Aromatase in hyperplasia and carcinoma of the human prostate

Prostate

Volumn 31, Issue 2, 1997, Pages 118-124

  Hiramatsu, Masayoshi ^a   Maehara, Ikuo ^a   Ozaki, Masahiko ^b   Harada, Nobuhiro ^c   Orikasa, Seiichi ^a   Sasano, Hironobu ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIPPON KAYAKU CO LTD   (Japan)

^c FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

aromatase; carcinoma; estrogen; hyperplasia; prostate

Indexed keywords

AROMATASE; ESTROGEN;

ADULT; AGED; ARTICLE; CANCER STAGING; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; ESTROGEN SYNTHESIS; EXON; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROSTATE HYPERTROPHY; STROMA CELL;

AGED; AGED, 80 AND OVER; AROMATASE; EXONS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; RNA, MESSENGER;

EID: 0030898475     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0045(19970501)31:2<118::AID-PROS7>3.0.CO;2-J     Document Type: Article

References (26)

1. Mobbs BG, Johnson IE, Liu Y: Quantitation of cytosolic and nuclear estrogen and progesterone receptors in benign, untreated, and treated malignant human prostatic tissue by radioligand binding and enzyme-immunoassays. Prostate 16:235-244, 1990.
2. Brolin J, Skoog L, Ekman P: Immunohistochemistry and biochemistry in detection of androgen, progesterone and estrogen receptors in benign and malignant human prostatic tissue. Prostate. 20:281-295, 1992.
3. Partin AW, Oesterling JE, Epstein JI, Horton R, Walsh PC: Influence of age and endocrine factors on the volume of benign prostatic hyperplasia. J Urol 145:405-409, 1991.
4. Santti R, Newbold RR, Makela S, Pylkkanen L, McLachlan JA: Development of estrogenization and prostatic neoplasia. Prostate 24:67-78, 1994.
5. Mendelson CR, Wright EE, Porter JC, Evans CT, Simpson ER: Preparation and characterization of polyclonal and monoclonal antibodies against human aromatase cytochrome P450 (P450arom), and their use in its purification. Arch Biochem Biophys 243:480-491, 1985.
6. Sasano H, Nagura H, Harada N, Goukon Y, Kimura M: Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Hum Pathol 25:530-535, 1994.
7. Watanabe K, Sasano H, Harada N, Ozaki M, Niikura H, Sato S, Yajima A: Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies. Am J Pathol 146:491-500, 1995.
8. Bulun SE, Economos K, Miller D, Simpson ER: CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors. J Clin Endocrinol Metab 79:1831-1834, 1994.
9. Brodie AMH, Son C, King A, Meyer KM, Inkster SE: Lack of evidence for aromatase in human prostatic tissues: Effects of 4-hydroxyandrostenedione and other inhibitors on androgen metabolism. Cancer Res 49:6551-6555, 1989.
10. Matzkin H, Soloway MS: Immunohistochemical evidence of the existence and localization of aromatase in human prostatic tissues. Prostate 21:309-314, 1992.
11. DiSalle E, Briatico G, Giudici D, Ornati G: Novel aromatase and 5 alpha-reductase inhibitors. J Steroid Biochem Mol Biol 49:289-294, 1994.
12. Gingell JC, Knönagel H, Kurth KH, Tunn UW, the Schering 90.062 Study: Placebo controlled double-blind study to test the efficacy of the aromatase inhibitor atamestane in patients with benign prostatic hyperplasia not requiring operation. J Urol 154: 399-401, 1995.
13. Japanese Urological Association: "General Rule for Clinical and Pathological Studies on Prostatic Cancer." 2nd Ed. Japanese Pathological Society, 1992.
14. Harada N: Novel properties of human placental aromatase cytochrome P450: Purification and characterization of a unique form of aromatase. J Biochem (Tokyo) 103:106-112, 1988.
15. Thompson EA Jr, Siiteri PK: Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione. J Biol Chem 249:5364-5372, 1974.
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275, 1951.
17. Harada N, Utsumi T, Takagi Y: Molecular and epidemiological analysis of abnormal expression of aromatase in breast cancer. Pharmacogenetics 5:S59-64, 1995.
18. Chirgwin JM, Przybla AE, MacDonald KJ, Utter WJ: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299, 1979.
19. Harada N, Yamada K, Foidart A, Balthazart J: Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone. Mol Brain Res 15:19-26, 1992.
20. Harada N, Yamada K: Ontogeny of aromatase messenger ribonucleic acid in mouse brain: Fluorometrical quantitation by polymerase chain reaction. Endocrinology 131:2306-2312, 1992.
21. Harada N, Utsumi T, Takagi Y: Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exons 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis. Proc Natl Acad Sci USA 90:11312-11316, 1993.
22. Kaburagi Y, Marino MB, Kirdani RY, Greco JP, Karr JP, Sandberg AA: The possibility of aromatization of androgen in human prostate. J Steroid Biochem 26:739-742, 1987.
23. Stone NN, Fair WR, Fishman J: Estrogen formation in human prostatic tissue from patients with and without benign prostatic hyperplasia. Prostate 9:311-318, 1986.
24. Smith T, Chisholm GD, Habib FK: Failure of human prostatic hyperplasia to aromatize testosterone. J Steroid Biochem 17:119-120, 1982.
25. Bulun SE, Simpson ER: Regulation of aromatase expression in human tissues. Breast Cancer Res Treat 30:19-29, 1994.
26. Mahendroo MS, Means GD, Mendelson CR, Simpson ER: Tissue-specific expression of human P450arom: The promoter responsible for expression in adipose tissue is different from that utilized in placenta. J Biol Chem 266:11276-11281, 1991.