Suppression of the metastatic phenotype of a mouse skin carcinoma cell line independent of E-cadherin expression and correlated with reduced levels of Ha-ras oncogene products

Molecular Carcinogenesis

Volumn 15, Issue 2, 1996, Pages 104-114

  Caulin, Carlos ^a,d   López Barcons, Lluis ^c   González Garrigues, Milagro ^c   Navarro, Pilar ^a,e   Lozano, Encarnación ^a   Rodrigo, Isabel ^a   Gamallo, Carlos ^b   Cano, Amparo ^a   Fabra, Angels ^c   Quintanilla, Miguel ^a,f  

^a CSIC   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c Institut de Recerca Oncologica   (Spain)

^d BURNHAM INSTITUTE   (United States)

^e MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^f INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

Carcinogenesis; E cadherin; Epidermis; Keratins; Metastasis; ras

Indexed keywords

CELL RECEPTOR; KERATIN; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; GENE EXPRESSION; HARVEY SARCOMA ONCOVIRUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; METASTASIS; MOUSE; NONHUMAN; ONCOGENE RAS; PHENOTYPE; PRIORITY JOURNAL; SKIN CARCINOMA;

ANIMALS; BLOTTING, NORTHERN; CADHERINS; CELL LINE; CHEMOTAXIS; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE EXPRESSION; GENES, RAS; HARVEY MURINE SARCOMA VIRUS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; LUNG NEOPLASMS; METHIONINE; MICE; MICE, NUDE; NEOPLASM METASTASIS; PHENOTYPE; PROTO-ONCOGENE PROTEINS P21(RAS); RECOMBINANT PROTEINS; RNA, MESSENGER; SKIN NEOPLASMS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; HARVEY MURINE SARCOMA VIRUS; MURINAE; MURINE SARCOMA VIRUS; MUS MUSCULUS; ONCOVIRINAE;

EID: 13344286301     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199602)15:2<104::AID-MC3>3.0.CO;2-J     Document Type: Article

References (39)

