Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure

Kidney International

Volumn 52, Issue 2, 1997, Pages 495-502

  Guttormsen, Anne B ^a   Ueland, Per M ^b   Svarstad, Einar ^b   Refsum, Helga ^b  

^a UNIVERSITY OF BERGEN   (Norway)

^b NONE

Author keywords

Cardiovascular disease; Chronic renal failure; Clearance; Folic acid; Homocysteine

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; BIOAVAILABILITY; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; KIDNEY CLEARANCE; KINETICS; MALE; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0030832486     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1997.359     Document Type: Article

References (40)

1. BOUSHEY CJ, BERESFORD SAA, OMENN GS, MOTULSKY AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes. JAMA 274:1049-1057, 1995
2. STAMPFER MJ, MALINOW MR, WILLETT WC, NEWCOMER LM, UPSON B, ULLMANN D, TISHLER PV, HENNEKENS CH: A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in United States physicians. JAMA 268:877-881, 1992
3. ARNESEN E, REFSUM H, BØNAA KH, UELAND PM, FØRDE OH, NORDREHAUG JE: Serum total homocysteine and coronary heart disease. Int J Epidemiol 24:704-709, 1995
4. PERKY IJ, REFSUM H, MORRIS RW, EBRAHIM SB, UELAND PM, SHAPER AG: Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 346: 1395-1398, 1995
5. UELAND PM, REFSUM H, STABLER SP, MALINOW MR, ANDERSSON A, ALLEN RH: Total homocysteine in plasma or serum. Methods and clinical applications. Clin Chem 39:1764-1779, 1993
6. ALLEN LH, CASTERLINE J: Vitamin B-12 deficiency in elderly individuals: Diagnosis and requirements. Am J Clin Nutr 60:12-14, 1994
7. FINKELSTEIN JD: Methionine metabolism in mammals. J Nutr Biochem 1:228-237, 1990
8. CHAUVEAU P, CHADEFAUX B, COUDÉ M, AUPETIT J, HANNEDOUCHE T, KAMOUN P, JUNGERS P: Hyperhomocysteinemia, a risk factor for atherosclerosis in chronic uremic patients. Kidney Int 41(Suppl 43): S72-S77, 1993
9. BRATTSTRÖM L, LINDGREN A, ISRAELSSON B, ANDERSSON A, HULTBERG B: Homocysteine and cysteine: Determinants of plasma levels in middle-aged and elderly subjects. J Intern Med 236:633-641, 1994
10. ARNADOTTIR M, HULTBERG B, NILSSON-EHLE P, THYSELL H: The effect of reduced glomerular filtration rate on plasma total homocysteine concentration. Scand J Clin Lab Invest 56:41-46, 1996
11. REFSUM H, HELLAND S, UELAND PM: Radioenzymic determination of homocysteine in plasma and urine. Clin Chem 31:624-628, 1985
12. GUTTORMSEN AB, SCHNEEDE J, UELAND PM, REFSUM H: Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate and cobalamin deficiency. Am J Clin Nutr 63:194-202, 1996
13. BOSTOM A, BROSNAN JT, HALL B, NADEAU MR, SELHUB J: Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis 116:59-62, 1995
14. GUTTORMSEN AB, MANSOOR MA, FISKERSTRAND T, UELAND PM, REFSUM H: Kinetics of plasma homocysteine in healthy subjects after peroral homocysteine loading. Clin Chem 39:1390-1397, 1993
15. CHRISTENSEN B, UELAND PM: Methionine synthase inactivation by nitrous oxide during methionine loading of normal human fibroblasts. Homocysteine remethylation as determinant of enzyme inactivation and homocysteine export. J Pharmacol Exp Ther 267:1298-1303, 1993
16. FRIEDMAN JA, DWYER JT: Hyperhomocysteinemia as a risk factor for cardiovascular disease in patients undergoing hemodialysis. Nutr Rev 53:197-201, 1995
17. WILCKEN DEL, DUDMAN NPB, TYRRELL PA, ROBERTSON MR: Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: Possible implications for prevention of vascular disease. Metabolism 37:697-701, 1988
18. COCKROFT DW, GAULT H: Prediction of creatinine clearance from serum creatinine. Nephron 16:31-41, 1976
