Treatment of hyperhomocysteinemia in renal transplant recipients. A randomized, placebo-controlled trial

Annals of Internal Medicine

Volumn 127, Issue 12, 1997, Pages 1089-1092

  Bostom, Andrew G ^a   Gohh, Reginald Y ^b   Beaulieu, Andrew J ^b   Nadeau, Marie R ^c   Hume, Anne L ^a   Jacques, Paul F ^c   Selhub, Jacob ^c   Rosenberg, Irwin H ^c  

^a MEMORIAL HOSPITAL OF RHODE ISLAND   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

^c TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 0031434837     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-127-12-199712150-00006     Document Type: Article

References (16)

1. Boushey CJ, Beresford SA, Omen GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995;274:1049-57.
2. Kasiske BL, Guijarro C, Massy Z, Wiederkehr MR, Ma JZ. Cardiovascular disease after renal transplantation. J Am Soc Nephrol. 1996;7:158-65.
3. Bostom AG, Gohh RY, Tsai MY, Hopkins-Garcia BJ, Nadeau MR, Bianchi LA, et al. Excess prevalence of fasting and PML hyperhomocysteinemia in stable renal transplant recipients. Arterioscl Thromb Vase Biol. 1997;17:1894-900.
4. Ubbink JB, Vermaak WJ, van der Merwe A, Becker PJ, Delport R, Potgieter HC. Vitamin requirements for the treatment of hyperhomocystinemia in humans. J Nutr. 1994;124:1927-33.
5. Naurath HJ, Joosten E, Riezler R, Stabler SP, Allen RH, Lindenbaum J. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. Lancet. 1995;346:85-9.
6. Wilcken DE, Gupta VJ, Betts AK. Homocysteine in the plasma of renal transplant recipients: effects of cofactors for methionine metabolism. Clin Sci. 1981;61:743-9.
7. Araki A, Sako Y. Determination of free and homocysteine in human plasma by high performance liquid chromatography with fluorescence detection. J Chromatogr. 1987;422:43-52.
8. Home DW, Patterson D. Lactobacillus casei assay of folic acid derivatives in 96-well microtiter plates. Clin Chem. 1988;34:2357-9.
9. Shin-Buering Y, Rasshofer R, Endres WA. A new enzymatic method for pyridoxal 5′-phosphate determination. J Inherit Metab Dis. 1981;4:123-4.
10. Brattstrom LA, Israelsson B, Norrving B, Bergqvist O, Thorne J, Hultberg B, et al. Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment. Atherosclerosis. 1990;81:51-60.
11. Franken DG, Boers GH, Blom HJ, Trijbels JM. Effect of various regimens of vitamin B6 and folic acid on mild hyperhomocystinemia in vascular patients. J Inherit Metab Dis. 1994;17:159-62.
12. Ubbink JB, van der Merwe A, Delport R, Allen RH, Stabler SP, Riezler R, et al. The effect of a subnormal vitamin B-6 status on homocysteine metabolism. J Clin Invest. 1996;98:177-84.
13. Selhub J, Miller JW. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr. 1992;55:131-8.
14. Miller JW, Nadeau MR, Smith J, Smith D, Selhub J. Folate-deficiency-induced homocysteinemia in rats: disruption of S-adenosylmethionine's coordinate regulation of homocysteine metabolism. Biochem J. 1994;298: 415-9.
15. Miller JW, Nadeau MR, Smith D, Selhub J. Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats. Am J Clin Nutr. 1994;59:1033-9.
16. Graham IM, Daly LE, Refsum HM, Robinson K, Brattström LE, Ueland PM, et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA. 1997;277:1775-81.