The influence of pre-operative radiotherapy on the expression of p53 and adhesion molecules: Correlation with treatment results in patients with squamous cell carcinoma or adenocarcinoma

Oncology Reports

Volumn 9, Issue 3, 2002, Pages 621-625

  Pomp, J ^a   Blom, J ^a   Linthorst, M ^b   Zwinderman, A H ^b   Van Krimpen, C ^a  

^a REINIER DE GRAAF HOSPITAL   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adhesion molecule; E cadherin; Preoperative radiotherapy; catenin

Indexed keywords

BETA CATENIN; CTNNB1 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; PROTEIN P53; TRANSACTIVATOR PROTEIN;

ADENOCARCINOMA; ARTICLE; BIOSYNTHESIS; CELL ADHESION; HUMAN; IMMUNOHISTOCHEMISTRY; LARYNX TUMOR; METABOLISM; MULTIMODALITY CANCER THERAPY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RECTUM TUMOR; SQUAMOUS CELL CARCINOMA; TREATMENT OUTCOME;

ADENOCARCINOMA; BETA CATENIN; CARCINOMA, SQUAMOUS CELL; CELL ADHESION; COMBINED MODALITY THERAPY; CYTOSKELETAL PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LARYNGEAL NEOPLASMS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECTAL NEOPLASMS; TRANS-ACTIVATORS; TREATMENT OUTCOME; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036584476     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.9.3.621     Document Type: Article

References (43)

