Receptor mediated and fluid phase pathways for internalization of the ER Hsp90 chaperone GRP94 in murine macrophages

Journal of Cell Science

Volumn 112, Issue 13, 1999, Pages 2167-2175

  Wassenberg, James J ^a   Dezfulian, Cameron ^a   Nicchitta, Christopher V ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

gp96; GRP94; Macrophage; Macropinocytosis; Receptor mediated endocytosis

Indexed keywords

5 (N,N DIMETHYL)AMILORIDE; CHAPERONE; HEAT SHOCK PROTEIN 90; MANNAN; MEMBRANE RECEPTOR; TRANSFERRIN;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CONTROLLED STUDY; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ENDOSOME; INTERNALIZATION; LYSOSOME; MACROPHAGE; MEMBRANE BINDING; MOUSE; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; BIOLOGICAL TRANSPORT, ACTIVE; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; IMMUNIZATION; MACROPHAGES, PERITONEAL; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MOLECULAR CHAPERONES; RECEPTORS, CELL SURFACE; SUBCELLULAR FRACTIONS; T-LYMPHOCYTES, CYTOTOXIC;

ANIMALIA; MURINAE;

EID: 0032856673     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Arnold, D., Faath, S., Rammensee, H.-G. and Schild, H. (1995). Cross-priming of histocompatability antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96. J. Exp. Med. 182, 885-889.
2. Bevan, M. J. (1987). Antigen recognition. Class discrimination in the world of immunology. Nature 325, 192-193.
3. Bevan, M. J. (1995). Antigen presentation to cytotoxic T lymphocytes in vivo. J. Exp. Med. 182, 639-641.
4. Brossart, P. and Bevan, M. J. (1997). Presentation of exogenous protein antigens on major histocompatibility complex class I molecules by dendritic cells: pathway of presentation and regulation by cytokines. Blood 90, 1594-1599.
5. Carbone, F. R., Kurts, C., Bennett, S. R. M., Miller, J. F. A. P. and Heath, W. R. (1998). Cross-presentation: a general mechanism for CTL immunity and tolerance. Immunol. Today 19, 103-109.
6. Harding, C. V. and Song, R. (1994). Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules. J. Immunol. 53, 4925-4933.
7. Harding, C. V. (1996). Class I MHC presentation of exogenous antigens. J. Clin. lmmunol. 16, 90-96.
8. Heemels, M.-T. and Ploegh, H. (1995). Generation, translocation and presentation of MHC Class I restricted peptides. Annu. Rev. Biochem. 64, 463-491.
9. Kovacsovics-Bankowski, M. and Rock, K. L. (1995). A phagosome-to-cytosol pathway for exogenous anatigens presented on class I MHC molecules. Science 267, 243-246.
10. Matzinger, P. and Bevan, M. J. (1977). Induction of H-2-restricted cytotoxic T cells: in vivo induction has the appearance of being unrestricted. Cell. Immunol. 33, 92-100.
11. Matzinger, P. (1994). Tolerance, danger and the extended family. Annu. Rev. Immunol. 12, 991-1045.
12. Miesenböck, G. and Rothman, J. E. (1995). The capacity to retrieve escaped ER proteins extends to the trans-most cisterna of the Golgi stack. J. Cell Biol. 129, 309-319.
13. Mitchell, D. A., Nair, S. K. and Gilboa, E. (1998). Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells. Eur. J. Immunol. 28, 1923-1933.
14. Moore, M. W., Carbone, F. R. and Bevan, M. J. (1988). Introduction of soluble protein into class I pathway of antigen processing and presentation. Cell 54, 777-785.
15. Nair, S., Wearsch, P., Mitchell, D. A., Wassenberg, J. J., Gilboa, E. and Nicchitta, C. V. (1999). Careticulin displays in vivo peptide binding activity and can elicit cytotoxic T lymphocyte responses against bound peptides. J. Immunol. 162, 6426-6432.
16. Nicchitta, C. V. (1998). Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94. Curr. Opin. Immunol. 10, 103-109.
