Mga2p processing by hypoxia and unsaturated fatty acids in Saccharomyces cerevisiae: Impact on LORE-dependent gene expression

Eukaryotic Cell

Volumn 1, Issue 3, 2002, Pages 481-490

  Jiang, Yide ^a   Vasconcelles, Michael J ^a   Wretzel, Sharon ^a   Light, Anne ^a   Gilooly, Laura ^a   McDaid, Kevin ^a   Oh, Chan Seok ^b   Martin, Charles E ^b   Goldberg, Mark A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYXOGASTRIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

ACYL COENZYME A DESATURASE; DELTA 9 FATTY ACID DESATURASE; DELTA-9 FATTY ACID DESATURASE; FUNGAL DNA; FUNGAL PROTEIN; OXYGEN; POLYSORBATE; SACCHAROMYCES CEREVISIAE PROTEIN; SPT23 PROTEIN, S CEREVISIAE; TRANSACTIVATOR PROTEIN; UNSATURATED FATTY ACID;

ARTICLE; BINDING SITE; DRUG EFFECT; FUNGAL GENE; GENE EXPRESSION; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN PROCESSING; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

BASE SEQUENCE; BINDING SITES; DNA, FUNGAL; FATTY ACID DESATURASES; FATTY ACIDS, UNSATURATED; FUNGAL PROTEINS; GENE EXPRESSION; GENES, FUNGAL; OXYGEN; POLYSORBATES; PROTEIN PROCESSING, POST-TRANSLATIONAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 0036616961     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.1.3.481-490.2002     Document Type: Article

References (43)

