Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion

European Journal of Biochemistry

Volumn 267, Issue 7, 2000, Pages 2008-2013

  Schromm, Andra B ^d   Brandenburg, Klaus ^d   Loppnow, Harald ^a   Moran, Anthony P ^b   Koch, Michel H J ^d   Rietschel, Ernst Th ^d   Seydel, Ulrich ^c  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c RESEARCH CENTER BORSTEL   (Germany)

^d NONE

Author keywords

Agonism; Antagonism; Lipid A; Molecular shape; X ray diffraction

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; INTERLEUKIN 6; LIPID A; VIRULENCE FACTOR;

ARTICLE; CHEMICAL STRUCTURE; DRUG ACTIVITY; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK; SIGNAL TRANSDUCTION; X RAY DIFFRACTION;

CARBOHYDRATE SEQUENCE; ENDOTOXINS; HUMANS; INTERLEUKIN-6; LIPID A; LIPOPOLYSACCHARIDES; MOLECULAR SEQUENCE DATA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; X-RAY DIFFRACTION;

BACTERIA (MICROORGANISMS); ENTEROBACTERIACEAE; MAMMALIA; NEGIBACTERIA;

EID: 0001654207     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01204.x     Document Type: Article

References (29)

1. Rietschel, E.Th., Brade, H., Holst, O., Brade, L., Müller-Loennies, S., Mamat, U., Zähringer, U., Beckmann, F., Seydel, U., Brandenburg, K., Ulmer, A.J., Mattern, T., Heine, H., Schletter, J., Hauschildt, S., Loppnow, H., Schönbeck, U., Flad, H.-D., Schade, U.F., Di Padova, F., Kusumoto, S. & Schumann, R.R. (1996) Bacterial endotoxin: chemical constitution, biological recognition, host response, and immunological detoxification. Curr. Top. Microbiol. Immunol. 216, 39-81.
2. Pugin, J., Ulevitch, R.J. & Tobias, P.S. (1995) Mechanism of cellular activation by endotoxin. Prog. Surg. 20, 8-17.
3. Mueller-Loennies, S., Zähringer, U., Seydel, U., Kusumoto, S., Ulmer, A.J. & Rietschel, E.Th. (1998) What we know and don't know about the chemical and physical structure of lipopolysaccharide in relation to biological activity. Prog. Clin. Biol. Res. 397, 51-72.
4. Schromm, A.B., Brandenburg, K., Loppnow, H., Zähringer, U., Rietschel, E.Th., Carroll, S.F., Koch, M.H.J., Kusumoto, S. & Seydel, U. (1998) The charge of endotoxin molecules influences their conformation and interleukin-6 inducing capacity. J. Immunol. 161, 5464-5471.
5. Seydel, U., Wiese, A., Schromm, A.B. & Brandenburg, K. (1999) A biophysical view on the function and activity of endotoxins. In Endotoxin in Health and Disease (Brade, H., Opal, S.M., Vogel, S.N. & Morrison, D.C., eds), pp. 195-220. Academic Press, New York.
6. Loppnow, H., Brade, H., Dürrbaum, I., Dinarello, C.A., Kusumoto, S. & Rietschel, E.Th. (1989) IL-1 induction-capacity of defined lipopolysaccharide partial structures. J. Immunol. 142, 3229-3238.
7. Loppnow, H., Libby, P., Freudenberg, M.A., Kraus, J.H., Weckesser, J. & Mayer, H. (1990) Cytokine induction by lipopolysaccharide (LPS) corresponds to the lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatus LPS. Infect. Immun. 58, 3743-3750.
8. Golenbock, D.T., Hampton, R.Y., Qureshi, N., Takayama, K. & Raetz, C.R.H. (1991) Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes. J. Biol. Chem. 266, 19490-19498.
9. Christ, W.J., Asano, O., Robidoux, L.C., Perez, M., Wang, Y., Dubuc, G.R., Gavin, W.E., Hawkins, L.D., McGuiness, P.D., Mullarkey, M.A., Lewis, M.D., Kishi, Y., Kawata, T., Bristol, J.R., Rose, J.R., Rossignol, D.P., Kobayashi, S., Hishinuma, I., Kimura, A., Asakawa, N., Katayama, K. & Yamatsu, I. (1995) E5531, a pure endotoxin antagonist of high potency. Science 268, 80-83.
10. Rose, J.R., Christ, W.J., Bristol, J.R., Kawata, T. & Rossignol, D.P. (1995) Agonistic and antagonistic activities of bacterially derived Rhodobacter sphaeroides lipid A: comparison with activities of synthetic material of the proposed structure and analogs. Infect. Immun. 63, 833-839.
11. Moran, A.P. (1995) Biological and serological characterization of Campylobacter jejuni lipopolysaccharides with deviating core and lipid A structures. FEMS Immunol. Med. Microbiol. 11, 121-130.
