Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides

Journal of Immunology

Volumn 168, Issue 9, 2002, Pages 4282-4286

  Berwin, Brent ^a   Hart, Justin P ^a   Pizzo, Salvatore V ^a   Nicchitta, Christopher V ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; GLYCOPROTEIN GP 96; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL SURFACE; CONTROLLED STUDY; ENDOCYTOSIS; INTERNALIZATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; T LYMPHOCYTE;

EID: 0036569356     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.9.4282     Document Type: Article

References (39)

1. Cutting edge: Tumor-secreted heat shock-fusion protein elicits CD8 cells for rejection
2. Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity
3. Heat shock protein-peptide complexes in cancer immunotherapy
4. Individually distinct transplantation antigens of chemically induced mouse tumors
5. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations
6. The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor
7. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway
8. Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis
9. Heat shock proteins: The "Swiss army knife" vaccines against cancers and infectious agents
10. The endoplasmic reticulum-resident stress protein gp96 binds peptides translocated by TAP
11. GRP94, an ER chaperone with protein and peptide binding properties
12. CD91: A receptor for heat shock protein gp96
13. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin
14. 2-macroglobulin, an independent ligand for the heat shock protein receptor CD91
15. 2-Macroglobulin, complement, and biologic defense: Antigens, growth factors, microbial proteases, and receptor ligation
16. 2-macroglobulin receptor
17. Role of RAP in the biogenesis of lipoprotein receptors
18. 2-macroglobulin receptor/low density lipoprotein receptor-related protein: Multiple regulatory sites for 39-kDa receptor-associated protein
19. 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein
20. Purification and partial molecular characterization of GRP94, an ER resident chaperone
21. 2-macroglobulin
22. 2M signaling receptor
23. Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages
24. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity
25. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides
26. Transfer of GRP94(gp96)-associated peptides onto endosomal MHC class I molecules
27. Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal Ab
28. Structures and functions of multiligand lipoprorein receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP)
29. Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A: Evidence that this protein is required for uptake and degradation of multiple ligands
30. Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma
31. 1 in the RAW 264.7 macrophage-like cell line
32. Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein
33. 2-macroglobulin receptor
34. α-macroglobulins: Enzyme-binding proteins modulating lymphocyte function
35. 2-macroglobulin: Evidence for a novel nascent state
36. 2-macroglobulin receptor
37. 2-macroglobulin signalling receptor on macrophages induces protein phosphorylation and an increase in cytosolic pH
38. 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages
39. 2-macroglobulin signaling receptor