The role of TLR4 in endotoxin responsiveness in humans

Journal of Endotoxin Research

Volumn 7, Issue 5, 2001, Pages 389-393

  Schwartz, D A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; ENDOTOXIN; GLYCINE; ISOLEUCINE; LIPOPOLYSACCHARIDE; THREONINE; TOLL LIKE RECEPTOR 4;

ADULT; AIRWAY; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE SEGREGATION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INHALATION; LUNG ALVEOLUS MACROPHAGE; MALE; MISSENSE MUTATION; MOUSE; NONHUMAN; NORMAL HUMAN; PHENOTYPE; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT DISEASE; SIGNAL TRANSDUCTION; STRESS;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; BRONCHI; BRONCHIAL HYPERREACTIVITY; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA PROTEINS; EPITHELIAL CELLS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MUTATION, MISSENSE; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TRACHEA;

ANIMALIA;

EID: 0035676740     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805101101532972     Document Type: Article

References (47)

1. Cotton dust and endotoxin exposure-response relationships in cotton textile workers
2. Exposure to cotton dust in an experimental cardroom
3. Endotoxin in cotton dust and respiratory function decrement among cotton workers in and experimental cardroom
4. Environmental and health studies of farm workers in Swedish swine confinement buildings
5. Lung reactions during poultry handling related to dust and bacterial endotoxin levels
6. Pulmonary function and symptoms after inhalation of endotoxin
7. The role of endotoxin in grain dust-induced lung disease
8. Determinants of longitudinal changes in spirometric functions among swine confinement operators and farmers
9. Effects in man and rabbits of inhalation of cotton dust or extracts and purified endotoxins
10. Reduction of alveolar-capillary diffusion after inhalation of endotoxin in normal subjects
11. Inflammatory response to acute inhalation of endotoxin in asthmatic patients
12. Effect of inhaled endotoxin on bronchial reactivity in asthmatic and normal subjects
13. Grain fever syndrome induced by inhalation of airborne grain dust
14. The effects of inhalation of grain dust extract and endotoxin on upper and lower airways
15. Grain dust-induced airflow obstruction and inflammation of the lower respiratory tract
16. Pulmonary function response to dust from standard and closed boll harvested cotton
17. Acute broncho-constriction induced by cotton dust: Dose-related responses to endotoxin and other dust factors
18. Inhaled endotoxin and decreased spirometric values: An exposure-response relation for cotton dust
19. Exposure to bacteria in swine-house dust and acute inflammatory reactions in humans
20. Endotoxin responsiveness and grain dust-induced inflammation in the lower respiratory tract
21. Role of endotoxin in grain dust-induced lung inflammation in mice
22. Grain dust-induced lung inflammation is reduced by Rhodobacter sphaeroides diphosphoryl lipid A
23. The kinetics of grain dust-induced inflammation of the lower respiratory tract
24. Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects
25. Domestic endotoxin exposure and clinical severity of asthma
26. Severity of asthma is related to endotoxin in house dust
27. Asthma and endotoxin: Lipopolysaccharide-binding protein and soluble CD14 in broncho-alveolar compartment
28. An association between air pollution and mortality in six U.S. cities
29. Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City
30. Stimulation of human and rat alveolar macrophages by urban air particulates: Effects on oxidant radical generation and cytokine production
31. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
32. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopoly-saccharide: Evidence for TLR4 as the Lps gene product
33. Involvement of class II MHC molecules in the LPS-induction of IL-1/TNF secretions by human monocytes: Quantitative differences at the polymorphic level
34. Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections
35. Variable airway responsiveness to inhaled lipopolysaccharide
36. TLR4 mutations are associated with endo toxin hyporesponsiveness in humans
37. Detection of mutations by single-strand confirmation polymorphism (SSCP) analysis and SSCP-hybrid methods
38. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
39. Adenovirus-mediated gene transfer to ciliated airway epithelia requires prolonged incubation time
40. A family of human receptors structurally related to Drosophila Toll
41. Expression of Escherichia coli β-galactosidease and rat HPRT in the CNS of Macaca mulatta following adenoviral mediated gene transfer
42. Toll, a new piece in the puzzle of innate immunity
43. Compartmentalization of the inflammatory response to inhaled grain dust
44. Effects of inhalation of steroids on lung permeability in patients with asthma
45. State of the art: Endotoxin and lung injury
46. 1, and five-year change in lung function