Heat shock proteins: The 'Swiss Army Knife' vaccines against cancers and infectious agents

Vaccine

Volumn 19, Issue 17-19, 2001, Pages 2590-2597

  Srivastava, Pramod K ^a   Amato, Robert J ^b  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cancer; Heat shock protiens; Infectious diseases

Indexed keywords

CANCER VACCINE; CELL RECEPTOR; CHAPERONE; CYTOKINE; HEAT SHOCK PROTEIN; IMMUNOLOGICAL ADJUVANT; PEPTIDE;

ANTIGEN PRESENTING CELL; ANTIGENICITY; CANCER; CANCER IMMUNOTHERAPY; CELL DEATH; CELL INTERACTION; CELL MATURATION; CLINICAL TRIAL; CONFERENCE PAPER; CYTOKINE RELEASE; DENDRITIC CELL; DRUG MECHANISM; DRUG SPECIFICITY; HUMAN; IMMUNOGENICITY; IMMUNOSTIMULATION; INFECTION; LEUKOCYTE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; TUMOR IMMUNITY; VACCINE PRODUCTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN-PRESENTING CELLS; CANCER VACCINES; COMMUNICABLE DISEASE CONTROL; COMMUNICABLE DISEASES; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOTHERAPY; NECROSIS; NEOPLASMS;

EID: 0035925608     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00492-8     Document Type: Conference Paper

References (68)

1. Individually distinct transplantation antigens of chemically induced mouse tumors
2. Expression of activated H-rasval12 in non-tumorigenic and non-cross-reactive syngeneic cells induces tumor antigens cross-reactive with rat mammary adenocarcinoma 13762
3. Immunogenicity and cross-reactivity of syngeneic murine melanomas
4. Cancer, differentiation and embryonic antigens: Some central problems
5. Cancer immunology: The search for specificity - G.H.A. Clowes Memorial lecture
6. A unique tumor antigen produced by a single amino acid substitution
7. Human tumor antigens recognized by T lymphocytes
8. A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma
9. A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes
10. Mutated mitogen-activated protein kinase: A tumor rejection antigen of mouse sarcoma
11. Heat shock proteins come of age: Primitive functions acquire new roles in an adaptive world
12. Calreticulin, a peptide-binding chaperone of the enoplasmic reticulum, elicits tumor- and peptide-specific immunity
13. Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70
14. Peptide-binding heat shock proteins in the endoplasmic reticulum: Role in immune response to cancer and in antigen presentation
15. Tumor-specific immunogenicity of stress-induced proteins: Convergence of two evolutionary pathways of antigen presentation?
16. Stress-induced proteins in immune response to cancer
17. Tumor rejection antigen gp96/grp94 is an ATPase: Implications for protein folding and antigen presentation
18. Heat shock protein 70-associated peptides elicit specific cancer immunity
19. Structural analysis of substrate binding by the molecular chaperone DnaK
20. Interaction of endoplasmic reticulum chaperone GRP94 with peptide substrates is adenine nucleotide-independent
21. Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum hsp90 chaperone GRP94
22. Identification of the peptide-binding site in the heat shock chaperone/tumor rejection antigen gp96 (Grp94)
23. Molecular mechanisms of peptide loading by the tumor rejection antigen/heat shock chaperone gp96 (GRP94)
24. Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence
25. Crystal structure of an Hsp90-geldanamycin complex: Targeting of a protein chaperone by an anti-tumor agent
26. Identification and structural characterization of the AYP/ADP-binding site in the hsp90 molecular chaperone
27. A molecular clamp in the crystal structure of the N-terminal domain of the yeast hsp90-chaperone
28. Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96
29. Influences of transporter associated with antigen processing (TAP) on the repertoire of peptides associated with the endoplasmic reticulum-resident stress protein gp96
30. Isolation of an immunodominant viral peptide that is endogenously bound to the stress protein GP96/GRP94
31. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity
32. Synthetic peptides non-covalently bound to bacterial hsp 70 elicit peptide-specific T-cell responses in vivo
33. Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70
34. Mutations of mitotic checkpoint genes in human cancers
35. Do human cancers express shared protective antigens? or the necessity of remembrance of things past
36. Differential recognition of murine tumor-associated oncofetal transplantation antigen and individually specific tumor transplantation antigens by syngeneic cloned BALB/c and RFM mouse T cells
37. T cell costimulation by B7/BB1 induces CD8 T cell-dependent tumor rejection: An important role of B7/BB1 in the induction, recruitment, and effector function of antitumor T cells
38. The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product
39. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
40. Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations
41. Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96
42. Immunization of cancer patients with autologous cancer-derived heat shock protein gp96: A pilot study
43. Active specific immunotherapy in patients with renal cell carcinoma (RCC) using autologous tumor derived heat shock protein-peptide complex-96 (HSPPC-96) vaccine
44. Active specific immunotherapy in patients with renal cell carcinoma (RCC) using autologous tumor derived heat shock protein-peptide complex-96 (HSPP-96) vaccine
45. Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients (PTS) with metastatic melanoma
46. Heat shock protein vaccines against cancer
47. Generation of heat shock protein-based vaccines by intracellular loading of gp96 with antigenic peptides
48. A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides
49. Immunization with a lymphocytic choriomeningitis virus peptide mixed with heat shock protein 70 results in protective antiviral immunity and specific cytotoxic T lymphocytes
50. Heat shock proteins transfer peptides during antigen processing and CTL priming
51. Minor H antigens introduced on H-2 different stimulating cells cross react at the cytotoxic T cell level during in vivo priming
52. Mycobacterial heat shock proteins as carrier molecules
53. Mycobacterial heat shock proteins as carrier molecules II: The use of the 70 kda mycobacterial heat shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and BCG priming
54. Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway
55. Cellular requirements for tumor-specific immunity elicited by heat shock proteins: Tumor rejection antigen gp96 primes CD8+ T cells in vivo
56. Cutting edge: Receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells
57. Cross-presentation of glycoprotein 96-associated antigens on major histocompatibility complex class I molecules requires receptor-mediated endocytosis
58. Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages
59. Events involved in re-presentation of heat shock protein-chaperoned peptides
60. CD91: A receptor for heat shock protein gp96
61. Receptor-mediated uptake of Antigen/Heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways
62. Heat shock proteins as novel mediators of cytokine secretion by macrophages
63. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NKκB pathway
64. Hsp70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine
65. News and Views: gp96 is the Swiss army knife of the immune system
66. Immunity and Invertebrates
67. The invertebrate phagocytic immunocyte: Clues to a common evolution of immune and neuroendocrine systems
68. Tolerance, danger, and the extended family