Elevated androgens and prolactin in aromatase-deficient mice cause enlargement, but not malignancy, of the prostate gland

Endocrinology

Volumn 142, Issue 6, 2001, Pages 2458-2467

  McPherson, Stephen J ^a   Wang, Hong ^a   Jones, Margaret E ^c   Pedersen, John ^d   Iismaa, Tiina P ^e   Wreford, Nigel ^b   Simpson, Evan R ^c   Risbridger, Gail P ^a  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b Department of Anatomy ^*  (Australia)

^c MONASH UNIVERSITY   (Australia)

^d MELBOURNE PATHOLOGY   (Australia)

^e GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; AROMATASE; PROLACTIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET; ENZYME DEFICIENCY; ESTROGEN DEFICIENCY; HORMONE ACTION; HORMONE DETERMINATION; KNOCKOUT MOUSE; MALE; NONHUMAN; ORGAN GROWTH; PRIORITY JOURNAL; PROSTATE; PROSTATE HYPERTROPHY;

EID: 0035015891     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.6.8079     Document Type: Article

References (38)

1. 1. Quigley CA, De Bellis A, Marschke KB, el-Awady MK, Wilson EM, French FS 1995 Androgen receptor defects: historical, clinical, and molecular perspectives. Endocr Rev 16:271-321
2. 2. Raijfer J, Coffey DS 1979 Effects of neonatal steroids on male sex tissues. Invest Urol 17:3-8
3. 3. Fisher CR, Graves KH, Parlow AF, Simpson ER 1998 Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 95:6965-6970
4. 4. vom Saal FS, Timms BG, Montano MM, Palanza P, Thayer KA, Nagel SC, Dhar MD, Ganjam VK, Parmigiani S, Welshons WV 1997 Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc Natl Acad Sci USA 94:2056-2061
5. 5. Santti R, Newbold RR, Pylkkanen MS, McLachlan JA 1994 Developmental estrogenization and prostatic neoplasia. Prostate 24:67-78
6. 6. Naslund MJ, Coffey DS 1986 The differential effects of neonatal androgen, estrogen and progesterone on adult rat prostate growth. J Urol 136:1136-1140
7. 7. Prins GS 1992 Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression. Endocrinology 130:3703-3714
8. 8. Prins GS, Birch L 1995 The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen. Endocrinology 136:1303-1314
9. 9. Pylkkanen L, Santti R, Newbold R, McLachlan JA 1991 Regional differences in the prostate of the neonatally estrogenized mouse. Prostate 18:117-129
10. 10. Pylkkanen L, Makela S, Valve E, Harkonen P., Toikkanen S, Santti R 1993 Prostatic dysplasia associated with increased expression of c-myc in neonatally estrogenized mice. J Urol 149:1593-1601
11. 11. Cook J, Johnson L, O'Connor J, Biegel L, Krams C, Frame S, Hurtt M 1998 Effects of dietary 17β-estradiol exposure on serum hormone concentrations and testicular parameters in male Cr1:CD BR rats. Toxicol Sci 44:155-168
12. 12. Jarred R, Cancilla B, Prins G, Thayer K, Cunha G, Risbridger G 2000 Evidence that estrogens directly alter androgen regulated prostate development. Endocrinology 141:3471-3477
13. 13. Prins GS, Birch L 1997 Neonatal estrogen exposure up-regulates estrogen receptor expression in the developing and adult rat prostate lobes. Endocrinology 138:1801-1809
14. 14. Singh J, Handelsmann DJ 1999 Imprinting by neonatal sex steroids on the structure and function of the mature mouse prostate. Biol Reprod 61:200-208
15. 15. Simpson ER, Zhao Y, Agarwal VR, Dodson MM, Bulun SE, Hinshelwood MM, Graham-Lorence S, Sun T, Fisher CR, Qin K, Mendelson CR 1997 Aromatase expression in health and disease. Recent Prog Horm Res 52:185-214
16. 16. Meacham S, McLachlan R, deKrester D, Robertson D, Wreford N 1996 Neonatal exposure of rats to recombinant follicle stimulating hormone increases adult sertoli and spermatogenic cell numbers. Biol Reprod 54:36-44
17. 17. O'Donnell L, Stanton F, Wreford N, Robertson D, McLachlan R 1996 Inhibition of 5α-reductase activity impairs the testosterone-dependent restoration of spermiogenesis in adult rats. Endocrinology 137:2703-2710