17. Norbury, C., Hewlett, L. J., Prescott, A. R., Shastri, N. and Watts, C. (1995). Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages. Immunity 3, 789-791.
18. Norbury, C., Chamber, B. J., Prescott, A. R., Ljunggren, H.-G. and Watts, C. (1997). Constitutive macropinocytosis allows TAP-dependent major histocompatability complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells. Eur. J. Immunol. 27, 280-288.
19. Ortmann, B., Copeman, J., Lehner, P. J., Sadasivan, B., Herberg, J. A., Grandea, A. G., Riddell, S. R., Tampe, R., Spies, T., Trowsdale, J. and Cressell, P. (1997). A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes. Science 277, 1306-1309.
20. Pfeifer, J. D., Wick, M. J., Roberts, R. L., Findlay, K. F., Normark, S. J. and Harding, C. V. (1993). Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature 361, 359-362.
21. Reis e Sousa, C. and Germain, R. (1995). Major histocompatability complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis. J. Exp. Med. 182, 841-851.
22. Sadasivan, B., Lehner, P. J., Ortmann, B., Spies, T. and Cressell, P. (1996). Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. Cell 5, 103-114.
23. Sallusto, F., Cella, M., Danieli, C. and Lanzavecchia, A. (1995). Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatability complex class II compartment: Downregulation by cytokines and bacterial products. J. Exp. Med. 182, 389-400.
24. Sandvig, K. and Van Duers, B. (1996). Endocytosis, intracellular transport and cytotoxic action of Shiga toxin and ricin. Physiol. Rev. 76, 949-966.
25. Solheim, J. C., Harris, M. R., Kindle, C. S. and Hansen, T. H. (1997). Prominence of beta 2-microglobulin, class I heavy chain conformation and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing. J. Immunol. 158, 2236-2241.
26. Srivastava, P. K., Udono, H., Blachere, N. E. and Li, Z. (1994). Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics 39, 93-98.
27. Srivastava, P. K., Menoret, A., Basu, S., Binder, R. J. and McQuade, K. L. (1998). Heat shock proteins come of age: primative functions acquire new roles in an adaptive world. Immunity 8, 657-665.
28. Stahl, P., Schelsinger, P. H., Sigardson, E., Rodman, J. J. and Lee, Y. C. (1980). Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: characterization and evidence for receptor recycling. Cell 19, 207-215.
29. Suto, R. and Srivastava, P. K. (1995). A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 269, 1585-1588.
30. Swanson, J. A. (1989). Phorbol esters stimulate macropinocytosis and soute flow through macrophates. J. Cell. Sci. 94, 135-142.
31. Swanson, J. A. and Watts, C. (1995). Macropinocytosis. Trends Cell Biol. 5, 424-428.
32. Udono, H., Levy, D. L. and Srivastava, P. K. (1994). Cellular requirements for tumor-specific immunity elicited by heat shock proteins: Tumor rejection antigen gp96 primes CD8+ T cells in vivo. Proc. Nat. Acad. Sci. USA 91, 3077-3081.
33. Walden, P. R. and Eisen, H. N. (1990). Cognate peptides induce self-destruction of CD8+ cytotoxic T lymphocytes. Proc. Nat. Acad. Sci. USA 87, 9015-9019.
34. Watts, C. (1997). Capture and processing of exogenous antigens for presentation on MHC molecules. Annu. Rev. Immunol. 15, 821-850.
35. Wearsch, P. A. and Nicchitta, C. V. (1996). Purification and partial molecular characterization of GRP94, an ER resident chaperone. Prot. Express. Purif. 7, 114-121.
36. 2+-ionophore regulated proteins. J. Biol. Chem. 258, 7102-7111.
37. West, M. A., Bretscher, M. S. and Watts, C. (1989). Distinct endocytic pathways in epidermal growth factor-stimulated human carcinoma. A431 cells. J. Cell Biol. 109, 2731-2739.
38. York, I. A. and Rock, K. L. (1996). Antigen processing and presentation by the class I major histocompatability complex. Annu. Rev. Immunol. 14, 369-396.