19. TROLLFORS B, ALESTIG K, JAGENBURG R: Prediction of glomerular filtration rate from serum creatinine, age, sex and body weight. Acta Med Scand 221:495-498, 1987
20. FISKERSTRAND T, REFSUM H, KVALHEIM G, UELAND PM: Homocysteine and other thiols in plasma and urine: Automated determination and sample stability. Clin Chem 39:263-271, 1993
21. REFSUM H, UELAND PM, SVARDAL AM: Fully automated fluorescence assay for determining total homocysteine in plasma. Clin Chem 35:1921-1927, 1989
22. KRISHNAMURTI CR, HEINDZE AM, GALZY G: Application of reversed-phase high-performance liquid chromatography using pre-column derivatization with o-phthaldialdehyde for the quantitative analysis of amino acids in adult and fetal sheep plasma, animal feeds and tissues. J Chromatogr 315:321-331, 1984
23. ULVIK A, REFSUM H, KLUIJTMANS LAJ, UELAND PM: C677T mutation of methylenetetrahydrofolate reductase gene determined in blood or plasma by multiple-injection capillary electrophoresis and laser-induced fluorescence detection. Clin Chem 43:261-272, 1997
24. YAMAOKA K, NAKAGAWA T, UNO T: Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacokinet Biopharm 6:165-175, 1978
25. WELLING PG: Pharmacokinetics. Processes and mathematics. ACS Monographs 185:290, 1986
26. ROWLAND M, TOZER TN: Clinical pharmacokinetics. Concepts and Applications, Philadelphia, Lea & Febiger, 1989
27. GREENBLATT DJ, KOCH-WESER J: Drug therapy. Clinical pharmacokinetics (first of two parts). N Engl J Med 293:702-705, 1975
28. UELAND PM: Homocysteine species as components of plasma redox thiol status. Clin Chem 41:340-342, 1995
29. NYGÅRD O, VOLLSET SE, REFSUM H, STENSVOLD I, TVERDAL A, NORDREHAUG JE, UELAND PM, KVÅLE G: Total plasma homocysteine and cardiovascular risk profile: The Hordaland Homocysteine Study. JAMA 274:1526-1533, 1995
30. ROBINS AJ, MILEWCZYK EM, BOOTH EM, MALLICK NP: Plasma amino acid abnormalities in chronic renal failure. Clin Chim Acta 42:215-217, 1972
31. SORIA C, CHADEFAUX B, COUDÉ M, GAILLARD O, KAMOUN P: Concentrations of total homocysteine in plasma in chronic renal failure. Clin Chem 36:2137-2138, 1990
32. DENNIS VW, ROBINSON K: Homocysteinemia and vascular disease in end-stage renal disease. Kidney Int 50(Suppl 57):S11-S17, 1996
33. BOSTOM AG, LATHROP L: Hyperhomocysteinemia in end-stage renal disease (ESRD): Prevalence, etiology, and potential relationship to arteriosclerotic outcomes. Kidney Int (in press)
34. TIZIANELLO A, FERRARI GD, GARIBOTTO G, GURRERI G, ROBAUDO C: Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest 65:1162-1173, 1980
35. DRUML W, FISCHER M, LIEBISCH B, LENZ K, ROTH E: Elimination of amino acids in renal failure. Am J Clin Nutr 60:418-423, 1994
36. ARNADOTTIR M, BRATTSTRÖM L, SIMONSEN O, THYSELL H, HULTBERG B, ANDERSSON A, NILSSON-EHLE P: The effect of high-dose pyridoxine and folic acid supplementation on serum lipid and plasma homocysteine concentrations in dialysis patients. Clin Nephrol 40:236-240, 1993
37. BOSTOM AG, SHEMIN D, LAPANE KL, HUME AL, YOBURN D, NADEAU MR, BENDICH A, SELHUB J, ROSENBERG IH: High dose B-vitamin treatment of hyperhomocysteinemia in dialysis patients. Kidney Int 49:147-152, 1996
38. CHAUVEAU P, CHADEFAUX B, COUDÉ M, AUPETIT J, KAMOUN P, JUNGERS P: Long-term folic acid (but not pyridoxine) supplementation lowers elevated plasma homocysteine level in chronic renal failure. Miner Electrol Metab 22:106-109, 1996
39. BOCOCK MA, ZLOTKIN SH: Hepatic sulfur amino acid metabolism in rats with chronic renal failure. J Nutr 120:691-699, 1990
40. VAN GULDENER C, JANSSEN MJFM, STEHOUWER CDA, DONKER AJM: Estimation of renal homocysteine extraction in patients with normal renal function. (abstract) Nephrol Dial Transplant 11:A228, 1996