reversed

Indexed keywords

GLUTAMIC ACID; NICERGOLINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; ELECTRON MICROSCOPY; HYPERTHERMIA; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BLOOD PRESSURE; BODY TEMPERATURE; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; CORPUS STRIATUM; GLUTAMIC ACID; MALE; NICERGOLINE; RATS; RATS, INBRED WKY;

EID: 0032801826     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00623-8     Document Type: Article

References (46)

1. Alps B.J. Drugs acting on calcium channels: potential treatment for ischaemic stroke. Br. J. Clin. Pharmacol. 34:1992;199-206.
2. Asai S., Iribe Y., Kohno T., Ishikawa K. Real time monitoring of biphasic glutamate release using dialysis electrode in rat acute brain ischemia. NeuroReport. 7:1996;1092-1096.
3. Asai S., Zhao H., Takahashi Y., Nagata T., Kohno T., Ishikawa K. Minimal effect of brain temperature changes on glutamate release in rat following severe global brain ischemia: a dialysis electrode study. NeuroReport. 9:1998;3863-3868.
4. Attwell D., Barbour B., Szatkowski M. Nonvesicular release of neurotransmitter. Neuron. 11:1993;401-407.
5. Barbour B., Szatkowski M., Ingledew N., Attwell D. Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells. Nature. 342:1989;918-920.
6. Benveniste H., Drejer J., Schousboe A., Diemer N.H. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43:1984;1369-1374.
7. Berridge M.J. Inositol trisphosphate and calcium signalling. Nature. 361:1993;315-325.
8. Bickler P.E., Hansen B.M. Alpha 2-adrenergic agonists reduce glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices during hypoxia. Neuropharmacology. 35:1996;679-687.
9. Bullock R., Butcher S.P., Chen M.H., Kendall L., McCulloch J. Correlation of the extracellular glutamate concentration with extent of blood flow reduction after subdural hematoma in the rat. J. Neurosurg. 74:1991;794-802.
10. Bullock R., Zauner A., Woodward J., Young H.F. Massive persistent release of excitatory amino acids following human occlusive stroke. Stroke. 26:1995;2187-2189.
11. Busto R., Globus M.Y., Dietrich W.D., Martinez E., Valdes I., Ginsberg M.D. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke. 20:1989;904-910.
12. Busto R., Globus M.Y., Neary J.T., Ginsberg M.D. Regional alterations of protein kinase C activity following transient cerebral ischemia, effects of intraischemic brain temperature modulation. J. Neurochem. 63:1994;1095-1103.
13. Butcher S.P., Bullock R., Graham D.I., McCulloch J. Correlation between amino acid release and neuropathologic outcome in rat brain following middle cerebral artery occlusion. Stroke. 21:1990;1727-1733.
14. Carfagna N., Cavanus S., Damiani D., Salmoiraghi P., Fariello R., Post C. Modulation of phosphoinositide turnover by chronic nicergoline in rat brain. Neurosci. Lett. 209:1996;189-192.
15. Casado M., Zafra F., Aragon C., Gimenez C. Activation of high-affinity uptake of glutamate by phorbol esters in primary glial cell cultures. J. Neurochem. 57:1991;1185-1190.
16. Casado M., Bendahan A., Zafra F., Danbolt N.C., Aragon C., Gimenez C., Kanner B.I. Phosphorylation and modulation of brain glutamate transporters by protein kinase C. J. Biol. Chem. 268:1993;27313-27317.
17. Choi D.W. Cerebral hypoxia, some new approaches and unanswered questions. J. Neurosci. 10:1990;2493-2501.
18. Choi D.W., Rothman S.M. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurosci. 13:1990;171-182.
19. Collingridge G.L., Lester R.A. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 41:1989;143-210.
20. Dietrich W.D., Halley M., Valdes I., Busto R. Interrelationships between increased vascular permeability and acute neuronal damage following temperature-controlled brain ischemia in rats. Acta. Neuropathol. Berl. 81:1991;615-625.
21. Ginsberg M.D., Busto R. Combating hyperthermia in acute stroke: a significant clinical concern. Stroke. 29:1998;529-534.
22. Ginsberg M.D., Lin B., Morikawa E., Dietrich W.D., Busto R., Globus M.Y. Calcium antagonists in the treatment of experimental cerebral ischemia. Arzneimittelforschung. 41:1991;334-337.