1. Alexandre, H., I. Rousseaux, and C. Charpentier. 1994. Relationship between ethanol tolerance, lipid composition and plasma membrane fluidity in Saccharomyces cerevisiae and Kloeckera apiculata. FEMS Microbiol. Lett. 124:17-22.
2. Brown, T., and K. Mackey. 1997. Analysis of RNA by Northern and slot blot hybridization, p. 4.9.1-4.9.14. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
3. Bunn, H. F., and R. O. Poyton. 1996. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76:839-885.
4. Carratu, L., S. Franceschelli, C. L. Pardini, G. S. Kobayashi, I. Horvath, L. Vigh, and B. Maresca. 1996. Membrane lipid perturbation modifies the set point of the temperature of heat shock response in yeast. Proc. Natl. Acad. Sci. USA 93:3870-3875.
5. Chellappa, R., P. Kandasamy, C. S. Oh, Y. Jiang, M. Vemula, and C. E. Martin. 2001. The membrane proteins, Spt23p and Mga2p, play distinct roles in the activation of Saccharomyces cerevisiae OLE1 gene expression: fatty acid-mediated regulation of Mga2p activity is independent of its proteolytic processing into a soluble transcription activator. J. Biol. Chem. 276:43548-43556.
6. Choi, J. Y., J. Stukey, S. Y. Hwang, and C. E. Martin. 1996. Regulatory elements that control transcription activation and unsaturated fatty acid-mediated repression of the Saccharomyces cerevisiae OLE1 gene. J. Biol. Chem. 271:3581-3589.
7. Cockman, M. E., N. Masson, D. R. Mole, P. Jaakkola, G. W. Chang, S. C. Clifford, E. R. Maher, C. W. Pugh, P. J. Ratcliffe, and P. H. Maxwell. 2000. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 275:25733-25741.
8. Collart, M. A., and S. Oliviero. 1997. Preparation of yeast RNA, p. 13.12.1-13.12.5. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
9. Daum, G., N. D. Lees, M. Bard, and R. Dickson. 1998. Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast 14:1471-1510.
10. Ebert, B. L., and H. F. Bunn. 1999. Regulation of the erythropoietin gene. Blood 94:1864-1877.
11. Elble, R. 1992. A simple and efficient procedure for transformation of yeasts. BioTechniques 13:18-20.
12. Fujiwara, D., H. Yoshimoto, H. Sone, S. Harashima, and Y. Tamai. 1998. Transcriptional co-regulation of Saccharomyces cerevisiae alcohol acetyltransferase gene ATF1 and delta-9 fatty acid desaturase gene OLE1 by unsaturated fatty acids. Yeast 14:711-721.
13. Hoffman, C. S. 1997. Rapid isolation of yeast chromosomal DNA, p. 13.11.2-13.11.4. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
14. Hoppe, T., K. Matuschewski, M. Rape, S. Schlenker, H. D. Ulrich, and S. Jentsch. 2000. Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. Cell 102:577-586.
15. Huang, L. E., Z. Arany, D. M. Livingston, and H. F. Bunn. 1996. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J. Biol. Chem. 271:32253-32259.
16. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 95:7987-7992.
17. 2 sensing. Science 292:464-468.
18. 2-regulated prolyl hydroxylation. Science 292:468-472.
19. Jiang, Y., M. J. Vasconeelles, S. Wretzel, A. Light, C. E. Martin, and M. A. Goldherg. 2001. MGA2 is involved in the low-oxygen response element-dependent hypoxic induction of genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 21:6161-6169.
20. Johnson, E. S., P. C. Ma, I. M. Ota, and A. Varshavsky. 1995. A proteolytic pathway that recognizes ubiquitin as a degradation signal. J. Biol. Chem. 270:17442-17456.
21. Kallio, P. J., I. Pongratz, K. Gradin, J. McGuire, and L. Poellinger. 1997. Activation of hypoxia-inducible factor 1α: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc. Natl. Acad. Sci. USA 94:5667-5672.
22. Kamura, T., S. Sato, K. Iwai, M. Czyzyk-Krzeska, R. C. Conaway, and J. W. Conaway. 2000. Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc. Natl. Acad. Sci. USA 97:10430-10435.
23. Kwast, K. E., P. V. Burke, B. T. Staahl, and R. O. Poyton. 1999. Oxygen sensing in yeast: evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes. Proc. Natl. Acad. Sci. USA 96:5446-5451.
24. Maxwell, P. H., M. S. Wiesener, G. W. Chang, S. C. Clifford, E. C. Vaux, M. E. Cockman, C. C. Wykoff, C. W. Pugh, E. R. Maher, and P. J. Ratcliffe. 1999. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275.
25. McDonough, V. M., J. E. Stukey, and C. E. Martin. 1992. Specificity of unsaturated fatty acid-regulated expression of the Saccharomyces cerevisiae OLE1 gene. J. Biol. Chem. 267:5931-5936.
26. 2 and unsaturated fatty acid repression of OLE1 in Saccharomyces cerevisiae. J. Bacteriol. 183:745-751.
27. Ntambi, J. M. 1999. Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol. J. Lipid Res. 40:1549-1558.
28. Ohh, M., C. W. Park, M. Ivan, M. A. Hoffman, T. Y. Kim, L. E. Huang, N. Pavletich, V. Chau, and W. G. Kaelin. 2000. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2:423-427.
29. Pfeifer, K., B. Arcangioli, and L. Guarente. 1987. Yeast HAP1 activator competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene. Cell 49:9-18.
30. Pugh, C. W., J. F. O'Rourke, M. Nagao, J. M. Gleadle, and P. J. Ratcliffe. 1997. Activation of hypoxia-inducible factor-1: definition of regulatory domains within the alpha subunit. J. Biol. Chem. 272:11205-11214.
31. Reynolds, A., V. Lundblad, D. Dorris, and M. Keaveney. 1997. Yeast vectors and assays for expression of cloned genes, p. 13.6.2-13.6.3. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seldman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
32. 2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15:551-578.
33. Sherbet, G. V. 1989. Membrane fluidity and cancer metastasis. Exp. Cell Biol. 57:198-205.
34. Stewart, L. C., and M. P. Yaffe. 1991. A role for unsaturated fatty acids in mitochondrial movement and inheritance. J. Cell Biol. 115:1249-1257.
35. Tanimoto, K., Y. Makino, T. Pereira, and L. Poellinger. 2000. Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein. EMBO J. 19:4298-4309.
36. Tooke, J. E. 2000. Possible pathophysiological mechanisms for diabetic angiopathy in type 2 diabetes. J. Diabet. Complicat. 14:197-200.
37. Treco, D. A., and F. Winston. 1997. Growth and manipulation of yeast, p. 13.2.1-13.2.12. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
38. Vasconcelles, M. J., Y. Jiang, K. McDaid, L. Gilooly, S. Wretzel, D. L. Porter, C. E. Martin, and M. A. Goldberg. 2001. Identification and characterization of a low oxygen response element involved in the hypoxic induction of a family of Saccharomyces cerevisiae genes. Implications for the conservation of oxygen sensing in eukaryotes. J. Biol. Chem. 276:14374-14384.
39. Wang, G. L., and G. L. Semenza. 1995. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270:1230-1237.
40. Winzeler, E. A., D. D. Shoemaker, A. Astromoff, H. Liang, K. Anderson, B. Andre, R. Bangham, R. Benito, J. D. Boeke, H. Bussey, A. M. Chu, C. Connelly, K. Davis, F. Dietrich, S. W. Dow, M. El Bakkoury, F. Foury, S. H. Friend, E. Gentalen, G. Giaever, J. H. Hegemann, T. Jones, M. Laub, H. Liao, R. W. Davis, et al. 1999. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285:901-906.
41. Zhang, S., T. J. Burkett, I. Yamashita, and D. J. Garfinkel. 1997. Genetic redundancy between SPT23 and MGA2: regulators of Ty-induced mutations and Ty1 transcription in Saccharomyces cerevisiae. Mol. Cell. Biol. 17:4718-4729.
42. Zhang, S., Y. Skalsky, and D. J. Garfinkel. 1999. MGA2 or SFT23 is required for transcription of the δ9 fatty acid desaturase gene, OLE1, and nuclear membrane integrity in Saccharomyces cerevisiae. Genetics 151:473-483.
43. Zitomer, R. S., and C. V. Lowry. 1992. Regulation of gene expression by oxygen in Saccharomyces cerevisiae. Microbiol. Rev. 56:1-11.