Abl kinase but not PI3-kinase links to the cytoskeletal defects in Bcr- Abl transformed cells

Experimental Hematology

Volumn 28, Issue 1, 2000, Pages 77-86

  Gaston, Isabelle ^a   Stenberg, Paula E ^a   Bhat, Arun ^b   Druker, Brian J ^b  

^a Depts Cell Devmtl Biol B   (United States)

^b Div of Hematol and Med Oncology   (United States)

Author keywords

Bcr Abl; Chronic myelogenous leukemia; Cytoskeleton; Phosphatidylinositol kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; IMATINIB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL STRAIN 3T3; CELL TRANSFORMATION; CHRONIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOSKELETON; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANIMALS; CELL ADHESION; CELL LINE, TRANSFORMED; CHROMONES; CYTOSKELETON; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FUSION PROTEINS, BCR-ABL; MICE; MORPHOLINES; ONCOGENE PROTEINS V-ABL; PHENOTYPE; PHOSPHORYLATION; PIPERAZINES; PYRIMIDINES; RATS; TRANSFECTION;

ANIMALIA;

EID: 0033959024     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(99)00130-7     Document Type: Article

References (40)

1. Nowell P.C., Hungerford D.A. A minute chromosome in human chronic ranulocytic leukemia. Science. 132:1960;1497.
2. Rowley J.D. A new consistent abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and giemsa staining. Nature. 243:1973;290.
3. Groffen J., Stephenson J.R., Heisterkamp N., de Klein A., Bartram C.R., Grosveld G. Philadelphia chromosome breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell. 36:1984;93.
4. Heisterkamp N., Stam K., Groffen J., de Klein A., Grosveld G. Structural organization of the bcr gene and its role in the Ph' translocation. Nature. 315:1985;758.
5. Ben-Neriah Y., Daley G.Q., Mes-Masson A.-M., Witte O.N., Baltimore D. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science. 233:1986;212.
6. Renshaw M.W., McWhirter J.R., Wang J.Y. The human leukemia oncogene bcr- abl abrogates the anchorage requirement but not the growth factor requirement for proliferation. Mol Cell Biol. 15:1995;1286.
7. Salgia R., Li J.L., Ewaniuk D.S., Pear W., Pisick E., Burky S.A., Ernst T., Sattler M., Chen L.B., Griffin J.D. BCR/ABL induces multiple abnormalities of cytoskeletal function. J Clin Invest. 100:1997;46.
8. McWhirter J.R., Wang J.Y.J. An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias. EMBO J. 12:1993;1533.
9. Verfaillie C.M., Hurley R., Lundell B.I., Zhao C., Bhatia R. Integrin-mediated regulation of hematopoiesis. do BCR-ABL-induced defects in integrin function underlie the abnormal circulation and proliferation of CML progenitors? Acta Hematol. 97:1997;40.
10. Van Etten R.A., Jackson P., Baltimore D., Sanders M., Matsudaira P., Janmey P. The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains wiht bundling activity. J Cell Biol. 124:1994;325.
11. Van Etten R.A., Jackson P., Baltimore D. The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization. Cell. 58:1989;669.
12. Wetzler M., Talpaz M., Van Etten R.A., Hirsh-Ginsberg C., Beran M., Kurzrock R. Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation. J Clin Invest. 92:1993;1925.
13. Varticovski L., Daley G.Q., Jackson P., Baltimore D., Cantley L.C. Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants. Mol Cell Biol. 11:1991;1107.
14. ten Hoeve J., Arlinghaus R.B., Guo J.Q., Heisterkamp N. Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia. Blood. 84:1994;1731.
15. Oda T., Heaney C., Hagopian J., Okuda K., Griffin J.D., Druker B.J. CRKL is the major tyrosine phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. J Biol Chem. 269:1994;22925.
16. Nichols G.L., Raines M.A., Vera J.C., Lacomis L., Tempst P., Golde D.W. Identification of CRKL as the constitutively phosphorylated 39-kD tyrosine phosphoprotein in chronic myelogenous leukemia cells. Blood. 84:1994;2912.
17. Andoniou C.E., Thien C.B.F., Langdon W.Y. Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J. 13:1994;4515.