1. Aberle H, Schwartz H and Kemier R: Cadherin-catenin complex: protein interactions and their implications for cadherin function. J Cell Biochem 61: 514-523, 1996. (Pubitemid 26240128)
2. Isaacs JT: Molecular markers for prostate cancer metastasis. Developing diagnostic methods for predicting the aggressiveness of prostate cancer. Am J Pathol 150: 1511-1521, 1997.
3. Dobson H, Pignatelli M, Hopwood D and D'Arrigo C: Cell adhesion molecules in oesophageal epithelium. Gut 35: 1343-1347, 1994. (Pubitemid 24310887)
4. Balsamo J, Leung T, Ernst H, Zanin MK, Hoffman S and Lilien J: Regulated binding of PTPIB-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin. J Cell Biol 134: 801-813, 1996. (Pubitemid 26271335)
5. Bracke ME, van Roy FM and Mareel MM: The E-cadherin/catenin complex in invasion and metastasis. Curr Top Microbiol Immunol 213: 123-161, 1996. (Pubitemid 26165088)
6. Shiozaki H, Oka H, Inoue M, Tamura S and Monden M: Ecadherin mediated adhesion system in cancer cells. Cancer 77 (Suppl. S): 1605-1613, 1996. (Pubitemid 26111841)
7. Shiozaki H, Doki Y, Oka H, Iihara K, Miyata M, Kadowaki T, Matsui S, Tamura S, Inoue M and Mori T: E-cadherin expression and cancer invasion and metastasis. Hum Cell 6: 94-99, 1993.
8. Doki Y, Shiozaki H, Tahara H, Inoue M, Oka H, Iihara K, Kadowaki T, Takeichi M and Mori T: Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line. Cancer Res 53: 3421-3426, 1993. (Pubitemid 23223320)
9. Shiozaki H: Mechanism of the lymph node metastasis in human esophageal cancer (epidermal growth factor causes the dysfunction of cadherin-mediated cell-cell adhesion). Hum Cell 9:31-36,1996.
10. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, Lochner D and Birchmeier W: E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113: 173-185, 1991. (Pubitemid 21909684)
11. Harington KJ and Syrigos KN: The role of E-cadherin-catenin complex: more than an intercellular glue? Ann Surg Oncol 7: 783-788,2001.
12. St. Croix B, Sheehan C, Rak JW, Florenes VA, Slingerland JM and Kerbel RS: E-cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27 (KIP1). J Cell Biol 142:557-571, 1998. (Pubitemid 28361560)
13. Akimoto T, Mitsuhashi N, Saito Y, Ebara T and Niibe H: Effect of radiation on the expression of e-cadherin and alpha-catenin and invasive capacity in human lung cancer cell line in vitro. Int J Radiat Oncol Biol Physics 41: 1171-1176, 1998. (Pubitemid 28377500)
14. Ebara T, Mitsuhashi N, Saito Y, Akimoto T and Niibe H: Change in e-cadherin expression after X-ray irradiation of a human cancer cell line in vitro and in vivo. Int J Radiat Oncol Biol Physics 41: 669-674, 1998. (Pubitemid 28275100)
15. Von Essen CF: Radiation enhancement of metastasis: a review. Clin Exp Metastasis 9: 77-104, 1991.
16. Orsulic S, Huber O, Aberle H, Arnold S and Kemier R: Ecadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1 -mediated transactivation. J Cell Sci 112: 1237-1245, 1999. (Pubitemid 29218912)
17. Bullions LC and Levine AJ: The role of beta-catenin in cell adhesion, signal transduction, and cancer. Curr Opin Oncol 10: 81-87, 1998. (Pubitemid 28039246)
18. Sadot E, Simcha I, Shtutman M, Ben-Ze'ev A and Geiger B: Inhibition of beta-catenin-mediated transactivation by cadherin derivatives. Proc Natl Acad Sci USA 95: 15339-15344, 1998. (Pubitemid 29018700)
19. Morin PJ: Beta-catenin signaling and cancer. Bioessays 21: 1021-1030, 1999.
20. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B and Craig RW: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51: 6304-6311,1991.
21. Cano A, Gamallo C, Kemp C J, Benito N, Palacios J, Quintanilla M and Balmain A: Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient mice. Int J Cancer 65: 254-262, 1996. (Pubitemid 26051688)
22. Bukholm IK, Nesland JM, Karesen R, Jacobsen U, Borresen Dale AL: Expression of E-cadherin and its relation to the p53 protein status in human breast carcinomas. Virchows Arch 431: 317-321, 1997. (Pubitemid 27487526)
23. Charpin C, Garcia S, Bouvier C, Devictor B, Andrac L, Choux R and Lavaut M: E-cadherin quantitative immunocytochemical assays in breast carcinomas. J Pathol 181: 294-300, 1997. (Pubitemid 27156842)
24. Pomp J, Davelaar J, Blom J, Vankrimpen C, Zwinderman A, Quint W and Immerzeel J: Radiotherapy for oesophagus carcinoma - the impact of p53 on treatment outcome. Radiother Oncol 46: 179-184, 1998. (Pubitemid 28109176)
25. Pomp J, Blom J, van Krimpen C, Zwinderman AH and Immerzeel JJ: E-cadherin expression in oesophageal carcinoma treated with high-dose radiotherapy: correlation with pretreatment parameters and treatment outcome. J Cancer Res Clin Oncol 125: 641-645, 1999. (Pubitemid 29502346)
26. Cordon Cardo C, Dalbagni G, Saez GT, Oliva MR, Zhang ZF, Rosai J, Reuter VE and Pellicer A: p53 mutations in human bladder cancer: genotypic versus phenotypic patterns. Int J Cancer 56: 347-353, 1994.
27. Wu H, Lotan R, Menter D, Lippman SM and Xu XC: Expression of E-cadherin is associated with squamous differentiation in squamous cell carcinomas. Anticancer Res 20: 1385-1390, 2001.
28. Umbas R, Isaacs WB, Bringuier PP, Schaafsma HE, Karthaus HF, Oosterhof GO, Debruyne FM and Schalken JA: Decreased Ecadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res 54: 3929-3933, 1994. (Pubitemid 24241218)
29. Ruijter E, Vandekaa C, Aalders T, Ruiter D, Miller G, Debruyne F and Schalken J: Heterogeneous expression of ecadherin and p53 in prostate cancer - clinical implications. Mod Pathol 11:276-281, 1998. (Pubitemid 28131538)
30. Sun Y, Wicha M and Leopold WR: Regulation of metastasis-related gene expression by p53: a potential clinical implication. Mol Carcinog 24: 25-28, 1999. (Pubitemid 29070240)
31. Toschi E, Rota R, Antonini A, Melillo G and Capogrossi MC: Wild-type p53 gene transfer inhibits invasion and reduces matrix metalloproteinase-2 levels in p53-mutated human melanoma cells. J Invest Dermatol 114: 1188-1194, 2000. (Pubitemid 30415238)
32. Wang JL, Sun Y and Wu S: Gamma-irradiation induces matrix metalloproteinase II expression in a p53-dependent manner. Mol Carcinog 27: 252-258, 2000. (Pubitemid 30191994)
33. Mareel M, Bracke M and van Roy F: Cancer metastasis: negative regulation by an invasion-suppressor complex. Cancer Detect Prev 19:451-464, 1995.
34. Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K and Birchmeier W: E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 51: 6328-6337, 1991.
35. Mohri Y: Prognostic significance of E-cadherin expression in human colorectal cancer tissue. Surg Today 27: 606-612, 1997.
36. Hao X, Palazzo JP, Ilyas M, Tomlinson I and Talbot IC: Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma. Anticancer Res 17: 2241-2247, 1997. (Pubitemid 27320976)
37. Dorudi S, Hanby AM, Poulsom R, Northover J and Hart IR: Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome. Br J Cancer 71: 614-616, 1995.
38. Kinsella AR, Lepts GC, Hill CL and Jones M: Reduced E-cadherin expression correlates with increased invasiveness in colorectal carcinoma cell lines. Clin Exp Metastasis 12: 335-342, 1994. (Pubitemid 24257072)
39. Caulin C, Lopez Barcons L, Gonzales Garrigues M, Navarro P, Lozano E, Rodrigo I, Gamallo C, Cano A, Fabra A and Quintanilla M: Suppression of the metastatic phenotype of a mouse skin carcinoma cell line independent of E-cadherin expression and correlated with reduced Ha-ras oncogene. products. Mol Carcinog 15: 104-114, 1996. (Pubitemid 26088824)
40. Van der Wurff AA, Vermeulen SJ, van der Linden EP, Mareel MM, Bosman FT and Arends JW: Patterns of alpha-and beta-catenin and E-cadherin expression in colorectal adenomas and carcinomas. J Pathol 182: 325-330, 1997. (Pubitemid 27285786)
41. Oka H, Shiozaki H, Kobayashi K, Inoue M, Tahara H, Kobayashi T, Takatsuka Y, Matsuyoshi N, Hirano S, Takeichi M, et al: Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 53: 1696-1701, 1993. (Pubitemid 23113254)
42. Takes RP, Baatenburg de Jong RJ, Keuning J, Hermans J, Schuuring E and van Krieken HJ: Protein expression of cancer associated genes: biopsy material compared to resection material in laryngeal cancer. Anticancer Res 18: 4787-4791, 1998. (Pubitemid 29042061)
43. Desai GR, Myerson RJ, Higashikubo R, Birnbaum E, Fleshman J, Fry R, Kodner I, Kucik N, Lacey D and Ribeiro M: Carcinoma of the rectum. Possible cellular predictors of metastatic potential and response to radiation therapy. Dis Colon Rectum 39: 1090-1096, 1996. (Pubitemid 26330516)