Engineering human chromosomes for gene therapy studies

Trends in Molecular Medicine

Volumn 7, Issue 6, 2001, Pages 235-237

  Choo, K H Andy ^a  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME; EXPRESSION VECTOR; GENE TECHNOLOGY; GENE THERAPY; GENETIC ENGINEERING; HUMAN; REGULATOR GENE;

EID: 0034965979     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(01)01951-7     Document Type: Review

References (25)

1. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
2. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector
3. Researchers and regulators reflect on first gene therapy death
4. Human gene therapy
5. Formation of de novo centromeres and construction of first-generation human artificial microchromosomes
6. Construction of YAC-based mammalian artificial chromosomes
7. Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences
8. Mammalian artificial chromosome formation from circular alphoid input DNA does not require telomere repeats
9. Artificial chromosomes coming to life
10. Novel generation of human satellite DNA based artificial chromosomes in mammalian cells
11. De novo chromosome formations by large-scale amplification of the centromeric region of mouse chromosomes
12. Generation of a human X-derived minichromosome using telomere-associated chromosome fragmentation
13. Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage
14. Centromere DNA dynamics: Latent centromeres and neocentromere formation
15. Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation
16. Centromerisation
17. Mammalian artificial chromosome pilot production facility: Large-scale isolation of functional satellite DNA-based artificial chromosomes
18. Functional expression and germline transmission of a human chromosome fragment in chimaeric mice
19. Transfer of YACs up to 2.3 Mb intact into human cells with polyethylenimine
20. Generation of transgenic mice and germline transmission of a mammalian artificial chromosome introduced into embryos by pronuclear microinjection
21. Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21
22. A structurally defined mini-chromosome vector for the mouse germ line
23. Cloning of male mice from adult tail-tip cells
24. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells
25. Artificial chromosomes: Ideal vectors?