18. 18. Lopez J, Talamantes F 1983 Secretion kinetics of prolactin and growth hormone by mouse anterior pituitaries in long term organ cultures. Life Sci 32:2103-2106
19. 19. Hayashi N, Sugimura Y, Kawamura J, Donjacour AA, Cunha GR 1991 Morphological and functional heterogeneity in the rat prostatic gland. Biol Reprod 45:308-321
20. 20. Wright A, Douglas R, Thomas L, Lazier C, Rittmaster R 1999 Androgen-induced regrowth in the castrated rat ventral prostate: role of 5α-reductase. Endocrinology 140:4509-4515
21. 21. Wennbo H, Kindblom J, Isaksson OG, Tornell J 1997 Transgenic mice over-expressing the prolactin gene develop dramatic enlargement of the prostate gland. Endocrinology 138:4410-4415
22. 22. Takeyama M, Nagareda T, Takatsuka D, Namiki M, Koizumi K, Aono T, Matsumoto K 1986 Stimulatory effect of prolactin on luteinizing hormone-induced testicular 5α-reductase activity in hypophysectomized adult rats. Endocrinology 118:2268-2275
23. 23. Yamanaka H, Kirdani R, Saroff J, Murphy G, Sandberg A 1975 Effects of testosterone and prolactin on rat prostatic weight, 5α-reductase, and arginase. Am J Physiol 229:1102-1109
24. 24. Prins G 1987 Prolactin influence on cytosol and nuclear androgen receptors in the ventral, dorsal, and lateral lobes of the rat prostate. Endocrinology 120:1457-1464
25. 25. Prins G 1989 Differential regulation of androgen receptors in the separate rat prostate lobes: androgen independent expression in the lateral lobe. J Steroid Biochem 33:319-326
26. 26. Nevalainen M, Valve E, Ingleton P, Nurmi M, Martikainen P, Harkonen P 1997 Prolactin and prolactin receptors are expressed and functioning in human prostate. J Clin Invest 99:618-627
27. 27. Nevalainen M, Valve E, Ahonen T, Yagi A, Paranko J, Harkonen P 1997 Androgen-dependent expression of prolactin in rat prostate epithelium in vivo and in organ culture. FASEB J 11:1297-1230
28. 28. Nevalainen M, Valve E, Makela S, Blauer M, Tuohimaa P, Harkonen P 1991 Estrogen and prolactin regulation of rat dorsal and lateral prostate in organ culture. Endocrinology 129:612-622
29. 29. Leav I, Merk F, Lee K, Loda M, Mandoki M, McNeal J, Ho S 1999 Prolactin receptor expression in the developing human prostate and in hyperplastic, dysplastic, and neoplastic lesions. Am J Pathol 154:863-870
30. 30. Singh J, Handelsman DJ 1999 Morphometric studies of neonatal estrogen imprinting in the mature mouse prostate. J Endocrinol 162:39-48
31. 31. Raijfer J, Coffey DS 1978 Sex steroid imprinting of the immature prostate. Long term effects. Invest Urol 16:186-190
32. 32. Lau K-M, Leav I, Ho S-M 1998 Rat estrogen receptor-α and -β, and progesterone receptor mRNA expression in various prostatic lobes and microdissected normal and dysplastic epithelial tissues of the Noble rats. Endocrinology 139:424-427
33. 33. Ho S, Leav I, Merk F, Yu M, Kwan P, Ziar J 1995 Induction of atypical hyperplasia, apoptosis, and type II estrogen-binding sites in the ventral prostates of Noble rats treated with testosterone and pharmacologic doses of estradiol-17β. Lab Invest 73:356-365
34. 34. Morton MS, Turkes A, Denis L, Griffiths K 1999 Can dietary factors influence prostatic diseases? Br J Urol Int 84:549-554
35. 35. Stephens FO 1997 Phytoestrogens and prostate cancer: possible preventive role. Med J Austr 167:138-140
36. 36. Kuiper GG, Lemmen JG, Carlson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA 1998 Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139:4252-4263
37. 37. Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson J-A, Smithies O 1998 Generation and reproductive phenotypes of mice lacking estrogen receptor β. Proc Natl Acad Sci USA 95:15677-15682
38. 38. Bhatia-Gaur R, Donjacour A, Sciavolino P, Kim M, Desai N, Young P, Norton C, Gridley T, Cardiff R, Cunha G, Abate-Shen C, Shen M 1999 Roles for Nkx3.1 in prostate development and cancer. Genes Dev 13:966-977