18. Sattler M., Salgia R., Okuda K., Uemura N., Durstin M.A., Pisick E., Xu G., Li J.L., Prasad K.V., Griffin J.D. The proto-oncogene product p120cbl and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR-ABL and p210BCR-ABL to the phosphatidylinositol-3′ kinase pathway. Oncogene. 12:1996;839.
19. Salgia R., Brunkhorst B., Pisick E., Li J.L., Lo S.H., Chen L.B., Griffin J.D. Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cells expressing p210BCR-ABL. Oncogene. 11:1995;1149.
20. Gotoh A., Miyazawa K., Ohyashiki K., Tauchi T., Boswell H.S., Broxmeyer H.E., Toyama K. Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein. Exp Hematol. 23:1995;1153.
21. Verfaillie C.M., McCarthy J.B., McGlave P.B. Mechanisms underlying abnormal trafficking of malignant progenitors inchronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV. J Clin Invest. 90:1992;1232.
22. Gordon M.Y., Dowding C.R., Riley G.P., Goldman J.M., Greaves M.F. Altered adhesive interactions with marrow stroma of haematopoietic progenitor cells in chronic myeloid leukaemia. Nature. 328:1987;342.
23. Carpenter C.L., Cantley L.C. Phosphoinositide kinases. Curr Opin Cell Biol. 8:1996;153.
24. Hawkins P.T., Eguinoa A., Qiu R.G., Stokoe D., Cooke F.T., Walters R. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr Biol. 5:1995;393.
25. Kotani K., Yonezawa K., Hara K., Ueda H., Kitamura Y., Sakaue H., Ando A., Chavanieu A., Calas B., Grigorescu F., Nishiyama M., Waterfield M.D.et al. Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling. EMBO J. 13:1994;2313.
26. Wennstrom S., Hawkins P., Cooke F., Hara K., Yonezawa K., Kasuga M., Jackson T., Claesson-Welsh L., Stephens L. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr Biol. 4:1994;385.
27. Kinashi T., Escobedo J.A., Williams L.T., Takatsu K., Springer T.A. Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways. Blood. 86:1995;2086.
28. Serve H., Yee N.S., Stella G., Sepp-Lorenzino L., Tan J.C., Besmer P. Differential roles of P13-kinase and Kit tyrosine 821 in Kitreceptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J. 14:1995;473.
29. Renshaw M.W., Kipreos E.T., Albrecht M.R., Wang J.Y.J. Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context. EMBO J. 11:1992;3941.
30. Lugo T.G., Witte O.N. The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc. Mol Cell Biol. 9:1989;1263.
31. Vlahos C.J., Matter W.F., Brown R.F., Traynor-Kaplan A.E. Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase. J Immuno. 5:1995;2413.
32. Druker B.J., Tamura S., Buchdunger E., Ohno S., Segal G.M., Fanning S., Zimmermann J., Lydon N.B. Effects of a selective inhibitor of the ABL tyrosine kinase on the growth of BCR-ABL positive cells. Nat Med. 2:1996;561.
33. Burridge K., Fath K., Kelly T., Nuckolls G., Turner C. Focal adhesions. transmembrane junctions between the extracellular matrix and the cytoskeleton Annu Rev Cell Biol. 4:1988;487.
34. Clark E.A., Brugge J.S. Integrins and signal transduction pathways. the road taken Science. 268:1995;233.
35. Salgia R., Li J.L., Lo S.H., Brunkhorst B., Kansas G.S., Sobhany E.S., Sun Y., Pisick E., Hallek M., Ernst T., Chen L.B., Griffin J.D. Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. J Biol Chem. 270:1995;5039.
36. Salgia R., Sattler M., Pisick E., Li J.L., Griffin J.D. p210BCR-ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-cbl. Exp Hematol. 24:1996;310.
37. Carroll M., Ohno-Jones S., Tamura S., Buchdunger E., Zimmermann J., Lydon N.B., Gilliland D.G., Druker B.J. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL and TEL-PDGFR fusion proteins. Blood. 90:1997;4947.
38. King W.G., Mattaliano M.D., Chan T.O., Tsichlis P.N., Brugge J.S. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf- 1/mitogen-activated protein kinase pathway activation. Mol Cell Biol. 17:1997;4406.
39. Ma A.D., Metjian A., Bagrodia S., Taylor S., Abrams C.S. Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3 kinase g, a rac guanosine exchange factor, and rac. Mol Cell Biol. 18:1998;4744.
40. Reif K., Nobes C.D., Thomas G., Hall A., Cantrell D.A. Phosphatidylinositol 3- kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr Biol. 6:1996;1445.