Prostate phenotypes in estrogen-modulated transgenic mice

Trends in Endocrinology and Metabolism

Volumn 13, Issue 4, 2002, Pages 163-168

  Jarred, Renea A ^a   McPherson, Stephen J ^a   Bianco, Joseph J ^a   Couse, John F ^b   Korach, Kenneth S ^b   Risbridger, Gail P ^a  

^a MONASH UNIVERSITY   (Australia)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; ESTROGEN; ESTROGEN RECEPTOR; ANDROSTANOLONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONTROLLED STUDY; ENDOCRINE FUNCTION; GENE OVEREXPRESSION; GROWTH; HORMONAL REGULATION; HORMONE ACTION; MALE; MALE GENITAL SYSTEM; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROSTATE; REPRODUCTION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BLOOD; GENETICS; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY; MOUSE MUTANT; ORGAN SIZE; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; AROMATASE; DIHYDROTESTOSTERONE; ESTROGENS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; ORGAN SIZE; PHENOTYPE; PROSTATE; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TESTOSTERONE;

EID: 0036581024     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(02)00575-1     Document Type: Review

References (48)

1. Huggins, C. and Hodges, C.V. (1941) Studies on prostatic cancer. The effect of castration, of estrogen and of androgen interaction on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res. 1, 293-297
2. Cox, R.L. and Crawford, E.D. (1995) Estrogens in the treatment of prostate cancer. J. Urol. 154, 1991-1998
3. Liehr, J.G. (2000) Is estradiol a genotoxic mutagenic carcinogen? Endocr. Rev. 21, 40-54
4. Miller, W. and Sharpe, R. (1998) Environmental oestrogens and human reproductive cancers. Endocr. Relat. Cancer 5, 69-96
5. vom Saal, F.S. et al. (1997) Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc. Natl. Acad. Sci. U. S. A. 94, 2056-2061
6. Prins, G.S. (1992) Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression. Endocrinology 130, 3703-3714
7. Prins, G.S. and Birch, L. (1997) Neonatal estrogen exposure upregulates estrogen receptor expression in the developing and adult rat prostate lobes. Endocrinology 138, 1801-1809
8. Jarred, R.A. et al. (2000) Evidence that estrogens directly alter androgen-regulated prostate development. Endocrinology 141, 3471-3477
9. Tsugaya, M. et al. (1996) Aromatase mRNA levels in benign prostatic hyperplasia and prostate cancer. Int. J. Urol. 3, 292-296
10. Hiramatsu, M. et al. (1997) Aromatase in hyperplasia and carcinoma of the human prostate. Prostate 31, 118-124
11. Matzkin, H. and Soloway, M.S. (1992) Immunohistochemical evidence of the existence and localization of aromatase in human prostatic tissues. Prostate 21, 309-314
12. Lubahn, D.B. et al. (1993) Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc. Natl. Acad. Sci. U. S. A. 90, 11162-11166
13. Krege, J.H. et al. (1998) Generation and reproductive phenotypes of mice lacking estrogen receptor β. Proc. Natl. Acad. Sci. U. S. A. 95, 15677-15682
14. Couse, J.F. and Korach, K. (1999) Estrogen receptor-null mice: what have we learned and where will they lead us? Endocr. Rev. 20, 358-417
15. Dupont, S. et al. (2000) Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes. Development 127, 4277-4291
16. Fisher, C.R. et al. (1998) Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the Cyp19 gene. Proc. Natl. Acad. Sci. U. S. A. 95, 6965-6970
17. Honda, S. et al. (1998) Disruption of sexual behavior in male aromatase-deficient mice lacking exons 1 and 2 of the Cyp19 gene, Biochem. Biophys. Res. Commun. 252, 445-449
18. Nemoto, Y et al. (2000) Altered expression of fatty acid-metabolizing enzymes in aromatase-deficient mice. J. Clin. Invest. 105, 1819-1825
19. McPherson, S.J. et al. (2001) Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland. Endocrinology 142, 2458-2467
20. Li, X. et al. (2001) Altered structure and function of reproductive organs in transgenic male mice overexpressing human aromatase. Endocrinology 142, 2435-2442
21. Sugimura, Y. et al. (1986) Morphogenesis of ductal networks in the mouse prostate. Biol. Reprod. 34, 961-971