12. Rau, H., Seydel, U., Freudenberg, M., Weckesser, J. & Mayer, H. (1995) Lipopolysaccharide of the phototrophic bacterium Rhodo-spirillum fulvum. System. Appl. Microbiol. 18, 154-163.
13. Imoto, M., Yoshimura, N., Kusumoto, S. & Shiba, T. (1984) Total synthesis of lipid A, active principle of bacterial endotoxin. Proc. Jpn. Acad. Series B 60, 285-288.
14. Lindner, B. (2000) Matrix-assisted desorption/ionization time-of flight mass spectrometry of lipopolysaccharides. In Methods in Molecular Biology (Holst, O., ed.). Humana Press, Totowa, in press.
15. Holst, O., Borowiak, D., Weckesser, J. & Mayer, H. (1983) Structural studies on the phosphate-free lipid A of Rhodomicrobium vannielii. Eur. J. Biochem. 137, 325-332.
16. Mayer, H., Krauss, J.H., Yokota, A. & Weckesser, J. (1990) Natural variants of lipid A. In Endotoxin (Friedman, A., Klein, T.W., Nakano, M. & Nowotny, A., eds), pp. 45-70. Plenum Press, New York and London.
17. Rietschel, E.Th., Brade, L., Holst, O., Kulshin, V.A., Lindner, B., Moran, A.P., Schade, U.F., Zähringer, U. & Brade, H. (1990) Molecular structure of bacterial endotoxin in relation to bioactivity. In Cellular and Molecular Aspects of Endotoxin Reactions (Nowotny, A., Spitzer, J.J. & Ziegler, E.J., eds), pp. 15-32. Elsevier Science Publishers, Amsterdam.
18. 11 structures of lipid A from Salmonella enterica serovar Minnesota by X-ray diffraction and freeze-fracture electron microscopy. Chem. Phys. Lipids 91, 53-69.
19. Brandenburg, K., Mayer, H., Koch, M.H.J., Weckesser, J., Rietschel, E.Th. & Seydel, U. (1993) Influence of the supramolecular structure of free lipid A on its biological activity. Eur. J. Biochem. 218, 555-563.
20. Jahr, T.G., Sundan, A., Lichenstein, H.S. & Espevik, T. (1995) Influence of CD14, LBP, and BPI in the monocyte response to LPS of different polysaccharide chain length. Scand. J. Immunol. 42, 119-127.
21. Schromm, A.B., Brandenburg, K., Rietschel, E.Th., Flad, H.-D., Carroll, S. & Seydel, U. (1996) Lipopolysaccharide-binding protein (LBP) mediates CD14-independent intercalation of lipopolysaccharide into phospholipid membranes. FEBS Lett. 399, 267-271.
22. Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J. & Mathison, J.C. (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249, 1431-1433.
23. Troelstra, A., Antal-Szalmas, P., DeGraaf-Miltenburg, L.A.M., Weersink, A.J.L., Verhoef, J., Van Kessel, K.P.M. & Van Strijp, J.A.G. (1997) Saturable CD14-dependent binding of fluorescein-labeled lipopolysaccharide to human monocytes. Infect. Immun. 65, 2272-2277.
24. Thieblemont, N., Thieringer, R. & Wright, S.D. (1998) Innate immune recognition of bacterial lipopolysaccharide: dependence on interactions with membrane lipids and endocytic movement. Immunity 8, 771-777.
25. Ingalls, R.R. & Golenbock, D.T. (1995) CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide. J. Exp. Med. 181, 1473-1479.
26. Hu, Y., Fisette, P.L., Denlinger, L.C., Guadarrama, A.G., Sommer, J.A., Proctor, R. A. & Bertics, P.J. (1998) Purinergic receptor modulation of lipopolysaccharide signaling and inducible nitric-oxide synthase expression in RAW 264.7 macrophages. J. Biol. Chem. 273, 27170-27175.
27. Yang, R.B., Mark, M.R., Gray, A., Huang, A., Xie, M.H., Zhang, M., Goddard, A., Wood, W.I., Gurney, A.L. & Godowski, P.J. (1998) Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395, 284-288.
28. Schromm, A.B., Brandenburg, K., Rietschel, E.T. & Seydel, U. (1995) Do endotoxin aggregates intercalate into phospholipid membranes in a nonspecific, hydrophobic manner? J. Endotoxin Res. 2, 313-323.
29. Martin, D.K., Bootcov, M.R., Campbell, T.J., French, P.W. & Breit, S.N. (1995) Human macrophages contain a stretch-sensitive potassium channel that is activated by adherence and cytokines. J. Membr. Biol. 147, 305-315.