Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants

Blood

Volumn 96, Issue 6, 2000, Pages 2226-2232

  Heisterkamp, N ^a   Voncken, J W ^a   Senadheera, D ^a   Gonzalez Gomez, I ^a   Reichert, A ^a   Haataja, L ^a   Reinikainen, A ^a   Pattengale, P K ^a   Groffen, J ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; PROTEIN TYROSINE KINASE;

ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARCINOGENICITY; CONTROLLED STUDY; GENE EXPRESSION; LEUKEMIA; LEUKEMOGENESIS; LYMPHOMA; MOUSE; NONHUMAN; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; TRANSGENE;

EID: 0034665766     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.6.2226.h8002226_2226_2232     Document Type: Article

References (36)

1. The molecular pathogenesis of the Philadelphia-positive leukemias: Implications for diagnosis and therapy
2. Ph-positive leukemia
3. Molecular pathogenesis of chronic myeloid leukemia: Implications for new strategies
4. Chronic myeloid leukemia
5. SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence
6. Activation of tyrosine kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins
7. An actin-binding function contributes to transformation by the BCR-ABL oncoprotein of Philadelphia chromosome positive human leukemias
8. The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin-binding domains with bundling activity
9. The C-terminus of c-Abl is required for proliferation and viability signalling in a c-Abl/erythropoietin receptor fusion protein
10. Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells
11. BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl
12. Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia
13. Differential signalling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)
14. Increased tyrosine phosphorylation of focal adhesion proteins in myetoid cell lines expressing p210BCR/ABL
15. Role of the adapter protein CRKL in signal transduction of normal hematopoieric and BCR/ABL transformed cells
16. Bcr/Abl expression stimulates integrin function in hematopoietic cells
17. Inhibition of BCR-ABL expression with antisense oligodeoxynucleotides restores beta1 integrin-mediated adhesion and proliferation inhibition in chronic myelogenous leukemia hematopoietic progenitors
18. BCR/ABL induces multiple abnormalities of cytoskeletal function
19. Integrin-mediated regulation of hematopoiesis: Do BCR/ABL-induced defects in integrin function underlie the abnormal circulation and proliferation of CML progenitors?
20. Pathophysiology of CML: Do defects in integrin function contribute to the premature circulation and massive expansion of the BCP/ABL positive clone?
21. Adhesion to fibronectin stimulates proliferation of wild-type and bcr/abl-transfected murine hematopoletic cells
22. Acute leukemia in BCR/ABL transgenic mice
23. Clonal development and karyotype evolution during leukemogenesis of BCR/ABL transgenic mice
24. Restricted oncogenicity of BCR/ABL p190 in transgenic mice
25. Clonal characteristics of acute lymphoblastic cells derived from bcr/abl p190 transgenic mice
26. Cellular interactions of CRKL, an SH2-SH3 adaptor protein
27. BCR/ABL P210 and p190 cause distinct leukemia in transgenic mice
28. The human BCR/ABL gene has a lethal effect on embryogenesis
29. The acute promyelocytic leukemia PML-RARα protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice
30. Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia
31. Identification of CRKL as the constitutively phosphorylated 39-kDa tyrosine phosphoprotein in chronic myelogenous leukemia cells
32. Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia
33. Physiological signals and oncogenesis mediated through crk family adapter proteins
34. Tyrosine phosphorylation of murine crkl
35. Interactions of p62dok with p210bcr-abl and Bcr-Abl-associated proteins
36. Polarized distribution of Bcr-Abl in migrating myeloid cells and co-localization of Bcr-Abl and its target proteins