22. Prins, G.S. and Birch, L. (1995) The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen. Endocrinology 136, 1308-1314
23. Risbridger. G.P. et al. (2001) The metaplastic effects of estrogen on mouse prostate epithelium: proliferation of cells with basal cell phenotype. Endocrinology 142, 2443-2450
24. Hayashi, N. et al. (1991) Morphological and functional heterogeneity in the rat prostatic gland. Biol. Reprod. 45, 308-321
25. Nemeth, J.A. and Lee. C. (1996) Prostatic ductal system in rats: regional variation in stromal organization. Prostate 28, 124-128
26. Lee, C. et al. (1990) Prostatic ductal system in rats: regional variation in morphological and functional activities. Biol. Reprod. 43, 1079-1086
27. McNeal, J.E. (1980) Anatomy of the prostate: an historical survey of divergent views. Prostate 1, 3-13
28. McNeal, J.E. (1981) The zonal anatomy of the prostate. Prostate 2, 35-49
29. vom Saal, F. et al. (1992) Chemically-induced alterations in sexual and functional development: the wildlife/human connection. In Sexual Differentiation in Mammals (Colburn, T. and Clement, C., eds), pp. 17-83, Princeton Scientific
30. Prins, G.S. et al. (2001) Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor α: studies with αERKO and βERKO mice. Cancer Res. 61, 6089-6097
31. Couse, J.F. et al. (2000) Receptor-null mice reveal contrasting roles for estrogen receptor α and β in reproductive tissues. J. Steroid Biochem. Mol. Biol. 74, 287-296
32. Risbridger, G. et al. (2001) Evidence that epithelial and mesenchymal estrogen receptor-α mediates effects of estrogen on prostatic epithelium. Dev. Biol. 229, 432-442
33. Weihua, Z. et al. (2001)A role for estrogen receptor in the regulation of growth of the ventral prostate. Proc. Natl. Acad. Sci. U. S. A. 98, 6330-6335
34. Couse, J.F. et al. (1999) Postnatal sex reversal of the ovaries in mice lacking estrogen receptors α and β. Science 286, 2328-2331
35. Toda, K. et al. (2001) Oestrogen at the neonatal stage is critical for the reproductive ability of male mice as revealed by supplementation with 17β-estradiol to aromatase gene (Cyp19)-knockout mice. J. Endocrinol. 168, 445-463
36. Eddy, E. et al. (1996) Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology 137, 4796-4805
37. Lindzey, J. et al. (1998) Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-α-knockout mice. Endocrinology 139, 4092-4101
38. Prins, G. (1989) Differential regulation of androgen receptors in the separate rat prostate lobes: androgen independent expression in the lateral lobe. J. Steroid Biochem. 33. 319-326
39. Hayward. S.W. et al. (1996) Stromal development in the ventral prostate, anterior prostate and seminal vesicle of the rat. Acta Anat. 155, 94-103
40. Hayward. S.W. et al. (1996) Epithelial development in the rat ventral prostate, anterior prostate and seminal vesicle. Acta Anat. 155, 81-93
41. Mora, G.R. et al. (1996) Autoregulation of androgen receptor protein and messenger RNA in rat ventral prostate is protein synthesis dependent. J. Steroid Biochem. Mol. Biol. 58, 539-549
42. Robertson, K. et al. (1999) Impairment of spermatogenesis in mice lacking a functional aromatase (Cyp19) gene. Proc. Natl. Acad. Sci. U. S. A. 96, 7986-7991
43. Ahonen, T.J. et al. (1999) Prolactin is a survival factor for androgen-deprived rat dorsal and lateral prostate epithelium in organ culture. Endocrinology 140, 5412-5421
44. Wennbo, H. et al. (1997) Transgenic mice overexpressing the prolactin gene develop dramatic enlargement of the prostate gland. Endocrinology 138, 441.0-4415
45. Maurer, R.A. et al. (1990) Regulation of prolactin gene expression by estradiol. Prog. Clin. Biol. Res. 322, 159-169
46. Scully, K.M. et al, (1997) Role of estrogen receptor-α in the anterior pituitary gland. Mol. Endocrinol. 11, 674-681
47. Prins, G.S. et al. (1996) Age-dependent expression of the androgen receptor gene in the prostate and its implication in glandular differentiation and hyperplasia. Dev. Genet. 18, 99-106
48. Putz, O. et al. (2001) Neonatal low- and high-dose exposure to estradiol benzoate in the male rat: I. Effects on the prostate gland. Biol. Reprod. 65, 1496-1505