1. Stetler-Stevenson WG, Aznavoonan S, Liotta LA Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 9:541-573, 1993.
2. Takeichi M Cadherin cell adhesion receptors as a inorphogenetic regulator. Science 251:1451-1455, 1991.
3. Takeichi M. Cadherins in cancer Implications for invasion and metastasis. Curr Opin Cell Biol 5.806-811, 1993
4. Birchmeier W, Behrens J Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1198:11-26, 1994.
5. Frixen UH, Behrens M, Sachs G, et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113:173-185, 1991
6. Vleminckx K, Vakaet Jr L, Mareel M, Fiers W, Van Roy F Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role Cell 66:107-119, 1991.
7. Boutwell RK. The function and mechanism of promoters of carcinogenesis. Crit Rev Toxicol 2 419-443, 1974.
8. Quintanilla M, Brown K, Ramsden M, Balmain A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis Nature 322 78-80, 1986
9. Brown K, Buchmann A, Balmain A Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression. Proc Natl Acad Sci USA 87.538-542, 1990
10. Bremner R, Balmain A Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity of mouse chromosome 7. Cell 61.407-417, 1990
11. Bianchi AB, Aldaz CM, Conti CJ. Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors Proc Natl Acad Sci USA 87:6902-6906, 1990.
12. Barbacid M Ras genes. Annu Rev Biochem 56.779-827, 1987.
13. Chambers AF, Tuck AB. Ras-responsive genes and tumor metastasis. Crit Rev Oncog 4 95-114, 1993
14. Navarro P, Gömez M, Pizarro A, Gamallo C, Quintanilla M, Cano A A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis. J Cell Biol 115:517-533, 1991.
15. Brown K, Quintanilla M, Ramsden M, Kerr IB, Young S, Balmain A. v-ras genes from Harvey- and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis Cell 46:447-456, 1986
16. Caulin C, Bauluz C, Gandarillas A, Cano A, Quintanilla M Changes in keratin expression during malignant progression of transformed mouse epidermal keratinocytes. Exp Cell Res 204:11-21, 1993
17. 2+ and vitamin A acid in mouse epidermal cell lines. Exp Cell Res 195:183-193, 1991
18. Navarro P, Lozano E, Cano A. Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin. J Cell Sci 105:923-934, 1993.
19. Caulin C, Gandarillas A, Scholl FG, Quintanilla M. Expression of intermediate filament proteins by normal and transformed mouse epidermal keratinocytes in culture Int J Oncol 2:373-379, 1993.
20. Ellis RW, De Feo D, Waryak JM, et al Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus. J Virol 36:408-420, 1980.
21. Larcher F, Bauluz C, Díaz-Guerra M, et al Aberrant expression of the simple epithelial type II keratin 8 by mouse skin carcinomas but not papillomas. Mol Cardnog 6:112-121, 1992
22. Goldfarb MP, Weinberg R Generation of novel, biologically active Harvey sarcoma viruses via apparent illegitimate recombination. J Virol 38:136-150, 1981.
23. Moll R, Franke WW, Schiller DL, Geiger B, Krepler R. The catalog of human cytokeratins: Pattern of expression in normal epithelia, tumors and cultured cells. Cell 31.11-24, 1982.
24. Schweizer J. Murine epidermal keratins. In. Darmon M, Blumenberg M (eds), Molecular Biology of the Skin. The Keratinocyte. Academic Press Inc., San Diego, 1993, pp. 33-78.
25. Díaz-Guerra M, Haddow S, Bauluz C, et al. Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations. Cancer Res 52:680-687, 1992.
26. Nischt R, Roop DR, Mehrel T, et al Aberrant expression during two-stage mouse skin carcinogenesis of a type 147-kDa keratin, K13, normally associated with terminal differentiation of internal stratified epithelia. Mol Carcinog 1:96-108, 1988
27. Hendrix MJC, Seftor EA, Chu YW, et al Coexpression of vimentin and keratins by human melanoma tumor cells Correlation with invasive and metastatic potential. J Natl Cancer Inst 84 165-174, 1992.
28. Chu YW, Runyan RB, Oshima RG. Expression of complete keratin filaments in mouse L cells augments cell migration and invasion Proc Natl Acad Sci USA 90:4261-4265, 1993.
29. Cheng W, Öbrink B Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells. J Cell Biol 114:319-327, 1991
30. Bonfil RD, Vinyals A, Bustuoabad O, et al. Stimulation of angiogenesis as an explanation of Matrigel-enhanced tumorigenicity Int J Cancer 58:233-239, 1994.
31. Dimanche-Boitrel MT, Vakaet Jr L, Pujuguet P, et al. In vivo and in vitro invasiveness of a rat colon-cancer cell line maintaining E-cadherin expression: An enhancing role of tumor-associated myofibroblasts. Int J Cancer 56:512-521, 1994.
32. Kemler R. From cadherins to catenins: Cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet 9 317-321, 1993.
33. Markey AC, Lane EB, Churchill LJ, MacDonald DM, Leigh IM. Expression of simple epithelial keratins K8 and K18 in epidermal neoplasia. J Invest Dermatol 97:763-770, 1991
34. EJ/pSV2neo or pSV2neo genes into rat mammary cells: Rapid stimulation of clonal diversification of spontaneous metastatic and cell-surface properties Oncogene 7.1127-1135, 1992.
35. Brissette JL, Missero C, Yuspa SH, Dotto GP Different levels of v-Ha-ras p21 expression in primary keratinocytes transformed with Harvey sarcoma virus correlate with benign versus malignant behavior Mol Carcinog 7:21-25, 1993.
36. Cheng C, Kilkenny AE, Roop RD, Yuspa SH The v-ras oncogene inhibits the expression of differentiation markers and facilitates expression of cytokeratins 8 and 18 in mouse keratinocytes. Mol Carcinog 3:363-373, 1990
37. 1 and TGF-α in primary keratinocytes and papillomas expressing v-Haras Mol Carcinog 4.210-219, 1991
38. Ha oncogene Cell Growth Differ 4.317-327, 1993
39. 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype. Cell Growth Differ, 6.1027-1035, 1995