23. Ginsberg M.D., Sternau L.L., Globus M.Y., Dietrich W.D., Busto R. Therapeutic modulation of brain temperature, relevance to ischemic brain injury. Cerebrovasc. Brain. Metab. Rev. 4:1992;189-225.
24. Globus M.Y., Busto R., Dietrich W.D., Martinez E., Valdes I., Ginsberg M.D. Effect of ischemia on the in vivo release of striatal dopamine, glutamate and gamma-aminobutyric acid studied by intracerebral microdialysis. J. Neurochem. 51:1988;1455-1464.
25. Hagberg H., Lehmann A., Sandberg M., Nystrom B., Jacobson I., Hamberger A. Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extracellular compartments. J. Cereb. Blood Flow Metab. 5:1985;413-419.
26. Heitz C., Descombes J.J., Miller R.C., Stoclet J.C. Alpha-adrenoceptor antagonistic and calcium antagonistic effects of nicergoline in the rat isolated aorta. Eur. J. Pharmacol. 123:1986;279-285.
27. Kanai Y. Family of neutral and acidic amino acid transporters, molecular biology: physiology and medical implications. Curr. Opin. Cell Biol. 9:1997;565-572.
28. Katsura K., Minamisawa H., Fkholm A., Folbergrova J., Siesjö B.K. Changes labile metabolites during anoxia in moderately hypo- and hyperthermic rats. Brain Res. 590:1992;6-12.
29. Kawai K., Nitecka L., Ruetzler C., Nagashima G., Joo F., Mies G., Thaddeus S., Nowak J., Saito N., Lohr J., Klatzo I. Global cerebral ischemia associated with cardiac arrest in the rat: I. Dynamics of early neuronal changes. J. Cereb. Blood Flow Metab. 12:1992;238-249.
30. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239:1982;57-69.
31. Kohno T., Asai S., Iribe Y., Hosoi I., Shibata K., Ishikawa K. An improved method for the detection of changes in brain extracellular glutamate levels. J. Neurosci. Methods. 81:1998;199-205.
32. Kohno T., Asai S., Iribe Y., Hosoi I., Shibata K., Ishikawa K. Oxygen independent real-time monitoring for the detection of changes in brain extracellular glutamate levels using ferrocene conjugated bovine serum albumin. J. Brain Sci. 24:1998;47-53.
33. Meldrum B., Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11:1990;379-387.
34. Miljanich G.P., Ramachandran J. Antagonists of neuronal calcium channels: structure, function, and therapeutic implications. Annu. Rev. Pharmacol. Toxicol. 35:1995;707-734.
35. Miller B., Sarantis M., Traynelis S.F., Attwell D. Potentiation of NMDA receptor currents by arachidonic acid. Nature. 355:1992;722-725.
36. Mitani A., Kataoka K. Critical levels of extracellular glutamate mediating gerbil hippocampal delayed neuronal death during hypothermia: brain microdialysis study. Neuroscience. 42:1991;661-670.
37. Morley P., Hogan M.J., Hakim A.M. Calcium-mediated mechanisms of ischemic injury and protection. Brain Pathol. 4:1994;37-47.
38. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 258:1992;607-614.
39. Sanfeliu C., Hunt A., Patel A.J. Exposure to N-methyl-D-aspartate increases release of arachidonic acid in primary cultures of rat hippocampal neurons and not in astrocytes. Brain Res. 526:1990;241-248.
40. Shintomi K., Itakura T., Yoshimoto K., Ogawa Y., Fukushima T., Matsuoka Y. Pharmacological study of nicergoline, protective effect on ischemic brain damage in animals. Folia. Pharmacol. Jpn. 87:1886;427-434.
41. Siesjö B.K. Cell damage in the brain: a speculative synthesis. J. Cereb. Blood Flow Metab. 1:1981;155-185.
42. Siesjö B.K., Zhao Q., Pahlmark K., Siesjö P., Katsura K., Folbergrova J. Glutamate, calcium and free radicals as mediators of ischemic brain damage. Ann. Thorac. Surg. 59:1995;1316-1320.
43. Szatkowski M., Attwell D. Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms. Trends Neurosci. 17:1994;359-365.
44. 2+ channels in rat isolated hippocampal CA1 pyramidal neurones. Br. J. Pharmacol. 100:1990;705-710.
45. Zhao H., Asai S., Kanematsu K., Kunimatsu T., Kohno T., Ishikawa K. Real-time monitoring of the effects of normothermia and hypothermia on extracellular glutamate re-uptake in the rat following global brain ischemia. NeuroReport. 8:1997;2389-2393.
46. Zhao H., Asai S., Kohno T., Ishikawa K. Effects of brain temperature on cerebral blood flow thresholds for extracellular glutamate release and reuptake in the striatum in a rat model of graded global ischemia. NeuroReport. 9:1998;3183-3188.