Overexpression of Icat induces G2 arrest and cell death in tumor cell mutants for adenomatous polyposis coli, β-catenin, or Axin

Cancer Research

Volumn 62, Issue 11, 2002, Pages 3322-3326

  Takashi, Sekiya ^a   Tsutomu, Nakamura ^a   Yasuhiro, Kazuki ^a   Mitsuo, Oshimura ^a   Kazuyoshi, Kohu ^a   Ken Ichi, Tago ^a   Susumu, Ohwada ^a   Akiyama, Tetsu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; AXIN; BETA CATENIN; CELL CYCLE PROTEIN; CELL PROTEIN; CYCLIN B1; PROTEIN CDC2; PROTEIN ICAT; RAN PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

ADENOVIRUS; ANCHORAGE INDEPENDENT GROWTH; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL DEATH; CELL MUTANT; CELL PROLIFERATION; CELLULAR DISTRIBUTION; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DEPHOSPHORYLATION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CELL ADHESION; CELL CYCLE PROTEINS; CELL DEATH; CELL DIVISION; COLORECTAL NEOPLASMS; COS CELLS; CYTOSKELETAL PROTEINS; G2 PHASE; GENES, APC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MUSCLE PROTEINS; MUTATION; PROTEINS; REPRESSOR PROTEINS; TRANS-ACTIVATORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0036606333     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Linking colorectal cancer to Wnt signaling
2. Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus
3. Wnt/β-catenin signaling
4. Lessons from hereditary colorectal cancer
5. The ABC of APC
6. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
7. Stabilization of β-catenin by genetic defects in melanoma cell lines
8. Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas
9. Activation of the β-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3
10. AXINI mutations in hepatocellular carcinomas and growth suppression in cancer cells by virus-mediated transfer of AXINI
11. β-catenin signaling and cancer
12. Inhibition of Wnt signaling by ICAT, a novel β-catenin-interacting protein
13. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
14. β-catenin regulates expression of cyclin D1 in colon carcinoma cells
15. The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
16. Suppression of β-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells
17. The β-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression
18. Identification of AF17 as a downstream gene of the β-catenin/T-cell factor pathway and its involvement in colorectal carcinogenesis
19. Universal control mechanism regulating onset of M-phase
20. Mechanisms of G2 arrest in response to overexpression of p53
21. 14-3-3σ is required to prevent mitotic catastrophe after DNA damage
22. 14-3-3 Τ is a p53-regulated inhibitor of G2/M progression
23. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase
24. Catenins as mediators of the cytoplasmic functions of cadherins
25. Presenilin I facilitates the constitutive turnover of beta-catenin: Differential activity of Alzheimer's disease-linked PS1 mutants in the β-catenin-signaling pathway
26. β-catenin associates with the actin-bundling protein fascin in a noncadherin complex