Initial conditions of serotonin transporter kinetics and genotype: Influence on SSRI treatment trial outcome

Biological Psychiatry

Volumn 51, Issue 9, 2002, Pages 723-732

  Rausch, Jeffrey L ^a,b   Johnson, Maria E ^a   Fei, You Jun ^a   Li, Jun Qing ^a   Shendarkar, Nitin ^a   Mac Hobby, Henry ^a   Ganapathy, Vadivel ^a   Leibach, Fred H ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

5 HT transport kinetics; 5 HTT; Antidepressants; Depression; Dose; Fluoxetine; Genetics; Serotonin; Serotonin transporter; SERT; SSRI; Treatment response

Indexed keywords

FLUOXETINE; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGED; ALLELE; ARTICLE; BLOOD ANALYSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RANDOMIZED CONTROLLED TRIAL; TRANSPORT KINETICS; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; CARRIER PROTEINS; DEPRESSIVE DISORDER; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUOXETINE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; TREATMENT OUTCOME;

EID: 0036569623     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(01)01283-5     Document Type: Article

References (48)

1. Autosomal recessive inheritance of affective disorders in families of responders to lithium prophylaxis?
2. Antidepressiver Effekt and Genetische Faktoren
3. Biological predictors of antidepressant treatment outcome
4. Fluoxetine: Relationships among dose, response, adverse events, and plasma concentrations in the treatment of depression
5. Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression
6. Molecular physiology of norepinephrine and serotonin transporters
7. Regulated phosphorylation and trafficking of antidepressant-sensitive serotonin transporter proteins
8. The statistical analysis of enzyme kinetic data
9. Stress-induced changes of extracellular 5-hydroxyindoleacetic acid concentrations followed in the nucleus raphe dorsalis and the frontal cortex of the rat
10. A novel functional polymorphism within the promoter of the serotonin transporter gene: Possible role in susceptibility to affective disorders
11. Predictive value of two endogenicity measures
12. A molecular and cellular theory of depression
13. Anxious depression in elderly patients. Response to antidepressant treatment
14. Role of serotonin in therapy of depression and related disorders
15. Clinical predictors of response to antidepressants in elderly patients
16. Prediction of response to nortriptyline and phenelzine by platelet MAO activity
17. Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene
18. Allelic variation of human serotonin transporter gene expression
19. Predictors of drug response in depression
20. Fluoxetine in patients with major depressive disorder-a responder analysis
21. Organization of the human serotonin transporter gene
22. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
23. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
24. Primary structure of the human platelet serotonin uptake site: Identity with the brain serotonin transporter
25. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels
26. Effect of antidepressant treatment on platelet 5-HT content and relation to therapeutic outcome in unipolar depressive patients
27. Predictors of hospital outcome without antidepressants in major depression
28. Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF)
29. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants
30. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
31. Pharmacogenetic response to antidepressants in a multicase family with affective disorder
32. Differentiation of two genetically specific types of depression by the response to antidepressant drugs
33. Differentiation of two genetically specific types of depression by the response to antidepressant treatment
34. Les Methodes Nouvelles de la Mecanique Celeste (New Methods of Celestrial Mechanics)
35. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression
36. Construction of human gene libraries from small amounts of peripheral blood: Analysis of B-like globin genes
37. Antidepressants, metabolites, and apparent drug resistance
38. Antidepressant- and cocaine-sensitive human serotonin transporter: Molecular cloning, expression, and chromosomal localization
39. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants
40. Biosynthesis, N-glycosylation, and surface trafficking of biogenic amine transporter proteins
41. An Hypothesis of Initial Conditions: Receptor-Effector Systems as Determinants of Psychopharmacologic Drug Response
42. Fluvoxamine treatment of mixed anxiety and depression: Evidence for serotonergically mediated anxiolysis
43. Correlations of drug action between human platelet and human brain 5-HTT
44. Prediction of early nortriptyline response
45. Pretreatment orthostatic hypotension as a predictor of response to nortriptyline in geriatric depression
46. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine
47. Low-dose fluoxetine therapy for depression